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白细胞计数的差别与冠心病事件的关系:对7个前瞻性研究中30374例患者的1764次事件的分析

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 29-29页

作者： Wheeler j.G. Mussolino M.E. Gillum R.F. danesh j. 郭宁 Dept. of Pub. Hl th. and Primary Care University of Cambridge Strangeways Site Wort’s Cswy. C. Cambridge United Kingdom

Aims We aimed to assess potentia l associations between different leucocyte components and coronary heart disease (CHD) in a prospective cohort study, and to put these findings in context of ot her relevant prospective studies in a meta analysis. Methods and results We rep ort data on differential leucocyte count and CHD derived from the first National Health and Nutrition Examination Survey (NHANES I) and the NHANES 1 Epidemiolog ic Follow up Study(NHEFS) involving 4625 individuals followed, on average, for 18 years. The NHEFS involved 914 incident CHD cases and yielded an adj.sted risk ratio of 1.09 (0.93-1.29) comparing individuals with neutrophil counts in the top third versus those in the bottom third of the population. In a meta analysi s involving the NHEFS and four other studies comprising a total of 1764 incident CHD cases, the association of CHD with neutrophil counts was somewhat stronger than those with other specific leucocyte components (combined risk ratio=1.33 [ 1 .17-1.50]) but there was substantial heterogeneity between the separate studie s (=18.0, p< 0.001). Conclusions Although the present synthesis provides the most comprehensive assessment so far of specific leucocyte components in CHD, additi onal prospective data will be needed to resolve whether neutrophil counts are mu ch stronger predictors of CHD risk than other components.

关键词：白细胞计数荟萃分析粒细胞计数国家健康中性粒细胞前瞻性队列研究随访研究风险预测特异性

冠心病中7个凝血基因的多态性:对66155例冠心病患者及91307例对照者的荟萃分析

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 8-9页

作者： Higgins j.P. j. danesh 马超 Department of Public Health and Primary Care University of Cambridge Strangeways Site Wort's Causeway Cambridge CB1 8RN United KingdomProf.

Background: Variants of certain haemostatic genes(such as that encoding factor V Leiden) are involved in the development of venous thrombosis, but studies of such variants in coronary disease have reported apparently conflicting results. We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls. Methods: Meta-analyses were done of 191 studies in relation to factor V G1691A(ie, factor V Leiden), factor VII G10976A, prothrombin G20210A, plasminogen activator inhibitor-1(PAI-1) [-675] 4G/5G, and three platelet glycoprotein(GP)receptor variants(GPIa C807T, GPIbα T[-5]C,GPIIIa C1565T), involving a total of 66 155 coronary disease cases and 91 307 controls. We explored potential sources of heterogeneity. Findings: In a combined analysis of all studies, the per-allele relative risks(RR) for coronary disease of factor V 1691A and of prothrombin 20210A were 1.17(95% CI 1.08-1.28) and 1.31(1.12-1.52), respectively. Combined analyses of studies of the PAI-1 [-675] 4G variant yielded a per-allele relative risk for coronary disease of 1.06(1.02-1.10), but there was an indication of publication bias in these studies. Combined analyses of the factor VII 10976A, GPIa 807T, GPIbα [-5]C, and GPIIIa 1565T variants showed no significant overall associations with coronary disease, yielding per-allele RRs of 0.97(0.91-1.04), 1.02(0.97-1.08), 1.05(0.96-1.13), and 1.03(0.98-1.07) , respectively. Interpretation: The 1691A variant of the factor V gene and the 20210A variant of the prothrombin gene, both of which increase circulating thrombin generation, might each be moderately associated with the risk of coronary disease. Further studies are merited to assess these associations in greater detail(including any gene-gene and gene-environment interactions) and to determine any implications with regard to potential therapies designed to reverse patients prothrombotic phenoty

关键词：凝血因子VII 基因的多态性冠心病患者荟萃分析纤溶酶原激活物抑制剂 G20210A 静脉血栓形成基因变异血小板糖蛋白

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 32-33页

作者： danesh-Meyer H. V. Gaskin B. j. j.yusundera T. 刘瑛(译) Department of Ophthalmology University of Auckland Auckland New Zealand 不详

Aim:To evaluate the relative diagnostic strength of cup to disc(C/D)ratio,clinical disc damage likelihood scale(DDLS),a new clinical method of documenting glaucomatous optic disc changes,and Heidelberg retina tomograph(HRT-II)in patients with glaucoma,glaucoma suspects,and normal ***:Consecutive observational case series.110 eyes from 110 patients categorised as glaucoma,glaucoma suspect,or normal were examined clinically to grade the DDLS ***-II examination was performed by an examiner masked to the clinical examination *** disc parameters and Moorfields regression analysis findings were *** of the optic disc were examined independently by two glaucoma specialists in masked fashion to determine the C/D *** SITA Standard 24-2 visual fields were obtained within 3 months of HRT-II and clinical *** each patient,the eye with the worse mean deviation of the visual field test was enrolled in the study,and each field was additionally graded by the four level Hodapp-Parrish-II-Anderson *** and sensitivity were calculated by receiver operating characteristic(ROC)***:Mean patient age was 58 years(SD 13.3)with 45 glaucoma patients,23 glaucoma suspects,and 42 *** mean deviation on Humphrey visual field assessment using SITA-Standard was-4.95 D(SD 5 D)Clinical examination using DDLS had the best predictive power with an area under the ROC curve value of 0.95 when glaucoma patients and suspects were separated from borderline or *** was followed by clinical examination of C/D ratio(0.84),and HRT-II Moorfields analysis(0.68).The order of diagnostic strength did not change when definite glaucoma was compared to borderline and ***:The DDLS grading performs well compared to C/D ratio and HRT-II *** to disc diameter and to rim width may increase the value of clinical optic disc examination.

关键词：临床诊断价值青光眼患者视盘损害断层摄影杯盘比视网膜 HRT-Ⅱ Anderson

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拟似缺血性视神经病变的成人浸润性胶质瘤

美国医学会眼科杂志（中文版） 2006年第1期18卷 40-45页

作者： Helen V. danesh-Meyer Peter j. Savino j.rij.R. Bilyk Robert C. Sergott 王静波（译）惠延年（校）

年龄大的患者出现急性发作的视力丧失、伴视盘水肿而无静脉充盈或视网膜出血，提示为前部缺血性视神经病变（AION）。在非动脉炎性AION，最具代表性的表现是视力下降在发作时最严重。然而，有一类AION患者，在最初的4周内视力呈进行性... 详细信息

年龄大的患者出现急性发作的视力丧失、伴视盘水肿而无静脉充盈或视网膜出血，提示为前部缺血性视神经病变（AION）。在非动脉炎性AION，最具代表性的表现是视力下降在发作时最严重。然而，有一类AION患者，在最初的4周内视力呈进行性下降’。在巨细胞性动脉炎，可因为AION或后部缺血性视神经病变而引起视力下降，后者没有视盘肿胀。这两种病情均可快速进展，甚至在数小时或数天内视力降至无光感。视神经的恶性或浸润性胶质瘤是一类最初可能与非动脉炎性或动脉炎性AION相混淆的病变，因为它们可具有视力变坏、

关键词：前部缺血性视神经病变浸润性胶质瘤巨细胞性动脉炎视力丧失 AION 成人视盘水肿视力下降视网膜出血急性发作

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

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World j.urnal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip j.Schulte Marij. Bogoj.vic Neha Deo Simon Zec Diana j.Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar j.hn C O'Horo j.an Pablo Domecq Allan j.Walkey Ognj.n Gaj.c Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adj.sted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adj.sted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

Assorted soliton structures of solutions for fractional nonlinear Schrodinger types evolution equations

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j.urnal of Ocean Engineering and Science 2022年第6期7卷 528-535页

作者： Md.Tarikul Islam Md.Ali Akbar j.F.Gómez-Aguilar E.Bonyah G.Fernandez-Anaya Department of Mathematics Hajee Mohammad Danesh Science and Technology UniversityDinajpurBangladesh Department of Applied Mathematics University of RajshahiRajshahiBangladesh CONACyT-Tecnológico Nacional de México/CENIDET.Interior Internado Palmira S/N Col.PalmiraC.P.62490CuernavacaMorelosMexico Department of Mathematics Education Akenten Appiah Menka University of Skills Training and Entrepreneurial DevelopmentKumasiGhana Departamento de Física y Matemáticas.Universidad Iberoamericana C.P.01219CDMXMexico

Fractional order nonlinear evolution equations have emerged in recent times as being very important model for depicting the interior behavior of nonlinear phenomena that exist in the real *** particular,Schrodinger-type fractional nonlinear evolution equations constitute an aspect of the field of quantum *** this study,the(2+1)-dimensional time-fractional nonlinear Schrodinger equation and(1+1)-dimensional time-space fractional nonlinear Schrodinger equation are revealed as having different and novel wave *** is shown by constructing appropriate analytic wave solutions.A success-ful implementation of the advised rational(1/φ'(ξ))-expansion method generates new outcomes of the considered equations,by comparing them with those already noted in the *** the basis of the conformable fractional derivative,a composite wave variable conversion has been used to adapt the suggested equations into the differential equations with a single independent variable before applying the ***,the well-furnished outcomes are plotted in different 3D and 2D profiles for the purpose of illustrating various physical characteristics of wave *** employed technique is competent,productive and concise enough,making it feasible for future studies.

关键词： The rational(1/φ'(ξ))-expansion method Wave variable transformation Nonlinear fractional Schrodinger equation Analytic solution Soliton

新型冠状病毒肺炎大流行对英国心血管病服务的间接影响

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中华高血压杂志 2021年第1期29卷 61-61页

作者：刘青练桂丽 Ball S Banerj.e A Berry C Boyle j. Bray B Bradlow W Chaudhry A Crawley R danesh j.Denniston A Falter F Figueroa j. Hall C Hemingway H j.fferson E j.hnson T King G Lee KK McKean P Mason S Mills NL Pearson E Pirmohamed M Poon MTC Priedon R Shah A Sofat R Sterne j.C Strachan FE Sudlow CLM Szarka Z Whiteley W Wyatt M CVD-COVID-UK Consortium

监测新型冠状病毒肺炎(coronavirus disease,COVID)-19大流行期间医院心血管病的表现、诊断和治,以了解COVID-19的间接影响。方法:采用2019年10月28日(COVID-19之前)至2020年5月10日(解除禁闭前)以及2018-2019年同一时间的医院活动数据,... 详细信息

监测新型冠状病毒肺炎(coronavirus disease,COVID)-19大流行期间医院心血管病的表现、诊断和治,以了解COVID-19的间接影响。方法:采用2019年10月28日(COVID-19之前)至2020年5月10日(解除禁闭前)以及2018-2019年同一时间的医院活动数据,对9家英国医院进行回顾性系列横断面研究。研究者分析了流行前和流行期间选定的心血管病的总体数据,并开发了一个在线可视化工具,可以近乎实时地监测变化趋势。结果:在9家医院中,禁闭后(2020年3月23日)的总住院人数和急诊科就诊人数较上年分别下降57.9%(57.1%~58.6%)和52.9%(52.2%~53.5%)。

关键词：就诊人数住院人数心血管病新型冠状病毒急诊科横断面研究肺炎流行期间

胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系

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中华高血压杂志 2017年第9期25卷 899-899页

作者： Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Nataraj.n P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson j. Bown Mj.Hall AS Braund PS Carey Dj.Murray MF Kirchner HL Leader j. Lavage DR Manus j. Hartze DN Samani Nj.Schunkert H Marrugat j.Elosua R McPherson R Farrall M Watkins H j.ang j. Hsiung CA Lin SY Wang j. Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter j. Lander ES Rader Dj.danesh j.Ardissino D Gabriel S Willer Cj.Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉叶鹏

随机对照试验结果表明,抑制胆固醇酯转运蛋白（cholesteryl ester transfer protein,CETP）的疗法并不能降低冠状动脉性心脏病（coronary heart disease,CHD）的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应... 详细信息

随机对照试验结果表明,抑制胆固醇酯转运蛋白（cholesteryl ester transfer protein,CETP）的疗法并不能降低冠状动脉性心脏病（coronary heart disease,CHD）的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。

关键词：冠状动脉性心脏病胆固醇酯转运蛋白蛋白基因发生风险蛋白质截断变异体随机对照试验 protein