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Platelet count and sustained virological response in hepatitis C treatment

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World Journal of Hepatology 2013年第4期5卷 182-188页

作者： Tatsuo Kanda Keizo Kato Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura daisuke Maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Narita Red Cross HospitalNarita 286-8523Japan Institute of Clinical Medicine and Research Jikei University School of MedicineKashiwa 277-8567Japan Department of Gastroenterology Toho University Sakura Medical CenterSakura 285-8741Japan Department of Gastroenterology Tokyo Women's Medical University Yachiyo Medical CenterYachiyo 276-8524Japan Department of Medicine Kikkoman HospitalNoda 270-0116Japan

AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis ***:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were *** examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological *** RNA was measured by the COBAS TaqMan HCV ***:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,*** logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced *** rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL ***,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL ***:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients.

关键词： Anemia Antiviral treatment Chronic hepatitis C Platelet count Sustained virological response

The Association between Activity of Daily Living and the Combination of Alzheimer’s Disease and Cataract in Elderly Requiring Nursing Care

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Health 2016年第10期8卷 994-1003页

作者： Toshio Hamagishi Toshimitsu Inagawa Yasuhiro Kambayashi Hiromasa Tsujiguchi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko Suzuki daisuke Hori Enoch Olando Anyenda Nguyen Thi Thu Thao Yuri Hibino Koichi Hayashi Aki Shibata Takiko Sagara Jiro Okochi Kiyoshi Takamoku Kotaro Hatta Tadashi Konoshita Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Department of Food Sciences and Nutrition School of Human Environmental Sciences Mukogawa Women’s University Hyogo Japan Department of Lifestyle Studies Kobe Shoin Women’s University Hyogo Japan Department of Nutritional Sciences for Well-Being Kansai University of Welfare Sciences Osaka Japan Japan Association of Geriatric Health Service Facilities Tokyo Japan Department of Psychiatry Juntendo University Nerima Hospital Tokyo Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

Some clinical and epidemiological studies have suggested that Alzheimer’s Disease (AD) and cataract, may share common pathogenetic mechanisms, subsequently a positive association between the prevalence of AD and cataract, although other studies found no significant relationship between dementia and visual impairment including cataract in the elderly. Little is known about the association between Activity of Daily Living (ADL) and the combination of AD and cataract. To examine the association between ADL and the combination of AD and cataract, we performed a national survey in nursing care institutions in Japan, examining the decreased ADL in elderly with and without AD and cataract for 453 elderly aged 85.0 ± 8.13 years. The proportion, 43.5% of AD in subjects without cataract was significantly higher than that, 23.5% with cataract. Almost all ADL in AD with cataract was significantly lower than that without cataract, although all ADL in cataract patients receiving surgery in AD was significantly (all p < 0.002) higher than that in cataract patients without surgery in AD, as was confirmed by the multiple regression analysis incorporating into the relevant factors as independent variables. These results showed that ADL scores including cognitive functions decreased by cataract were increased by the surgery in the patients with AD. A significantly negative association between AD and cataract seen in our data, which was inconsistent with the previous result, might lead to the necessities of the clinical diagnosis for slight severity of cataract for patients with AD.

关键词： Alzheimer’s Disease Cataract Elderly Activity of Daily Living Cognitive Function

Perforation of the duodenum during the retrograde cholangiopancreatography treated without surgery

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Focal fatty change in the liver that developed after cholecystectomy

Case Reports in Clinical Medicine（临床医学病理报告） 2012年第2期

作者： Akira Tsuji daisuke Hashimoto Tetsu Ozaki Akira Chikamoto Toru Beppu Hideo Baba

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World Journal of Radiology 2014年第12期6卷 932-936页

作者： Akinobu Osame Toshimichi Mitsufuji Shinichi Kora Kengo Yoshimitsu daisuke Morihara Hideo Kunimoto Department of Radiology Faculty of Medicine Fukuoka University Department of Gastroenterology Faculty of Medicine Fukuoka University

Focal fatty change of the segment IV of the liver has been attributed to local systemic venous inflow replacing the portal venous supply, which could develop or be accentuated after gastrectomy. However, focal fatty change due to aberrant pancreaticoduodenal vein that developed after cholecystectomy has never been reported. We report a 30-year-old man with such a rare lesion, which was initially misdiagnosed as a hepatocellular carcinoma, but was confirmed on computed tomography during selective gastroduodenal arteriography. The lesion disappeared 12 mo later without any intervention.

关键词： Focal fatty liver Cholecystectomy Aberrant venous inflow

线粒体DNA分析揭示北山羊新疆种群（Capra sibirica）具有不同的支系

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线粒体DNA分析揭示北山羊新疆种群（Capra sibirica）具有不同的...

各种引气剂以及抑泡剂对混凝土经时变化状态等的影响

第十六届全国野生动物生态与资源保护学术研讨会

作者：王蕊蕊董培培 daisuke Hirata 夏米西丁·阿不都热依木石河子大学生命科学学院圣彼得堡彼得大帝理工大学北京大学生命科学学院石河子大学绿洲城镇与山盆系统生态兵团重点实验室

线粒体DNA有助于揭示许多分类群的系统发育关系和分化时间。北山羊(Capra sibirica)是典型的高山动物,为山羊属的残遗种,其亚种分类一直存在争议。本文分析来自我国新疆58个北山羊样本的mtDNA基因,以揭示北山羊种群内亲缘关系及其分化... 详细信息

线粒体DNA有助于揭示许多分类群的系统发育关系和分化时间。北山羊(Capra sibirica)是典型的高山动物,为山羊属的残遗种,其亚种分类一直存在争议。本文分析来自我国新疆58个北山羊样本的mtDNA基因,以揭示北山羊种群内亲缘关系及其分化时间。系统发育关系和单倍型网格图的结果表明,北山羊的mtDNA序列分为两个谱系:由新疆乌恰县和叶城县及印度和塔吉克斯坦的样本组成的南方谱系,与捻角山羊(Capra falconeri)的亲缘关系较近;北方谱系根据其地理起源进一步分为四个单系,即分支A-D,其中来自乌鲁木齐市、沙湾县和伊吾县的样本形成了一个单系分支C。北山羊各分支间(A-E)的遗传距离为3.0%-8.6%,FST值为0.839-0.960,表明北山羊各分支间存在显著的遗传分化。山羊属物种之间的分化发生在中新世晚期(约6.75 Mya)。北方谱系在5.88 Mya左右发生分化,随后在上新世晚期和更新世早期(3.30 Mya-1.92 Mya)分支A-D发生分化。南方谱系和Capra falconeri之间的分化发生在更新世早期(2.29 Mya)。本研究结果强调广泛采样在高山哺乳动物遗传研究中的重要性,并呼吁进一步的基因组研究得出明确结论。

关键词：北山羊 mtDNA 种内关系分化时间

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混凝土 2009年第3期 70-72页

作者：绿川雅之三敏铃木大介翟汉昭山宗化学上海华耕化工科技有限公司上海200233

众所周知,采用粉煤灰制备混凝土,因粉煤灰成分中含有未燃炭等微粒子,容易造成阴离子型引气剂吸附在这些微粒子上,导致含气量经时损失。同时在混凝土的制备、运输过程中,因受采用的材料、拌和状态等物理因素影响,还会发生含气量经时增加... 详细信息

众所周知,采用粉煤灰制备混凝土,因粉煤灰成分中含有未燃炭等微粒子,容易造成阴离子型引气剂吸附在这些微粒子上,导致含气量经时损失。同时在混凝土的制备、运输过程中,因受采用的材料、拌和状态等物理因素影响,还会发生含气量经时增加的现象。所以在制备、管理混凝土时,如何保证出机初期一定的含气量、缓解含气量的经时损失或经时增加,是一项极其关键的技术。本文将就采用能改善上述状态的引气剂、抑泡剂拌和混凝土,对混凝土的经时变化以及抗冻融性等特征产生的影响进行论述。

关键词：引气剂抑泡剂含气量粉煤灰经时变化抗冻融性

真鲷饵料生物褶皱臂尾轮虫和眼点拟微绿藻的大量培养

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海洋科学 2000年第5期24卷 47-51页

作者：刘新富雷霁霖刘忠强柳学周中国水产科学研究院黄海水产研究所青岛266071

于1992～1994年 ,在中国水科院黄海水产研究所小麦岛试验基地(青岛)进行的“中日合作真鲷增殖放流项目”执行期间 ,对真鲷饵料生物———眼点拟微绿藻 (Nannochloropsisoculata)和L型褶皱臂尾轮虫 (Branchionus plicatilis)进行了大量... 详细信息

于1992～1994年 ,在中国水科院黄海水产研究所小麦岛试验基地(青岛)进行的“中日合作真鲷增殖放流项目”执行期间 ,对真鲷饵料生物———眼点拟微绿藻 (Nannochloropsisoculata)和L型褶皱臂尾轮虫 (Branchionus plicatilis)进行了大量培养。眼点拟微绿藻的平均接种密度为1211.3×104个/ml,经5～6d的室内或室外露天培养即可达到平均为2341.0×104 个/ml的收获密度 ;采用眼点拟微绿藻和新鲜面包酵母作为混合饵料 ;褶皱臂尾轮虫 (L型 )培养3～4d即可由接种时平均密度148.0个/ml,增长至平均216.8个/ml的采收密度。眼点拟微绿藻和轮虫的日间增殖密度分别是12.8 %和26.6 %。每生产108个褶皱臂尾轮虫需要消耗0.73m3眼点拟微绿藻 (密度为2000×104/ml)和790.8g 鲜面包酵母。采用此法 ,作者连续3a成功地为每年百万尾以上真鲷苗种提供了足够的生物饵料。总结3a苗种培育和生物饵料培养之间的关系 ,作者认为 ,大规模稳定生产海水鱼类苗种时,育苗与饵料生物培养 (褶皱臂尾轮虫和眼点拟微绿藻 )水体的合理比例应为1∶1～1.5∶3。

关键词：铒料生物褶皱臂尾轮虫眼点拟微绿球藻真鲷

利用仿真的停车距离分布倾向评价防滑系统的性能

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国外铁道机车与动车 2020年第6期 9-14页

作者： [日]土方大輔彭惠民(译者) 刘景宝(校者) 不详

为评价车轮防滑(WSP)性能,采用一种特定黏着条件的仿真方法。该方法可独立地设定难以在轨道试验中再现的黏着条件,可显著减少轨道试验的次数,从而降低试验成本和劳动力。为了提高仿真法的性能评价可信度,设计了一种利用停车距离分布规... 详细信息

为评价车轮防滑(WSP)性能,采用一种特定黏着条件的仿真方法。该方法可独立地设定难以在轨道试验中再现的黏着条件,可显著减少轨道试验的次数,从而降低试验成本和劳动力。为了提高仿真法的性能评价可信度,设计了一种利用停车距离分布规律进行评价的方法。

关键词：滑行控制仿真性能评价轮轨间黏着

The Effect of Bioturbation Activity of the Ark Clam Scapharca subcrenata on the Fluxes of Nutrient Exchange at the Sediment–Water Interface

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