Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

作     者：Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno 

作者机构：Division of Genome BiologyNational Cancer Center Research InstituteTokyoJapan Department of Clinical GenomicsNational Cancer Center Research InstituteTokyoJapan Laboratory for Statistical AnalysisCenter for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic MedicineResearch InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping DevelopmentCenter for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine TherapyResearch HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Centerand Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and DevelopmentNational Cancer Center Research InstituteTokyoJapan Center for Genomic MedicineGraduate School of MedicineKyoto UniversityKyotoJapan Department of Medical OncologyJapanese Red Cross Medical CenterTokyoJapan Department of Thoracic OncologyNational Cancer Center Hospital EastJapan Department of Thoracic OncologyNational Cancer Center HospitalTokyoJapan Department of Cellular and Organ PathologyGraduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory MedicineTokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic SurgeryDepartment of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical ScienceDivision of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract SurgeryFukushima Medical University School of MedicineFukushimaJapan StaGen Co.LtdTokyoJapan Division of Thoracic SurgeryNational Cancer Center HospitalTokyoJapan Department of Thoracic SurgeryNational Cancer Center Hospital EastChibaJapan Division of Translational InformaticsExploratory Oncology Research and Clinical Trial Center(EPOC)National Cancer CenterChibaJapan Department of Thoracic SurgeryTokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Molecular Pathology and Genetics DivisionKanagawa Cancer Center Research InstituteKanagawaJapan Department of Chest SurgeryFukushima Medical University School of MedicineFukushimaJapan Fundamental Innovative Oncology Core CenterNational Cancer Center Research InstituteTokyoJapan Department of Genetic Medicine and ServicesNational Cancer Center HospitalTokyoJapan Division of EpidemiologyNational Cancer Center Institute for Cancer ControlTokyoJapan Department of Thoracic SurgeryKyoto University HospitalKyotoJapan Departments of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Second Department of SurgeryUniversity of Occupational and Environmental HealthKitakyushuJapan Department of Pathology and Molecular DiagnosticsAichi Cancer CenterNagoyaJapan Department of Preventive MedicineFaculty of MedicineSaga UniversitySagaJapan Tohoku Medical Megabank OrganizationTohoku UniversitySendaiJapan Iwate Tohoku Medical Megabank OrganizationIwate Medical UniversityIwateJapan Department of Diagnostic PathologyNational Cancer Center HospitalTokyoJapan Department of Preventive MedicineNagoya University Graduate School of MedicineNagoyaJapan Division of Thoracic SurgeryDepartment of SurgeryKeio University School of MedicineTokyoJapan Division of Cancer Information and ControlAichi Cancer Center Research InstituteNagoyaJapan Department of Thoracic SurgeryKanagawa Cancer CenterKanagawaJapan Department of PathologyKanagawa Cancer CenterYokohamaJapan Department of Thoracic SurgeryGraduate School of MedicineAkita UniversityAkitaJapan Division of Cohort ResearchNational Cancer Center Institute for Cancer ControlTokyoJapan Laboratory of Clinical Genome SequencingDepartment of Computational Biology and Medical ScienceGraduate School of Frontier SciencesThe University of TokyoTokyoJapan Department of Molecular CytogeneticsMedical Research Institute and Bioresource Research CenterTokyo Medical and Dental UniversityTokyoJapan Division of Genome Analysis Platform DevelopmentNational Cancer Center Research InstituteTokyoJapan Division of Cancer ImmunologyResearch InstituteNational Cancer CenterTokyoJapan Division of Molecular PathologyInstitute of Medical ScienceThe University of TokyoTokyoJapan Division of Molecular and Clinical EpidemiologyAichi Cancer Center Research InstituteNagoyaJapan 

出 版 物：《Cancer Communications》 (癌症通讯（英文）)

年 卷 期：2024年第44卷第2期

页      面：287-293页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This research was supported in part by the Japan Agency for Medical Research and Development(AMED)(JP15ck0106096 to TK) Japan Science and Tech-nology Agency(JST)Core Research for Evolutionary Science and Technology(JPMJCR1689 to RH) Artifi-cial Intelligence,Big Data,IoT,Cyber Security Integration Project of the Public/Private R&D Investment Strategic Expansion Program(JPMJCR18Y4 to RH) the Japan Soci-ety for the Promotion of Science(JSPS)Grant-in-Aid for Scientific Research(S)(17H06162 to HN),Grant-in-Aid for Scientific Research(B)(20H03695 to KS),Grants-in-Aid for the Tailor-Made Medical Treatment Program(BioBank Japan Project)from the Japanese Ministry of Education,Culture,Sports,ScienceandTechnology(MEXT),Princess Takamatsu Cancer Research Fund,and National Cancer Center Research and Development Fund(NCC Biobank and NCC Core Facility).The J-MICC study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer(No.17015018 to KW) Innovative Areas(No.221S0001 to KW)from MEXT by JSPS Grant-in-Aid for Scientific Research Grant(No.16H06277[CoBiA]) The JPHC Study was supported by National Cancer Center Research and Development Fund since 2011(latest grant number:2020-J4)and a Grant-in-Aid for Cancer Research from the Ministry of Health,Labor and Welfare of Japan(1989-2010).ToMMoissupportedinpartbyMEXT-JSTand AMED(most recent grant numbers:JP20km0105001 and JP20km0105002) Iwate Tohoku Medical Megabank Orga-nization(Iwate Medical University)is supported in part by MEXT-JST and AMED(most recent grant numbers:JP20km0105003 and JP20km0105004) 

主　　题：adenocarcinoma lung Lung 

摘      要：Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.