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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： dae-hwan kim Chunyan Ren Chongsuk Ryou Jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of Undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of Pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

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Identifying the relationships between subsurface absorber defects and the characteristics of kesterite solar cells

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Carbon Energy 2023年第8期5卷 42-54页

作者： dae-Ho Son Dong-hwan Jeon dae-hwan kim Jin-Kyu Kang Shi-Joon Sung Jaebaek Lee Taeseon Lee Enkhjargal Enkhbayar JunHo kim Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea

Understanding the defect characteristics that occur near the space-charge regions(SCRs)of kesterite(CZTSSe)solar cells is important because the recombination loss at the CZTSSe/CdS interface is considered the main cause of their low *** surfaces with different elemental compositions were formed without polishing(C00)and with polishing for 20 s(C20)and 60 s(C60).For C60,a specific region near the SCR was excessively Cu-rich and Zn-poor compared to C00 and *** charged defects formed where the elemental variation was *** the main deep acceptor defect energy level(E_(a2))near the SCR increased,the efficiency,open-circuit voltage deficit,and current density degraded,and this phenomenon was especially rapid for large E_(a2) *** the E_(a2) near the SCR became deep,the carrier diffusion length decreased more for the CZTSSe solar cells with a low carrier mobility than for the CuInGaSe_(2)(CIGSe)solar *** large amplitude of the electrostatic potential fluctuation in the CZTSSe solar cells induced a high carrier recombination and a short carrier ***,the properties of the CZTSSe solar cells were more strongly degraded by defects with deep energy levels near the SCR than those of the CIGSe solar cells.

关键词： defect density defect energy level elemental variation kesterite space charge region

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Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells

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World Journal of Gastroenterology 2009年第3期15卷 310-320页

作者： Chan Woo Cheon dae hwan kim Dong Heon kim Yong Hoon Cho Jae Hun kim Department of Surgery School of MedicineMedical Research InstitutePusan National UniversityBusan 602-739South Korea

AIM:To determine the cytological and molecular effects of peroxisome proliferation-activated receptor(PPAR)-γ and PPAR-γ agonists on stomach cancer ***:To determine the proliferation-suppressive effects of troglitazone and ciglitazone,SNU-216 and SNU-668 stomach cancer cells were plated in media containing 40 μmol/L troglitazone and ciglitazone at a density of 1 × 104 cells/*** 3,5 and 7 d,the cells were counted with a *** assess the appearance of PPAR-γ,a reverse-transcription polymerase chain reaction analysis was *** day 7,Western blotting was used to determine the effects of troglitazone and ciglitazone on the expression of p21 and phosphorylated-ERK(pERK) *** cytometry analysis was used to determine which portion of the cell cycle was delayed when troglitazone was used to suppress cell *** order to clarify the mechanism underlying the activity of troglitazone,microarray analysis was ***:PPAR-γ was manifested in both SNU-216 and SNU-668 *** and troglitazone suppressed cell growth,and troglitazone was a stronger suppressor of stomach cancer cells than ciglitazone,an inducer of cell cycle arrest in the G1 ***-668 cells were also determined to be more sensitive to ciglitazone and troglitazone than SNU-216 *** troglitazone and ciglitazone were administered to stomach cancer cells,levels of p21 expression were increased,but ERK phosphorylation levels were *** GW9662,an antagonist of PPAR-γ,was applied in conjunction with ciglitazone and troglitazone,the cell growth suppression effect was *** gene transcription program revealed a variety of alterations as the consequence of troglitazone treatment,and multiple troglitazone-associated pathways were *** genes whose expression was increased by troglitazone treatment were associated with cell development,differentiation,signal transmission between cells,and cell adhesion,and were also associated

关键词： Peroxisome proliferating-activated receptor-γ Ciglitazone Troglitazone Stomach cancer cells

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Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： dae-Ho Son Ha Kyung Park dae-hwan kim Jin-Kyu Kang Shi-Joon Sung dae-Kue hwang Jaebaek Lee Dong-hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo kim Sang-Hoon Nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

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Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2) Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun Yoo Hoang Van Quy Inpyo Lee Seung Taek Jo Tae Ei Hong JunHo kim dae-hwang Yoo Jinwook Shin Walter Commerell dae-hwan kim Jong Wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

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Is it possible to differentiate gastric GISTs from gastric leiomyomas by EUS?

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World Journal of Gastroenterology 2009年第27期15卷 3376-3381页

作者： Gwang Ha kim Do Youn Park Suk kim dae hwan kim Dong Heon kim Cheol Woong Choi Jeong Heo Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute Pusan National University HospitalBusan 602-739 South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739 South Korea Department of Radiology Pusan National University School of MedicineBusan 602-739 South Korea Department of Surgery Pusan National University School of MedicineBusan 602-739South Korea

AIM: To evaluate the ultrasonog raphy (EUS) features of gastric gastrointestinal stromal tumors (GISTs) as compared with gastric leiomyomas and then to determine the EUS features that could predict malignant ***: We evaluated the endoscopic EUS features in 53 patients with gastric mesenchymal tumors conf irmed by histopathologic diagnosis. The GISTs were classif ied into benign and malignant groups according to the histological risk classif ***: Immunohistochemical analyses demon-strated 7 leiomyomas and 46 GISTs. Inhomogenicity, hyperechogenic spots, a marginal halo and higher echogenicity as compared with the surrounding muscle layer appeared more frequently in the GISTs than in the leiomyomas (P < 0.05). The presence of at least two of these four features had a sensitivity of 89.1% and a specifi city of 85.7% for predicting GISTs. Except for tumor size and irregularity of the border, most of the EUS features were not helpful for predicting the malignant potential of GISTs. On multivariate analysis, only the maximal diameter of the GISTs was an independent predictor. The optimal size for predicting malignant GISTs was 35 mm. The sensitivity and specificity using this value were 92.3% and 78.8%, ***: EUS may help to differentiate gastric GISTs from gastric leiomyomas. Once GISTs are suspected, surgery should be considered if the size is greater than 3.5 cm.

关键词： Endoscopic ultrasonography, Gastrointestinal stromal tumor Stomach

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Flammable carbon nanotube transistors on a nitrocellulose paper substrate for transient electronics

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Nano Research 2017年第1期10卷 87-96页

作者： Jinsu Yoon Juhee Lee Bongsik Choi Dongil Lee dae hwan kim Dong Myong kim Dong-II Moon Meehyun Lim Sungho kim Sung-Jin Choi School of Electrical Engineering Kookmin University Seou102707 Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 3414 I Republic of Korea Center for Nanotechnology NASA Ames Research Center Moffett Field CA 94035 USA Test&Package Technology Group Mechatronics R&D Center Samsung Electronics Gyeonggi-do 18448 Repubfic of Korea Department of Electrical Engineering Sejong University Seou105006 Republic of Korea

Transient electronics represent an emerging class of technology comprising materials that can vanish in a controlled manner in response to stimuli. In contrast to conventional electronic devices that are designed to operate over the longest possible period, transient electronics are defined by operation typically over a short and well-defined period; when no longer needed, transient electronics undergo self-deconstruction and disappear completely. In this work, we demonstrate the fabrication of thermally triggered transient electronic devices based on a paper substrate, specifically, a nitrocellulose paper. Nitrocellulose paper is frequently used in acts of magic because it consists of highly flammable components that are formed by nitratil^g cellulose by exposure to nitric acid. Therefore, a complete and rapid destruction of electronic devices fabricated on nitrocellulose paper is possible without producing any residue （i.e., ash）. The transience rates can be modified by controlling radio frequency signal-induced voltages that are applied to a silver （Ag） resistive heater, which is stamped on the backside of the nitrocellulose paper. The Ag resistive heater was prepared by a simple, low-cost stamping fabrication, which requires no harsh chemicals or complex thermal treatments. For the electronics on the nitrocellulose paper substrate, we employed semiconducting carbon nanotube （CNT） network channels in the transistor for superior electrical and mechanical properties.

关键词： carbon nanotube,paper substrate,flammable,transient security

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Intracorporeal esophagojejunostomy using the double stapling technique after laparoscopic total gastrectomy:A retrospective case-series study

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World Journal of Gastroenterology 2015年第10期21卷 2973-2981页

作者： Jae Hun kim Chang In Choi Dong Il kim dae hwan kim Tae Yong Jeon Dong Heon kim Do Youn Park Department of Surgery Pusan National University Hospital 2nd Bio Medical Research Institute Pusan National University Hospital Department of Pathology Pusan National University Hospital

AIM:To introduce a simple and safe anvil insertion technique to esophagus during laparoscopic total gastrectomy(LTG).METHODS:Between July 2010 and December 2012,58 consecutive patients with early gastric cancer underwent LTG were *** performed a simple and safe Roux-en-Y esophagojejunostomy using the double stapling technique to all *** patients’characteristics,perioperative outcome and histopathologic data were analyzed ***:The mean age and body mass index were59.3±9.7 years and 22.7±2.6 kg/*** mean operation,reconstruction and anvil insertion times(from gastric incision to linear stapling)were 251.8±57.0,43.1±2.8 and 4.2±1.9 min,*** blood loss was 204.6±156.3 m L and there was no open *** postoperative complications were in 8 cases(delayed gastric emptying in 4 cases,pulmonary complication in 2cases,pancreatitis in 1 case,anastomotic stricture in 1case).Anastomotic stricture occurred after discharge and was recovered by endoscopic *** patients were discharged at a mean of 9.6±2.0 d after *** leakage nor bleeding from the esophagojejunostomy occurred *** mean proximal margin of specimen was 2.7±2.8 cm CONCLUSION:Roux-en Y esophagojejunostomy usingthe double stapling technique is simple and rapid,and it may offer a solid,alternative reconstruction method for LTG or proximal gastrectomy.

关键词： Laparoscopic surgery Surgical stapling Roux-en-Y a

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Solitary Peutz-Jeghers-type appendiceal hamartomatous polyp growing into the terminal ileum

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World Journal of Gastroenterology 2014年第16期20卷 4822-4826页

作者： Chang In Choi dae hwan kim Tae Yong Jeon Dong Heon kim Na Ri Shin Do Youn Park Department of Surgery Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea Department of Pathology Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea

Solitary Peutz-Jeghers type hamartomatous polyp is *** is considered to be related to a variant PeutzJeghers syndrome(PJS)and may be a separate disease entity.A 50-year-old man was referred to our hospital with a diagnosis of intussusception in the terminal ileum and underwent segmental ileal resection with *** identified a 3.5-cm diameter polyp arising from the appendix with ingrowth into the terminal *** polyp was confirmed to be a hamartomatous polyp of Peutz-Jeghers-type,***,the patient had no characteristic manifestations of PJS such as mucocutaneous pigmentation and family *** are few reports of appendiceal hamartomatous polyp in PJS patients and solitary appendiceal hamartomatous polyp is even ***,rather than telescoping,ours is the first reported intussuscepted lesion,to the best of our knowledge.

关键词： Peutz-Jeghers syndrome Hamartomatous intestinal polyposis Neoplasms Intussusception Intestinal obstruction

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Flexible kesterite thin-film solar cells under stress

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npj Flexible Electronics 2022年第1期6卷 863-870页

作者： Ha Kyung Park Yunae Cho Juran kim Sammi kim Sungjun kim Jeha kim Kee-Jeong Yang dae-hwan kim Jin-Kyu Kang William Jo Department of Physics Ewha Womans UniversitySeoul 03760Republic of Korea Division of Energy Technology Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Solar&Energy Engineering Cheongju UniversityCheongju 28503Republic of Korea

Understanding the stress-induced phenomena is essential for improving the long-term application of flexible solar cells to non-flat ***,we investigated the electronic band structure and carrier transport mechanism of Cu2ZnSn(S,Se)4(CZTSSe)photovoltaic devices under mechanical *** efficient flexible CZTSSe devices were fabricated controlling the Na *** electronic structure of CZTSSe was deformed with stress as the band gap,valence band edge,and work function *** properties of the bent CZTSSe surface were probed by Kelvin probe force microscopy and the CZTSSe with Na showed less degraded carrier transport compared to the CZTSSe without *** local open-circuit voltage(VOC)on the bent CZTSSe surface decreased due to limited carrier *** reduction of local VOC occurred larger with convex bending than in concave bending,which is consistent with the degradation of device *** study paves the way for understanding the stress-induced optoelectronic changes in flexible photovoltaic devices.

关键词： optoelectronic stress bending

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