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二次脑创伤对鼠脑EAA、TXA2及PGI2代谢的影响及意义

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二次脑创伤对鼠脑EAA、TXA2及PGI2代谢的影响及意义

The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：费舟章翔易声禹 I.R.Piper d.thomson J.d.Miller 第四军医大学西京医院神经外科英国爱丁堡大学临床神经科学研究所

目的是探讨合并二次脑创伤如低血压或高热时鼠脑海马细胞外液兴奋性氨基酸(EAA)与皮层血栓素A(TXA)、前列环素(PGI)含量变化及意义。在大鼠加速性弥漫性脑损伤模型基础上,造成低血压及高热形成二次脑创伤,32只Sd大鼠随机分为假手术对照... 详细信息

目的是探讨合并二次脑创伤如低血压或高热时鼠脑海马细胞外液兴奋性氨基酸(EAA)与皮层血栓素A(TXA)、前列环素(PGI)含量变化及意义。在大鼠加速性弥漫性脑损伤模型基础上,造成低血压及高热形成二次脑创伤,32只Sd大鼠随机分为假手术对照、脑损伤、二次脑创伤及脑损伤并二次脑创伤4组。在二次创伤后1h检测EAA含量,4h断头处死大鼠检测TXA与PGI含量。结果:与假手术组对比,单纯二次脑创伤组有EAA及PGI含量增高(P<0.05);合并二次脑创伤组EAA、TXA及PGI含量均显著增高(P<0.05)。结论:单纯二次脑创伤组PGI这个脑保护剂含量增加,可能与参予脑损伤修复有关。在合并二次脑创伤组,EAA、TXA及PGI含量均增高提示其参予加重原发性脑损伤。

关键词：脑损伤兴奋性氨基酸血栓素A2 前列环素低血压高热

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Animal Models and Experimental Medicine 2024年第2期7卷 145-155页

作者： Yingfang Fan Jean Yuh Sashank Lekkala Mehmet d.Asik Andrew thomson Madeline McCanne Mark A.Randolph Antonia F.Chen Ebru Oral Harris Orthopaedic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA department of Orthopaedic Surgery Harvard Medical SchoolBostonMassachusettsUSA department of Surgery Harvard Medical SchoolBostonMassachusettsUSA department of Orthopaedic Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin di Pan Yanting Li Liang Su Robert thomson Koji Mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** deepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and direct Linear Transformation(dLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB deepSORT Social-LSTM

Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target

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中华医学杂志(英文版) 2024年第14期137卷 1663-1673页

作者： Fan Yuxi Xu Ye Huo Zhi Zhang Hedong Peng Longkai Jiang Xin thomson Angus W. dai Helong department of Immunology School of Basic Medical Science Central South University Changsha Hunan China department of Kidney Transplantation Center of Organ Transplantation The Second Xiangya Hospital of Central South University Changsha Hunan China Medical College of Guangxi University Nanning Guangxi China department of Organ Transplantation The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People’s Hospital) Zhengzhou Henan China department of Surgery Thomas E. Starzl Transplantation Institute University of Pittsburgh School of Medicine Pittsburgh PA USA

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.

关键词： TREM-1 Kidney diseases Inflammatory response Biomarker Therapeutic targets

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音-义连接经验对自然拼读教学法效果的影响

心理发展与教育 2024年 368-376页

作者：姜莹盖笑松 Jenny thomson 东北师范大学心理学院吉林省普通高等学校人文社会科学重点研究基地东北师范大学心理健康教育研究中心谢菲尔德大学人类语言交际科学学院

非英语母语国家的英语语音教学中，越来越多引入了英语母语国家的自然拼读教学法。然而，缺乏先前音-义连接经验的非英语母语者能否从这种形-音对应训练中同等获益呢?为了检验非英语母语者中音-义连接经验对拼读教学法效果的影响，以12... 详细信息

非英语母语国家的英语语音教学中，越来越多引入了英语母语国家的自然拼读教学法。然而，缺乏先前音-义连接经验的非英语母语者能否从这种形-音对应训练中同等获益呢?为了检验非英语母语者中音-义连接经验对拼读教学法效果的影响，以120名四年级小学生为被试，采用单因素三水平(前置音-义连接训练组作为实验组，前置首音辨别训练组作为积极对照组，无前置训练组作为消极对照组)被试间实验设计，考查了拼读法训练效果。结果发现，在前置训练中建立起单词音-义连接的儿童从随后的拼读法训练中受益更多，表现出更强的单词拼读能力，并且在新词材料中表现出了近迁移效应。该结果提示在汉语母语者中引进自然拼读教学法的局限性以及解决思路。

关键词：拼读教学法语音意识音-义连接单词拼读外语教学

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez dan Bhwana thomson Lakwo Gasim Abd-Elfarag Sebastien d.Pion Global Health Institute University of AntwerpAntwerpBelgium department of Neurology Heilig Hart ZiekenhuisLierBelgium department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(dZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious disease Analysis and London Centre for Neglected Tropicaldisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text during the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG KE LI BHARAT PANT MARTIN EBERT XINGZHAO YAN MEHdI BANAKAR dEHN T.TRAN CALLUM G.LITTLEJOHNS FUWAN GAN GRAHAM REEd dAVId J.thomson Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

Scanning electron microscope as a flexible tool for investigating the properties of UV-emitting nitride semiconductor thin films

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Photonics Research 2019年第11期7卷 I0017-I0026页

作者： C.Trager-Cowan A.Alasmari W.Avis J.Bruckbauer P.R.Edwards B.Hourahine S.Kraeusel G.Kusch R.Johnston G.Naresh-Kumar R.W.Martin M.Nouf-Allehiani E.Pascal L.Spasevski d.thomson S.Vespucci P.J.Parbrook M.d.Smith J.Enslin F.Mehnke M.Kneissl C.Kuhn T.Wernicke S.Hagedorn A.Knauer V.Kueller S.Walde M.Weyers P.-M.Coulon P.A.Shields Y.Zhang L.Jiu Y.Gong R.M.Smith T.Wang A.Winkelmann department of physics supauniversity of strathclydeglasgow G4 onguk Tyndall national institute university college corkcork t12 r5cpireland Institute of solid state physics lechnische universitat berlin10623 berlingermany Ferdinand-braun-lnstitut leibniz-lnstitut fur hochstfrequenztechnik12489 berlingermany department of electronic and electrical engineering centre of nanoscience&nanotechnologyuniversity of bathbath ba27ayuk department of electronic and electrical engineering university of sheffieldsheffield s13jduk Laser components department laser zentrum hannover 5.v.30419 hannovergermany

In this paper we describe the scanning electron microscopy techniques of electron backscatter diffraction, electron channeling contrast imaging, wavelength dispersive X-ray spectroscopy, and cathodoluminescence hyperspectral imaging. We present our recent results on the use of these non-destructive techniques to obtain information on the topography, crystal misorientation, defect distributions, composition, doping, and light emission from a range of UV-emitting nitride semiconductor structures. We aim to illustrate the developing capability of each of these techniques for understanding the properties of UV-emitting nitride semiconductors, and the benefits were appropriate, in combining the techniques.

关键词： electron nitride doping

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONATHAN PELTIER WEIWEI ZHANG LEOPOLd VIROT CHRISTIAN LAFFORGUE LUCAS dENIEL dELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR dENH TRAN XINGZHAO YAN CALLUM G.LITTLEJOHNS CARLOS ALONSO-RAMOS KE LI dAVId J.thomson GRAHAM REEd LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the dC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large dC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the dC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external dC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect