The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

作     者：Yingfang Fan Jean Yuh Sashank Lekkala Mehmet D.Asik Andrew Thomson Madeline McCanne Mark A.Randolph Antonia F.Chen Ebru Oral Yingfang Fan;Jean Yuh;Sashank Lekkala;Mehmet D.Asik;Andrew Thomson;Madeline McCanne;Mark A.Randolph;Antonia F.Chen;Ebru Oral

作者机构：Harris Orthopaedic LaboratoryDepartment of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA Department of Orthopaedic SurgeryHarvard Medical SchoolBostonMassachusettsUSA Department of SurgeryHarvard Medical SchoolBostonMassachusettsUSA Department of Orthopaedic SurgeryBrigham and Women's HospitalBostonMassachusettsUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2024年第7卷第2期

页      面：145-155页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported in part by the Ruth Jackson Orthopedic Society and the Harris Orthopedic Laboratory approved by the Institutional Care and Use Committee of Massachusetts General Hospital(2020N000081) 

主　　题：arthrofibrosis range of motion total knee arthroplasty vitamin E 

摘      要：Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–Dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.