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Rifaximin improves survival in cirrhotic patients with refractory ascites: A real-world study

World Journal of Gastroenterology 2020年第2期26卷 199-218页

作者： Xin-Yue Lv Hui-Guo Ding Jun-Fu Zheng chun-lei fan lei Li Department of Gastroenterology and Hepatology Beijing You An Hospital Capital Medical University

BACKGROUND Rifaximin has been shown to reduce the incidence of hepatic encephalopathy and other complications in patients with ***,few studies have investigated the effect of rifaximin in cirrhotic patients with refractory *** To evaluate the effects of rifaximin in the treatment of refractory ascites and to preliminarily explore its possible *** A total of 75 cirrhotic patients with refractory ascites were enrolled in the study(50 in a rifaximin and 25 in a control group).Patients in the rifaximin group were divided into two subgroups according to the presence of spontaneous bacterial peritonitis and treatment with or without other antibiotics(19 patients treated with rifaximin and 31 patients treated with rifaximin plus intravenous antibiotics).All patients received conventional treatment for refractory ascites,while patients in the rifaximin group received oral rifaximin-α200 mg four times daily for at least 2 *** ascites grade,fasting weight,liver and kidney function,and inflammatory factors in the plasma were evaluated before and after *** addition,the gut microbiota was determined by metagenomics sequencing to analyse the changes in the characteristics of the gut microbiota before and after rifaximin *** patients were followed for 6 *** Compared with the control group,the fasting weight of patients significantly decreased and the ascites significantly subsided after treatment with rifaximin(P=0.011 and 0.009,respectively).The 6-mo survival rate of patients in the rifaximin group was significantly higher than that in the control group(P=0.048).The concentration of interferon-inducible protein 10 decreased significantly in the rifaximin group compared with that in the control group(P=0.024).The abundance of Roseburia,Haemophilus,and Prevotella was significantly reduced after rifaximin treatment,while the abundance of Lachnospiraceae_noname,Subdoligranulum,and Dorea decreased and the abundance of Co

关键词： Rifaximin Cirrhosis Refractory ascites Inflammatory factors Gut microbiota Metagenomics sequencing

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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit

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World Journal of Clinical Cases 2025年第7期13卷 28-38页

作者： Mai-Qing Shi Jun Chen Fu-Hai Ji Hao Zhou Ke Peng Jun Wang chun-lei fan Xu Wang Yang Wang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Intensive Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains *** To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic *** In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were *** were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with ***,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of ***,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the *** is highly recommended that hypernatremia be

关键词： Hypernatremia Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation Immunosuppression Catabolism syndrome Chronic critical illness Prognosis

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Resting energy expenditure and glucose, protein and fat oxidation in severe chronic virus hepatitis B patients

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World Journal of Gastroenterology 2008年第27期14卷 4365-4369页

作者： chun-lei fan Yan-Jing Wu Zhong-Ping Duan Bin Zhang Pei-Ling Dong Hui-Guo Ding Department of Hepatology & Gastroenterology Beijing You'an Hospital affiliated to Capital Medical University Beijing 100069 China

AIM: To study and determine the resting energy ex- penditure (REE) and oxidation rates of glucose, fat and protein in severe chronic hepatitis B patients. METHODS: A total of 100 patients with liver diseases were categorized into three groups: 16 in the acute hepatitis group, 56 in the severe chronic hepatitis group, and 28 in the cirrhosis group. The REE and the oxidation rates of glucose, fat and protein were as- sessed by indirect heat measurement using the CCM-D nutritive metabolic investigation system. RESULTS: The REE of the severe chronic hepatitis group (20.7 ± 6.1 kcal/d per kg) was significantly lower than that of the acute hepatitis group (P = 0.014). The respiratory quotient (RQ) of the severe chronic hepatitis group (0.84 ± 0.06) was significantly lower than that of the acute hepatitis and cirrhosis groups (P = 0.001). The glucose oxidation rate of the severe hepatitis group (39.2%) was significantly lower than that of the acute hepatitis group and the cirrhosis group (P < 0.05), while the fat oxidation rate (39.8%) in the severe hepatitis group was markedly higher than that of the other two groups (P < 0.05). With improve- ment of liver function, the glucose oxidation rate in- creased from 41.7% to 60.1%, while the fat oxidation rate decreased from 26.3% to 7.6%. CONCLUSION: The glucose oxidation rate is signifi-cantly decreased, and a high proportion of energy is provided by fat in severe chronic hepatitis. These re- sults warrant a large clinical trail to assess the optimal nutritive support therapy for patients with severe liver disease.

关键词： Chronic severe viral hepatitis Energy metabolism Respiratory quotient Malnutrition

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Expressions of type I collagen, α2 integrin and β1 integrin in sclera of guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 54-58页

作者： Xiao-Dan Tian Yong-Xia Cheng Gui-Bo Liu Su-Fen Guo chun-lei fan Li-Hui Zhan Yan-chun Xu Department of Ophthalmology the First Hospital Affiliated to China Medical University Department of Ophthalmology the Fourth People's Hospital of Shenyang Department of Pathology Mudanjiang Medical University Department of Anatomy Mudanjiang Medical University

AIM:To investigate the expressions of type I collagen, α2 integrin and β1 integrin in the posterior sclera of guinea pigs with defocus myopia and whether basic fibroblast growth factor (bFGF) injection inhibits the formation and development of myopia by upregulating the expression of type I collagen, α2 integrin and β1 integrin. METHODS:After 14 days of treatment, the refractive state and axial length were measured and the levels of type I collagen, α2 integrin and β1 integrin were assayed in the posterior sclerae of groups of guinea pigs that wore a monocular-7D polymethylmethacrylate (PMMA) lens or had -7D lens wear followed by the peribulbar injection of Phosphate Buffer Solution (PBS) or bFGF. The untreated fellow eye served as a control. Guinea pigs with no treatment served as normal group. ·RESULTS:The results showed that 14 days of monocular defocus increased axial eye length and refraction, while bFGF delivery inhibited them markedly. Further, it was also found that the monocular-7D lens could decrease the levels of type I collagen, α2 integrin and β1 integrin expressions, while, unlike PBS, bFGF increased them significantly in comparison to contralateral control eyes and normal eyes. CONCLUSION:bFGF can prevent the formation anddevelopment of defocus myopia by upregulating the expressions of type I collagen, α2 integrin and β1 integrin. Taken together, our results demonstrate that bFGF promotes sclera remodeling to prevent myopia in guinea pigs.

关键词： defocus myopia type I collagen α2 integrin β1 integrin bFGF

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Antiviral drug resistance increases hepatocellular carcinoma:A prospective decompensated cirrhosis cohort study

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World Journal of Gastroenterology 2013年第45期19卷 8373-8381页

作者： lei Li Wei Liu Yu-Han Chen chun-lei fan Pei-Ling Dong Fei-Li Wei Bing Li De-Xi Chen Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical University Department of Internal Medicine Beijing Ji Shui Tan HospitalAffiliated with Peking University Viral Laboratory of Liver Diseases Research Institute Capital Medical University

AIM:To study the clinical outcome of antiviral therapy in hepatitis B-related decompensated cirrhotic ***:Three hundred and twelve patients with decompensated hepatitis B cirrhosis were evaluated in a prospective *** two years of follow-up,198patients in the group receiving antiviral therapy with nucleos(t)ide analogues and 39 patients in the control group without antiviral treatment were ***:Among the antiviral treatment patients,162had a complete virological response(CVR),and 36 were drug-resistant(DR).The two-year cumulative incidence of hepatocellular carcinoma(HCC)in the DR patients(30.6%)was significantly higher than that in both the CVR patients(4.3%)and the control group(10.3%)(P<0.001).Among the DR patients in particular,the incidence of HCC was 55.6%(5/9)in those who failed rescue therapy,which was extremely *** rtA181T mutation was closely associated with rescue therapy failure(P=0.006).The Child-Pugh scores of the CVR group were significantly decreased compared with the baseline(8.9±2.3 vs 6.0±1.3,P=0.043).CONCLUSION:This study showed that antiviral drug resistance increased the risk of HCC in decompensated hepatitis B-related cirrhotic patients,especially in those who failed rescue therapy.

关键词： Hepatitis B Decompensated cirrhosis Nucleos(t)ide analogues Hepatocellular carcinoma Drug resistance

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Clinical efficacy of tolvaptan for treatment of refractory ascites in liver cirrhosis patients

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World Journal of Gastroenterology 2014年第32期20卷 11400-11405页

作者： Xin Zhang Shu-Zhen Wang Jun-Fu Zheng Wen-Min Zhao Peng Li chun-lei fan Bing Li Pei-Ling Dong lei Li Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical University

AIM: To evaluate the efficacy and safety of tolvaptan to treat refractory ascites in decompensated liver cirrhosis patients with or without further complications, such as hepatorenal syndrome and/or hepatocellular car... 详细信息

关键词： Tolvaptan Refractory ascites Hyponatremia Decompensation Liver cirrhosis

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Spontaneous viral clearance after 6-21 years of hepatitis B and C viruses coinfection in high HBV endemic area

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World Journal of Gastroenterology 2003年第9期9卷 2012-2016页

作者： chun-lei fan Lai Wei Dong Jiang Hong-Song Chen Yan Gao Ruo-Bing Li Yu Wang Institute of Hepatology,People’s Hospital,Peking University,Beijing 100044,China Institute of Hepatology People's Hospital Peking University Beijing 100044 China.

AIM: To investigate the clinical and virological course of coinfection by hepatitis B virus (HBV) and hepatitis C virus (HCV) in ***: We enrolled 40 patients with chronic HBV and HCV coinfection (Group BC), 16 patients with chronic HBV infection (Group B) and 31 patients with chronic HCV infection (Group C). They infected HBV and/or HCV during 1982 to *** of all the 87 patients were collected in 1994 and 2002respectively. We detected biochemical and virologic markers and serum HBV DNA and HCV RNA levels of all the patients. Btype ultrasound detection was performed in some ***: In Group BC, 67.5% of the patients cleared HBsAg,and 92.5% of the patients cleared HBeAg. The clearance rate of HBV DNA was 87.5%. There was no significant difference of HBV clearance between Group BC and Group B. In Group BC, 85.7% of males and 47.4% of females cleared HBV, and males were easier to clear HBV (x2=6.686, P=0.010). Such a tendency was also found in Group B. The clearance rate of HCV RNA in Group BC was 87.5%, significantly higher than that in Group C (x2=22.963, P＜0.001). Less than 40% of the patients in all groups had elevated liver enzyme values. The highest value of alanine aminotransferase (ALT) was 218 u/L (normal range for ALT is 0-40 u/L). In most patients the ultrasonogram presentations changed ***: The clinical manifestations of patients with HBV/HCV coinfection are mild and occult. High clearance rate of HBV and easy to clear HBV in male patients are the characteristics of HBV infection in adults in China. HBV can inhibit HCV replication, but no evidence has been found in our data that HCV suppresses HBV replication.

关键词：乙型肝炎病毒丙型肝炎病毒同时感染临床研究病理学中国

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Synthesis, Structural Characterization and Antibacterial Activities of Series of（Z）-4-oxo-4-（arylamino）but-2-enoic Acid Derivatives

Synthesis, Structural Characterization and Antibacterial Act...

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中国化学会第九届全国有机化学学术会议

作者： Meng-Chao Yao Zhong-Cheng Song chun-lei fan Miao-Miao Qin Xiao Ye Qiao-Ye Ding School of Life Science Zhejiang Chinese Medical University

Series of（Z）-4-oxo-4-（arylamino）but-2-enoic acid derivatives were synthesized. Their structures were characterized by NMR spectrum. The results showed that cis-structure were the main products, which exhibited the C=C double bond was on the both sides of carbonyl groups in all compounds. The anti-biological activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the aromatic ring in the same location and the same substitution group on the aromatic ring in the different location.

关键词： Synthesis Structural characterization (Z)-4-oxo-4-(arylamino)but-2-enoic Acid

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Synthesis, Structural Characterization and Antibacterial Activities of Series of Chalcone Derivatives

Synthesis, Structural Characterization and Antibacterial Act...

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中国化学会第九届全国有机化学学术会议

作者： Zhi-Peng Ni Zhong-Cheng Song chun-lei fan Miao-Miao Qin Xiao-Kang Song Xiao-Chang Mei School of Life Science Zhejiang Chinese Medical University

Series of chalcone derivatives were synthesized. Their structures were characterized by NMR spectrum. The results showed that trans-structure were the main products, which exhibited the C=C double bond was on the both sides of the aromatic rings in all compounds. The antibacterial activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the both sides of the aromatic ring in the same location and the same substitution group on the both sides of the aromatic ring in the different location.

关键词： Synthesis Structural characterization Chalcone

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Synthesis, Structural Characterization and Antibacterial Activities of N-halogen-Substituted Benzylidene Aromatic Amine

Synthesis, Structural Characterization and Antibacterial Act...

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中国化学会第九届全国有机化学学术会议

作者： Miao-Miao Qin Zhong-Cheng Song chun-lei fan Zhi-Peng Ni Yuan-Yuan fang Meng-Chao Yao School of Life Science Zhejiang Chinese Medical University

Series of N-halogen-substituted benzylidene aromatic amine were synthesized. Their structures were characterized by NMR spectrum. Some crystal structures were refined through the SHELXL97 software processing. The results showed that trans-structure were the main products, which exhibited the C=N double bond was on the both sides of the aromatic rings in all compounds. The antibacterial activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the both sides of the aromatic ring in the same location and the same substitution group on the both sides of the aromatic ring in the different location.

关键词： Synthesis Structural characterization Benzylidene aromatic amine

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