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Leech-Centipede Granules Suppress EndMT to Improve Erectile Dysfunction in Rats with Diabetes Mellitus via TGF-β/Smad Pathway

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Chinese Journal of Integrative Medicine 2023年第1期29卷 28-36页

作者： ZHANG Hui FENG chu-hui HE shan DENG Ming-xia MENG Hao CHEN Ming LIU Hong Department of Urology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510000China Department of Urology the Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510000China The First Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou510000China

Objective:To investigate whether Leech-Centipede(LC) Granules can improve erectile function in rats with diabetes mellitus-associated erectile dysfunction(DMED) through endothelial-to-mesenchymal transition(EndMT) ***:Components of LC Granules were identified via ultra-high-performance liquid *** male Sprague Dawley rats were injected with streptozotocin and fed continuously for 8weeks to establish the DMED rat *** with erectile dysfunction symptoms diagnosed using apomorphine were divided into DMED and low-,medium-,and high-doses LC groups(n=6 in each).The negative control(NC, n=6) and DMED groups were given 5 mL of deionized water via intragastric gavage,and the low-,mediumand the high-doses LC groups were administered LC at 1.6,3.2,and 6.4 g/kg,respectively,via intragastric gavage for 4 *** intracavernous pressure(ICP),mean arterial pressure(MAP),and nitric oxide(NO) levels in cavernous tissue were measured for each *** reverse transcription-polymerase chain reaction and Western blot were used to detect mRNA and protein expressions of endothelial and mesenchymal *** staining was used to observe α-SMA, and Masson’s trichrome staining was performed to determine the myofiber/collagen ***:A total of 474 active components were *** treatment,the ICP/MAP value and NO level were significantly higher in the medium-and high-dose LC groups than in the DMED group(P0.05).α-SMA expression was significantly higher in the DMED group and was reduced in all LC intervention groups(P>0.05).The myofiber/collagen ratio in the LC grou

关键词： Leech-Centipede Granules erectile function diabetes mellitus endothelial cell endothelial-to-mesenchymal transition tumor growth factor-beta/Smad pathway

Research on fault location technology based on BP neural network in DWDM optical network

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Optoelectronics Letters 2008年第6期4卷 452-455页

作者： LIAO Xiao-min ZHANG Yin-fa YANG Shi-ping LIN chu-shan Optical Communication Laboratory of Xi＇an Communication Institute Xi ＇an 710106 China

BP neural network is introduced to the fault location field of DWDM optical network in this paper. The alarm characteris-tics of the optical network equipments are discussed,and alarm vector and fault vector diagrams are generated by analyzing some typical instances. A 17×14×18 BP neural network structure is constructed and trained by using MATLAB. By comparing the training performances,the best training algorithm of fault location among the three training algorithms is chosen. Numerical simulation results indicate that the sum squared error (SSE) of fault location is less than 0.01,and the processing time is less than 100 ms. This method not only well deals with the missing alarms or false alarms,but also improves the fault location accuracy and real-time ability.

关键词：断层定位 DWDM BP 神经网络光学应用

针刺对脑缺血再灌注损伤大鼠海马组织miR-29a-3p、miR-29b-3p表达的影响

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时珍国医国药 2024年第2期35卷 485-488页

作者：王瑶江姗姗谢灿明向静唐红汪红娟李展富刘晓月陈楚淘田浩梅湖南中医药大学针灸推拿与康复学院湖南长沙410208

目的观察针刺干预72 h后脑缺血再灌注损伤(CIRI)大鼠缺血侧海马区miR-29a-3p、miR-29b-3p的表达,探讨针刺促CIRI修复的机制。方法30只SD大鼠随机分为假手术组、模型组和针刺组,每组10只,造模组大鼠使用线栓法制备CIRI模型,假手术组只剥... 详细信息

目的观察针刺干预72 h后脑缺血再灌注损伤(CIRI)大鼠缺血侧海马区miR-29a-3p、miR-29b-3p的表达,探讨针刺促CIRI修复的机制。方法30只SD大鼠随机分为假手术组、模型组和针刺组,每组10只,造模组大鼠使用线栓法制备CIRI模型,假手术组只剥离血管不插入线栓;假手术组和模型组只捆绑不针刺,针刺组捆绑后针刺“大椎”“百会”“水沟”穴,一天治疗两次,共治疗7次。采用Garcia评分法对神经功能进行评定,TTC染色法检测脑梗死面积比,qRT-PCR法检测缺血侧海马区miR-29a-3p、miR-29b-3p的表达。结果干预前与假手术组比较,造模组Garcia评分显著降低(P<0.01),脑梗死面积比显著增加(P<0.01),患侧海马区miR-29a-3p、miR-29b-3p表达量降低(P<0.05,P<0.01);干预72h后与模型组比较,针刺组Garcia评分明显上升(P<0.01),脑梗死面积比显著下降(P<0.01),患侧海马组织miR-29a-3p、miR-29b-3p的表达量明显增加(P<0.01)。结论针刺可减少CIRI大鼠缺血侧脑梗死面积、改善神经功能损伤、发挥脑保护作用,可能与干预72h后上调缺血侧海马区miR-29a-3p、miR-29b-3p表达有关。

关键词：针刺脑缺血再灌注损伤 miR-29a-3p miR-29b-3p

S incorporated RuO_(2)-based nanorings for active and stable water oxidation in acid

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Nano Research 2022年第5期15卷 3964-3970页

作者： Qing Yao Zhiyong Yu Ying-Hao chu Yu-Hong Lai Ting-shan Chan Yong Xu Qi Shao Xiaoqing Huang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Materials Science and Engineering "National Yang Ming Chiao Tung University"Hsinchu 30010TaiwanChina "National Synchrotron Radiation Research Center" 101 Hsin-Ann RoadHsinchu 30076TaiwanChina Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China

The design of highly active and stable RuO_(2)-based nanostructures for acidic oxygen evolution reaction(OER)is extremely important for the development of water electrolysis technology,yet remains great *** here demonstrate that the incorporation of S into RuCuO nanorings(NRs)can significantly enhance the acidic OER *** investigations show that the incorporation of S can optimize the interaction of Ru and O,and therefore significantly suppresses the dissolution of Ru in acidic *** optimized catalyst(SH-RuCuO NRs)displays superior OER performance to the commercial RuO_(2)/***,the SH-RuCuO NRs can exhibit significantly enhanced stability for 3,000 cycles of cyclic voltammetry test and more than 250 h chronopotentiometry test at 10 mA·cm^(-2)in 0.5 M H_(2)SO_(4).This work highlights a potential strategy for designing active and stable RuO_(2)-based electrocatalysts for acidic OER.

关键词： S incorporation RuCu nanoring stable acidic oxygen evolution reaction

Eight novel mutations in the ABCD1 gene and clinical characteristics of 25 Chinese patients with X-linked adrenoleukodystrophy

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World Journal of Pediatrics 2015年第4期11卷 366-373页

作者： shan-shan chu Jun Ye Hui-Wen Zhang Lian-Shu Han Wen-Juan Qiu Xiao-Lan Gao Xue-Fan Gu Department of Pediatric Endocrinology and Genetic Metabolism Shanghai Institute for Pediatric ResearchXinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background:X-linked adrenoleukodystrophy(X-ALD)is a fatal neurodegenerative disease caused by mutations in the adenosine triphosphate-binding cassette D1(ABCD1)*** study aimed to retrospectively investigate the clinical characteristics of 25 patients with X-ALD including members of large pedigrees,to analyze ABCD1 gene mutations,the effect of gene novel variants on ALD protein(ALDP)structure and function,and to expand gene mutation spectrum of Chinese ***:Twenty-five male patients diagnosed with X-ALD were enrolled in this *** clinical characteristics of the patients were retrospectively summarized by reviewing medical records or telephone ***1 gene mutations were *** pathogenicity of novel missense variants was analyzed using cobalt constraint-based multiple protein alignment tool,polymorphism phenotyping,sorting intolerant from tolerant,Align-Grantham variation and Grantham deviation,and Swiss-Program Database Viewer 4.04 software,***:Childhood cerebral form ALD(CCALD)is the most common phenotype(64%)in the 25 patients with *** progressive deterioration of neurological and cognitive functions is the main clinical *** demyelination of the brain white matter and elevated plasma very long chain fatty acids(VLCFAs)were found in all *** phenotypes were also presented within family members of the ***-two different mutations including 8 novel mutations in the ABCD1 gene were identifi ed in the 25 *** the mutations,63.6%were missense mutations and 34.8%located in exon *** amino acid residues of three novel missense mutations in eight species were highly conserved,and were predicted to be"probably"damaging to ALDP *** other five novel mutations were splice,nonsense,deletion or duplication ***:CCALD is the most common phenotype(64%)in our patients with *** novel mutations in the ABCD1 gene identifi ed are disease-causing muta

关键词： ABCD1 protein adrenoleukodystrophy adrenoleukodystrophy protein missense variant mutation

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呼吸、麻醉用面罩注册现状及审评要点分析

中国医疗器械信息 2024年第1期30卷 5-8页

作者：王亚琳柴谦王晓晨闫芳杜文新楚姗姗山东省食品药品审评查验中心山东济南250014

呼吸、麻醉用面罩产品注册申报量较多,且临床应用比较广泛,迄今为止该类产品没有统一的国家标准、行业标准。文章将简单介绍该类产品的注册情况并总结注册申报资料中的一些常见问题,以期对产品的注册申报提供一定帮助,提高注册及审评效率。

关键词：呼吸、麻醉用面罩注册审评

Direct Visual Evidence for Neutral and Charged Hexaphyrin Aromaticity with and without Keto-Defect

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Chinese Journal of Chemical Physics 2012年第5期25卷 563-570,I0003页

作者： shan Zhang Peng Song Sha Wang Yu-ling chu Yuan-zuo Li Zhong Yang Yong Ding Feng-cai Ma Department of Physics Liaoning UniversityShenyang 110036China Physical and Electronic and Information Engineering Institute Chifeng UniversityChifeng 024001China College of Science Northeast Forestry UniversityHarbin 150040China

We use density functional theory and time-dependent together with a set of extensive mul- tidimensional visualization techniques to characterize the influence of keto effect on charge distribution at ground state and electronic transitions for neutral and charged hexaphyrin aromaticity with and without keto-defect. It is found that the aromaticity is the key fac- tor to influence the ground state Mulliken charges distribution properties, other than the meso-aryl-substituted effect. But with the enhancement of the keto-defect, the distribution changes of Mulliken charges on the hexaphyrin groups are larger than those on the pentaflu- orophenyl substituted groups, following with the aromaticity changes from nonaromatic to aromatic. Furthermore, through characterizing by transition density and charge difference density, direct visual evidence for neutral and charged aromaticity with and without keto- defect can be clearly derived, and the ability of charge transfer between units of monoradical （nonaromaticity） and singlet biradical （aromaticity） forms is much stronger than that of neutral forms.

关键词： Aromaticity Keto-defect Porphyrin Charge difference density Transitiondensity

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基于信息熵的济南市用水结构演变分析

水利科学与寒区工程 2024年第9期7卷 137-140页

作者：韦力方褚丽丽孟岩单博尹自文黑龙江大学水利电力学院黑龙江哈尔滨150080 黑龙江省水利科学研究院黑龙江哈尔滨150080

根据济南市用水现状,基于***信息熵理论,运用信息熵和均衡度对2012—2021年济南市用水结构的演变特征进行分析,并结合主成分分析法进行了用水结构演变驱动力分析。结果表明:农业、工业、生活、生态环境用水在总用水量中所占比重分别为52... 详细信息

根据济南市用水现状,基于***信息熵理论,运用信息熵和均衡度对2012—2021年济南市用水结构的演变特征进行分析,并结合主成分分析法进行了用水结构演变驱动力分析。结果表明:农业、工业、生活、生态环境用水在总用水量中所占比重分别为52%、14%、23%、11%;过去10 a,全市的用水总量经历了一个先下降后上升的变化,农业用水总体上呈现波动下降的趋势,工业用水量则表现为无序的波动状态,生活用水量和生态环境用水量则呈现缓慢上升的趋势,全市和各县区的用水结构信息熵和均衡度都在缓慢增大,表示水资源利用正在往均衡化发展;人口、地区生产总值、农业生产总值、工业生产总值、灌溉面积、粮食总产量、降水量为代表的因子是用水结构变化主要的驱动力,耕地面积对用水结构演变也有重要影响。

关键词：用水结构信息熵均衡度驱动力

Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses

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Journal of Animal Science and Biotechnology 2021年第3期12卷 891-903页

作者： Jiaqi Liu Jie Li Wentao Chen Xintao Xie Xingang chu Teresa G.Valencak Yizhen Wang Tizhong shan College of Animal Sciences Zhejiang UniversityHangzhouChina Key Laboratory of Molecular Animal Nutrition(Zhejiang University) Ministry of EducationHangzhouChina Key Laboratory of Animal Feed and Nutrition of Zhejiang Province 866 Yuhangtang RoadHangzhouChina

Background:Meat quality is largely driven by fat deposition,which is regulated by several genes and signaling *** cyclic adenosine monophosphate(cAMP)-regulated transcriptional coactivator 3(CRTC3)is a coactivator of cAMP response element binding protein(CREB)that mediates the function of protein kinase A(PKA)signaling pathway and is involved in various biological processes including lipid and energy ***,the effects of CRTC3 on the metabolome and transcriptome of porcine subcutaneous adipocytes have not been studied ***,we tested whether porcine CRTC3 expression would be related to fat deposition in Heigai pigs(a local fatty breed in China)and Duroc×Landrace×Yorkshire(DLY,a lean breed)pigs in *** effects of adenovirus-induced CRTC3 overexpression on the metabolomic and transcriptomic profiles of subcutaneous adipocytes were also determined in vitro by performing mass spectrometry-based metabolomics combined with RNA sequencing(RNA-seq).Results:Porcine CRTC3 expression is associated with fat deposition in *** addition,CRTC3 overexpression increased lipid accumulation and the expression of mature adipocyte-related genes in cultured porcine subcutaneous *** to the metabolomic analysis,CRTC3 overexpression induced significant changes in adipocyte lipid,amino acid and nucleotide metabolites in *** RNA-seq analysis suggested that CRTC3 overexpression alters the expression of genes and pathways involved in adipogenesis,fatty acid metabolism and glycerophospholipid metabolism in ***:We identified significant alterations in the metabolite composition and the expression of genes and pathways involved in lipid metabolism in CRTC3-overexpressing *** results suggest that CRTC3 might play an important regulatory role in lipid metabolism and thus affects lipid accumulation in porcine subcutaneous adipocytes.

关键词： CRTC3 Energy metabolism Metabolomics Overexpression Subcutaneous adipocytes Transcriptomics