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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Coverage and determinants of infant postnatal care in Nigeria:A population-based cross-sectional study

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Pediatric Investigation 2024年第1期8卷 27-36页

作者： Bolaji Emmanuel Egbewale Olusola Oyedeji Jesse Bump christopher Robert Sudfeld Department of Global Health and Population Takemi Program in International HealthHarvard T.H.Chan School of Public HealthBostonMassachusettsUSA Department of Community Medicine College of Health SciencesLadoke Akintola University of TechnologyOgbomosoNigeria Department of Pediatrics and Child Health College of Health SciencesLadoke Akintola University of TechnologyOgbomosoNigeria

Importance:In 2019,Nigeria had the largest number of under-5 child deaths globally and many of these deaths occurred within the first week of *** World Health Organization recommends infant postnatal care(PNC)attendance to support newborn survival;however,utilization of PNC is known to be low in many ***:This study examined coverage and individual-level determinants of infant PNC attendance in ***:Nigeria Demographic Health Survey(NDHS)2018 data were used to evaluate infant PNC coverage and *** PNC was defined as receipt of care within 2 days of *** delivered up to 2 years before the 2018 NDHS were *** examined predictors of infant PNC with modified Poisson regression models to estimate relative risks(RRs).Results:The national coverage of infant PNC was 37.3%(95%confidence interval[CI]:35.8%–38.7%).Significant heterogeneity in PNC attendance existed at state and regional *** delivery was strongly associated with the uptake of PNC(RR:6.07;95%CI:5.60–6.58).Greater maternal education,maternal employment,urban residence,female head of household,and greater wealth were also associated with an increased likelihood of PNC ***:The uptake of infant PNC is low and interventions are urgently needed to promote equity in access and increase demand for PNC in Nigeria.

关键词： Infant postnatal care Epidemiology Coverage Determinants Nigeria

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Diagnostic Dilemma of Intracardiac Mass: Tumor versus Thrombus-Case Series and Systematic Review

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Journal of Biosciences and Medicines 2024年第7期12卷 141-150页

作者： Indira Acharya Ashik Pokharel Raktim Ghosh christopher J. Haas Department of Internal Medicine Internal Medicine Residency Program Medstar Health Baltimore MD USA Department of Cardiology MedStar Union Memorial Hospital MedStar Health Baltimore MD USA School of Medicine Georgetown University Washington D.C. USA

Background: The differential diagnosis for intracavitary cardiac masses is limited, typically including vegetations, tumors, or thrombi. Cardiac thrombi can often mimic cardiac tumors on imaging, creating a diagnostic challenge. Primary cardiac tumors are rare and usually benign, whereas most cardiac tumors result from metastases, commonly originating from malignancies in the breast, lung, or melanoma. Aim: This report highlights the importance of distinguishing various cardiac masses based on clinical presentations, clinical courses, and radiological features. Case Presentation: We describe two cases of cardiac masses with unique and diverse clinical features. Each case posed significant diagnostic challenges due to their distinct presentations and clinical progressions. Conclusion: These cases underscore the importance of considering both benign and metastatic origins in the differential diagnosis of intracavitary cardiac masses. Accurate differentiation between thrombi and tumors is crucial for appropriate management and treatment.

关键词： Echocardiography Cardiac Masses Arrhythmias Cardiac Magnetic Resonance Imaging Cardiac Thrombi

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Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli christopher D.F.Rogers Runming Yao fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main *** GBGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

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How to establish an endoscopic bariatric practice

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 178-186页

作者： Daniel B Maselli Lauren L Donnangelo Brian Coan christopher E McGowan Clinical Research True You Weight LossAtlantaGA 30342United States Clinical Research True You Weight LossCaryNC 27513United States

Obesity is a chronic,progressive,and relapsing disease of excess adiposity that contributes to more than two hundred medical conditions and is projected to affect more than half the adult population of the United States by the year *** the limited penetrance of traditional bariatric surgery,as well as the cost and adherence barriers to anti-obesity medications,there is growing interest in the rapidly evolving field of endoscopic bariatric therapies(EBTs).EBTs are minimally invasive,same-day,per-oral endoscopic procedures and include endoscopic sleeve gastroplasty,intragastric balloons,and endoscopic bariatric revisional *** field represents an exciting and innovative subspe-cialty within ***,building a successful endoscopic bariatric practice requires intentional,coordinated,and sustained efforts to overcome the numerous obstacles to *** barriers include acquisition of the technical and cognitive skillset,practice limitations including the availability of nutrition counseling,facility capabilities,direct-to-consumer marketing,and financial pressures such as facility and anesthesia *** the highest-volume center for metabolic and bariatric endoscopy in the United States,we provide insights into successfully establishing an endoscopic bariatric program.

关键词： Obesity Endoscopic bariatric therapies Bariatric endoscopy Endoscopic sleeve gastroplasty Intragastric balloon Practice management

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利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya Masanobu Oshima christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

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A Rare Case of Aortic Valve Endocarditis and Acute Meningitis Due to Haemophilus influenzae

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Case Reports in Clinical Medicine 2024年第6期13卷 207-211页

作者： Zachary M. Visinoni Justin D. Tse christopher F. Pease Department of Graduate Medical Education Internal Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medical Group Roseville USA

HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, modern laboratory techniques have made this less common. In this case, we present a 74-year-old man who presented with acute onset altered mentation, fever, and sepsis. He was ultimately found to have Haemophilus influenzae meningitis, cerebral empyema, aortic valve endocarditis, psoas myositis, and L2 - L3 diskitis with osteomyelitis. Although HACEK organisms are commonly found in the oropharynx and upper respiratory tract in humans, our patient did not report recent preceding dental or ENT procedures. H. influenzae is responsible for approximately 0.16% of all cases of bacterial endocarditis, representing a very limited subset. Although generally considered low virulent pathogens, this case demonstrates the unusual extent of infection from a HACEK organism, H. influenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute meningitis.

关键词： HACEK Haemophilus influenzae Aortic Valve Endocarditis Bacterial Meningitis Cerebral Empyema

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高压电缆中铠装损耗的三维模拟

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电气时代 2024年第6期 16-19页

作者： BRIANNE christopher COMSOL公司

位于瑞典卡尔斯克鲁纳的NKT公司使用数值模型来研究电磁场,并计算了三维电缆设计中的铠装损耗。他们通过实验测量,对仿真结果的准确性进行了验证。全球线缆行业的市场价值高达数千亿美元。据Infinium Global Research报道,截至2025年,... 详细信息

位于瑞典卡尔斯克鲁纳的NKT公司使用数值模型来研究电磁场,并计算了三维电缆设计中的铠装损耗。他们通过实验测量,对仿真结果的准确性进行了验证。全球线缆行业的市场价值高达数千亿美元。据Infinium Global Research报道,截至2025年,电缆市场规模有望达到2200亿美元~([1])。

关键词：高压电缆卡尔斯克鲁纳线缆行业三维模拟电缆设计数值模型

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Development of a Simple Extraction Method for Tetracycline Analogues from Bovine Milk

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Advances in Biological Chemistry 2024年第4期14卷 111-120页

作者： Oscar Cordova Thien Le christopher Lambert Devin Brodie Stephany Ramirez Francis Sandoval Karno Ng Department of Chemistry & Biochemistry California State University San Marcos San Marcos USA

Tetracycline and analogues are among the most used antibiotics in the dairy industry. Besides the therapeutic uses, tetracyclines are often incorporated into livestock feed as growth promoters. A considerable amount of antibiotics is released unaltered through milk from dairy animals. The presence of antibiotic residues in milk and their subsequent consumption can lead to potential health impacts, including cancer, hypersensitivity reactions, and the development of antibiotic resistance. Thus, it is important to monitor residual levels of tetracyclines in milk. The purpose of this study is to develop a quick and simple method for simultaneously extracting five tetracycline analogues from bovine milk. Specifically, five tetracycline analogues: Chlortetracycline (CTC), demeclocycline (DEM), doxycycline (DC), minocycline (MC), and tetracycline (TC) were simultaneously extracted from milk using trifluoroacetic acid. Subsequently, the extracted analogues were separated by reverse-phase high-performance liquid chromatography (RP-HPLC) and detected at 355 nm using UV/Vis. Calibration curves for all five tetracycline analogues show excellent linearity (r2 value > 0.99). Percent recovery for MC, TC, DEM, CTC, and DC were: 31.88%, 96.91%, 151.29, 99.20%, and 85.58% respectively. The developed extraction method has good precision (RSD < 9.9% for 4 of the 5 analogues). The developed method with minimal sample preparation and pretreatment has the potential to serve as an initial screening test.

关键词： Antibiotics Tetracyclines Extraction Milk HPLC

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在芝加哥尽享世界美食——男子希望不离乡就能吃遍世界各国料理

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 28-29,46,47页

作者： christopher Borrelli 不详

我初次与凯姆·布兰森见面时,他正进行到字母E开头的国家:爱沙尼亚、厄立特里亚和埃及。我们的午餐是埃塞俄比亚料理,他打算第二天吃厄瓜多尔料理。布兰森已经试过智利、古巴、喀麦隆和克罗地亚料理,接下来还规划了芬兰、斐济、密克罗... 详细信息

我初次与凯姆·布兰森见面时,他正进行到字母E开头的国家:爱沙尼亚、厄立特里亚和埃及。我们的午餐是埃塞俄比亚料理,他打算第二天吃厄瓜多尔料理。布兰森已经试过智利、古巴、喀麦隆和克罗地亚料理,接下来还规划了芬兰、斐济、密克罗尼西亚联邦与法国。

关键词：厄立特里亚埃塞俄比亚料理爱沙尼亚厄瓜多尔美食喀麦隆克罗地亚

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