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量子悖论只是想象？

环球科学 2013年第7期 66-71页

作者：汉斯·克里斯蒂安·冯贝耶尔(Hans christian von Baeyer) 阳曦(翻译)

新版本的量子理论将微观世界里的种种奇怪悖论一扫而空。但是也要付出代价，按照新理论，量子信息只不过是存在于想象中的东西。

关键词：量子理论想象悖论微观世界量子信息

职业教育和学术教育的相互融合——以复合材料制造领域职业进修为例

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应用型高等教育研究 2019年第4期4卷 19-26页

作者： Stefan Bramer Linda Vieback christian Vogel 陈颖(翻译) 马格德堡大学德国马格德堡39106 德国联邦职业教育研究所德国波恩53175 奥斯纳布吕克应用科学大学

多年来,就职业教育和学术(继续)教育在传统上制度分离这一问题争议不断。尽管教育政策已提出了在教育体系内部增加互通性的要求,但在不同教育领域中实现课程设置和教学方法的融合还仅仅是个别情况。以复合材料制造职业领域为例,阐述了... 详细信息

多年来,就职业教育和学术(继续)教育在传统上制度分离这一问题争议不断。尽管教育政策已提出了在教育体系内部增加互通性的要求,但在不同教育领域中实现课程设置和教学方法的融合还仅仅是个别情况。以复合材料制造职业领域为例,阐述了如何通过融合职业和学术继续教育来实现跨教育体系和跨专业的学习途径,从而把职业实践和科学知识学习更有意义地结合起来,以实现灵活又个性化的学习途径。

关键词：混合教育理念互通性继续教育职业与学术继续教育

3D-printed facet-attached microlenses for advanced photonic system assembly

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Light(Advanced Manufacturing) 2023年第2期4卷 1-17页

作者： Yilin Xu Pascal Maier Mareike Trappen Philipp-Immanuel Dietrich Matthias Blaicher Rokas Jutas Achim Weber Torben Kind Colin Dankwart Jens Stephan Andreas Steffan Amin Abbasi Padraic Morrissey Kamil Gradkowski Brian Kelly Peter O’Brien Wolfgang Freude christian Koos Institute of Photonics and Quantum Electronics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstr.576131 KarlsruheGermany Institute of Microstructure Technology(IMT) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Vanguard Automation GmbH Gablonzer Strasse.1076185 KarlsruheGermany ficon TEC Service GmbH Im Finigen 328832 AchimGermany II-VI Inc. Reuchlinstraße 10/1110553 BerlinGermany Photonics Research Group Ghent University-imecTechnologiepark-Zwijnaarde 126B-9052 GentBelgium Tyndall National Institute T12 R5CP CorkIreland Eblana Photonics Ltd. West Pier Business Campus3 Old Dunleary RdDún LaoghaireDublinA96 A621Ireland

Wafer-level mass production of photonic integrated circuits(PIC)has become a technological mainstay in the field of optics and photonics,enabling many novel and disrupting a wide range of existing ***,scalable photonic packaging and system assembly still represents a major challenge that often hinders commercial adoption of PIC-based ***,chip-to-chip and fiber-to-chip connections often rely on so-called active alignment techniques,where the coupling efficiency is continuously measured and optimized during the assembly *** unavoidably leads to technically complex assembly processes and high cost,thereby eliminating most of the inherent scalability advantages of PIC-based *** this paper,we demonstrate that 3D-printed facet-attached microlenses(FaML)can overcome this problem by opening an attractive path towards highly scalable photonic system assembly,relying entirely on passive assembly techniques based on industry-standard machine vision and/or simple mechanical *** can be printed with high precision to the facets of optical components using multi-photon lithography,thereby offering the possibility to shape the emitted beams by freely designed refractive or reflective ***,the emitted beams can be collimated to a comparatively large diameter that is independent of the device-specific mode fields,thereby relaxing both axial and lateral alignment ***,the FaML concept allows to insert discrete optical elements such as optical isolators into the free-space beam paths between PIC *** show the viability and the versatility of the scheme in a series of selected experiments of high technical relevance,comprising pluggable fiber-chip interfaces,the combination of PIC with discrete micro-optical elements such as polarization beam splitters,as well as coupling with ultra-low back-reflection based on non-planar beam paths that only comprise tilted optical *** on our re

关键词： Photonic integration Photonic assembly Photonic packaging Additive laser manufacturing Multi-photon lithography Facet-attached microlenses Optical alignment tolerances Fiber-chip coupling Hybrid multi-chip modules

Introducing the Open Energy Ontology: Enhancing data interpretation and interfacing in energy systems analysis

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Energy and AI 2021年第3期5卷 53-66页

作者： Meisam Booshehri Lukas Emele Simon Flügel Hannah Förster Johannes Frey Ulrich Frey Martin Glauer Janna Hastings christian Hofmann Carsten Hoyer-Klick Ludwig Hülk Anna Kleinau Kevin Knosala Leander Kotzur Patrick Kuckertz Till Mossakowski Christoph Muschner Fabian Neuhaus Michaja Pehl Martin Robinius Vera Sehn Mirjam Stappel Institute for Applied Ecology BerlinGermany Institute for Applied Informatics(InfAI)/Leipzig University Germany Department of Energy Systems Analysis Institute of Networked Energy SystemsGerman Aerospace Center(DLR)StuttgartGermany Faculty of Computer Science Otto-von-Guericke-Universität MagdeburgGermany Reiner Lemoine Institut BerlinGermany Institute of Techno-economic Systems Analysis(IEK-3) Forschungszentrum JülichJülichGermany Institute of Energy Economics and Rational Energy Use University of StuttgartGermany Potsdam Institute for Climate Impact Research PotsdamGermany Fraunhofer Institute for Energy Economics and Energy System Technology KasselGermany

Heterogeneous data,different definitions and incompatible models are a huge problem in many domains,with no exception for the field of energy systems ***,it is hard to re-use results,compare model results or couple models at *** provide a precisely defined vocabulary to build a common and shared conceptu-alisation of the energy ***,we present the Open Energy Ontology(OEO)developed for the domain of energy systems *** the OEO provides several benefits for the ***,it enables consistent annotation of large amounts of data from various research *** example is the Open Energy Platform(OEP).Adding such annotations makes data semantically searchable,exchangeable,re-usable and ***,computational model coupling becomes much *** advantages of using an ontology such as the OEO are demonstrated with three use cases:data representation,data annotation and interface *** also describe how the ontology can be used for linked open data(LOD).

关键词： Collaborative ontology development Linked open data Metadata annotation Energy systems analysis

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

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Bone Research 2020年第2期8卷 157-168页

作者： Tobias Schwerd Freia Krause Stephen R.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer Miryam Müller Santiago Manrique Neele Schumacher Steven A.Wall Jonathan Jung Timo Damm Claus-christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Holm H.Uhlig Translational Gastroenterology Unit John Radcliffe HospitalUniversity of OxfordOxfordUK Department of Pediatrics Dr von Hauner Children’s HospitalLMU MunichMunichGermany christian-Albrechts-University Kiel Institute of BiochemistryKielGermany Clinical Genetics Group MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordUK Center for Molecular Neurobiology Hamburg(ZMNH) University Medical Center Hamburg-EppendorfHamburgGermany Division of Structural Biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK Craniofacial Unit Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK Section Biomedical Imaging Department of Radiology and NeuroradiologyUniversity Medical Center Schleswig-HolsteinKielGermany Institute of Biochemistry and Molecular Biology Ⅱ Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Department of Paediatrics University of OxfordOxfordUK NIHR Oxford Biomedical Research Centre OxfordUK The Beatson Institute for Cancer Research GlasgowUK School of Medicine University of GlasgowGlasgowUK

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.R279 Q. We show that human GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSM, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 RA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects.

关键词： IL11 cytokine facial

Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

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Cancer Communications 2023年第11期43卷 1280-1285页

作者： Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl Division of Molecular and Experimental Surgery Translational Research CenterUniversitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN) ErlangenBavariaGermany Chair of Medical Informatics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Fraunhofer Institute of Toxicology and Experimental Medicine Lower saxonyHannoverGermany Institute of Human Genetics Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Medicine 3 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Institute of Pathology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Internal Medicine 5 – Hematology and Oncology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Gastroenterology and Hepatology University Hospital ZurichUniversity of ZurichCanton ZurichZurichSwitzerland Department of Medicine 1 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Surgery Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany

Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy *** endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in ***,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关键词： imprinting colon interferon

稳定与变革：德国景观规划在空间规划中的基础作用及社会变化下的挑战

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风景园林 2020年第1期27卷 41-46页

作者：文晨 [德]克里斯汀·阿尔伯特 [德]克里斯蒂娜·冯·哈伦华中科技大学建筑与城市规划学院景观学系德国汉诺威大学环境规划系德国汉诺威大学

中国的国土空间规划体系正在经历变革,规划编制和管控技术需要风景园林的视角。针对空间规划和风景园林的衔接问题,通过总结相关文献和报告,介绍德国景观规划的发展经验。德国作为实行空间规划体系的国家其景观规划对自然保护和景观多... 详细信息

中国的国土空间规划体系正在经历变革,规划编制和管控技术需要风景园林的视角。针对空间规划和风景园林的衔接问题,通过总结相关文献和报告,介绍德国景观规划的发展经验。德国作为实行空间规划体系的国家其景观规划对自然保护和景观多种功能的平衡做出了重要贡献。研究梳理德国景观规划的目标、层级、基础作用、模块设置以及对社会发展需求的灵敏反应。德国景观规划对中国风景园林衔接新的空间规划体系具有借鉴意义,特别是模块式的任务构建,在各尺度层级保持连贯的目标体系,以及系统地革新理论框架。

关键词：风景园林景观规划德国社会变化国土空间规划

National Forest Inventories capture the multifunctionality of managed forests in Germany

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Forest Ecosystems 2021年第1期8卷 50-68页

作者： Nadja K.Simons María R.Felipe-Lucia Peter Schall christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser Terrestrial Ecology Research Group Technische Universität MünchenHans-Carl-von-Carlowitz-Platz 285354 FreisingGermany Present address:Ecological Networks Technische Universität DarmstadtSchnittspahnstraße 364287 DarmstadtGermany Helmholtz Centre for Environmental Research-UFZ Department of Ecosystem ServicesDeutscher Platz 5e04103 LeipzigGermany Present address:German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Silviculture and Forest Ecology of the Temperate Zones University of GöttingenBüsgenweg 137077 GöttingenGermany Centre for Biodiversity and Sustainable Land-use University of GöttingenBüsgenweg 137073 GöttingenGermany Chair of Silviculture Faculty of Environment and Natural ResourcesUniversity of FreiburgTennenbacherstr.479106 FreiburgGermany Ecological Networks Technische Universität DarmstadtSchnittspahnstraße 364287 DarmstadtGermany Institute of Plant Sciences University of BernAltenbergrain 213013 BernSwitzerland Biodiversity and Conservation Biology WSL Swiss Federal Research InstituteZürcherstrasse 1118903 BirmensdorfSwitzerland Helmholtz Centre for Environmental Research-UFZ Department of Soil EcologyTheodor-Lieser-Straße 406120 Halle(Saale)Germany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Forest Entomology WSL Swiss Federal Research InstituteZürcherstrasse 1118903 BirmensdorfSwitzerland Department of Environmental Systems Science Institute of Terrestrial EcosystemsETH ZürichUniversitätstr 168092 ZürichSwitzerland Environmental Informatics University of MarburgDeutschhausstraße 1235032 MarburgGermany Evolutionary Ecology and Conservation Genomics Ulm UniversityAlbert-Einstein-Allee 1189069 UlmGermany Senckenberg Biodiversity and Climate Research Centre Senckenberganlage 2560325 Frankfurt am MainGermany Geoecology University of TübingenRümelinstraße 19-2372070 TübingenGermany Present address:Department of Sustaina

Background:Forests perform various important ecosystem functions that contribute to ecosystem *** many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem ***,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem *** on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem *** use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory ***:Looking at the potential supply of ecosystem services,we found trade-offs(*** both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(*** temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in *** single forest type provided all ecosystem services *** ecosystem services showed comparable levels across forest types(*** or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(*** availability or cover of edible plants)or tree species composition(*** nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental ***,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree ***:Our results show that forest multifunctionality is limited to subsets of ecosystem *** importance of tree species composition highlights that a lack of multifunctionality at the stand lev

关键词： Ecosystem processes and services Forest management Structural diversity Tree species composition Trade-offs and synergies Forest productivity

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国