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Enhancing 3D Reco.structio. Accuracy o. FIB To.o.raphy Data Using Multi‑vo.tage Images and Multimo.al Machine Learning

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Nano.anufacturing and Metro.o.y 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmano. Yo.g Li Lukas Riedel Shan Shi christian J.Cyro. Ro.and C.Aydin Martin ritter Institute fo. Co.tinuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electro. Micro.co.y Unit Hamburg University of TechnologyHamburgGermany Institute o. Materials Physics and Techno.o.y Hamburg University of TechnologyHamburgGermany Institute o. Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Gro.p o. Integrated Metallic Nano.aterials Systems Hamburg University of TechnologyHamburgGermany Institute o. Material Systems Mo.eling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM to.o.raphy is a po.erful technique that integrates a fo.used io. beam(FIB)and a scanning electro. micro.co.e(SEM)to.capture high-reso.utio. imaging data o. *** appro.ch invo.ves co.lecting in-plane SEM imagesand using FIB to.remo.e material layers fo. imaging subsequent planes,thereby pro.ucing image ***,theseimage stacks in FIB-SEM to.o.raphy are subject to.the shine-thro.gh effect,which makes structures visible fro. thepo.terio. regio.s o. the current *** artifact intro.uces an ambiguity between image intensity and structures in thecurrent plane,making co.ventio.al segmentatio. metho.s such as thresho.ding o. the k-means algo.ithm *** study,we pro.o.e a multimo.al machine learning appro.ch that co.bines intensity info.matio. o.tained at differentelectro. beam accelerating vo.tages to.impro.e the three-dimensio.al(3D)reco.structio. o. *** treatingthe increased shine-thro.gh effect at higher accelerating vo.tages as a fo.m o. additio.al info.matio.,the pro.o.ed metho.significantly impro.es segmentatio. accuracy and leads to.mo.e precise 3D reco.structio.s fo. real FIB to.o.raphy data.

关键词： Multimo.al machine learning Multi-vo.tage images FIB-SEM o.erdeterministic systems 3D reco.structio. FIB to.o.raphy

Perceived value o. micro.inance and SME perfo.mance: The ro.e o. explo.ato.y inno.atio.

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Internatio.al Jo.rnal o. Inno.atio. Studies 2024年第2期8卷 172-185页

作者： christian Sarfo.Jing A.Zhang Co.o. o.Kane Paula o.Kane Department o. Management University of LincolnBrayford PoolLincoln LN67TSUnited Kingdom Department o. Management Otago Business SchoolUniversity of OtagoPO Box 56Dunedin9054New Zealand

This study examines ho. perceived value o. micro.inance and explo.ato.y inno.atio. affect small and medium-sized enterprises(SME)perfo.mance in the co.text o. a develo.ing *** o. the strategic inno.atio. and micro.inance literature,we hypo.hesize that(1)perceived value o. micro.inance affects explo.ato.y inno.atio. and SME perfo.mance,and(2)explo.ato.y inno.atio. serves as an effective mechanism thro.gh which micro.inance enhances SME *** emplo. partial least squares structural equatio. mo.eling(PLS-SEM)to.test o.r *** a sample o. 581 Ghanaian SMEs with micro.inance,the results o. the PLS SEM suppo.t o.r *** further co.ducted a qualitative analysis o. co.ments pro.ided by the SMEs(n=144)to.gain a deeper understanding o. explo.ato.y inno.atio. in develo.ing *** findings sho. that SMEs purpo.efully attempt to.strengthen their explo.ato.y inno.vatio. in *** discuss the theo.etical and practical implicatio.s o. these findings as well as future research avenues.

关键词： Perceived value o. micro.inance Explo.ato.y inno.atio. SME perfo.mance

Gust respo.se o. an elasto.flexible mo.phing wing using fluid–structure interactio. simulatio.s

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Chinese Jo.rnal o. Aero.autics 2024年第2期37卷 45-57页

作者： Jo.athan PFLÜGER christian BREITSAMTER Department o. Mechanical Engineering Technical University of MunichGarching 85748Germany

Small and micro.unmanned aircraft are the fo.us o. scientific interest due to.their wide range o. *** o.ten o.erate in a highly unstable flight enviro.ment where the applicatio. o. new mo.phing wing techno.o.ies o.fers the o.po.tunity to.impro.e flight *** investigated co.cept co.prises po.t and starbo.rd adjustable wings,and an adaptive elasto.lexible membrane serves as the lifting *** fo.us is o. the benefits o. the defo.ming membrane during the impact o. a o.e-minus-co.ine type *** a lo. Reyno.ds number o. Re=264000,the mo.phing wing mo.el is investigated numerically by unsteady fluid-structure interactio. ***,the numerical results are validated by experimental data fro. fo.ce and mo.ent,flo. field,and defo.matio. ***,with the rigid wing as the baseline,the flexible case is investigated,fo.using o. the advantages o. the elastic *** all co.figuratio.s studied,the maximum amplitude o. the lift co.fficient under gust lo.d sho.s go.d agreement between the experimental and numerical *** the decay o. the gust,they differ mo.e the higher the aspect ratio.o. the *** co.sidering the flo. field,the main differences are due to.the separatio. behavio. o. the upper side o. the *** flo. reattaches earlier in the experiments than in the simulatio.s,which explains the higher lift values o.served in the *** at o.e intermediate co.figuratio. do.s the lift amplitude o. the rigid co.figuratio. exceeds that o. the flexible by abo.t 12%,with the elastic membrane resulting in a smaller and mo.e unifo.m peak lo.d,which is also.evident in the wing lo.ding and hence in the ro.t bending mo.ent.

关键词： Membrane wing Mo.phing wing Flexible wing surface Co.putatio.al fluid dynam-ics Fluid-structure interactio. Unsteady inflo. co.ditio. Gust respo.se

Aggreso.e-aggrephagy transitio. pro.ess:geting clo.er to.the functio.al ro.es o. HDAC6 and BAG3

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Neural Regeneratio. Research 2024年第6期19卷 1181-1182页

作者： Hagen Körschgen christian Behl The Auto.hagy Lab Institute of PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Misfo.ding o. pro.eins as well as their aggregatio. is a majo. driver o. age-related neuro.egenerative ***,cells have evo.ved so.histicated pro.ein quality co.tro. *** the ubiquitin-pro.easo.e-system(UPS)and the auto.... 详细信息

关键词： clo.er system transitio.

Ray tracing particle image velo.imetry-Challenges in the applicatio. to.a packed bed

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Particuo.o.y 2024年第1期84卷 194-208页

作者： Christin Velten Mirko.Ebert christian Lessig Katharina Zahringer Lehrstuhl für Strömungsmechanik und Strömungstechnik Otto-von-Guericke-Universität Magdeburg39106MagdeburgGermany Institut für Simulatio. und Graphik Otto-von-Guericke-Universität Magdeburg39106MagdeburgGermany

Ray tracing Particle Image Velo.imetry(RT-PIV)is an o.tical technique fo. high reso.utio. velo.ity measurements in challenging o.tical systems,such as transparent packed beds,that uses ray tracing to.co.rect fo. disto.tio.s intro.uced by transparent geo.etries in the light *** ray tracing based co.rectio. is a po.t pro.essing step applied to.the raw PIV particle images befo.e classical PIV *** this study,RT-PIV is perfo.med in the to. layer o. a bo.y centred cubic(bcc)sphere packing with gaseo.s flo.,where o.tical access is o.tained by the use o. transparent N-BK7 glass balls with a diameter o. d=40 ***-PIV intro.uces new experimental and numerical challenges,fo. example a limited field o. view,illuminatio. difficulties,a very large required depth o. field and high sensitivity to.geo.etric parameters used in the ray tracing *** challenges and their implicatio.s are the main sco.e and discussed in the present ***,the validatio. o. the ray tracing reco.structio. step is presented and examples fo. the o.tained co.rected vecto. fields in a packed bed are *** results sho. the strength o. the metho. in reco.structing velo.ity fields behind transparent spheres that wo.ld no. have been accessible by o.tical measurement techniques witho.t the ray tracing co.rectio..

关键词： Ray tracing particle image velo.imetry(RT-PIV) Transparent spherical particles Packed bed Disto.tio. co.rectio. Gas flo.

Diabetes and pulmo.ary infectio.:ho. hyperglycaemia shapes the immune system

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Signal Transductio. and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： christian Herder Michael Ro.en Nico.as Venteclef Institute fo. Clinical Diabeto.o.y German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center fo. Diabetes Research(DZD) Partner Düsseldorf85764München-NeuherbergGermany Department o. Endo.rino.o.y and Diabeto.o.y Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,No.s and co.leagues aimed to.identify no.el mechanisms that may explain why diabetes is asso.iated with an increased susceptibility to.viral respirato.y *** analyses revealed a central ro.e o. lung dendritic cells(DC)which exhibited several functio.al defects induced by hyperglycaemia and co.sequently result in impaired antiviral immune respo.ses.

关键词： impaired lung respirato.y

Clustering o. vo.tage-gated io. channels as an evo.utio.ary trigger o. myelin fo.matio.

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Neural Regeneratio. Research 2024年第8期19卷 1631-1632页

作者： Henrike o.m Simo.e Rey christian Klambt Institut fur Neuro.und Verhaltensbio.o.ie MunsterGermany

Neuro.s carry apical dendrites that perceive info.matio. and a basal axo. that transmits the co.puted info.matio. to.ards its to.*** axo. o.iginates at the axo. hillo.k which is fo.lo.ed by the axo. initial ***,actio. po.entials are initiated that are based o. milliseco.d lo.g o.enings o. specific vo.tagegated so.ium and po.assium channels that are co.served in all paraho.o.o.(Placo.o.,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry po.assium

Pro.apo.in hyperglyco.ylatio.: a no.el tumo. immune escape mechanism and implicatio.s fo. cancer immuno.herapy

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Signal Transductio. and Targeted Therapy 2024年第8期9卷 3150-3152页

作者： Matthias Peipp Diana Dudziak christian Kellner Divisio. o. Antibo.y-Based Immuno.herapy Department of Medicine IChristian-Albrechts University and University Hospital Schleswig-HolsteinKielGermany institute o. Immuno.o.y Jena University HospitalFriedrich-Schiller-UniversityJenaGermany Co.prehensive Cancer Center Central Germany Jena/Leipzig JenaGermany Divisio. o. Transfusio. Medicine Cell Therapeutics and HaemostaseologyLMU University HospitalLMU MunichMunichGermany

In a recent article published in Science,Sharma et *** the essential ro.e o. sapo.ins in cro.s-presentatio. o. tumo. membraneasso.iated antigens by dendritic cells(DC)to.CD8^(+)T cells.1 Ho.ever,antigen cro.s-presentatio.,which is fundamental in cancer cell eliminatio.,is hindered in tumo. DC by hyperglyco.ylatio. o. the co.mo. sapo.in precurso. pro.apo.in(pSAP)leading to.impaired T cell tumo. immunity-yet,the po.ential o. reco.binant pSAP to.re-establish T cell respo.ses may o.fer a no.el way to.co.nteract immune evasio. in a therapeutic appro.ch.

关键词： impaired immunity al.

A numerical and experimental co.pariso. o. heat transfer in a quasi two.dimensio.al packed bed

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Particuo.o.y 2024年第1期84卷 136-144页

作者： Matthias Tyslik Mirko.Ebert Martin Schiemann Siegmar Wirtz christian Lessig Department o. Energy Plant Techno.o.y Ruhr-University BochumGermany Institute fo. Simulatio. and Graphics Otto-von-Guericke-Universität MagdeburgGermany

Heat transfer plays a majo. ro.e in many industrial pro.esses taking place in packed *** accurate and reliable simulatio. o. the heat exchange between particles is therefo.e crucial fo. a reliable o.eratio. and to.o.timize the pro.esses in the *** discrete o.dinates metho.(Do.)pro.ides an established numerical technique to.mo.el radiative heat transfer in granular media that o.fers the po.sibility to.co.sider the directio.al dependence o. the radiatio. *** this wo.k,Do. is co.pared with Mo.te Carlo.ray tracing,which pro.ides an alternative metho. fo. heat transfer ***-rically simple co.figuratio.s are used to.investigate the influence o. the angular discretizatio. o. the accuracy o. the results and the co.putatio. time in bo.h *** o.tained insights are then transferred to.a mo.e co.plex co.figuratio. o. a quasi two.dimensio.al test rig co.sisting o. metal ro.s fo. which also.experimental results are *** results sho. that bo.h Do. and Mo.te Carlo.ray tracing allo. fo. an accurate simulatio. o. heat transfer in packed *** Carlo.ray tracing requires thereby co.putatio. times that are surprisingly co.petitive(altho.gh still so.ewhat slo.er)co.pared to.Do. and allo.s fo. an easier co.putatio. o. highly accurate reference *** o.r preliminary co.pariso. to.the experimental test rig,Mo.te Carlo.ray tracing also.pro.ides the advantage that it can mo.e easily mo.el highly specular materials such as stainless *** metho.s are co.parable fo. diffuse materials such as magnesium o.ide.

关键词： Heat transfer Discrete o.dinates metho. Mo.te Carlo.ray tracing