Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system

作     者：Christian Herder Michael Roden Nicolas Venteclef Christian Herder;Michael Roden;Nicolas Venteclef

作者机构：Institute for Clinical DiabetologyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for Diabetes Research(DZD)Partner Düsseldorf85764München-NeuherbergGermany Department of Endocrinology and DiabetologyMedical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM)UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第4期

页      面：1245-1246页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a grant from Horizon Europe (INTERCEPT-T2D,101095433) supported by the German Diabetes Center (DDZ),which is funded by the German Federal Ministry of Health (Berlin,Germany) the Ministry of Culture and Science of the state North Rhine-Westphalia (Düsseldorf,Germany) receives additional funding from the German Federal Ministry of Education and Research (BMBF)through the German Center for Diabetes Research (DZD e.V.) 

主　　题：impaired lung respiratory 

摘      要：In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.