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Polyherbal formula SC-E3 inhibits rheumatoid arthritis activity in a mouse model of type-Ⅱcollagen-induced arthritis

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Journal of Integrative Medicine 2021年第3期19卷 265-273页

作者： Ju-Yeon Park Young-Won Kwon Sun-Ah kim Sun-Dong Park Chang-Hyun kim Jin-hee kim Ju-hee Lee College of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Biomedical Laboratory Science College of Health ScienceCheongju UniversityCheongju 28503Republic of Korea

Objective:SC-E3 is a polyherbal formula that contains five medicinal herbs used frequently in traditional herbal *** our previous study,we demonstrated the antioxidant and anti-inflammatory effects of *** present study examined the effects of SC-E3 in a mouse model of type-II collagen-induced arthritis(CIA).Methods:In vivo,male DBA/1 J mice were immunized by intradermal injection of bovine type-II collagen and complete or incomplete Freund’s adjuvant,to induce ***-E3 was orally administered daily for 23 *** vitro,bone marrow-derived macrophages(BMMs)were treated with macrophage colony-stimulating factor(M-CSF)and receptor activator of nuclear factor-j B ligand(RANKL)in the absence or presence of ***:Administrations of SC-E3 were found to have anti-arthritic effects in the joints of CIA mice,as evidenced by reduced paw swelling,bone erosion and deformation,inflammatory cell infiltration,and inflammation in synovial ***-E3 also reduced serum levels of tumor necrosis factor-a,interleukin-1 b,aspartate aminotransferase and alanine ***,tartrateresistant acid phosphatase-positive osteoclast numbers in the joints were significantly lower in SC-E3-treated CIA mice than in CIA *** addition,the differentiations of BMMs to multinucleated osteoclasts induced by M-CSF and RANKL stimulation were dose-dependently reduced by ***:These results suggest that SC-E3 possesses substantial anti-arthritic activity because it inhibits pro-inflammatory cytokines and osteoclastogenesis,and that SC-E3 has potential therapeutic use for the treatment of rheumatoid arthritis.

关键词： Herbal formula Anti-inflammatory Rheumatoid arthritis Collagen-induced arthritis Osteoclastogenesis

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Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1113-1116页

作者： Joonku Hahn Hwi kim Yongjun Lim Eun-hee kim Byoungho Lee School of Electrical Engineering Seoul National University

We propose a novel spatial phase-shifting interferometry that exploits a genetic algorithm to compensate for geometric errors. Spatial phase-shifting interferometry is more suitable for measuring objects with properties that change rapidly in time than the temporal phase-shifting interferometry. However, it is more susceptible to the geometric errors since the positions at which interferograms are collected are different. In this letter, we propose a spatial phase-shifting interferometry with separate paths for object and reference waves. Also, the object wave estimate is parameterized in terms of geometric errors, and the error is compensated by using a genetic algorithm.

关键词： Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm

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Cloud Radiative Effects and Changes Simulated by the Coupled Model Intercomparison Project Phase 5 Models

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Advances in Atmospheric Sciences 2017年第7期34卷 859-876页

作者： Sun-hee SHIN Ok-Yeon kim Dongmin kim Myong-In LEE Climate Research Department APEC Climate Center Busan 48058 Republic of Korea School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Republic of Korea

Using 32 CMIP5（Coupled Model Intercomparison Project Phase 5） models, this study examines the veracity in the simulation of cloud amount and their radiative effects（CREs） in the historical run driven by observed external radiative forcing for 1850-2005, and their future changes in the RCP（Representative Concentration Pathway） 4.5 scenario runs for2006-2100. Validation metrics for the historical run are designed to examine the accuracy in the representation of spatial patterns for climatological mean, and annual and interannual variations of clouds and CREs. The models show large spread in the simulation of cloud amounts, specifically in the low cloud amount. The observed relationship between cloud amount and the controlling large-scale environment are also reproduced diversely by various models. Based on the validation metrics,four models-ACCESS1.0, ACCESS1.3, Had GEM2-CC, and Had GEM2-ES-are selected as best models, and the average of the four models performs more skillfully than the multimodel ensemble *** models project global-mean SST warming at the increase of the greenhouse gases, but the magnitude varies across the simulations between 1 and 2 K, which is largely attributable to the difference in the change of cloud amount and distribution. The models that simulate more SST warming show a greater increase in the net CRE due to reduced low cloud and increased incoming shortwave radiation, particularly over the regions of marine boundary layer in the subtropics. Selected best-performing models project a significant reduction in global-mean cloud amount of about-0.99% K^-1and net radiative warming of 0.46 W m^-2K^-1, suggesting a role of positive feedback to global warming.

关键词： warming cloud radiative historical CMIP interannual greenhouse ACCESS oceans seasonal

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Risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第1期12卷 99-104页

作者： Bong-Wan kim Young-Bae kim hee-Jung Wang Myung-Wook kim Department of Surgery Ajou University School of MedicineWonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea Department of Pathology Ajou University School of Medicine.Wonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea

瞄准：调查 clinicopathological 风险因素因为肝细胞癌(HCC ) 的立即的手术后的致命的复发，它可以有实际牵连并且贡献高建立对 HCC 复发为外科手术前或手术后的预防措施冒病人的风险。方法：从 1994 年 6 月到 2004 年 5 月，为 HCC ... 详细信息

瞄准：调查 clinicopathological 风险因素因为肝细胞癌(HCC ) 的立即的手术后的致命的复发，它可以有实际牵连并且贡献高建立对 HCC 复发为外科手术前或手术后的预防措施冒病人的风险。方法：从 1994 年 6 月到 2004 年 5 月，为 HCC 收到了药品切除术的 269 个病人被考察。这些病人，在外科以后在 6 瞬间以内表明了弥漫的 intra 肝或多重的全身的周期性的损害的那些被调查(致命的复发组) 。留下的病人被指定为控制组，并且二个组为临床病理风险因素被比较。结果：在考察的 269 个病人之中， 30 个病人在致命的复发组被注册。在后者之中， 20 个病人证明弥漫的 intra 肝的复发类型和 10 显示出的多重全身的复发打字。在致命的复发组和控制组之间的 Multivariate 分析证明那外科手术前的浆液 alpha-fetoprotein (法新社) 水平比 1,000 microg/L 大(P = 0.02；机会比率 = 2.98 ) ，比 6.5 厘米大的肿瘤尺寸(P = 0.03；或 = 2.98 ) ，并且微脉管的侵略的存在(P = 0.01；或 = 4.89 ) 是在致命的复发组的风险因素。有所有三个风险因素的 48.1% 病人和有二个风险因素的 22% 那些在外科以后在 6 瞬间以内经历了致命的复发。结论：为在药品切除术以后的 HCC 的立即的手术后的致命的复发的三个不同风险因素是外科手术前的浆液法新社水平 > 1,000 microg/L，肿瘤尺寸 > 6.5 厘米，和微脉管的侵略。有二的高风险病人或更多的风险因素应该是各种各样的辅助临床的试用的候选人。

关键词：肝细胞癌固化剂临床表现治疗

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Facile synthesis of graphitic carbon-nitride supported antimony-doped tin oxide nanocomposite and its application for the adsorption of volatile organic compounds

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Journal of Environmental Sciences 2019年第5期31卷 35-42页

作者： Devi Prashad Ojha Jun hee Song Han Joo kim Department of Convergence Technology Engineering Chonbuk National University Eco-friendly Machine Parts Design Center Chonbuk National University

Antimony-doped tin oxide(ATO) nanoparticles with an average size of ～ 6 nm were prepared by co-precipitation and subsequent heat treatment. Graphitic carbon nitride(g-CN)/ATO hybrid nanocomposite was designed by the combination of thermally synthesized g-CN and ATO nanoparticles by ultrasonication. The materials were characterized using N2 adsorption/desorption(BET), X-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), transmission electron microscopy(TEM) and Fourier transform infrared spectroscopy(FTIR). A mixture of five volatile organic compounds(VOCs, chloroform, benzene, toluene, xylene and styrene) was used to compare the adsorption capacity of the samples. The adsorption capacity of ATO nanoparticles was improved by the addition of g-CN. Experimental data showed that, among the five VOCs,chloroform was the least adsorbed, regardless of the samples. The g-CN/ATO showed nearly three times greater adsorption capacity for the VOC mixture than pure ATO. The unchanged efficiency of VOC adsorption during cyclic use demonstrated the completely reversible adsorption and desorption behavior of the nanocomposite at room conditions. This economically and environmentally friendly material can be a practical solution for outdoor and indoor VOC removal.

关键词： Antimony-doped tin oxide(ATO) Graphitic carbon nitride(g-CN) Volatile organic compounds(VOC) Adsorption

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Development of polyimide films reinforced with boron nitride and boron nitride nanosheets for transparent flexible device applications

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Nano Research 2018年第5期11卷 2366-2378页

作者： You Jin Min Kyeong-hee Kang Dae-Eun kim Department of Mechanical Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea

The benefits of reinforcing polyimide （PI） films with boron nitride （BN） particles and boron nitride nanosheets （BNNSs） were assessed with the aim of enhancing their thermal, optical, and mechanical properties for flexible device applications. BNNSs were prepared from BN particles using a liquid-phase exfoliation method assisted by an ultrasonic probe-type sonicator and centrifugator. PI-based composite films blended with BNNSs and BN particles were fabricated at various concentrations via mechanical stirring and spin coating. The transparency of the PI/BNNS composite films remained almost the same as that of pure PI films up to 3 wt.% whereas the transparency of the PI/BN composite films decreased with increasing concentration of the BN fillers at 550 nm. The thermal stability improved significantly with increasing concentrations of both BN and BNNS relative to that of pure PI films. The temperature for 5% weight loss of the PI/BNNS composite film was higher than that of the PI/BN composite film at the same filler concentration. The composite films with 2 wt.% BN or BNNS showed the lowest wear rate, and the PI/BNNS composite films showed more stable frictional behavior compared to the PI/BN composite films. In addition, bending tests showed that the PI/BNNS composite films exhibited excellent flexibility compared to the PI/BN composite films. Overall, the results indicate that the BNNS can be effectively used as a filler that can enhance the thermal and mechanical properties of polymer materials for flexible device applications.

关键词： polyimide (PI) boron nitride (BN) transparency thermal properties flexibility tribology

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Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer?

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World Journal of Gastrointestinal Oncology 2017年第8期9卷 319-326页

作者： Jae Seung Soh Hyun Lim Ho Suk Kang Jong Hyeok kim Kab choong kim Department of Internal Medicine University of Hallym College of Medicine Hallym University Sacred Heart Hospital Department of Surgery University of Hallym College of Medicine Hallym University Sacred Heart Hospital

AIM To investigate the clinicopathological variables in early gastric cancer(EGC) patients in relation to differentiation *** The data of 265 specimens from 240 patients with EGC, who had undergone radical operation at Hallym University Sacred Heart Hospital from 2010 to 2015, were retrospectively analyzed. We evaluated clinical, endoscopic, and histopathological data according to histological *** Clinically significant discrepancy rate showed the difference in differentiated type(well and moderately differentiated) and undifferentiated type(poorly differentiated and signet ring cell) between endoscopic biopsies and postoperative specimens was 9.4%(25/265). There were no differences in tumor location, size, gross pattern, and number of biopsies. Specimens having histological discrepancy showed more submucosal invasion(72.0% vs 49.6%, P = 0.033) and lymph node involvement(24.0% vs 7.9%, P = 0.009) than specimens having non-discrepancy. The rate of a positive epidermal growth factor receptor status was higher in specimens having discrepancy than in specimens having non-discrepancy(81.0% vs 55.4%, P = 0.035).CONCLUSION The discordance of histologic differentiation is associated with higher submucosal invasion and lymph node metastases in EGC. Patients have histological discrepancy may require additional surgical treatments.

关键词：早胃的癌症组织学的差异区别 Clinicopathological 因素内视镜的治疗外科的治疗

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Atomic Dispersion of Rh on Interconnected Mo_(2)C Nanosheet Network Intimately Embedded in 3D Ni_(x)MoO_(y) Nanorod Arrays for pH-Universal Hydrogen Evolution

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Energy & Environmental Materials 2023年第5期6卷 236-250页

作者： Thi Luu Luyen Doan Dinh Chuong Nguyen Patrick M.Bacirhonde Ahmed S.Yasin Abdelrahman I.Rezk Nelson Y.Dzade Cheol Sang kim Chan hee Park Department of Bionanotechnology and Bioconvergence Engineering Graduate SchoolJeonbuk National UniversityJeonju Jeollabuk-do 54896Korea Department of Nano Convergence Engineering Jeonbuk National UniversityJeonju Jeollabuk-doJeonbuk 54896Korea Graduate School of Energy Science and Technology Chungnam National UniversityDaejeon 34134Korea Department of Energy and Mineral Engineering The Pennsylvania State UniversityUniversity Park State CollegePA 16802USA Division of Mechanical Design Engineering School of EngineeringJeonbuk National UniversityJeonju Jeollabuk-do 54896Korea Department of Bionanosystem Engineering Graduate School Jeonbuk National UniversityJeonju Jeollabuk-do 54896Korea

Herein,a simple synthetic approach is employed for the atomic dispersion of Rh atoms(Rh SAs)over the surface of interconnected Mo_(2)C nanosheets intimately embedded in a three-dimensional Ni_(x)MoO_(y)nanorod arrays(Ni_(x)MoO_(y)NRs)framework;we found that the introduction of both isolated Rh SAs and Ni_(x)MoO_(y)NRs adjusts the electrocatalytic function of the host Mo_(2)C toward the direction of being an advanced and highly stable electrocatalyst for efficient hydrogen evolution at pH-universal *** a result,the proposed catalyst outperforms most recently reported transition metal-based catalysts,and its performance even rivals that of commercial Pt/C,as demonstrated by its ultralow overpotentials of 31.7,109.7,and 95.4 mV at a current density of 10 mA cm^(-2),along with its small Tafel slopes of 42.4,51.2,and 46.8 mV dec^(-1)in acidic,neutral,and alkaline conditions,*** addition,the catalyst shows remarkable long-term stability over all pH values with good maintenance of its catalytic activity and structural characteristics after continuous operation.

关键词： hydrogen evolution reaction Mo_(2)C nanosheets Ni_(x)MoO_(y)nanorod arrays pH-universal catalyst single Rh atoms

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Mechanical characteristics of fused cast basalt tube encased in steel pipe for protecting steel surface

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中国有色金属学会会刊：英文版 2009年第4期19卷 935-940页

作者： Jee-Seok WANG Jong-Do kim hee-Jong YOON Division of Mechanical and Information Engineering Korea Maritime University Division of Marine System Engineering Korea Maritime University Department of Research and Development Dongdo Basalt Industry Co.Ltd

Because of the various excellent characteristics of cast basalt materials,such as,anti-corrosion,anti-wearing,good hardness,high chemical stability,of which steel may not possess,the steel-basalt composite pipes are used in severe environments for compensating the defects of *** limit of bending moment with which steel-basalt composite pipe may safely endure was calculated and the limit curvature of the composite pipe in the safe range was *** application temperature of steel-basalt pipe was examined due to a different coefficient among basalt,mortar and mild steel.

关键词：玄武岩钢管表面保护机械特性包裹熔铸化学稳定性复合管

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Korean red ginseng promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2020年第5期15卷 887-893页

作者： Sun Ryu Hyongjun Jeon hee-Young kim Sungtae Koo Seungtae kim Korean Medicine Research Center for Healthy Aging Pusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea

Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and *** red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still ***,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the ***-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 ***,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral *** in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then ***-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated *** Morris water maze test showed that KRG administration enhanced the learning and memory abilities *** also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to *** of KRG promotes learning and memory abilities,possibly by enhancing hippocampal *** study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval ***-2016-1071) on January 19,2016.

关键词： bromodeoxyuridine cerebral dopamine neurotrophic factor ciliary neurotrophic factor doublecortin ginseng hippocampus Korean red ginseng learning memory neurogenesis proliferating cell nuclear antigen red ginseng

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