Polyherbal formula SC-E3 inhibits rheumatoid arthritis activity in a mouse model of type-Ⅱcollagen-induced arthritis

作     者：Ju-Yeon Park Young-Won Kwon Sun-Ah Kim Sun-Dong Park Chang-Hyun Kim Jin-Hee Kim Ju-Hee Lee Ju-Yeon Park;Young-Won Kwon;Sun-Ah Kim;Sun-Dong Park;Chang-Hyun Kim;Jin-Hee Kim;Ju-Hee Lee

作者机构：College of Korean MedicineDongguk UniversityGoyang 10326Republic of Korea Department of MedicineCollege of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Biomedical Laboratory ScienceCollege of Health ScienceCheongju UniversityCheongju 28503Republic of Korea 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2021年第19卷第3期

页      面：265-273页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Research Foundation of Korea grant funded by the Korea government(No.2019R1F1A1062998) 

主　　题：Herbal formula Anti-inflammatory Rheumatoid arthritis Collagen-induced arthritis Osteoclastogenesis 

摘      要：Objective:SC-E3 is a polyherbal formula that contains five medicinal herbs used frequently in traditional herbal *** our previous study,we demonstrated the antioxidant and anti-inflammatory effects of *** present study examined the effects of SC-E3 in a mouse model of type-II collagen-induced arthritis(CIA).Methods:In vivo,male DBA/1 J mice were immunized by intradermal injection of bovine type-II collagen and complete or incomplete Freund’s adjuvant,to induce ***-E3 was orally administered daily for 23 *** vitro,bone marrow-derived macrophages(BMMs)were treated with macrophage colony-stimulating factor(M-CSF)and receptor activator of nuclear factor-j B ligand(RANKL)in the absence or presence of ***:Administrations of SC-E3 were found to have anti-arthritic effects in the joints of CIA mice,as evidenced by reduced paw swelling,bone erosion and deformation,inflammatory cell infiltration,and inflammation in synovial ***-E3 also reduced serum levels of tumor necrosis factor-a,interleukin-1 b,aspartate aminotransferase and alanine ***,tartrateresistant acid phosphatase-positive osteoclast numbers in the joints were significantly lower in SC-E3-treated CIA mice than in CIA *** addition,the differentiations of BMMs to multinucleated osteoclasts induced by M-CSF and RANKL stimulation were dose-dependently reduced by ***:These results suggest that SC-E3 possesses substantial anti-arthritic activity because it inhibits pro-inflammatory cytokines and osteoclastogenesis,and that SC-E3 has potential therapeutic use for the treatment of rheumatoid arthritis.