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Fabry病患者的常规超声心动图及左心二维斑点追踪超声应变特征

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中华高血压杂志（中英文） 2024年第6期32卷 565-571页

作者：于扬王崇慧王涵杨颖刘琳范芳芳赵亚雯张巍马为北京大学第一医院心内科北京100034 北京大学国际医院心内科北京100034 北京大学第一医院神经内科北京100034

目的通过常规超声心动图及左心二维斑点追踪超声心动图(2D-STE)分析Fabry病患者心肌受累情况,探讨Fabry病患者左心房、左心室应变特征。方法回顾性选取2014年8月至2023年2月在北京大学第一医院心内科、神经内科、肾内科就诊且在心内科... 详细信息

目的通过常规超声心动图及左心二维斑点追踪超声心动图(2D-STE)分析Fabry病患者心肌受累情况,探讨Fabry病患者左心房、左心室应变特征。方法回顾性选取2014年8月至2023年2月在北京大学第一医院心内科、神经内科、肾内科就诊且在心内科行超声心动图检查的69例Fabry病患者作为Fabry病组,同期纳入年龄、性别匹配,无心血管、脑血管、肾脏、代谢及自身免疫性等疾病且超声心动图检查无明显异常的患者69例作为对照组。收集研究对象的临床资料、实验室检查,进行常规超声心动图测量和2D-STE分析左心房应变以及左心室纵向应变,比较组间相关参数的差异。结果与对照组相比,Fabry病组患者的体重指数、体表面积更小,心率更慢,估算的肾小球滤过率(eGFR)更低,脑利尿钠肽(BNP)、心肌肌钙蛋白I(cTnI)更高(均P<0.05)。Fabry病组的室间隔舒张早期反向峰(E'med)减低[(8.4±3.4)比(9.9±2.8)cm/s,t=2.821,P=0.006],而E峰、E峰减速时间、肺动脉收缩压升高,室间隔、左心室后壁厚度,左心室质量指数、二尖瓣口舒张早期峰值/室间隔舒张早期反向峰(E/E')升高(均P<0.05);Fabry病组左心房应变(包括储存期应变、管道期应变、泵血期应变)、左心室整体纵向应变减低,节段纵向应变中除下壁基底段、下壁中间段应变外,余节段纵向应变明显降低(均P<0.05)。结论Fabry病患者通常有肾脏、心脏等多器官受累。超声心动图通常表现为不同程度的心肌肥厚和舒张功能障碍,左室射血分数正常,而左心房应变、左心室整体及节段纵向应变均可出现不同程度的下降。

关键词： Fabry病左心室肥厚应变二维斑点追踪超声

Characterization of road surfacing aggregates based on their mineralogical fingerprint

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第5期9卷 880-891页

作者： Dawei wang Yulin He chonghui wang Zeyu Zhang Guoyang Lu Pengfei Liu Markus Oeser School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China Institute of Highway Engineering RWTH Aachen UniversityAachen 52074Germany Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina

To ensure the safety of infrastructure users,the long-term skid resistance is a crucial factor and is determined in large by the mineralogical and morphological characteristics of surfacing *** studies have investigated these aggregate properties separately without considering the interrelation between one *** objective of this study is to consider the morphological characteristics as well as the mineralogical fingerprint of aggregate to develop an innovative approach to optimize the aggregate selection *** investigations are based on 11 different aggregate types with a broad range of mineralogy,commonly used in *** long-term influence of polishing and wearing on the surface aggregate was simulated by means of the Aachen Polishing Machine and the MicroDeval test *** evaluate the impact of these tests,the aggregate shape was characterized by means of an imaging system called Aggregate Image Measurement System while the skid resistance of aggregates was evaluated with the British Pendulum *** test results show that the quartz and calcite are the key crystals to determine the anti-wear resistance of aggregates.A correlation between the skid resistance,morphological properties and mineralogy is derived,which proves the mineralogical fingerprint technology is practical for characterization of aggregates used in pavement surface layers.

关键词： Skid resistance Morphological properties Mineralogical fingerprint identification Road surface Accelerating polish

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T形橡胶密封圈压缩模优化设计

模具工业 2024年第3期50卷 48-52页

作者：方鹏胡阿林白亚玲王宠惠中航飞机起落架有限责任公司陕西汉中723000

飞机起落架T形橡胶密封圈模压成型过程中,分型面选择不合理导致飞边去除困难,且易伤及密封圈密封面;溢料槽距离型腔较远,余料不能全部流出,导致尺寸超差;料室、柱塞张角太大,浪费原料。通过分析T形橡胶密封圈使用功能,优化后将模具分型... 详细信息

飞机起落架T形橡胶密封圈模压成型过程中,分型面选择不合理导致飞边去除困难,且易伤及密封圈密封面;溢料槽距离型腔较远,余料不能全部流出,导致尺寸超差;料室、柱塞张角太大,浪费原料。通过分析T形橡胶密封圈使用功能,优化后将模具分型面设计在密封圈R0.5mm圆弧与直边转接处;溢料槽设计成等腰梯形,且边缘距离型腔1 mm;模具采用小角度锥面定位,定位精度高,保证同轴度;调整模具各型腔制造公差。模压成型的零件表面质量高,尺寸稳定性好,飞边去除简单方便,零件合格率达98%以上。

关键词： T形橡胶密封圈分型面溢料槽模压成型

Synthesis and Characterization of 2-cetyl-3-20 keto acid(N-ethyl perfluorinated octyl sulfonamide) N-ethyl ester

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Journal of Wuhan University of Technology(Materials Science) 2009年第2期24卷 292-294页

作者：翁睿 Department of Composites Wuhan University of Technology

2-Cetyl-3-20 keto acid（N-ethyl perfluorinated octyl sulfonamide） N-ethyl ester was synthesized by the reaction of N-ethyl-N-hydroxyethyl perfluorinated octyl sulfonamide and alky ketene dimer. The experimental results show that the yield of products can be 89% when the molar ratio of perfluorinated octyl sulfonamide to ketene dimer is 1 ： 1.1 and the reaction lasts about four hours at 80 ℃. The structure of the product was characterized by FTIR and ^1HNMR. The product can dissolve in polar solvents such as NMP, DMAC, THF, DMSO, CHCl3, and 10% weight-loss temperature measured by TGA is 202℃.

关键词： keto ester N-ethyl-N-hydroxyethyl perfluorinated octyl sulfonamide thermal performance

Lesson Learned from COVID-19 Retrospective Study: An Entropy-Based Clinical-Interpretable Scorecard for Mortality Risk Control at ICU Admission

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Tsinghua Science and Technology 2024年第1期29卷 34-45页

作者： Chong Yao chonghui Huangqi Anpeng Huang Laboratory of Network Information Security Beihang UniversityBeijing 100191China Andrew and Erna Viterbi School of Engineering University of Southern CaliforniaLos AnglesCA 90089USA Beijing Goodwill Information and Technology Co. Ltd.and Mobile Health LaboratoryPeking UniversityBeijing 100871China

With severe acute respiratory syndrome coronavirus 2 spreading globally and causing 2019 coronavirus disease(COVID-19),a challenge that we unprepared for was about how to optimally plan and distribute limited top-medical resources for patients in need of urgent *** address this challenge,physicians desperately needed a scientific tool to methodically differentiate between cases with varying *** this study,the unique data of COVID-19 intensive care unit(ICU)patients provided by the national medical team in Wuhan were classified into discrete and continuous variable *** continuous data were discretized using an entropy-based method and transformed into serial information margins,in which each information margin is related to a specific symptom or clinical ***,all these native and processed discrete data were used to configure a readable scorecard through logistic regression,which is the desired scientific tool aforementioned.A total of 322 ICU patients(age:[median:64,interquartile range:54-75],males:178[55.28%],and death:72[22.36%])were included in the *** of mortality in COVID-19 patients can be evaluated using a scorecard model(calibration slope:1.343,Brier:0.048,Dxy=0.972,and population stability index=0.071),with desired model performances(accuracy=0.948,area under curve=0.99,sensitivity=1,and specificity=0.939).This new model can interpret clinical meanings from complex data,and compare it with existing machine learning methods through a black-box *** new data-information model answers a critical question of how a computing algorithm produces clinically meaningful results that will help physicians logically allocate medical resources for COVID-19 ***,this tool has limitations,giving that this research is a retrospective ***,this tool will be tested further and optimized for adaptation to similar clinical cases in the future.

关键词： COVID-19 scorecard clinical-interpretable machine learning ICU admission control

Synthesis of the Novel Fluoride-containing Organic Silane

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Journal of Wuhan University of Technology(Materials Science) 2009年第4期24卷 644-646页

作者：汪水平 School of Materials Science and Technology Wuhan University of Technology

A fluoride-containing organic silane was synthesized by the reaction of N-ethyl- N-hydroxy-etbyl perfluorinated octyl sulfonamide （EHPOS）, N-（β-aminoethyl）-γ-aminopropyl trimethoxy silane （ATS） and cis-butenedioic anhydride （CA）. The experimental results show that the yield of product is up to 87% when the molar ratio ofEHPOS ： CA ： ATS is 1 ： 1.05 ： 1.1. EHPOS and CA were maintained at 115 ℃ for 3 hours, then after cooling the reaction solution to 75 ℃, ATS was added and reacted for another 3.5 hours at 145 ℃. The structure of the product and thermal properties were characterized by Fourier transform infrared （FTIR） and thermogravimetric analysis （TGA）, respectively. Results show that fluoride-containing organic silane has excellent thermal stability below 185℃.

关键词： N-ethyl-N-hydroxyethyl perfluorinated octyl sulfonamide cis-butenedioic anhydride N-(β-arninoethyl)-γ-aminopropyl trimethoxy silane

Rhyscotus subrisus Li&Jiang,***.,representing a new record family Rhyscotidae from China(Isopoda:Oniscidea)

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Zoological Systematics 2024年第2期49卷 181-183页

作者： chonghui Yao Chao Jiang Weichun Li College of Agronomy Jiangxi Agricultural UniversityNanchang 330045China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese MateriaMedicaChina Academy of Chinese Medical SciencesBeijing 100700China

The family Rhyscotidae Budde-Lund,1904 contains two genera:Rhyscotoides Schmalfuss&Ferrara,1978 and Rhyscotus Budde-Lund,*** date,twenty-one species within the family are known,occurring in the subtropic and tropic regions(Schmalfuss,2003;Schmidt,2003;Boyko et al.,2022).The members of the family can be recognized by the cephalon with a strongly inflated frons,the antennae with two-jointed flagellum,the maxillae are almost semicircular,the maxillipeds have short palpus and endite,and pleopod exopodites without pseudotracheae(Schmalfuss&Ferrara,1978).Before this study,the members of Rhyscotidae were unknown in *** present research describes a new species of the genus Rhyscotus from Hainan Island,representing a new record of the family Rhyscotidae from China.

关键词： record family

Genetic diversity of RNA viruses infecting invertebrate pests of rice

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Science China(Life Sciences) 2024年第1期67卷 175-187页

作者： Haoran wang Shufen Chao Qing Yan Shu Zhang Guoqing Chen chonghui Mao Yang Hu Fengquan Yu Shuo wang Liang Lv Baojun Yang Jiachun He Songbai Zhang Liangsheng Zhang Peter Simmonds Guozhong Feng State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 311400China State Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Institute of Plant Protection&Soil Fertilizer Hubei Academy of Agricultural SciencesWuhan 430064China Institute of Plant Protection Guizhou Academy of Agricultural SciencesGuiyang 550000China Institute of Plant Protection Liaoning Academy of Agricultural SciencesShenyang 110161China Sanya Agricultural Technology Extension and Service Centre Sanya 572000China College of Agriculture Yangtze UniversityJingzhou 434000China Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology Fujian Agriculture and Forestry UniversityFuzhou 350002China Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310012China Nuffield Department of Medicine Peter Medawar Building for Pathogen ResearchUniversity of OxfordOxford OX13SYUnited Kingdom

Invertebrate species are a natural reservoir of viral genetic diversity,and invertebrate pests are widely distributed in crop ***,information on viruses infecting invertebrate pests of crops is *** this report,we describe the deep metatranscriptomic sequencing of 88 invertebrate samples covering all major invertebrate pests in rice *** identified 296 new RNA viruses and 13 known RNA *** viruses clustered within 31 families,with many highly divergent viruses constituting potentially new families and *** the identified viruses,13 RNA viruses clustered within the Fiersviridae family of bacteriophages,and 48 RNA viruses clustered within families and genera of *** detected known rice viruses in novel invertebrate hosts at high ***,some novel RNA viruses have genome structures closely matching to known plant viruses and clustered within genera of several plant virus *** potential insect pathogenic RNA viruses were detected in invertebrate *** analysis revealed that host taxonomy plays a major role and geographical location plays an important role in structuring viral ***-species transmission of RNA viruses was detected between invertebrate *** identified viral genomes showed extensive variation for invertebrate viral families or ***,the large-scale metatranscriptomic analysis greatly expands our understanding of RNA viruses in rice invertebrate species,the results provide valuable information for developing efficient strategies to manage insect pests and virus-mediated crop diseases.

关键词： invertebrate species metatranscriptome viral diversity viral transmission viral genomes

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基于组合模型的沥青路面车辙预测

北京工业大学学报 2016年第8期42卷 1208-1214页

作者：张琛汪海年王宠惠长安大学道路结构与材料交通行业重点实验室西安710064

为了对沥青路面车辙进行预测研究,结合陕西某高速公路沥青路面的车辙病害现状,以美国AASHTO新力学经验法中的Pavement-ME预测模型(PME模型)和灰色预测理论为基础,对PME预测模型的参数进行了本地化处理,提出了考虑数据时效的动态灰色预... 详细信息

为了对沥青路面车辙进行预测研究,结合陕西某高速公路沥青路面的车辙病害现状,以美国AASHTO新力学经验法中的Pavement-ME预测模型(PME模型)和灰色预测理论为基础,对PME预测模型的参数进行了本地化处理,提出了考虑数据时效的动态灰色预测模型DGM(1,1),并采用数理统计方法对车辙的发育趋势进行基于组合模型的预测研究.研究结果表明:PME模型和DGM灰色模型的拟合精度分别为0.963和0.941,可以作为组合模型的子模型;DGM-PME组合模型的预测精度要高于单一子模型的预测精度,其中采用误差平方和倒数法定权得到的组合模型的预测精度相对最高,其子模型权重分配为L12=0.601和L22=0.399,预测精度最高为0.004 5;DGM-PME组合模型在个别时期的预测效果不如单一子模型,属于正常的误差现象;用DGM-PME组合模型来替代单一子模型进行沥青路面车辙的预测研究是可行的,本文所建立的组合模型适用于项目级沥青路面的车辙发育趋势预测.

关键词：沥青路面车辙预测 Pavement-ME 灰色预测理论组合模型