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香芹酚-壳聚糖纳米颗粒的制备及抑菌活性研究

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食品与发酵工业 2022年第22期48卷 82-88页

作者：邢承宇王璐陈星光陆健吴殿辉粮食发酵与食品生物制造国家工程研究中心(江南大学) 江苏无锡214122 工业生物技术教育部重点实验室生物工程学院(江南大学)江苏无锡214122 江苏省生物活性制品加工工程技术研究中心江苏无锡214122

禾谷镰刀菌(Fusarium graminearum)及其产生的真菌毒素严重危害着谷物的质量与安全,开发新型的绿色抗菌剂是控制粮食霉变和保障食品安全的重要途径之一。该研究采用乳化交联法制备了香芹酚-壳聚糖纳米颗粒,结果显示,香芹酚的包封率在35%... 详细信息

禾谷镰刀菌(Fusarium graminearum)及其产生的真菌毒素严重危害着谷物的质量与安全,开发新型的绿色抗菌剂是控制粮食霉变和保障食品安全的重要途径之一。该研究采用乳化交联法制备了香芹酚-壳聚糖纳米颗粒,结果显示,香芹酚的包封率在35%~60%,所得纳米颗粒呈现规则分布的球形,尺寸为40~100 nm。通过对香芹酚和香芹酚-壳聚糖纳米颗粒的加速贮藏考察了其对禾谷镰刀菌的抑菌稳定性。在35℃环境下贮藏50 d后,香芹酚和香芹酚-壳聚糖纳米颗粒对禾谷镰刀菌的菌丝抑制率分别从82.2%降至25.1%以及70.5%降至47.7%,表明纳米颗粒的制备提高了香芹酚的抑菌稳定性。扫描电子显微镜结果表明,香芹酚-壳聚糖纳米颗粒可以显著破坏禾谷镰刀菌的细胞膜和细胞壁,从而抑制其生长。该研究为解决粮食霉变和粮食中真菌毒素的污染提供了新的思路。

关键词：禾谷镰刀菌香芹酚壳聚糖纳米颗粒包封率抑菌稳定性

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菠菜的无公害生产

农业技术与装备 2009年第01X期 26-26,28页

作者：张彩霞邢承玉山西省太原市农业技术推广站

菠菜营养价值丰富,含有人体所需的多种营养成分,是一种深受广大消费者喜爱的保健蔬菜。根据菠菜的生理特性和各个生育期的生物学特点,提出菠菜的无公害蔬菜生产技术。

关键词：菠菜无公害生产

枸橼酸坦度螺酮和盐酸丁螺环酮治疗第二代抗抑郁药所致性功能障碍的对照研究

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浙江医学 2017年第11期39卷 911-914页

作者：顾成宇邢葆平张滢魏红辉孙宁宁浙江省立同德医院精神科浙江省精神卫生中心杭州310012

目的比较枸橼酸坦度螺酮和盐酸丁螺环酮治疗第二代抗抑郁药所致性功能障碍中的疗效和安全性。方法选取56例符合DSM-IV-TR药物所致性功能障碍诊断标准的患者,按照随机数字表法分为枸橼酸坦度螺酮研究组(研究组)和盐酸丁螺环酮标准对照组... 详细信息

目的比较枸橼酸坦度螺酮和盐酸丁螺环酮治疗第二代抗抑郁药所致性功能障碍中的疗效和安全性。方法选取56例符合DSM-IV-TR药物所致性功能障碍诊断标准的患者,按照随机数字表法分为枸橼酸坦度螺酮研究组(研究组)和盐酸丁螺环酮标准对照组(对照组),每组28例。两组患者分别接受6周枸橼酸坦度螺酮(40mg/d)或盐酸丁螺环酮(40mg/d)治疗。基线时和治疗第2、4、6周采用亚利桑那性体验量表(ASEX)和不良反应量表(TESS)评定疗效和不良反应。结果两组患者ASEX总分在治疗第2、4、6周和基线相比均明显降低(均P0.05)。两组TESS总分在第2周均较基线明显增高(均P0.05)。结论枸橼酸坦度螺酮和盐酸丁螺环酮均能有效治疗抗抑郁药所致性功能障碍,且不良反应均较少,有较好的临床应用价值。

关键词：枸橼酸坦度螺酮盐酸丁螺环酮抗抑郁药性功能障碍

Cooperative Search of UAV Swarm Based on Ant Colony Optimization with Artificial Potential Field

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第6期36卷 912-918页

作者： xing Dongjing ZHEN Ziyang ZHOU chengyu GONG Huajun College of Automation Engineering Nanjing University of Aeronautics and Astronautics

An ant colony optimization with artificial potential field(ACOAPF)algorithm is proposed to solve the cooperative search mission planning problem of unmanned aerial vehicle(UAV)*** algorithm adopts a distributed architecture where each UAV is considered as an ant and makes decision *** each decision step,the ants choose the next gird according to the state transition rule and update its own artificial potential field and pheromone map based on the current search *** iterations of this process,the cooperative search of UAV swarm for mission area is *** state transition rule is divided into two *** the artificial potential force is larger than a threshold,the deterministic transition rule is adopted,otherwise a heuristic transition rule is *** deterministic transition rule can ensure UAVs to avoid the threat or approach the target *** the heuristics transition rule considering the pheromone and heuristic information ensures the continuous search of area with the goal of covering more unknown area and finding more ***,simulations are carried out to verify the effectiveness of the proposed ACOAPF algorithm for cooperative search mission of UAV swarm.

关键词： ant colony optimization artificial potential field cooperative search unmanned aerial vehicle(UAV)swarm

Genetic segregation analysis of unsaturated fatty acids content in the filial generations of high-linolenic-acid rapeseed(Brassica napus)

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Oil Crop Science 2021年第4期6卷 169-174页

作者： Xiaohan Zhang Jinglong Lian Chunyan Dai Xiaoli Wang Mingzheng Zhang xing Su Yaohua Cheng chengyu Yu College of Agronomy Northwest A&F UniversityTaicheng Road 3YanglingShaanxi712100China Institute of Agricultural Sciences Garze Prefecture.Lucheng South Road 88KangdingSichuan626000China

Alpha linolenic acid(ALA)is an essential polyunsaturated fatty acids that can improve human *** is the second largest oil crop in the world but the ALA content in its seed fatty acids is only about 10%.Two rapeseed germplasms YH25005 and R8Q10 with high content(up to 21%)ALA were developed by intervarietal *** were used as the maternal parent(P_(1))when crossed with a low ALA parent SW(P2)to produce the seeds of the F1 hybrid,F2,and backcrosses to P1(BCP1)and P2(BCP2).A multigeneration joint segregation analysis was conducted to determine major gene t polygene effects of the content of three major unsaturated fatty acids including oleic(OA),linoleic(LA)and *** results showed that,although some genes favorable to ALA accumulation were not allelic in R8Q10 and YH25005,all the inheritances of OA,LA and ALA in YH25005×SW and R8Q10×SW followed a genetic model of‘two pairs of additive major genes t additive-dominant polygenes’.It is suggested that the contents of OA,LA and ALA are closely related and the major genes in the parent SW containing loss-of-function mutations in FAD2 and FAD3 loci had strong effect to reduce ALA and elevate ***,total genetic effect of the polygenes was greater than that of the two major genes,especial on ALA *** indicated that it is necessary to employ a larger F2 population to find the plant that accumulate enough minor-effect polygenes for high ALA *** results are useful for high ALA rapeseed breeding and future work of gene mapping.

关键词： Rapeseed High linolenicacid Fattyacid Genetic analysis Major gene Polygene

Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.

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Acta Pharmaceutica Sinica B 2013年第5期3卷 328-332页

作者： Ruizhi Men Ning Li Yachao xing Yingzhan Tang chengyu Tan Fantong Meng Juan Zhang Hui Ni Xiaoguang Jia Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China Marine Environmental Engineering College Dalian Ocean UniversityDalian 116023China Xinjiang Institute of Chinese Materia Medica and Ethnodrug Urumqi 830002China

Suaeda physophora *** a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous *** order to have a better utilization of halophytes,a screening for ACE inhibitors from halophytes growing in Xinjiang was carried *** result showed that the 70%EtOH extract and n-BuOH extract of *** *** significant ACE inhibitory *** we focused on its biochemical constituents *** new quinazoline alkaloid,namely Suaedine(1),along with six known compounds(2–7)was isolated from the aerial parts of *** *** structure of the new quinazoline alkaloid was established by one-and two-dimensional nuclear magnetic resonance,optical rotation and mass spectrometry *** flavonoid compounds(2–4)and phenolic compound(5)exhibited significant ACE *** was the first time to focus on the chemical constituents and bioactivities of this plant.

关键词： Desert plant Suaeda physophora Pall. Chemical constituents ACE inhibitory activity

The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells

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Journal of Molecular Cell Biology 2011年第4期3卷 221-229页

作者： Ning Yang Xiaoxu Hong Penghui Yang Xiangwu Ju Yuguo Wang Jun Tang Chenggang Li Quanshui Fan Fuqiang Zhang Zhongwei Chen Li xing Zhongpeng Zhao Xiao Gao Guoyang Liao Qihan Li Xiliang Wang Dangsheng Li chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesPeking Union Medical CollegeTsinghua UniversityChinese Academy of Medical SciencesBeijing 100005China Department of Viral Immunology Institute of Medical BiologyChinese Academy of Medicine SciencePeking Union Medical CollegeKunming 650118China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Centre for Disease Prevention and Control Cheng Du Military RegionKunming 650032China Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031China

In 2009,a novel swine-origin H1N1 influenza virus emerged in Mexico and quickly spread to other countries,including *** 2009 pandemic H1N1 can cause human respiratory disease,but its pathogenesis remains poorly ***,we studied the infection and pathogenesis of a new 2009 pandemic strain,A/Wenshan/01/2009 H1N1,in China in human airway epithelial cell lines compared with contemporary seasonal H1N1 influenza *** results showed that viral infection by the A/Wenshan H1N1 induced significant apoptotic cell death in both the human nasopharyngeal carcinoma cell line CNE-2Z and the human lung adenocarcinoma cell line *** A/Wenshan H1N1 virus enters both of these cell types more efficiently than the seasonal influenza *** entry in both cell lines was shown to be mediated by clathrin-and dynamin-dependent ***,we discovered that the 2009 pandemic H1N1 strain,A/Wenshan/01/2009,can induce apoptotic cell death in epithelial cells of the human respiratory tract,suggesting a molecular pathogenesis for the 2009 pandemic H1N1.

关键词： apoptosis respiratory S-OIV H1N1 influenza virus

Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils

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Journal of Molecular Cell Biology 2018年第6期10卷 573-585页

作者： Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li xing Lingna Zhao Shanshan Zhou Min Xia chengyu Jiang Xiliang Wang Penghui Yang State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Chinese PLA General Hospital Beijing 100853China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology Third Military Medical UniversityChongqing 400038China Beijing 307 Hospital of PLA Affiliated with the Chinese Academy of Medical Sciences Beijing 100070China Beijing 302 Hospital of PLA Beijing 100039China

Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the *** infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully *** this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and ***2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling ***2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and *** importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected *** on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting ***,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.

关键词： influenza H1N1 virus recombinant FGF2 protein neutrophil recruitment FGFR2-PI3K-AKT-NFκB signaling therapeutic target

锈蚀钢筋混凝土梁承载能力分析的变角桁架模型

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建筑结构学报 2019年第1期40卷 97-104页

作者：罗大明杨成雨邢国华牛荻涛西安建筑科技大学省部共建西部绿色建筑国家重点实验室陕西西安710055 西安建筑科技大学土木工程学院陕西西安710055 长安大学建筑工程学院陕西西安710061

为了研究侵蚀环境下锈蚀钢筋混凝土梁在长期荷载作用下的承载能力,以荷载作用下锈蚀钢筋混凝土梁为研究对象,分析了钢筋锈蚀对混凝土梁黏结强度的影响,基于拉-压杆模型和标准桁架模型分别对锈蚀梁进行了承载力计算,进一步采用考虑钢筋... 详细信息

为了研究侵蚀环境下锈蚀钢筋混凝土梁在长期荷载作用下的承载能力,以荷载作用下锈蚀钢筋混凝土梁为研究对象,分析了钢筋锈蚀对混凝土梁黏结强度的影响,基于拉-压杆模型和标准桁架模型分别对锈蚀梁进行了承载力计算,进一步采用考虑钢筋锈蚀影响的修正变角桁架模型计算锈蚀钢筋混凝土梁的承载力,并通过49组锈蚀混凝土梁的试验数据对建议模型进行验证。结果表明:锈蚀钢筋混凝土梁承载力的试验值与变角桁架模型理论计算值之比的平均值为0.990,方差为0.071,二者吻合较好。采用变角桁架模型可精确计算锈蚀钢筋混凝土梁的承载力并预测其破坏模式,建议模型可用于锈蚀钢筋混凝土梁承载能力分析研究。

关键词：锈蚀钢筋混凝土梁拉-压杆模型标准桁架模型变角桁架模型承载能力