Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils

作     者：Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang 

作者机构：State Key Laboratory of Pathogens and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijing 100071China Chinese PLA General HospitalBeijing 100853China State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Institute of ImmunologyThird Military Medical UniversityChongqing 400038China Beijing 307 Hospital of PLA Affiliated with the Chinese Academy of Medical SciencesBeijing 100070China Beijing 302 Hospital of PLABeijing 100039China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2018年第10卷第6期

页      面：573-585页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：funding from the National High Technology Research and Development Program of China (SS2015AA020924) the National Natural Science Foundation of China (81771700) the Ministry of Science and Technology of China (2013ZXI0004003 and SS2012AA020905) the National Major Research and Development Program (2016YFA0502203 and 2017YFC1200800) P.Y.was supported by the Beijing Nova Program (Z141107001814054) 

主　　题：influenza H1N1 virus recombinant FGF2 protein neutrophil recruitment FGFR2-PI3K-AKT-NFκB signaling therapeutic target 

摘      要：Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the *** infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully *** this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and ***2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling ***2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and *** importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected *** on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting ***,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.