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Prescribed-Time Fully Distributed Nash Equilibrium Seeking Strategy in Networked Games

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 261-263页

作者： cheng qian Lei Ding the Institute of Advanced Technology for Carbon Neutrality College of Automation&the College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

Dear Editor, This letter is concerned with prescribed-time fully distributed Nash equilibrium seeking for networked games under directed graphs. An adaptive algorithm is proposed to ensure the convergence of all players to the Nash equilibrium without requiring any knowledge of global parameters. Moreover, it is theoretically proved that the convergence time of the proposed seeking strategy can be predefined based on practical requirements. Finally, a numerical example is presented to validate the effectiveness of the proposed method.

关键词： parameters seeking prescribed

淫羊藿苷预处理增强人牙周膜干细胞对M1型巨噬细胞的影响

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中国组织工程研究 2025年第7期29卷 1328-1335页

作者：喻婷吕冬梅邓浩孙涛程钎西南医科大学口颌面修复重建和再生泸州市重点实验室四川省泸州市646000 西南医科大学口腔医学研究所四川省泸州市646000 西南医科大学附属口腔医院正畸科四川省泸州市646000 西南医科大学口腔医学院四川省泸州市646000

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养... 详细信息

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养原代人牙周膜干细胞,并进行鉴定。对THP-1细胞进行诱导,采用免疫荧光染色及PCR进行M1型巨噬细胞鉴定。用含浓度10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷的α-MEM完全培养基培养人牙周膜干细胞1,3,5,7 d,采用CCK-8法筛选合适的淫羊藿苷浓度进行实验。将α-MEM完全培养基、未处理的人牙周膜干细胞α-MEM条件培养基及淫羊藿苷预处理24 h的人牙周膜干细胞α-MEM条件培养基与RPMI-1640完全培养基以1∶1的比例对M1型巨噬细胞进行条件培养,分别为对照组、未处理组及预处理组,24 h后RT-PCR法检测M1型巨噬细胞炎症因子的mRNA表达情况;ELISA法检测M1型巨噬细胞炎症因子的蛋白表达情况;Western blot检测M1/M2型巨噬细胞表面标记物及核转录因子κB通路相关蛋白的表达。结果与结论:(1)CCK-8检测结果显示,10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷对人牙周膜干细胞均无细胞毒性,且从第5天起,各浓度都提高了细胞活力,促进细胞增殖,选择10^(-4)mol/L淫羊藿苷进行后续实验。(2)RT-PCR法及ELISA检测结果显示,与对照组相比,未处理组及预处理组均降低了M1型巨噬细胞白细胞介素1β、白细胞介素6及肿瘤坏死因子α的表达与分泌(P<0.05),且预处理组低于未处理组(P<0.05)。(3)Western blot检测结果显示,与未处理组相比,预处理组CD86的表达明显降低(P<0.05);与对照组相比,未处理组和预处理组M2型巨噬细胞表面标志物CD206的表达均升高(P<0.01),且预处理组明显高于未处理组(P<0.01);M1型巨噬细胞经24 h条件培养后,与对照组相比,核转录因子κB/P65的表达在未处理组和预处理组均有降低(P<0.01),p-IκBα的表达仅在预处理组降低(P<0.01);与未处理组相比,预处理组核转录因子κB/P65和p-IκBα的表达均显著降低(P<0.05),而IκBα在3组中的表达差异无显著性意义。(4)上述结果证实,淫羊藿苷增强了人牙周膜干细胞对M1型巨噬细胞的抑制作用,此作用可能与抑制了巨噬细胞的核转录因子κB信号通路相关。

关键词：人牙周膜干细胞淫羊藿苷巨噬细胞条件培养基共培养表面标志物炎症因子抗炎核转录因子κB信号通路

Reversing the mitochondrial stress-induced exhaustion of CD8^(+)T cells for improving cancer immunotherapy

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Cellular & Molecular Immunology 2021年第7期18卷 1634-1637页

作者： cheng qian Xuetao Cao National Key Laboratory of Medical Immunology Institute of ImmunologySecond Military Medical UniversityShanghaiChina Laboratory of Immunity and Inflammation College of Life SciencesNankai UniversityTianjinChina

Antigen-specific CD8+T cells that infiltrate tumor tissue have been considered the primary cytotoxic lymphocytes that exert antitumor effects,building a foundation for current immunotherapies against ***,in the face of continuous antigenic stimulation during chronic infections and cancer,T-cell differentiation leads to a state of incapacitation called T-cell exhaustion,which is a critical barrier to successful T-cell immunotherapy of *** explosive growth of malignant tumor cells accompanied by a dysfunctional vascular system and metabolite competition leads to a stressful tumor microenvironment characterized by low-oxygen tension,acidic interstitial pH,and insufficient *** evidence for the contribution of the tumor microenvironment to the metabolic reprogramming of exhausted CD8+T cells has been increasing,but the response of intratumoral T cells to metabolic stress signals is still not fully *** of a study by Scharping et al.,1 together with other recent evidence,have highlighted that the tumor microenvironment can influence the mitochondrial stress of T cells and drive the trajectory of T-cell differentiation toward *** findings add new perspectives on and insights into the molecular initiators of T-cell exhaustion and the combination of strategies that should be utilized to improve the efficacy of immunotherapy,and these perspectives are discussed in this review.

关键词： immunotherapy cancer stimulation

Spine maturation and pruning during development: Cadherin/Catenin complexes come to help

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Science China(Life Sciences) 2015年第9期58卷 929-930页

作者： qian cheng LI YuLong State Key Laboratory of Membrane Biology Peking University School of Life Sciences PKU-IDG/Mc Govern Institute for Brain Researchand Peking-Tsinghua Center for Life Sciences School of Life Sciences PTN Joint Graduate Program Tsinghua University

Structural and functional alterations of synaptic connections underlay experience-dependent neuronal plasticity and are crucial for many brain functions, including learning and memory. Their defects, on the other hand, have been asso- ciated with neurological disorders such as autism. Although the molecular mechanism underlying long-term functional alterations of synaptic connections, including LTP and LTD, are becoming increasingly clear, the molecular mechanism for structural plasticity, such as spine pruning, remains largely unknown, especially in vivo.

关键词：蛋白复合物钙粘蛋白开发过程修剪神经可塑性成熟脊柱神经系统疾病

Deadline-aware network coding for video on demand service over P2P networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 755-763页

作者： CHI Hui-cheng ZHANG qian Department of Computer Science Hong Kong University of Science and Technology Hong Kong China Department of Computer Science Hong Kong University of Science and Technology Hong Kong China

We are interested in providing Video-on-Demand (VoD) streaming service to a large population of clients using peer-to-peer (P2P) approach. Given the asynchronous demands from multiple clients, continuously changing of the buffered contents, and the continuous video display requirement, how to collaborate with potential partners to get expected data for future content delivery are very important and challenging. In this paper, we develop a novel scheduling algorithm based on deadline- aware network coding (DNC) to fully exploit the network resource for efficient VoD service. DNC generalizes the existing net- work coding (NC) paradigm, an elegant solution for ubiquitous data distribution. Yet, with deadline awareness, DNC improves the network throughput and meanwhile avoid missing the play deadline in high probability, which is a major deficiency of the con- ventional NC. Extensive simulation results demonstrated that DNC achieves high streaming continuity even in tight network conditions.

关键词： Video on Demand (VoD), Peer-to-Peer (P2P), Network coding (NC), Deadline-aware network coding (DNC)

以地理模拟与优化系统(GeoSOS)模型进行的升金湖湿地景观模拟与演变预测

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东北林业大学学报 2025年第1期53卷 79-85页

作者：程倩王杰马靖博王梦茹周旭安徽大学合肥230601

以升金湖国际重要湿地为研究区,根据2010—2020年Landsat系列遥感影像,分析该湿地景观变化特征及驱动因素,利用地理模拟与优化系统(GeoSOS)模型对2025年该湿地在不同发展情景(自然情景、耕地保护情景和生态保护情景)进行景观模拟与预测... 详细信息

以升金湖国际重要湿地为研究区,根据2010—2020年Landsat系列遥感影像,分析该湿地景观变化特征及驱动因素,利用地理模拟与优化系统(GeoSOS)模型对2025年该湿地在不同发展情景(自然情景、耕地保护情景和生态保护情景)进行景观模拟与预测,探究该湿地景观的未来演变趋势,并提出相关规划建议。研究表明:(1)2010—2020年间,草地面积略微减少,滩涂和水体面积有部分增加,景观结构趋于复杂化,主要受到年降水(自然因素)及GDP(人文因素)的影响;(2)GeoSOS模型中,人工神经网络-元胞自动机(ANN-CA)算法的模拟精度最高,总体精度达到63.28%,Kappa系数达到0.503,品质因数(FoM)达到0.122,适用于湖泊湿地景观模拟与预测;(3)根据2025年不同发展情景湿地景观预测结果,采取生态保护策略最能有效保障自然湿地面积,维持湿地景观的多样性与稳定性。

关键词：湿地景观景观模拟地理模拟与优化系统模型地理探测器发展情景

Schlieren Visualization of Acoustic Propagation Characteristics in a One-Dimensional Phononic Crystal

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Chinese Physics Letters 2013年第8期30卷 99-102页

作者： JIANG Xue-Ping qian Meng-Lu cheng qian Institute of Acoustics Tongji UniversityShanghai 200092

The acoustic propagation characteristics of a finite one-dimensional water-glass phononic crystal(PC)are studied using the Schlieren visualization method,which is fast and *** band structures of this PC are measured experimentally with continuous acoustic waves incident on it using the Schlieren method,and the results are highly consistent with the theoretical *** dynamic acoustic field in the PC at different frequencies is imaged and the resonance phenomena in the components of the PC are *** results show that the Schlieren method is an effective means of studying the interactions between acoustic waves and PCs.

关键词： Schlieren method Acoustic

Impact of ethanol on the flotation efficiency of imidazolium ionic liquids as collectors:Insights from dynamic surface tension and solvation analysis

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International Journal of Minerals,Metallurgy and Materials 2024年第12期31卷 2645-2656页

作者： qian cheng Zerui Lei Guangjun Mei Jianhua Chen Key Laboratory of Green Utilization of Critical Non-metallic Mineral Resources Ministry of EducationWuhan University of TechnologyWuhan 430070China MOE Key Laboratory of New Processing Technology for Non-ferrous Meta1s and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China

To conduct extensive research on the application of ionic liquids as collectors in mineral flotation,ethanol(EtOH)was used as a solvent to dissolve hydrophobic ionic liquids(ILs)to simplify the reagent *** phenomena were observed in which EtOH exerted different effects on the flotation efficiency of two ILs with similar *** EtOH was used to dissolve 1-dodecyl-3-methylimidazolium chloride(C12[mim]Cl)and as a collector for pure quartz flotation tests at a concentration of 1×10^(−5)mol·L^(−1),quartz recovery increased from 23.77%to 77.91%compared with ILs dissolved in ***,quartz recovery of 1-dodecyl-3-methylim-idazolium hexafluorophosphate(C12[mim]PF6)decreased from 60.45%to 24.52%under the same *** conditional experi-ments under 1×10^(−5)mol·L^(−1)ILs for EtOH concentration and under 2vol%EtOH for ILs concentration confirmed this *** being affected by EtOH,the mixed ore flotation tests of quartz and hematite showed a decrease in the hematite concentrate grade and re-covery for the C12[mim]Cl collector,whereas the hematite concentrate grade and recovery for the C12[mim]PF6 collector *** the basis of these differences and observations of flotation foam,two-phase bubble observation tests were carried *** EtOH promoted the foam height of two ILs during *** accelerated static froth defoaming after aeration stopped,and the foam of C12[mim]PF6 de-foaming especially *** the discussion of flotation tests and foam observation,an attempt was made to explain the reasons and mechanisms behind the diverse phenomena using the dynamic surface tension effect and solvation effect results from *** solva-tion effect was verified through Fourier transform infrared(FT-IR),X-ray photoelectron spectroscopy(XPS),and Zeta potential ***-though EtOH affects the adsorption of ILs on the ore surface during flotation negatively,it holds an positive value of inhibiting foam mer-ging during flotation a

关键词： ionic liquid ethanol flotation foam solvation dynamic surface tension

Adaptive Trajectory Tracking Error Constraint Control of Unmanned Underwater Vehicle Based on a Fully Actuated System Approach

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Journal of Systems Science & Complexity 2024年第6期37卷 2633-2653页

作者： ZHANG Liuliu WANG Peng qian cheng HUA Changchun School of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

This paper focuses on the trajectory tracking control problem of unmanned underwater vehicles(UUVs)with unknown dead-zone *** primary objective is to design an adaptive trajectory tracking error constraint controller using the fully actuated systems(FAs)approach to enable UUVs to asymptotically track target ***,a novel error constraint fully actuated systems(ECFAs)approach is proposed by incorporating the tracking error dependent normalized function and barrier function along with time-varying ***,in order to deal with the model uncertainties of the UUVs,adaptive radial basis function neural networks(RBFNNs)is combined with the ECFAs ***,a positive time-varying integral function is introduced to completely eliminate the effect of the residual effect caused by unknown dead-zone inputs,and it is proved that the trajectory tracking error converges to zero asymptotically based on the Lyapunov ***,the simulation results demonstrate the effectiveness of the designed adaptive controller.

关键词： Adaptive control radial basis function neural networks the fully actuated systems approach trajectory tracking error constraint