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硫酸吗啡栓含量测定方法的比较和优化

药物分析杂志 2024年第6期44卷 1097-1104页

作者：吕蓓蓓张敏娟魏文芝陈学艳青海省药品检验检测院西宁810016 国家药品监督管理局中药(藏药)质量控制重点实验室西宁810016 青海省中藏药现代化研究重点实验室西宁810016

目的:针对硫酸吗啡栓含量测定方法中萃取溶剂毒性较高以及色谱条件专属性、通用性欠佳的问题进行优化。方法:供试品溶液制备方法的优化是采用冰浴冷冻法和正庚烷萃取法制备供试品溶液,并与美国药典方法(三氯甲烷萃取)制备的供试品溶液... 详细信息

目的:针对硫酸吗啡栓含量测定方法中萃取溶剂毒性较高以及色谱条件专属性、通用性欠佳的问题进行优化。方法:供试品溶液制备方法的优化是采用冰浴冷冻法和正庚烷萃取法制备供试品溶液,并与美国药典方法(三氯甲烷萃取)制备的供试品溶液进行含量测定结果的比较。含量测定色谱条件的优化是在综合比较美国药典、英国药典以及YBH标准的基础上,最终采用Symmetry C18色谱柱(150 mm×4.6 mm, 5μm),以含0.202%庚烷磺酸钠的0.01 mol·L^(-1)磷酸二氢钾溶液(含0.1%三乙胺,用磷酸调节pH至2.5)-甲醇(70∶30)为流动相,流速为1.0 mL·min^(-1),柱温为30℃,检测波长为284 nm,进样体积为20μL。结果:采用冰浴冷冻法测得的含量偏低,而正庚烷萃取与三氯甲烷萃取的含量测定结果基本一致,说明可采用正庚烷替代卤代烷烃作为萃取溶剂。采用新建色谱方法,硫酸吗啡的线性范围为2.12~105.94μg·mL^(-1)(r=0.999 9),定量限为10.60 ng;系统精密度、重复性、中间精密度、稳定性的RSD均小于2%;平均回收率为98.6%~99.6%,RSD为0.21%~0.66%;供试品溶液经强制降解后主峰与各降解杂质均能够实现良好的分离,专属性良好;通过改变流速、柱温、pH、流动相比例以及色谱柱品牌,均能够实现主峰与各杂质峰的良好分离,耐用性良好。结论:本研究优化了硫酸吗啡栓的含量测定方法,供试品溶液的制备采用正庚烷代替了高毒性的卤代烷烃,同时改善了色谱条件,提高了方法的环保性、专属性和适用性,可用于硫酸吗啡栓含量的测定。

关键词：硫酸吗啡栓冰浴萃取三氯甲烷正庚烷优化含量测定高效液相色谱

Evaluation of visual quality of spherical and aspherical intraocular lenses by Optical Quality Analysis System

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 914-918页

作者： yan chen xue Wang Chuan-Di Zhou Qiang Wu Department of Ophthalmology Shanghai Jiao Tong University Affiliated First People＇s Hospital Shanghai 200080 China

AIM： To evaluate the impact of spherical and aspherical intraocular lenses on the postoperative visual quality of age-related cataract patients using Optical Quality Analysis System （OQAS）. METHODS： Seventy-four eyes with age-related cataracts were randomly divided into spherical and aspherical lens implantation groups. Best-corrected visual acuity （BCVA） was measured preoperatively, one day, one week, two weeks, one month and two months after surgery. A biometric systems analysis using the OQAS objective scattering index （OSI） was performed. RESULTS： There were no significant differences in visual acuity （P〉0.05） before and after spherical and aspheric lens implantation. There was a negative linear correction between the OSI value and BCVA （t-=-0.634, P=-0.000）, and positive corrections between the OSI value and the lens LOCUS III value of nucleus color （NC）, nucleus opacity （NO）, cortex （C） and posterior lens capsular （P）（r=0.704, P=0.000; r=0.514, P=0.000; r=0.276, P=0.020; r=0.417, P=-0.000, respectively）. OSI values of spherical vs aspherical lenses were 11.5±3.6 vs 11.8±3.4, 4.1±0.9 vs 3.3±0.8, 3.5±0.9 vs 2.7±0.7, 3.3±0.8 vs 2.6±0.7, 3.2±0.7 vs 2.5±0.8, and 3.2±0.8 vs 2.50.8 before and ld, 1, 2wk, 1 and 2mo after surgery, respectively. All time points varied significantly （P〈0.01） between the two groups. CONCLUSION： Aspherical IOLs does not significantly affect visual acuity compared with spherical IOLs. The OSI value, was significantly lower in the aspherical lens group compared with the spherical lens. This study shows that objective visual quality of aspheric IOLs is better than that of the spherical lens by means of OQAS biological measurement method.

关键词： optical quality analysis system age-relatedcataract spherical lens aspherical lens objective scatteringindex

Coupled DEM-FDM analyses of the effects of falling rock’s shape and impact angle on response of granular cushion and rock shed

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3353-3364页

作者： Jingyu xue chen Cao Jianhua yan Yaopeng Ji Jianping chen College of Construction Engineering Jilin UniversityChangchun130026China School of Earth Sciences and Engineering Hohai UniversityNanjing210098China

Rock shed is an effective protection measure against *** investigate the influences of falling rock’s shape and impact angle on the impact effect of the cushioned rock shed,a modeling approach for a rock shed with a cushion layer using *** granular cushion is modeled as an aggregate of discrete non-cohesion particles,while the concrete plate and the beam are modeled as *** falling rock with different sphericities and impact angles is modeled as a rigid *** numerical model is validated by comparing the simulation results with experimental and numerical results from previous *** model is applied to analyze the effects of rock shape and impact angle on the dynamic interaction effects between falling rock and cushioned rock shed,including the impact force,transmitted bottom force,penetration depth,and plate *** numerical results show that the variation in the falling rock’s shape has different effects on the falling rock with different impact *** findings could support rock shed design by revealing the limitations of the assumptions in the past research,which may result in unsafe rock sheds for some rockfall cases.

关键词： Rockfall Coupled DEM-FDM analysis Rock’s shape Impact angle Granular cushion Rock shed

Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

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Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang yan Junjian Li Li yan xue Li Jie-Guang chen School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

A Strong,Tough,and Self-Healing Strengthening Thioctic Acid-based Elastomer for Highly Reliable Flexible Strain Sensor

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Chinese Journal of Polymer Science 2024年第10期42卷 1610-1618,I0016页

作者： Xin-Yu chen Yu-Bing Fu xue-Ling yan Lan Liu School of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Polymer MaterialsSouth China University of TechnologyGuangzhou510641China

Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a *** this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis *** strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good *** PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.

关键词： Thioctic acid Ion clusters Multiple dynamic networks Self-healing strengthening Flexible strain sensor

Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

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Military Medical Research 2024年第4期11卷 589-615页

作者： Shuai Hao He Huang Rui-yan Ma xue Zeng chen-yang Duan Department of Anesthesiology the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Research Institute of General Surgery Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Cardiovascular Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China Institute for Brain Science and Disease Chongqing Medical UniversityChongqing 400010China

Hypoxic-ischemic injury is a common pathological dysfunction in clinical *** are sensitive organelles that are readily damaged following ischemia and ***-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic ***,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic ***,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and ***,potential clinical translation prospects for targeting Drp1 are *** review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.

关键词： Dynamin-related protein 1(Drp1) Hypoxic-ischemic injury Mitochondrial quality imbalance Cell dysfunction Organ damage

Reconfigurable memlogic long wave infrared sensing with superconductors

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Light(Science & Applications) 2024年第5期13卷 908-920页

作者： Bingxin chen Huanyi xue Hong Pan Liping Zhu Xiaomi yan Jingzhe Wang yanru Song Zhenghua An State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Department of PhysicsFudan UniversityShanghai 200438China. ShanghaiTech Quantum Device Lab ShanghaiTech UniversityShanghai 201210China. Shanghai Qi Zhi Institute 41th FloorAI TowerNo.701 Yunjin RoadXuhui DistrictShanghai 200232China. Yiwu Research Institute of Fudan University Chengbei RoadYiwu City 322000 ZhejiangChina. Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China

Optical sensors with in-cell logic and memory capabilities offer new horizons in realizing machine vision beyond von Neumann architectures and have been attempted with two-dimensional materials,memristive oxides,phasechanging materials *** the unparalleled performance of superconductors with both quantum-limited optical sensitivities and ultra-wide spectrum coverage,here we report a superconducting memlogic long-wave infrared sensor based on the bistability in hysteretic superconductor-normal phase *** cooperatively by electrical and optical pulses,the device offers deterministic in-sensor switching between resistive and superconducting(hence dissipationless)states with persistence>105 *** results in a resilient reconfigurable memlogic system applicable for,e.g.,encrypted ***,a high infrared sensitivity at 12.2μm is achieved through its in-situ metamaterial perfect absorber *** work opens the avenue to realize all-in-one superconducting memlogic sensors,surpassing biological retina capabilities in both sensitivity and wavelength,and presents a groundbreaking opportunity to integrate visional perception capabilities into superconductor-based intelligent quantum machines.

关键词： wave superconductor quantum

Insights into the mechanism of L-malic acid on drip loss of chicken meat under commercial conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1312-1324页

作者： Haijun Sun xue yan Lu Wang Ruimin Zhu Meixia chen Jingdong Yin Xin Zhang State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China New Hope Liuhe Co. Ltd./Key Laboratory of Feed and Livestock and Poultry Products Quality&Safety ControlMinistry of AgricultureChengduSichuan 610023China Institute of Animal Husbandry and Veterinary Medicine Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Background A deterioration in the meat quality of broilers has attracted much more attention in recent years.L-malic acid(MA)is evidenced to decrease meat drip loss in broilers,but the underlying molecular mechanisms are still ***’s also not sure whether the outputs obtained under experimental conditions can be obtained in a com-mercial ***,we investigated the effects and mechanisms of dietary MA supplementation on chicken meat drip loss at large-scale *** Results showed that the growth performance and drip loss were improved by MA *** metabolome revealed that L-2-aminoadipic acid,β-aminoisobutyric acid,eicosapentaenoic acid,and nicotinamide,as well as amino acid metabolism pathways connected to the improvements of meat quality by MA *** transcriptome analysis further indicated that the effect of MA on drip loss was also related to the proper immune response,evidenced by the enhanced B cell receptor signaling pathway,NF-κB signaling pathway,TNF signaling pathway,and IL-17 signaling *** We provided evidence that MA decreased chicken meat drip loss under commercial *** and transcriptome revealed a comprehensive understanding of the underlying ***,MA could be used as a promising dietary supplement for enhancing the water-holding capacity of chicken meat.

关键词： Drip loss Immune response L-malic acid Meat quality Metabolome Transcriptome

Spin-Polarized Electron Injection in Co/Cu/Fe Sandwich Structure

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Chinese Physics Letters 2000年第8期17卷 603-605页

作者： WANG Shou-guo chen yan-xue WANG Zhi-he chen Qiang chen Jmg-Lin SHEN Hong-Lie LIU Yi-Hua XIE Shi-jie MEI Liang-mo Department of Physics Shandong UniversityJi Jnan 250100 Shanghai Metallurgy Institute Chinese Academy of SciencesShanghai 200050 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031

A material asymmetry Co/Cu/Fe junction structure has been prepared for studying the spin-polarized electron injection at *** sample performance was demonstrated to be analogous to that of a bipolar *** maximal value of the output pulse voltage between Cu and Fe layers could reach the order of severalμV when the bias current between Co and Cu layers was 10μ*** interface roughness,photograph of material,magnetic loop and injection characteristic curves have been *** important points on this topic have been discussed.

关键词： Co/Cu Electron roughness