Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

作     者：Shuai Hao He Huang Rui-Yan Ma Xue Zeng Chen-Yang Duan Shuai Hao;He Huang;Rui-Yan Ma;Xue Zeng;Chen-Yang Duan

作者机构：Department of Anesthesiologythe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Research Institute of General SurgeryJinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Cardiovascular SurgeryXinqiao HospitalArmy Medical UniversityChongqing 400037China Institute for Brain Science and DiseaseChongqing Medical UniversityChongqing 400010China 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2024年第11卷第4期

页      面：589-615页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(82272252,82270378) the Senior Medical Talents Program of Chongqing for Young and Middle-aged the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University 

主　　题：Dynamin-related protein 1(Drp1) Hypoxic-ischemic injury Mitochondrial quality imbalance Cell dysfunction Organ damage 

摘      要：Hypoxic-ischemic injury is a common pathological dysfunction in clinical *** are sensitive organelles that are readily damaged following ischemia and ***-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic ***,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic ***,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and ***,potential clinical translation prospects for targeting Drp1 are *** review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.