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Therapeutic effects of dental pulp stem cells on vascular dementia in rat models

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Neural Regeneration Research 2021年第8期16卷 1645-1651页

作者： Xue-Mei zhang Yang Sun Ying-Lian Zhou Zhuo-Min Jiao Dan Yang Yuan-Jiao Ouyang Mei-Yu Yu Jin-yue Li Wei Li Duo Wang Hui yue Jin Fu Department of Neurology The 2nd Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang ProvinceChina

Dental pulp stem cells are a type of adult stem cells with strong proliferative ability and multi-differentiation potential. There are no studies on treatment of vascular dementia with dental pulp stem cells. In the present study, rat models of vascular dementia were established by two-vessel occlusion, and 30 days later, rats were injected with 2 × 10^(7) dental pulp stem cells via the tail vein. At 70 days after vascular dementia induction, dental pulp stem cells had migrated to the brain tissue of rat vascular dementia models and differentiated into neuronlike cells. At the same time, doublecortin, neurofilament 200, and Neu N m RNA and protein expression levels in the brain tissue were increased, and glial fibrillary acidic protein m RNA and protein expression levels were decreased. Behavioral testing also revealed that dental pulp stem cell transplantation improved the cognitive function of rat vascular dementia models. These findings suggest that dental pulp stem cell transplantation is effective in treating vascular dementia possibly through a paracrine mechanism. The study was approved by the Animal Ethics Committee of Harbin Medical University(approval No. KY2017-132) in 2017.

关键词： animal model dental pulp stem cells paracrine repair stem cells transplantation vascular dementia

Simulation of Vertical Planetary Mill Based on Virtual Prototyping

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Journal of University of Science and Technology Beijing 2001年第2期8卷 86-90页

作者： Ruitao Li, Mei Fang, Wenming zhang, yue Ma (Civil and Environmental Engineering School, University of Science and Technology Beijing, Beijing 100083, China) Univ Sci & Technol Beijing Civil & Environm Engn Sch Beijing 100083 Peoples R China

The mechanical model of vertical planetary mill is set up, whose dynamic and kinetic characteristics are described as well. Based on the analysis of system dynamics of vertical planetary mill, virtual prototyping technology is applied in the simulation of this mill. The development of virtual prototype of equipment, virtual test and optimization of virtual prototype are stated in detail. Some useful conclusions which have theoretical meaning for the manufacturing of vertical planetary mill have been obtained. Furthermore, it is pointed out that virtual prototyping technology shows great advantage and is bound to become a main method of developing product in the future.

关键词： virtual prototype vertical planetary mill dynamics simulation ADAMS

Importance of oxygen-containing functionalities and pore structures of biochar in catalyzing pyrolysis of homologous poplar

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Chinese Journal of Chemical Engineering 2024年第1期65卷 200-211页

作者： Li Qiu chao Li Shu zhang Shuang Wang Bin Li Zhenhua Cui Yonggui Tang Obid Tursunov Xun Hu School of Material Science and Engineering University of JinanJinan 250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Shandong BASAN Graphite New Material Plant Zibo 255311China Department of Power Supply and Renewable Energy Sources National Research University TIIAMETashkent 100000Uzbekistan

Biochar and bio-oil are produced simultaneously in one pyrolysis process,and they inevitably contact and may interact,influencing the composition of bio-oil and modifying the structure of *** this sense,biochar is an inherent catalyst for *** this study,in order to investigate the influence of functionalities and pore structures of biochar on its capability for catalyzing the conversion of homologous volatiles in bio-oil,three char catalysts(600C,800C,and 800AC)produced via pyrolysis of poplar wood at 600 or 800℃or activated at 800℃,were used for catalyzing pyrolysis of homologous poplar wood at 600℃,*** results indicated that the 600C catalyst was more active than 800C and 800AC for catalyzing cracking of volatiles to form more gas(yield increase by 40.2%)and aromatization of volatiles to form more light or heavy phenolics,due to its abundant oxygen-containing functionalities acting as active *** developed pores of the 800AC showed no such catalytic effect but could trap some volatiles and allow their further conversion via sufficient ***,the interaction with the volatiles consumed oxygen on 600C(decrease by 50%),enhancing the aromatic degree and increasing thermal *** dominance of deposition of carbonaceous material of a very aromatic nature over 800C and 800AC resulted in net weight gain and blocked micropores but formed additional *** in situ diffuse reflectance infrared Fourier transform spectroscopy characterization of the catalytic pyrolysis indicated superior activity of 600C for removal of -OH,while conversion of the intermediates bearing C=O was enhanced over all the char catalysts.

关键词： Poplar wood Catalytic pyrolysis Char catalyst Volatile-char interaction Bio-oil

Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus

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Neural Regeneration Research 2018年第10期13卷 1753-1758页

作者： Bao-Liang zhang yue-Shan Fan Ji-Wei Wang Zi-Wei Zhou Yin-Gang Wu Meng-Chen Yang Dong-Dong Sun Jian-Ning zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin China

Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy. In this study, we examined the relationship between traumatic brain injury-induced neuronal loss and subsequent hippocampal regional excitability. We used hydraulic percussion to generate a rat model of traumatic brain injury. At 7 days after injury, the mean modified neurological severity score was 9.5, suggesting that the neurological function of the rats was remarkably impaired. Electrophysiology and immunocytochemical staining revealed increases in the slope of excitatory postsynaptic potentials and long-term depression（indicating weakened long-term inhibition）, and the numbers of cholecystokinin and parvalbumin immunoreactive cells were clearly reduced in the rat hippocampal dentate gyrus. These results indicate that interneuronal loss and changes in excitability occurred in the hippocampal dentate gyrus. Thus, traumatic brain injury-induced loss of interneurons appears to be associated with reduced long-term depression in the hippocampal dentate gyrus.

关键词： nerve regeneration long-term depression traumatic brain injury hippocampus interneurons excitability dentate gyrus parvalbumin cholecystokinin electrophysiology quantification neural regeneration

Transferring CdTe Nanoparticles from Liquid Phase to Polyvinylpyrrolidone Nanofibers by Electrospinning and Detecting Its Photoluminescence Property

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Chemical Research in Chinese Universities 2008年第4期24卷 459-463页

作者： WANG Shu-gang YANG Qing-biao BAI Jie SONG Yan zhang chao-qun LI Yao-xian Department of Organic Chemistry College of Chemistry Jilin University Changchun 130021 P R. China

The major aim of this work was to synthesize thio-stabilized CdTe nanoparticles（NPs） in an aqueous solution, which was then enwrapped with cetyltrimethylammonium bromide（CTAB）, and finally transferred to the polyvinylpyrrolidone（PVP） matrix by electrospinning. The PVP nanofibers containing CdTe NPs were characterized by scanning electron microscopy（SEM） and transmission electron microscopy（TEM）, to observe the morphology of the nanofibers and the distribution of CdTe NPs. The selective area electronic diffraction（SAED） pattern verified that CdTe NPs were cubic lattice. The photoluminescence（PL） spectrum indicated that CdTe NPs existed in an optical style in PVP nanofibers. Moreover, X-ray photoelectron spectra（XPS） revealed that thiol-stabilized CdTe NPs were enwrapped by CTAB, and PVP acted as a dispersant in the process of electrospinning.

关键词： CTAB Electrospinning Nanofiber Nanoparticle Photoluminescence

Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2303-2306页

作者： Shu Wang ChangDong Lin yue Li ZhaoYuan Liu JunLei Wang YouHua zhang ZhanJun Yan yueBin zhang GuoHui Li JianFeng Chen State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Deportment of Orthopedics Suzhou Ninth People's HospitalSoochow UniversitySuzhou 215000China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)***4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of ***4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1.

关键词： α4β7 acute gp120

RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3382-3385页

作者： Chuge Zhou Xiaodong Zai Ziqing Zhou Ruihua Li yue zhang Yaohui Li Ying Yin Jun zhang Junjie Xu Wei Chen Beijing Institute of Biotechnology No.20 Dongdajie StreetFengtai District100071 BeijingChina

Dear Editor,To date,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 223 million confirmed cases of coronavirus disease 2019(COVID-19),including 4.6 million deaths(https://***/).Since 2020,several SARS-CoV-2 variants including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)with immune evasiveness have emerged and fast *** a global research effort,scientists proposed multiple effective vaccine strategies to respond to the ongoing COVID-19 *** vaccines currently in use or in clinical development target the SARS-CoV-2 Spike(S)glycoprotein,a homotrimer decorates on the viral surface;within it,a distinct receptor-binding domain(RBD,residues 331–524)is responsible for mediating cell entry and interaction with host receptor angiotensin-converting enzyme 2(ACE2).

关键词： vaccine acute respiratory

Cavernous Transformation of the Portal Vein Secondary to Cholecystolithiasis

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Chinese Medical Journal 2018年第11期131卷 1373-1374页

作者： Ya-Feng Wan yue Zhou chao He Zhong Jia Department of Hepatobiliary Surgery Hangzhou First People's Hospital Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases Hangzhou. Zhejiang 310006 China Nanjing Medical University Affiliated Hangzhou Hospital Hangzhou Zhejiang 310006 China Zhejiang Chinese Medicine Hospital Affiliated 4th Clinical Teaching Hospital Hangzhou Zhejiang 310006 China

To the Editor： A 58-year-old man with tip to a 5-year history of cholecystolithiasis presented with a 1-day history of mild abdominal pain with tenderness in the right upper quadrant before this hospital admission. He complained of similar sylnptoms about 5 years ago and recovered after 11 days of conservative therapy in the same hospital. The temperature was normal, and no special findings were noted on laboratory testing. Ultrasonography revealed multiple small gallstones in the lumen of the gallbladder. Unexpectedly.

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Mutational landscape of TP53 and CDH1 in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 276-283页

作者： Hong-Qiao Cai Li-yue zhang Li-Ming Fu Bin Xu Yan Jiao Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Critical Care Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Traditional Chinese Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

In this editorial we comment on an article published in a recent issue of the World J Gastrointest Surg.A common gene mutation in gastric cancer(GC)is the TP53 *** a tumor suppressor gene,TP53 is implicated in more than half of all tumor ***53 gene mutations in GC tissue may be related with clinical pathological *** TP53 mutation arose late in the progression of GC and aided in the final switch to ***1 encodes E-cadherin,which is involved in cell-to-cell adhesion,epithelial structure maintenance,cell polarity,differentiation,and intracellular signaling pathway ***1 mutations and functional loss can result in diffuse GC,and CDH1 mutations can serve as independent prognostic indicators for poor *** patients can benefit from genetic counseling and testing for CDH1 *** therapy may assist to postpone the onset and progression of *** investigation of TP53 and CDH1 gene mutations in GC allows for the investigation of the relationship between these two gene mutations,as well as providing some basis for evaluating the prognosis of GC patients.

关键词： TP53 CDH1 Gastric cancer Gene mutation Methylation