RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern

作     者：Chuge Zhou Xiaodong Zai Ziqing Zhou Ruihua Li Yue Zhang Yaohui Li Ying Yin Jun Zhang Junjie Xu Wei Chen Chuge Zhou;Xiaodong Zai;Ziqing Zhou;Ruihua Li;Yue Zhang;Yaohui Li;Ying Yin;Jun Zhang;Junjie Xu;Wei Chen

作者机构：Beijing Institute of BiotechnologyNo.20 Dongdajie StreetFengtai District100071 BeijingChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第12期

页      面：3382-3385页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：ACKNOWLEDGEMENTS The work is supported by the grant from the National Key Research and Development Program of China(2020YFC0841400) the National Natural Science Foundation of China(31800770,82041019) 

主　　题：vaccine acute respiratory 

摘      要：Dear Editor,To date,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 223 million confirmed cases of coronavirus disease 2019(COVID-19),including 4.6 million deaths(https://***/).Since 2020,several SARS-CoV-2 variants including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)with immune evasiveness have emerged and fast *** a global research effort,scientists proposed multiple effective vaccine strategies to respond to the ongoing COVID-19 *** vaccines currently in use or in clinical development target the SARS-CoV-2 Spike(S)glycoprotein,a homotrimer decorates on the viral surface;within it,a distinct receptor-binding domain(RBD,residues 331–524)is responsible for mediating cell entry and interaction with host receptor angiotensin-converting enzyme 2(ACE2).