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Maternal.and infant vitamin D status during l.ctation: Is l.titude important?

Heal.h 2013年第12期5卷 2004-2013页

作者： carol l. wagner Cynthia R. Howard Thomas C. Hul.ey Ruth A. l.wrence Myl. Ebel.ng Judy Shary Pamel. G. Smith Kristen Morel.a Sarah N. Tayl.r Bruce W. Hol.is Department of Pediatrics Medical University of South Carolina Charleston South Carolina USA Department of Pediatrics University of Rochester Rochester New York USA

Background: The effect of l.titude on maternal.and infant vitamin D status during l.ctation is presumed to be strongl. associated with higher rates of deficiency in those l.ving at higher l.titudes, yet with l.festyl. changes, this concl.sion may no l.nger be correct. Objective: To ascertain if higher l.titude adversel. affects the vitamin D status of l.ctating women and their ful.y breastfeeding infants. Study Design/Methods: Ful.y breastfeeding women and their infants were el.gibl. for participation in this study as part of a l.rger prospective vitamin D suppl.mentation trial. Women were recruited from two sites of differing l.titude: Charl.ston, SC at 32°N and Rochester, NY at l.titude 43°N. Maternal.and infant basel.ne vitamin D status, intact parathyroid hormone (IPTH), serum cal.ium and phosphorus as a function of site/l.titude were measured. The primary outcome was maternal.and infant total.circul.ting 25(OH)D at basel.ne by center/l.titude, and the secondary outcome was the percent of women and infants who had achieved a basel.ne concentration of at l.ast 20 ng/ml. meeting the Institute of Medicine’s definition of sufficiency at 4 to 6 weeks postpartum. Statistical.anal.sis was performed using SAS version 9.3. Resul.s: Higher l.titude adversel. affected vitamin D status onl. in l.ctating Caucasian women. African American and Hispanic women and infants l.ving in Rochester compared to Charl.ston had improved vitamin D status, an effect that was no l.nger significant when control.ing for socioeconomic factors and season. Overal., there was a significant vitamin D deficiency at basel.ne in l.ctating mothers, and a far greater deficiency in their infants. Maternal.basel.ne 25(OH)D concentration remained positivel. associated with being Caucasian, BMI and summer months. Breastfeeding infant vitamin D status mirrored maternal.status and remained positivel. associated with being Caucasian and summer months. Those infants who had been on a vitamin D suppl.ment at the

关键词： Vitamin D Chol.cal.iferol l.ctation l.titude

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Why shoul. l.mphocytes immune profil. matter in sepsis?

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Worl. Journal.of Critical.Care Medicine 2025年第2期14卷 18-26页

作者： wagner Nedel.l.l.an R Henrique l.is Val.or Portel. Department of Intensive Care Unit Conceição Hospital GroupPorto Alegre 91350200Brazil Department of Biochemistry Institute of Basic Health SciencesFederal University of Rio Grande do SulPorto Alegre 90035-003Brazil

The gl.bal.incidence of critical.il.ness has been steadil. increasing,resul.ing in higher mortal.ty rates thereby presenting substantial.chal.enges for cl.nical.*** these conditions,sepsis stands out as the l.ading cause of critical.il.ness,underscoring the urgent need for continued research to enhance patient care and deepen our understanding of its compl.x ***-cytes pl.y a pivotal.rol. in both innate and adaptive immune responses,acting as key regul.tors of the bal.nce between pro-infl.mmatory and anti-infl.m-matory processes to preserve immune *** the context of sepsis,an impaired immunity has been associated with disrupted l.mphocytic metabol.c activity,persistent pro-infl.mmatory state,and subsequent *** disruptions not onl. impair pathogen cl.arance but al.o predispose pati-ents to secondary infections and hinder recovery,highl.ghting the importance of targeting l.mphocyte dysfunction in sepsis ***,studies have identified absol.te l.mphocyte counts and derived parameters as promising cl.nical.biomarkers for prognostic assessment and therapeutic *** particul.r,neutrophil.to-l.mphocyte ratio,and l.mphopenia have gained reco-gnition in the l.terature as a critical.prognostic markers and therapeutic target in the management of *** review aims to el.cidate the mul.ifaceted rol. of l.mphocytes in pathophysiol.gy,with a focus on recent advancements in their use as biomarkers and key findings in this evol.ing fiel..

关键词： l.mphocytes Neutrophil.to-l.mphocyte ratio Sepsis Septic shock Chronic critical.il.ness Persistent infl.mmation,immunosuppression,and catabol.sm syndrome

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New insights into the vitamin D requirements during pregnancy

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Bone Research 2017年第3期5卷 161-176页

作者： Bruce W Hol.is carol l.wagner Department of Pediatrics Darby Children's Research Institute Medical University of South Carolina

Pregnancy represents a dynamic period with physical.and physiol.gical.changes in both the mother and her devel.ping fetus. The dramatic 2-3 fol. increase in the active hormone 1,25（OH）2D concentrations during the earl. weeks of pregnancy despite minimal.increased cal.ium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodul.tory rol. in preventing fetal.rejection by the mother. Whil. there have been numerous observational.studies that support the premise of vitamin D＇s rol. in maintaining maternal.and fetal.wel.-being, until.recentl., there have been few randomized cl.nical.trial. with vitamin D suppl.mentation. One has to exhibit caution, however, even with RCTs, whose resul.s can be probl.matic when anal.zed on an intent-to-treat basis and when there is high non-adherence to protocol.（as if often the case）, thereby dil.ting the potential.good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circul.ting 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are anal.zed using the biomarker 25（OH）D instead of treatment dose, there are notabl. differences in maternal.and fetal.outcomes across diverse racial.ethnic groups, with improved heal.h in those women who attain a circul.ting 25（OH）D concentration of at l.ast 100 nmol. l.1 （40 ng. ml.1）. Because ,an important issue is the timing or initiation of vitamin D treatment/suppl.mentation, and given the potential.effect of vitamin D on pl.cental.gene expression and its effects on infl.mmation within the pl.centa, it appears crucial.to start vitamin D treatment before pl.centation （and trophobl.st invasion）; however, this question remains unanswered. Additional.work is needed to decipher the vitamin D requirements of pregnant women and the optimal.timing of s

关键词： New insights into the vitamin D requirements during pregnancy

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Morphol.gy and phyl.geny of two species of Bathypathes from the tropical.western Pacific,with description of a new species

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Journal.of Oceanol.gy and l.mnol.gy 2025年第1期43卷 248-260页

作者： Ting l. Zifeng ZHAN Kuidong XU l.boratory of Marine Organism Taxonomy and Phyl.geny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China l.boratory for Marine Biol.gy and Biotechnol.gy Laoshan LaboratoryQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The bl.ck coral.genus Bathypathes Brook,1889 represents a rel.tivel. diverse and ecol.gical.y important assembl.ge comprising the deep-sea hard substrate *** phyl.genetic investigations have reveal.d the pol.phyl.tic nature of Bathypathes,urging further morphol.gical.anal.sis to understand its *** combing morphol.gical.and mol.cul.r data,we describe Bathypathes mul.ifurcata *** report *** Mol.dtsova,Opresko&wagner,2022based on the specimens col.ected from the tropical.western *** phyl.genetic topol.gy reconstructed using nucl.ar ITS1-5.8S-ITS2 and three mitochondrial.fragments suggests the separation of Bathypathes into four *** anal.sis of morphol.gical.characters,particul.rl. the col.ny branch and pinnul. patterns al.o roughl. cl.ssify Bathypathes into four morphol.gical.groups A–*** A is characterized by the unbranched col.ny and the subopposite arrangement of *** contrast to Group A,Groups B–D have the al.ernatel. arranged *** these,Group C exhibits a distinctl. l.ng unpinnul.ted stem compared to Groups B and *** B has unbranched col.ny,rel.tivel. short unpinnul.ted stem,and spines on pinnul.s have bl.nt *** Group D,l.rge col.nies(higher than 40 cm)have one or a few branches,smal. col.nies(l.ss than 40 cm)are unbranched,and spines on pinnul.s have acute *** data particul.rl. those species without sequences are necessary to verify the cl.ssification of these groups.

关键词： Antipatharia bl.ck coral taxonomy phyl.geny seamount western Pacific

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l.crimal.gl.nd tumors in Turkey：types,frequency,and outcomes

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2018年第8期11卷 1296-1302页

作者： Yagmur Seda Yesil.as Ahmet Kaan Gundiiz Esra Erden carol l. Shiel.s Department of Ophthal.ol.gy Ankara University Faculty of Medicine Ankara 06620 Turkey Department of Pathol.gy Ankara University Faculty of Medicine Ankara 06230 Turkey Ocul.r Oncol.gy Service Wills Eye Hospital Thomas Jefferson University Philadelphia PA 19107 USA

AIM： To eval.ate the cl.nical. radiol.gical. and treatment features of l.crimal.gl.nd ***： Retrospective review of 99 eyes of 92 patients with l.crimal.gl.nd tumors diagnosed and managed in a singl. institution between January 1999 and March 2017. Cl.nical.and radiol.gical.features, histopathol.gy, treatment methods, and prognosis were ***： The mean patient age was 40.3（range： 7-80）*** diagnosis was made histopathol.gical.y in 91（91.9%） tumors and on a cl.nical.and radiol.gical.basis in 8（8.1%） tumors. Final.diagnoses incl.ded idiopathic orbital.infl.mmation（pseudotumor） in 46（46.5%） l.sions, pl.omorphic adenoma in 14（14.1%）, adenoid cystic carcinoma in 12（12.1%）, granul.matous infl.mmation in 10（10.1%）, l.mphoma in 5（5.0%）, benign reactive l.mphoid hyperpl.sia in 3（3.0%）, dacryops in 3（3.0%）, carcinoma ex pl.omorphic adenoma in 2（2.0%）, adenocarcinoma in 1（1.0%）, dermoid cyst in 1（1.0%）, cavernous hemangioma in 1（1.0%）, and l.ukemic infil.ration in 1（1.0%）. Nonepithel.al.tumors comprised 64.6%（n=64） of al. l.crimal.gl.nd tumors, epithel.al.tumors 32.3%（n=32）, dermoid cyst 1%（n=1）, cavernous hemangioma 1%（n=1）, and l.ukemic infil.ration 1%（n=1）. There were in total.78（78.8%） benign and 21（21.2%） mal.gnant tumors. CONCl.SION： Overal., 65% of l.crimal.gl.nd tumors were of non-epithel.al.origin and 32% of epithel.al.origin. By histopathol.gy and cl.nical.eval.ation, 79% of l.crimal.gl.nd tumors were benign. The most common l.crimal.gl.nd tumors incl.de idiopathic orbital.infl.mmation（46.5%）, epithel.al.32.3%）, and l.mphoprol.ferative（8.1%） l.sions.

关键词： orbit l.crimal.gl.nd tumor infl.mmation epithel.al.tumor non-epithel.al.tumor

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Barring the gates to the battl.ground:DDR1 promotesimmune excl.sion in sol.d tumors

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Signal.Transduction and Targeted Therapy 2022年第2期7卷 339-340页

作者： Dimitrios l.wagner Enrico Kl.tzsch Berl.n Center for Advanced Therapies(BeCAT)and BIH Center for Regenerative Therapies(BCRT) Charité-Universitätsmedizin BerlinAugustenburger Platz 113353BerlinGermany Institute for Biol.gy Experimental Biophysics/MechanobiologyHumboldt University of BerlinBerlinGermany l.boratory of Appl.ed Mechanobiol.gy Department for Health Sciences and TechnologyETH ZurichZurichSwitzerland

In a recent articl. in Nature,Sun et al.1 identify a novel.mechanism of how sol.d tumors prevent immune cel. infil.ration into cancer tissue by ***,they devel.p and test a new monocl.nal.antibody that may be used as a... 详细信息

关键词： tumors immune

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Tunabl. photocycl. kinetics of a hybrid bacteriorhodopsin/quantum dot system

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Nano Research 2019年第2期12卷 365-373页

作者： Terianna J. Wax Jordan A. Greco Shutang Chen Nicol. l. wagner Jing Zhao Robert R. Birge 55 North Eagl.vil.e Rd Department of Chemistry University of Connecticut Storrs CT 06269-3060 USA

The incl.sion of inorganic nanoparticl.s in biol.gical.environments has l.d to the creation of hybrid nanosystems that are empl.yed in a variety of appl.cations. One such system incl.des quantum dots (QDs) coupl.d with the photoactive protein, bacteriorhodopsin (BR), which has been expl.red in devel.ping enhanced photovol.aic devices. In this work, we have discovered that the kinetics of the BR photocycl. can be manipul.ted using CdSe/CdS (core/shel.) QDs. The photocycl. l.fetime of protein sampl.s with varying QD amounts were monitored using time-resol.ed absorption spectroscopy. Concentration-dependent el.ngations of the bR and M state l.fetimes were observed in the kinetic traces, thus suggesting that excitonic coupl.ng occurs between BR and QDs. We propose that the pairing of BR with QDs has the potential.to be util.zed in protein-based computing appl.cations, specifical.y for real.time hol.graphic processors, which depend on the temporal.dynamics of the bR and M photointermediates.

关键词： bacteriorhodopsin photocycl. bionanotechnol.gy photochromism quantum dot hybrid material.

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Biomaterial. for refractive correction:corneal.onl.ys and inl.ys

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Science China Chemistry 2014年第4期57卷 501-509页

作者： WU Jian FUNDERBURGH James l.wagner Wil.iam R McGowan Institute for Regenerative Medicine University of Pittsburgh Department of Surgery University of Pittsburgh School of Medicine Department of Ophthal.ol.gy University of Pittsburgh School of Medicine Department of Bioengineering University of Pittsburgh

Corneal.inl.ys and onl.ys represent a means of providing patients with permanent refractive error correction. As an al.ernative to conventional.spectacl.s and contact l.ns, these techniques are l.ss invasive compared with l.ser-based refractive surgery and are reversibl.. In this review, we provide a brief overview of the anatomic microstructure of the human cornea, indicating the primary physiol.gical.function for each component. Next, the wide range of biomaterial. used as corneal.inl.ys and onl.ys are considered, from synthetic pol.mers to biol.gical.components derived from the extracel.ul.r matrix. The l.mitations and chal.enges associated with the most common material. are discussed as is the need to improve their properties to achieve l.ng-term, compl.cation-free intraocul.r impl.ntation. Final.y, the prospect of appl.ing tissue engineering strategies is noted for its potential.to generate autol.gous corneal.tissue that coul. be impl.nted as the optimal.inl.y or onl.y material..

关键词： refractive error onl.ys inl.ys synthetic pol.mer biol.gical.extracel.ul.r matrix refractive surgery

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The hidden hal. comes into the spotl.ght: Peeking inside the bl.ck box of root devel.pmental.phases

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Pl.nt Communications 2022年第1期3卷 36-52页

作者： Joao Antonio Siqueira wagner C.Otoni wagner l.Araujo Departamento de Biol.gia Vegetal Universidade Federal de Vic¸osaVic¸osaMG 36570-900Brazil

Efficient use of natural.resources(e.g.,l.ght,water,and nutrients)can be improved with a tail.red devel.pmental.program that maximizes the l.fetime and fitness of *** pl.nt shoots,a devel.pmental.phase represents a time window in which the meristem triggers the devel.pment of unique morphol.gical.and physiol.gical.traits,l.ading to the emergence of l.aves,fl.wers,and *** devel.pmental.phases in pl.nt shoots have been shown to enhance food production in crops,this phenomenon has remained poorl. investigated in *** l.ght of recent advances,we suggest that root devel.pment occurs in three main phases:root apical.meristem appearance,foraging,and *** provide compel.ing evidence suggesting that these phases are regul.ted by at l.ast four devel.pmental.pathways:autonomous,non-autonomous,hormonal.and *** devel.pmental.pathways differential.y coordinate organ pl.sticity,promoting morphol.gical.al.erations,tissue regeneration,and cel. death ***,we suggest how nutritional.checkpoints may al.ow progression through the devel.pmental.phases,thus compl.ting the root l.fe *** insights highl.ght novel.and exciting advances in root biol.gy that may hel. maximize the productivity of crops through more sustainabl. agricul.ure and the reduced use of chemical.fertil.zers.

关键词： devel.pmental.transitions pl.sticity cel. fates nutritional.checkpoints root devel.pment root cl.ck

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To Bring Fl.wers or Do a Runner：, Gibberel.ins Make the Decision

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Mol.cul.r Pl.nt 2018年第1期11卷 4-6页

作者： Auxil.adora O. Martins Adriano Nunes-Nesi wagner l. Aradjo Al.sdair R. Femie Max-Pl.nck Partner Group at the Departamento de Biol.gia Vegetal Universidade Federal de Vi~osa 36570-900 Vicosa Minas Gerais Brazil Departamento de Biol.gia Vegetal Universidade Federal de Vi~osa 36570-900 Vk~osa Minas Gerais Brazil Max Pl.nck Institute of Mol.cul.r Pl.nt Physiol.gy 14476 Potsdam-Golm Germany

Gibberel.ins （GAs） are invol.ed in several.growth and devel.p- mental.processes ranging from stem el.ngation, l.af expansion, transition to fl.wering, pol.en maturation, fruit set, and seed germination （Figure 1）.

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