Biomaterials for refractive correction:corneal onlays and inlays

作     者：WU Jian FUNDERBURGH James L WAGNER William R 

作者机构：McGowan Institute for Regenerative Medicine University of Pittsburgh Department of Surgery University of Pittsburgh School of Medicine Department of Ophthalmology University of Pittsburgh School of Medicine Department of Bioengineering University of Pittsburgh 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2014年第57卷第4期

页      面：501-509页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：the financial support from NIH grants(EY016415)to J.L.Funderburgh Core grant(P30-EY08098) Other support was received from the Ocular Tissue Engineering and Regenerative Ophthalmology(OTERO)program of the Louis J Fox Center for Vision Restoration the McGowan Institute for Regenerative Medicine,Research to Prevent Blindness Inc 

主　　题：屈光矫正 生物材料 角膜 隐形眼镜 合成聚合物 细胞外基质 屈光不正 显微结构 

摘      要：Corneal inlays and onlays represent a means of providing patients with permanent refractive error correction. As an alternative to conventional spectacles and contact lens, these techniques are less invasive compared with laser-based refractive surgery and are reversible. In this review, we provide a brief overview of the anatomic microstructure of the human cornea, indicating the primary physiological function for each component. Next, the wide range of biomaterials used as corneal inlays and onlays are considered, from synthetic polymers to biological components derived from the extracellular matrix. The limitations and challenges associated with the most common materials are discussed as is the need to improve their properties to achieve long-term, complication-free intraocular implantation. Finally, the prospect of applying tissue engineering strategies is noted for its potential to generate autologous corneal tissue that could be implanted as the optimal inlay or onlay materials.