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Comparison of clinical outcomes between unrelated single umbilical cord blood and"ex-vivo"T-cell depleted haploidentical transplantation in children with hematological malignancies

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World Journal of Pediatrics 2021年第6期17卷 609-618页

作者： carmen Gomez-santos Marta Gonzalez-Vicent Blanca Molina Natalia Deltoro Blanca Herrero Julia Ruiz Antonio Perez-Martinez Miguel A Diaz Department of Pediatrics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospital Infantil Universitario"La Pa"Madrid MadridSpain

Background Over the last two decades,umbilical cord blood(UCB)and haploidentical transplantation(HaploHSCT)have emerged as alternative sources of hematopoietic stem cell for allogeneic *** are few retrospective studies and no prospective studies comparing both types of alternative transplantation in pediatric *** We analyzed the data of 134 children with hematological malignancies who received a hematopoietic stem cell transplantation from a single umbilical cord blood(UCB)(n=42)or an"tex-vivo"T-cell depleted transplant from a haploi-dentical-related donor(HaploHSCT)(n=92)between 1996 and *** recovery was faster after HaploHSCT than the UCB transplant group(median times to neutrophil and platelet recovery:13 vs.16 days,10 vs.57 days,respectively)(P<0.001).The HaploHSCT group had a significantly early immune reconstitution based on NK and CD8+T cells compared with the UCB ***,after the first year *** had a lower number of CD4+ T and B lymphocytes compared with the UCB transplant *** cumulative incidence of TRM was 29±8%in the HaploHSCT group versus 40±5%in the UCB *** incidence was 21±7%in the HaploHSCT group and 19±8%in the UCB *** of DFS was 58±8%in the HaploHSCT group versus 40±9%in the UCB group(P=0.051).Conclusions TCD haploidentical transplant is associated with advantages in terms of engraftment and early immune reconstitution *** haploidentical transplant was associated with lower incidence of infectious and non-infectious complications,especially in the early phases of the transplant compared with UCB transplant ***,there are no advantages in transplant outcomes compared with UCB transplant.

关键词： Children Cord blood transplant Hematologic malignancies Immune reconstitution TCD haploidentical transplant

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Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 330-339页

作者： Ana Mora-Boza Francisco J.Aparicio Maria Alcaire carmen López-santos Juan P.Espinós Daniel Torres-Lagares Ana Borrás Angel Barranco Consejo Superior de Investigaciones Cientificas. Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla) c/Americo Vespucio 49 41092 SevillaSpain Facultad de Odontologia Universidad de Sevilla (USE) c/Avicena41009 SevillaSpain

Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against Escherichia coli K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

关键词： plasma polymers conformal plasma deposition chlorhexidine bactericide PDMS biocompatibility

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Storage time and condensed tannin content of high-moisture sorghum grains:Effects on in vitro fermentation and mold populations

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Animal Nutrition 2020年第1期6卷 92-97页

作者： carmen García y santos Lina Bettucci Sebastián Brambillasca Cecilia Cajarville Laboratorio de Toxicología Facultad de VeterinariaUniversidad de la RepúblicaLasplaces 1550PC 11.600MontevideoUruguay Laboratorio de Micología Facultad de Ciencias-Facultad de IngenieríaUniversidad de la RepúblicaJulio Herrera y Reissig 565PC 11.300MontevideoUruguay Instituto de Producción Animal Facultad de VeterinariaUniversidad de la RepúblicaRuta 1km 42.200PC 80.100San JoseUruguay

Silage of high moisture sorghum grains is a highly relevant source of energy in cattle production systems in South *** is little information related to the chemical characteristics,the kinetics of fermentation and the toxic fungal populations of these *** aim of this study was to evaluate the effect of storage time and condensed tannins content of the grain on chemical composition,in vitro fermentation parameters,and toxicogenic fungal populations of moist sorghum grain stored in *** of 2 varieties of sorghum grains(high-tannin[HT]and low-tannin[LT]),were obtained during the grain harvest before silage making and after 30,90,and 180 d of storage(n=16).High-tannin grains had higher acid detergent fiber,tannins,gas production(P<0.05)and lower starch and rate of gas production(P<0.01).Interaction variety x storage time were observed for all chemical parameters(P<0.01),except for neutral detergent fiber assayed with a heat stable amylase and expressed inclusive of residual ash(aNDF)and *** and protein content increased in both varieties,tannins decreased in HT and LT,and organic matter(OM)increased in HT and declined in LT(P<0.05).The rate of gas production increased with the storage time for HT and LT(P<0.01).A linear reduction in the Aspergillus number of colonies in the HT varieties was observed(P<0.01),whereas a linear increase in Penicillium isolation was detected in the LT sorghums(P<0.01).The storage time was beneficial in terms of decreasing the condensed tannins,increasing fractional rate of gas production and minimizing fungal contamination,particularly on HT grains.

关键词： Sorghum grains silages Condensed tannins Toxicogenic fungal populations Storage time

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal carmen-Lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos santos Gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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Production and Recovery of Rhamnolipids Using Sugar Cane Molasses as Carbon Source

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Journal of Chemistry and Chemical Engineering 2010年第11期4卷 27-33页

作者： Ana carmen santos Marcio Silva Bezerra Heloize dos santos Pereira Everaldo Silvino dos santos GoreteRibeiro de Macedo Federal University of Rio Grande do Norte Center of Technology Chemical Engineering Department Biochemical Engineering Laboratory Campus Universitario Lagoa Nova 3000 CEP.＇59072-970 Natal Rio Grande do Norte Brazil

Biosurfactants were synthesized by Pseudomonas aeruginosa （P.A.）, using sugar cane molasses as carbon source. Assays were conducted in a shaker with agitation speed of 200 rpm, temperature of 38 ℃ and aeration ratio （Vm/Vf） of 0.4 and 0.6. A concentration of 3.0% was used for the carbon and energy source （molasses） and of 0.3% for the nitrogen source （NaNO3）. Samples were removed at regular times until 96 hours of cultivation. The reduction in surface tension was measured using the ring method; cell concentration was obtained by the dry mass and substrate consumption by the DNS method. The metabolite produced was extracted and quantified by the thioglycolic method. The results showed a maximum surface tension reduction of 46.57% after 60 h, 3.63 g/L of biomass after 8 h （μXmax =0.15 h^-1）, 79.60% of substrate consumption （μs= 0.67 h-1） and 4.47 g/L of rhamnolipid （μp=0.029 h^-1）.

关键词： Biosurfactants molasses rhamnolipids Pseudomonas aeruginosa.

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Shared and tailored common bean transcriptomic responses to combined fusarium wilt and water deficit

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Horticulture Research 2021年第1期8卷 2163-2180页

作者： Susana T.Leitao carmen santos Susana de Sousa Araujo Diego Rubiales Maria Carlota Vaz Patto Instituto de Tecnologia Quimica e Biologica Antonio Xavier Universidade Nova de LisboaOeirasPortugal Association BLC3-Technology and Innovation Campus Centre Bio R&D UnitLagares da BeiraPortugal Institute for Sustainable Agriculture CSICCordobaSpain

Common bean(Phaseolus vulgaris L.),one of the most consumed food legumes worldwide,is threatened by two main constraints that are found frequently together in nature,water deficit(WD)and fusarium wilt(Fop).To understand the shared and unique responses of common bean to Fop and WD,we analyzed the transcriptomic changes and phenotypic responses in two accessions,one resistant and one susceptible to both stresses,exposed to single and combined *** responses(photosynthetic performance and pigments quantification)and disease progression were also *** combined FopWD imposition negatively affected the photosynthetic performance and increased the susceptible accession disease *** susceptible accession revealed a higher level of transcriptional changes than the resistant one,and WD single stress triggered the highest transcriptional *** 89 differentially expressed genes were identified exclusively in combined stresses for the susceptible accession,35 were identified in the resistant *** genes belong mainly to“stress”,“signaling”,“cell wall”,“hormone metabolism”,and“secondary metabolism”functional *** the up-regulated genes with higher expression in the resistant accession,the cysteine-rich secretory,antigen 5 and Pr-1(CAP)superfamily protein,a ribulose bisphosphate carboxylase family protein,and a chitinase A seem promising targets for multiple stress breeding.

关键词： metabolism assessed stress

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Exercise benefits meet the esophagus

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Journal of Sport and Health Science 2024年第5期13卷 685-686页

作者： Alejandro santos-Lozano Pedro L.Valenzuela carmen Fiuza-Luces Alejandro Lucia i+HeALTH European University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(“imas12”) Madrid 28041Spain Department of Systems Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Sciences Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroesophageal reflux disease(GERD)is defined by recurrent and troublesome heartburn and effortless regurgitation or by the specific complications of this condition—that is,esophagitis,esophageal peptic strictures,and Barrett esophagus.1Although GERD is caused by gastric contents'reaching the esophagus,gastric juices can also reach other anatomical locations(pharynx,mouth,larynx,and airways),leading to(or worsening)extra-esophageal conditions(notably asthma)or symptoms(e.g.,wheezing,cough).1 Together with obesity,GERD is the main risk factor for gastroesophageal malignancies.

关键词： esophagus esophageal Barrett

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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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First genetic linkage map of Lathyrus cicera based on RNA sequencing-derived markers: Key tool for genetic mapping of disease resistance

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Horticulture Research 2018年第1期5卷 345-358页

作者： carmen santos Nuno Felipe Almeida Mara Lisa Alves Ralf Horres Nicolas Krezdorn Susana Trindade Leitão Thaïs Aznar-Fernández Björn Rotter Peter Winter Diego Rubiales Maria Carlota Vaz Patto Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de LisboaAv.da RepúblicaOeiras2780-157Portugal GenXPro GmbH Frankfurt am MainD-60438Germany Institute for Sustainable Agriculture CSICCórdobaE-14004Spain

The Lathyrus cicera transcriptome was analysed in response to rust(Uromyces pisi)infection to develop novel molecular breeding tools with potential for genetic mapping of resistance in this robust orphan legume *** RNA-seq library each was generated from control and rust-inoculated leaves from two *** genotypes with contrasting quantitative resistance,de novo assembled into contigs and sequence polymorphisms were *** toto,19,224 SNPs differentiate the susceptible from the partially resistant genotype’s *** addition,we developed and tested 341 expressed E-SSR markers from the contigs,of which 60.7%varied between the two *** genotypes.A first *** linkage map was created using part of the developed markers in a RIL population from the cross of the two *** map contains 307 markers,covered 724.2 cM and is organised in 7 major and 2 minor linkage groups,with an average mapping interval of 2.4 *** genic markers also enabled us to compare their position in *** map with the physical position of the same markers mapped on Medicago truncatula genome,highlighting a high macrosyntenic conservation between both *** study provides a large new set of genic polymorphic molecular markers with potential for mapping rust *** represents the first step towards genomics-assisted precision breeding in ***.

关键词： breeding linkage resistance

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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