Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

作     者：Ana Mora-Boza Francisco J.Aparicio Maria Alcaire Carmen López-Santos Juan P.Espinós Daniel Torres-Lagares Ana Borrás Angel Barranco 

作者机构：Consejo Superior de Investigaciones Cientificas. Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla) c/Americo Vespucio 4941092 SevillaSpain Facultad de OdontologiaUniversidad de Sevilla (USE) c/Avicena41009 SevillaSpain 

出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)

年 卷 期：2019年第13卷第2期

页      面：330-339页

核心收录：

学科分类：0817[工学-化学工程与技术] 08[工学] 

基　　金：the Agencia Estatal de Investigacion (AEI) and EU (FEDER program) under 

主　　题：plasma polymers conformal plasma deposition chlorhexidine bactericide PDMS biocompatibility 

摘      要：Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against Escherichia coli K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.