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Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility

Asian Journal of Andrology 2004年第1期6卷 59-65页

作者： Nicolás Garrido Marcos Meseguer carlos simon Antonio Pellicer José Remohi Instituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Department of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia Spain

Oxidative stress is a common condition suffered by biological systems in aerobic conditions. Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions. The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. The paper is a systematic review of publications that evaluate oxidative stress in semen. The Cochrane Library, Medline (1966-2003), Embase (1988-2003), SciSearch (1981-2003) and the conference papers were searched. When sperm samples from fertile and infertile males were analyzed, some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered. In conclusion, the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate, in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.

关键词： oxidative stress antioxidants semen spermatozoa male fertility

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Completion thyroidectomy:is timing important for transcervical and remote access approaches?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第3期6卷 165-170页

作者： Juan Pablo Duenas carlos simon Duque Laura Cristancho Manuela Mendez Hospital Pablo Tobon Uribe Instituto de Cancerologia IDC Las AmericasClfnica Universitaria BolivarianaClinica el Rosario Sede el Tesoro(CLID)MedellinColombia Universidad Militor Nueva Granada BogotaDCColombia Universidad CES MedellinColombia Hospital Pablo Tobon Uribe Clfnica Las AmericasMedellinColombia

Completion thyroidectomy(CT)is employed after lobectomy when histopathological results mandates total removal of the gland as in case of well differentiated thyroid carcinoma(DTC).It is also employed as a second stage thyroid surgery when unfavorable events occur as in recurrent laryngeal nerve injury or when the surgeon finds out the case is beyond his/her expertise in an attempt to protect the contralateral side and allowing time for recovery or for an expert surgeon to help.

关键词： Completion thyroidectomy Total thyroidectomy Complications Nerve monitoring

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A simple,azulene-based colorimetric probe for the detection of nitrite in water

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 90-96,F0004页

作者： Lloyd C.Murfin carlos M.Lopez-Alled Adam C.Sedgwick Jannis Wenk Tony D.James simon E.Lewis Department of Chemistry University of BathBath BA27AYUK Centre for Sustainable Chemical Technologies University of BathBath BA27AYUK Department of Chemical Engineering and Water Innovation and Research Centre(WIRC@Bath) University of BathBath BA27AYUK

We describe the synthesis and evaluation of an azulene-based chemodosimeter for *** probe was found to undergo two distinct color changes upon introduction of aqueous nitrite ion.A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite,followed by the formation of a deep-yellow/orange color,the endpoint from which quantitative data can be *** azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water,and is selective for nitrite over other *** azulene probe was applied to determine nitrite content in cured meat,and compared with the British Standard testing procedure(Griess test).The value obtained from the azulene-based probe agreed closely with the standard *** procedure only requires the preparation of one standard solution,instead of the three required for the standard Griess test.

关键词： azulene nitrite diazoquinone

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Tracking leaf area index and coefficient of light extinction over the harvesting cycle of black wattle

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Journal of Forestry Research 2016年第6期27卷 1211-1217页

作者： Aiexandre Behling carlos Roberto Sanquetta Ana Paula Dalla Corte Sylvio Pellico Netto Aurelio Lourenco Rodrigues Braulio Otomar Caron Augusto Arlindo simon Federal University of Parana 900Lothario Meissner AvCuritibaParana 80210-170Brazil Federal University of Santa Maria 1000 Roraima AvSanta MariaRio Grande do SulBrazil TANAC SA 199 Torbjom Weibull StMontenegroRio Grande do SulBrazil

The amount of photosynthetic radiation inter- cepted by a crop is a function of the incident solar radiation on the plants, the leaf area index （LAI）, and the light extinction coefficient （k）. We quantified LAI and k in stands of black wattle （Acacia mearnsii De Wild.） over a 7-year growth cycle at two locations in the state of Rio Grande do Sul, Brazil. Our study was conducted in commercial stands in agroecological regions with high densities of black wattle plantations. LAI was calculated as the ratio between the leaf area of a tree and its planting space, and k was derived from Beer＇s law. LAI depends on the planting site and stand age. Between the two sites, the LAI was similar over time, the amount of variation differed. Values of k depended only on stand age, with the highest average observed for stands up to 5 years old. The trend of k during the plantation cycle was inversely proportional to LAI and was correlated with LAI, leaf area, leaf dry mass, canopy volume, height, branches dry mass, total dry mass, and crown diameter.

关键词： Leaf area - Light attenuation Tree canopy Biomass Photosynthetic radiation intercepted

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Design and Construction of an Equipment for the Radiochemistry Process of Molecules Marked for the Sector Health

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Journal of Environmental Science and Engineering(A) 2015年第4期4卷 196-202页

作者： Jose Alanis Hector Flores simon de la Cruz Jose carlos Vazquez Department of Radioactive Waste Nuclear Center of Mexico ININ Oeoyoacac Edo. de Mexico 52 750 Mexico Department of Chemical Analyses Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department Manufacture of Prototypes Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico Department of A utomation Nuclear Center of Mexico ININ Ocoyoacac Edo. de Mexico 52750 Mexico

At the Plant of Production of Radioisotopes part of Nuclear Center of Mexico （ININ）, weekly radiofarmaceutics of sodium iodohippurate and meta-iodobenzyl-guanidine are prepared, these compounds are known as marked molecules with iodine-131. Currently the processes for the preparation of these compounds are carried out individually and in manual form, in box of gloves, presenting radiological risks. To avoid these risks, this work, shows equipment that is inside a warm cell with the finality of minimizing the radiological risks. Also, this semi-automated equipment has the purpose of to reduce the radiation exposure of personnel involved in the process of marking molecules. The routine industrial production with this equipment starts with the preparation of 9 marked doses of sodium iodohippurate of 2.73 mCi of iodine-131, each of the vials with saline solution of 4.5 mL and the product that containing the marked molecules of 0.5 mL with a percentage of marked of 95.6%. The innovation of this work consists in presenting a new design of equipment, for marked molecules, formed by electrical, mechanical, vacuum systems, and air extraction system.

关键词： Construction equipment molecules marked sector health

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Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park simon Rousseau Lorenzo E.Ferri Thoracic and Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada Department of Experimental Surgery and Department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada Department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA Department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to determine the effects of NOD1 on ***1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate ***130,a specific NOD1 inhibitor,was used to block C12-iE-DAP *** knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus ***,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase *** data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell ***,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with ***,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and *** effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)*** is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.

关键词： NOD1 iE-DAP ML130 colon cancer metastasis cancer-extracellular matrix adhesion cancer migration p38 MAPK activation intravital microscopy survival analysis

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Probabilistic Distributions for <i>Acacia Mearnsii</i>De Wild Total Height and the Influence of Environmental Factors

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Journal of Applied Mathematics and Physics 2014年第3期2卷 1-10页

作者： carlos Roberto Sanquetta Alexandre Behling Allan Libano Pelissari Ana Paula Dalla Corte Sylvio Péllico Netto Augusto Arlindo simon Department of Forest Science University Federal of Paraná Curitiba Brazil

This paper discusses the hypothesis of height distribution on a forest stand of Acacia mearnsii De Wild, known as black wattle. It remains constant at varied growing environments and, in addition, they are not influenced by age factor. The Wakeby equation was applied. The research was carried out in a black wattle stand at varied age levels and over two different agroecological regions where plantations are found: Serra do Sudeste and Encosta do Sudeste, Rio Grande do Sul State, Brazil. It was observed that as the age rises there is an increase in the stand total height;while the number of trees decreases for the lower classes, it increases for the upper ones. This resulted in lengthening of the curve tail to the left and mode shift to the right, generating negative asymmetrical curves. Two types of height distribution were found: the sharp increase of probability in a specific class and some similar probabilities in successive classes. The distribution curves between the cultivation areas were statistically different and therefore the height distribution was dependent of environment.

关键词： Wakeby Distribution Forest Stand Age Cultivation Area Forest Structure

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Epidemics on networks: Reducing disease transmission using health emergency declarations and peer communication

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Infectious Disease Modelling 2020年第1期5卷 12-22页

作者： Asma Azizi Cesar Montalvo Baltazar Espinoza Yun Kang carlos Castillo-Chavez School of Human Evolution and Social Change Simon A.Levin Mathematical Computational Modeling Science CenterArizona State UniversityTempeAZ85281USA Division of Applied Mathematics Brown UniversityProvidenceRI02906USA Sciences and Mathematics Faculty College of Integrative Sciences and ArtsArizona State UniversityMesaAZ85212USA

Understanding individual decisions in a world where communications and information move instantly via cell phones and the internet,contributes to the development and implementation of policies aimed at stopping or ameliorating the spread of *** this manuscript,the role of official social network perturbations generated by public health officials to slow down or stop a disease outbreak are studied over distinct classes of static social *** dynamics are stochastic in nature with individuals(nodes)being assigned fixed levels of education or *** may change their epidemiological status from susceptible,to infected and to *** importantly,it is assumed that when the prevalence reaches a pre-determined threshold level,P*,information,called awareness in our framework,starts to spread,a process triggered by public health *** is assumed to spread over the same static network and whether or not one becomes a temporary informer,is a function of his/her level of education or wealth and epidemiological *** simulations show that threshold selection Pand the value of the average basic reproduction number impact the final epidemic size *** the ErdÖos-Rényi and Small-world networks,an optimal choice for Pthat minimize the final epidemic size can be identified under some conditions while for Scalefree networks this is not case.

关键词： Awareness spread Behavior change Outbreak and epidemic threats ErdÖos-rényi network Small-world network Scale-free network

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Role of short-term dispersal on the dynamics of Zika virus in an extreme idealized environment

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Infectious Disease Modelling 2017年第1期2卷 21-34页

作者： Victor M.Moreno Baltazar Espinoza Derdei Bichara Susan A.Holechek carlos Castillo-Chavez simon A.Levin Mathematical Computational and Modeling Sciences CenterArizona State UniversityP.O.Box 873901TempeAZ 85287-3901United States Biodesign Center for Infectious Diseases and Vaccinology Biodesign InstituteArizona State UniversityTempeAZ 85287-5401United States School of Life Sciences Arizona State UniversityTempeAZ 85287-4501United States Department of Mathematics and Center for Computational and Applied Mathematics California State UniversityFullertonCA 92831United States Departamento the Ingenieria Biomedica Universidad de Los AndesBogotaColombia Rector's Office Yachay Tech UniversityUrcuquiEcuador

In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two *** agencies began implementing control measures that included vector control and recommending an increased use of ***,in response to the alarming and growing number of microcephaly cases in Brazil,the importance of avoiding pregnancies for two years was *** this paper,we explore the role of mobility within communities characterized by extreme poverty,crime and ***,the role of short term mobility between two idealized interconnected highly distinct communities is explored in the context of ZIKV *** make use of a Lagrangian modeling approach within a two-patch setting in order to highlight the possible effects that short-term mobility,within highly distinct environments,may have on the dynamics of ZIKV outbreak when the overall goal is to reduce the number of cases not just in the most affluent areas but *** depend on existing mobility patterns,levels of disease risk,and the ability of federal or state public health services to invest in resource limited areas,particularly in those where violence is *** results of simulations in highly polarized and simplified scenarios are used to assess the role of *** quickly became evident that matching observed patterns of ZIKV outbreaks could not be captured without incorporating increasing levels of *** number of distinct patches and variations on patch connectivity structure required to match ZIKV patterns could not be met within the highly aggregated model that is used in the simulations.

关键词： Vector-borne diseases Zika virus Residence times Multi-patch model

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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio Perez-simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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