Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility

作     者：Nicolás Garrido Marcos Meseguer Carlos Simon Antonio Pellicer José Remohi NICOLAS GARRIDO;MARCOS MESEGUER;CARLOS SIMON;ANTONIO PELLICER;JOSE REMOHIINSTITUTO VALENCIANO DE INFERTILIDAD VALENCIA;VALENCIA;SPAINFUNDACION INSTITUTO VALENCIANO DE INFERTILIDAD;VALENCIA;SPAINDEPARTMENT OF PEDIATRICS;OBSTETRICS AND GYNECOLOGY;VALENCIA UNIVERSITY SCHOOL OF MEDICINE;SPAIN DEPARTMENT OF OBSTETRICS AND GYNECOLOGY HOSPITAL DR. PESET;SPAIN

作者机构：Instituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Department of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia Spain 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2004年第6卷第1期

页      面：59-65页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：oxidative stress antioxidants semen spermatozoa male fertility 

摘      要：Oxidative stress is a common condition suffered by biological systems in aerobic conditions. Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions. The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. The paper is a systematic review of publications that evaluate oxidative stress in semen. The Cochrane Library, Medline (1966-2003), Embase (1988-2003), SciSearch (1981-2003) and the conference papers were searched. When sperm samples from fertile and infertile males were analyzed, some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered. In conclusion, the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate, in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.