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Evaluation of Novel 3D Architectures Based on Knitting Technologies for Engineering Biological Tissues

Journal of Donghua University(English Edition) 2013年第5期30卷 421-426页

作者： ribeiro Viviana Pinto ribeiro Ana Soares SILVA carla Joana DURES Nelson Feio BONIFCIO Graa CORRELO Vitor Manuel MARQUES Alexandra Pinto SOUSA Rui Amandi OLIVEIRA Ana Leite REIS Rui Luís 3B's Research G roup-Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine ICVS /3B's-PT G overnment Associated Laboratory University of Minho CeNTI Centre for Nanotechnology and Smart MaterialsV. N. CITEVE Technological Centre for Textile and Clothing IndustryV. N. CBQF-School of Biotechnology Portuguese Catholic University

Textile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering( TE) applications. We describe the use of two polymers,namely polybutylene succinate( PBS) and silk fibroin(SF) to produce fiber-based finely tuned porous architectures by weft and warp knittings. The obtained knitted constructs are described in terms of their morphology, mechanical properties,swelling ability,degradation behaviour,and cytotoxicity. Each type of polymer fibers allows for the processing of a very reproducible intra-architectural scaffold geometry,with distinct characteristics in terms of the surface physicochemistry,mechanical performance,and degradation capability,which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed( acid /alkaline treatment, UV radiation,and plasma) for modulating cell behavior. An increase of cell-material interactions were observed,indicating the important role of materials surface in the first hours of culturing. Human adipose-derived stem cells( hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion,proliferation,and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers,it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone,skin,ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.

关键词： textile-based technologies silk polybutylene succinate(PBS) surface modifications human adipose-derived stem cells(hASCs) tissue engineering(TE)

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Longitudinal assessment of liver stiffness by transient elastography for chronic hepatitis C patients

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World Journal of Clinical Cases 2022年第17期10卷 5566-5576页

作者： Anya Mezina Arunkumar Krishnan Tinsay A Woreta Kevin B Rubenstein Eric Watson Po-Hung Chen carla Rodriguez-Watson Department of Medicine Johns Hopkins School of MedicineBaltimoreMD 21287United States Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21231United States Mid-Atlantic Permanente Research Institute Kaiser Permanente Mid-Atlantic StatesRockville 20852United States Department of Health Policy and Management Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21287United States Innovation in Medical Evidence Development and Surveillance(IMEDS)Program Reagan-Udall Foundation for the FDAWashington20036United States

BACKGROUND Liver fibrosis is a common pathway of liver injury and is a feature of most chronic liver *** progression varies markedly in patients with hepatitis C virus(HCV).Liver stiffness has been recommended as a parameter of fibrosis progression/regression in patients with *** To investigate changes in liver stiffness measured by transient elastography(TE)in a large,racially diverse cohort of United States patients with chronic hepatitis C(CHC).METHODS We evaluated the differences in liver stiffness between patients treated with direct-acting antiviral(DAA)therapy and untreated *** had≥2 TE measurements and no prior DAA *** used linear regression to measure the change in liver stiffness between first and last TE in response to treatment,controlling for age,sex,race,diabetes,smoking status,human immunodeficiency virus status,baseline alanine aminotransferase,and baseline liver *** regression models analyzed the change in liver stiffness as measured by kPa,stratified by cirrhosis *** Of 813 patients,419(52%)initiated DAA *** liver stiffness was 12 kPa in 127(16%).Median time between first and last TE was 11.7 and 12.7 mo among treated and untreated patients,*** was no significant change in liver stiffness observed over time in either the group initiating DAA treatment(0.016 kPa/month;CI:-0.051,0.084)or in the untreated group(0.001 kPa/mo;CI:-0.090,0.092),controlling for covariates.A higher baseline kPa score was independently associated with decreased liver *** DAA treatment was not associated with a differential change in liver stiffness over time in patients with CHC compared to untreated patients.

关键词： Chronic hepatitis C Liver stiffness Cirrhosis Transient elastography Direct-acting antiviral therapy

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Reply to"Six-minute walking test performance is associated with survival in cirrhotic patients"to the editor

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World Journal of Hepatology 2022年第5期14卷 1047-1049页

作者： carla Malaguti Carlos Alberto Mourão-Junior Júlio Maria Chebli Departament of Cardiorespiratory and Skeletal Muscle Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil Department of Physiology Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil Department of Medicine Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil

Use of the six-minute walk test has been proposed as a prognostic marker in liver *** the Letter to the Editor presented here,the authors highlight some important points,which were raised after the article was publish... 详细信息

关键词： Six-minute walking test Liver cirrhosis Hospital admission and mortality

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Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： Antonella Antonelli carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

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Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

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World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life Sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B

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Adult neurogenesis and regeneration in zebrafish brain: are the neurotrophins involved in?

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Neural Regeneration Research 2019年第12期14卷 2067-2068页

作者： Pietro Cacialli carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Neurotrophins (NTs) are implicated in the maintenance and survival of the peripheral and central nervous systems and mediate several forms of synaptic plasticity. Members of the family include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT3, and NT4. NTs were first identified as survival factors for developing neurons, but are pleiotropic molecules that can exert a variety of functions, including the regulation of neuronal differentiation, axonal and dendritic growth, and synaptic plasticity (Bothwell, 2014). NTs interact with two distinct types of receptors: the common p75 neurotrophin receptor, which belongs to the tumor necrosis factor receptor superfamily of death receptors and the Trk receptor tyrosine kinase family.

关键词： Adult neurogenesis regeneration neurotrophins

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Effect of Waste Oil-Cracking Catalyst Incorporation on Durability of Mortars

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Materials Sciences and Applications 2014年第13期5卷 905-914页

作者： carla Costa M. Sofia ribeiro Nuno Brito Department of Civil Engineering High Institute of Engineering of Lisbon (ISEL) Lisbon Portugal Materials Department National Laboratory for Civil Engineering (LNEC) Lisbon Portugal

This paper presents research on transport properties and alkali-silica reaction (ASR) susceptibility of mortars containing a pozzolanic waste generated in the fluid catalytic cracking (wFCC) unit by the Portuguese oil-refinery. For this purpose, two series of mortars were prepared by partially replacing cement with 5%, 10% and 15% of wFCC catalyst. The main difference between the two series of mortars is the sand reactivity used in their composition. The results revealed that wFCC catalyst blended cement mortars exhibit an increased resistance against capillary water absorption and chloride migration, as well as a considerable inhibition effect on deleterious ASR expansion. However, under the adopted experimental conditions the incorporation of wFCC catalyst in mortars decreases their carbonation resistance.

关键词： Waste Oil-Cracking Catalyst Blended Cement Mortars Water Absorption Chloride Migration Resistance to Carbonation Alkali-Silica Reaction Durability

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Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center

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Chinese Journal of Cancer Research 2018年第5期30卷 546-552页

作者： adriana vaz safatle-ribeiro elisa ryoka baba rodrigo corsato scomparin sheila friedrich faraj marcelo simas de lima luciano lenz bruno costa martins carla gusmon fábio shiguehissa kawaguti caterina pennacchi bruno zilberstein ulysses ribeiro jr. fauze maluf-filho Endoscopy Unit of Department of Gastroenterology Sao Paulo Cancer Institute University of Sao Paulo Medical School (ICESP-HCFMUSP) Sao Paulo 01246-000 Brazil

Objective： Probe-based confoeal laser endomicroscopy （pCLE） technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution in vivo images at the cellular and mierovaseular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric ***： Twenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Diagnostic pCLE was followed by biopsies or endoscopic resection of suspected lesions. A senior pathologist evaluated the specimens and was blinded to the pCLE ***： Patients＇ mean age was 68.3 （range, 42-83） years and six were men. Thirteen suspicious flat or elevated lesions （classified as 0-Is, 0-IIa or 0-IIa ＋ IIc） and seven pre-malignant lesions （atrophy and intestinal metaplasia） were evaluated. One patient was studied during his long-term follow-up after partial gastrectomy and presented severe atrophy, intestinal metaplasia, and xanthomas at the stump mucosa. The location of gastric lesions was in the body （n=10 lesions）, the antrum （n=9） and the incisura angularis （n=1）. All neoplastic lesions and all but one benign lesion were properly diagnosed by pCLE. pCLE incorrectly diagnosed one small antrum lesion as adenoma, however the final diagnosis was intestinal metaplasia. The final histological diagnosis was neoplastic in 9 and benign lesions in 11. In this small case series, pCLE accuracy was 95% （19/20 lesions）.Conclusions： pCLE is accurate for real time histology of gastric lesions, pCLE may change the management of patients with gastric mucosal lesions, guiding biopsies and endoscopic resection, and avoiding further diagnostic workup or unnecessary therapy.

关键词： Probe-based confocal endomieroscopy gastric cancer intestinal metaplasia atrophy gastric adenoma endoscopic resection

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World Journal of Gastroenterology 2022年第12期28卷 1226-1238页

作者： Nadia Marascio Salvatore Rotundo Angela Quirino Giovanni Matera Maria carla Liberto Chiara Costa Alessandro Russo Enrico Maria Trecarichi Carlo Torti Department of Health Sciences Unit of MicrobiologyUniversity“Magna Graecia”of CatanzaroCatanzaro 88100Italy Department of Medical and Surgical Sciences Unit of Infectious and Tropical Diseases"Magna Graecia"University of CatanzaroCatanzaro 88100Italy

Hepatitis E virus(HEV)and hepatitis C virus(HCV)are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic *** E is usually a viral acute fecal-oral transmitted and self-limiting disease presenting with malaise,jaundice,nausea and ***,HEV causes a chronic infection in immunocompromised persons and severe fulminant hepatitis in pregnant *** HCV infection is typically asymptomatic for decades until chronic complications,such as cirrhosis and cancer,*** being two very different viruses in terms of phylogenetic and clinical presentations,HEV and HCV show many similarities regarding possible transmission through organ transplantation and blood transfusion,pathogenesis(production of antinuclear antibodies and cryoglobulins)and response to treatment with some direct-acting antiviral *** both HEV and HCV are well studied individually,there is a lack of knowledge about coinfection and its *** aim of this review is to analyze current literature by evaluating original articles and case reports and to hypothesize some interactions that can be useful for research and clinical practice.

关键词： Hepatitis C virus Hepatitis E virus Co-infection Genomic variability Extrahepatic diseases Vaccine

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Rhyacian-Orosirian tectonic history of the Juiz de Fora Complex:Evidence for an Archean crustal reservoir within an island-arc system

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Geoscience Frontiers 2022年第5期13卷 350-369页

作者： Rasec Almeida Vitalino Elizeu Henrique Bruno Samuel Moreira Bersan Lucas Eduardo de Abreu Barbosa Araujo Ivo Dussin Claudio de Morisson Valeriano carla Neto Monica Heilbron Universidade do Estado do Rio de Janeiro Faculdade de GeologiaTektos–Grupo de Pesquisa em GeotectônicaRua São Francisco Xavier 524MaracanãRio de JaneiroBrazil Laboratório de Geocronologia e Isótopos Radiogênicos Universidade do Estado do Rio de JaneiroRua São Francisco Xavier 524MaracanãRio de JaneiroBrazil

The southern São Francisco Paleocontinent(SFP)comprises Archean nuclei and Paleoproterozoic complexes encompassing magmatic arcs juxtaposed during a Rhyacian to Orosirian orogenic *** Juiz de Fora Complex(JFC)represents an imbricated thrust system that comprises orthogranulites with a wide compositional range formed in an intra-oceanic setting during the Siderian to the Orosirian and later accreted to the southeastern margin of the *** we report new petrological,geochemical,whole-rock Nd and Sr data,as well as zircon U–Pb ages from felsic and mafic orthogranulites from the *** new data is combined with a regional compilation that enables an evaluation of the interaction between magmatism and orogenetic episodes in the context of the consolidation of São Francisco Paleocontinent during the Rhyacian–*** collisional Island Arc tholeiites(IAT),Tonalites-Tron dhjemites-Granodiorites(TTGs)and sanukitoid magmatism occurred from 2200 Ma to 2085 *** was followed by post-collisional magmatism,which is represented by hybrid granitoids coeval with the emplacement of E-MORB basic *** signatures for the Rhyacian to Orosirian evolution are highlighted by the dominance of negativeεNd(t)associated with Meso-to Neoarchean Nd TDMmodel ages as well as inherited zircon grains from the hybrid *** JFC is extensively highlighted in the literature as a primitive intra-oceanic arc,but here we propose the reworking or recycling of ancient crustal segments within the mature arc stage of the JFC,suggesting a Mesoarchean crustal source involved in the JFC evolution.

关键词： Juiz de Fora complex Paleoproterozoic magmatic arc TTG and sanukitoid São Francisco Paleocontinent

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