Adult neurogenesis and regeneration in zebrafish brain: are the neurotrophins involved in?

作     者：Pietro Cacialli Carla Lucini 

作者机构：Department of Veterinary Medicine University of Naples Federico Ⅱ 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第12期

页      面：2067-2068页

核心收录：

学科分类：10[医学] 

主　　题：Adult neurogenesis regeneration neurotrophins 

摘      要：Neurotrophins (NTs) are implicated in the maintenance and survival of the peripheral and central nervous systems and mediate several forms of synaptic plasticity. Members of the family include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT3, and NT4. NTs were first identified as survival factors for developing neurons, but are pleiotropic molecules that can exert a variety of functions, including the regulation of neuronal differentiation, axonal and dendritic growth, and synaptic plasticity (Bothwell, 2014). NTs interact with two distinct types of receptors: the common p75 neurotrophin receptor, which belongs to the tumor necrosis factor receptor superfamily of death receptors and the Trk receptor tyrosine kinase family.