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integrative Zoology 2018年第6期13卷 783-794页

作者： Enith espinosa Kathleen s.CURTis Oklahoma state University-Center for Health sciences TulsaOklahomaUSA

Estrogens are well known to increase locomotor activity in laboratory rodents;however,the underlying mechanism remains *** used voluntary wheel running by female rats as an index of locomotor behavior to investigate this *** first determined whether the estrogen-induced increase in locomotion was susceptible to inhibition by a physiological challenge,and next whether it was associated with dopaminergic activation in the central reward area,nucleus *** rats were given estradiol or the oil vehicle and housed in cages with or without running *** rats were given regular rodent chow for 1 week,a sodium-deficient diet for the next week,and then were returned to a regular diet for another *** the end of the last week,all rats were killed,brains were extracted and dopamine levels in the nucleus accumbens were *** expected,estradiol treatment increased distance ***,dietary sodium deprivation further increased running,but this appeared to be related to experience with wheel running,rather than to sodium deprivation,per *** was greater in the nucleus accumbens of estradiol-treated rats that ran compared to all other ***,the estrogen-induced increase in locomotion is a robust phenomenon that is not inhibited by a body sodium challenge and is associated with elevated levels of dopamine in reward *** findings raise the possibility that the estrogen-induced increase in locomotor activity,which occurs during a hormonal milieu conducive to reproduction,may reflect mate-seeking behavior and,thereby,maximize reproductive success.

关键词： locomotor activity reproductive hormones reward pathways

A review of selected parasitic plants in Nigeria:converting harms to benefits

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Natural Therapy Advances 2024年第3期7卷 14-28页

作者： Funmilayo i.D.Afolayan Ridwan A.salaam Ebenezer s.Oladokun samson D.Adesoye Department of Zoology University of IbadanIbadan 200132Nigeria

Parasitic plants are challenging to agricultural crops and forestry development,which are sources of major revenues in several countries,including ***,parasitic plants are important to human society as they have an abundance of bioactive compounds with pharmacological ***,it becomes expedient to know the benefits of these plants and potential means of *** review discusses four selected parasitic plants in Nigeria,namely Viscum album,striga hermonthica,Tapinanthus bangwensis and Cuscuta *** information about their pharmacological relevance and biocontrol was obtained from credible databases,including the National Library of Medicine,sCOPUs,and Google *** review showed that all four plants have been extensively studied for their antioxidant and antitumor ***,antimicrobial and anti-inflammatory activities are common pharmacological values among parasitic *** are largely due to the presence of abundant beneficial classes of ***,there is an increasing number of biocontrol studies on the use of microorganisms,such as Phaeobotryosphaeria visci,sphaeropsis visci,Pandoraea pulminicol,Colletotrichum gloeosporioides,and Fusarium oxysporum in controlling and managing these seemingly disastrous *** is hoped that this review will spur further studies into the conservation and proper management of parasitic plants using strategically developed biocontrol.

关键词： parasitic plants pharmacological values biocontrol plant management and control ethnopharmacology

Dependence of thermodynamic quantities at freeze-out on pseudorapidity and collision energy in p-p collisions at LHC energies

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Chinese Physics C 2024年第10期48卷 235-246页

作者： Murad Badshah Yahia A.H.Obaidat Haifa i.Alrebdi M.Waqas Muhammad Ajaz Refka Ghodhbani Department of Physics Abdul Wali Khan University MardanMardan 23200Pakistan Department of Physics College of ScienceUniversity of BishaBisha 61922Saudi Arabia Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia school of Mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002China Department of Computer sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafhaSaudi Arabia

The transverse momentum distributions of charged hadrons produced in proton-proton collisions at center-of-mass energies(√s)of 0.9 TeV and 2.36 TeV,as measured by the CMs detector at the Large Hadron Collider(LHC),have been analyzed within various pseudorapidity classes utilizing the thermodynamically consistent Tsallis *** fitting procedure resulted in the key parameters,namely,effective temperature(T),non-extensivity parameter(q),and kinetic freezeout volume(V).Additionally,the mean transverse momentum()and initial temperature(T_(i))of the particle source are determined through the fit function and string percolation method,*** alternative method is employed to calculate the kinetic freezeout temperature(T_(0))and transverse flow velocity(β_(T))from ***,thermodynamic quantities at the freezeout,including energy density(ε),particle density(n),entropy density(s),pressure(P),and squared speed of sound(C_(s)^(2)),are computed using the extracted T and *** is also observed that,with a decrease in pseudorapidity,all thermodynamic quantities except V and q *** trend is attributed to greater energy transfer along the mid pseudorapidity.q increases towards higher values of pseudorapidity,indicating that particles close to the beam axis are far from ***,V remains nearly independent of *** excitation function of these parameters(q)shows a direct(inverse)correlation with collision *** ε,n,s,and P show a strong dependence on collision energies at low *** verification of the thermodynamic inequality ε≥3P suggests the formation of a highly dense droplet-like Quark-Gluon Plasma(QGP).Additionally,the inequality T_(i)>T>T_(0)is explicitly confirmed,aligning with the evolution of the produced fireball.

关键词： charged hadrons tsallis statistics effective temperature non-extensivity parameter pseudorapidity kinetic freeze-out stage multiple freeze-out scenario QGP QCD matter squared speed of sound

Optimizing oncolytic virus design:a“swiss army knife”approach to create a systemically delivered therapeutic

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signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina s.ilkow John Cameron Bell Ottawa Hospital Research institute 501 Smyth RoadOttawaONK1H 8L6Canada

in a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

Photosynthetic response to a winter heatwave in leading and trailing edge populations of the intertidal red alga Corallina offi-cinalis(Rhodophyta)

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Acta Oceanologica sinica 2024年第7期43卷 70-77页

作者： Regina Kolzenburg Federica Ragazzola Laura Tamburello Katy R.Nicastro Christopher D.McQuaid Gerardo i.Zardi UmeåMarine sciences Centre UmeåUniversity90571 NorrbynSweden University of Portsmouth Institute of Marine SciencePortsmouth PO49LYUK stazione Zoologica Anton Dohrn Genova Marine CenterGenova 16126Italy stazione Zoologica Anton Dohrn Sicily Marine CenterPalermo 90149Italy Department of Zoology and Entomology Rhodes UniversityMakhanda(Grahamstown)6139South Africa Centre of Marine sciences University of AlgarveFaro 8005-139Portugal Laboratoire d’Océanologie et de Géosciences Universitéde LilleLille 59000France Universitéde Caen Normandie Laboratoire de Biologie des Organismes et des Ecosystèmes AquatiquesCaen 14032France

Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem *** conditions experienced by marine organisms across their distribution,particularly towards the equator,are likely to approach their physiological limits,resulting in extensive mortality and subsequent changes at the population *** at the margins of their species’distribution are thought to be more sensitive to climate-induced environmental pressures than central populations,but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is *** a laboratory simulation study,we tested whether two leading(iceland)and two trailing(spain)peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency(Fv/Fm)resilience to current and future winter MHWs *** study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of ***,which exhibited stable photosynthetic efficiency throughout the *** edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs *** and equatorward populations did not produce significantly different results,with winter MHWs having no negative affect on Fv/Fm of either ***,we found no long-term regional or population-level influence of a winter MHWs on this species’photosynthetic ***,we found no statistically significant difference in thermal stress responses between leading and trailing ***,*** showed a trend towards higher stress responses in southern than northern *** responses rest on a variety of local population traits,they are difficult to predict based solely on thermal pressures.

关键词： marginal population coralline algae climate change ecophysiology photophysiology macroalgae Fv/Fm

impact of sTAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-sosa Juan JoséMontesinos-Montesinos Mauricio salcedo ismael Brito-Toledo Felipe Vaca-Paniagua Luis i Terrazas Unidad de investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(sTATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating sTAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using sTAT ***,we analyze the impact of different sTATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts signal transducer and activator of transcription signaling Colorectal cancer immunity immunosuppression

On the Geometry of the Anti-canonical Bundle of the Bott–samelson–Demazure–Hansen Varieties

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Acta Mathematica sinica,English series 2024年第8期40卷 1920-1940页

作者： indranil BisWAs s.senthamarai KANNAN Pinakinath sAHA school of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** s={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

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Particuology 2024年第7期90卷 364-382页

作者： Barış Gürel Gülşah Karaca Dolgun Osman ipek Ali Keçebaş Department of Mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of GLi-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with ilgın lignite showcasing low NO_(x) but high sO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and sO_(2)emissions Energy production efficiency

Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?

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Asian Journal of Urology 2024年第3期11卷 391-405页

作者： Ria Margiana Younes Pilehvar Fatkhurrohmah LAmalia silvia WLestari supardi supardi Reny i’tishom Department of Anatomy Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Master’s Programme Biomedical sciences Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Andrology Program Faculty of MedicineUniversitas AirlanggaSurabayaIndonesia Dr.soetomo General Academic Hospital SurabayaIndonesia indonesia General Academic Hospital DepokIndonesia Ciptomangunkusumo General Academic Hospital JakartaIndonesia Cellular and Molecular Research Center Cellular and Molecular Medicine Research InstituteUrmia University of Medical ScienceUrmiaIran Dr.Kariadi Hospital SemarangIndonesia Department of Medical Biology Faculty of MedicineUniversitas IndonesiaJakartaIndonesia Department of Biomedical science Faculty of MedicineUniversitas Airlangga SurabayaIndonesia

Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MsCs),holds therapeutic promise in regenerative *** review aimed to explore the therapeutic potential of the MsC secretome in regenerative urology,particularly for treating erectile dysfunction(ED),and to provide an overview of preclinical and clinical research on MsCs in ED treatment and subsequently to highlight the rationales,mechanisms,preclinical investigations,and therapeutic potential of the MsC secretome in this ***:The review incorporated an analysis of preclinical and clinical research involving MsCs in the treatment of ***,it delved into the existing knowledge regarding the MsC secretome,exploring its therapeutic *** methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MsC secretome.

关键词： Erectiledysfunction Mesenchymal stem cell Mesenchymal stem cell secretome Mesenchymal stem cell-derived exosome

Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMiR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita sánchez iñaki Lekuona Marcelo sanmartín Fernán-dez Vivencio Barrios carl.s Perez Muñoz Juan Cosín-sales Alejandro iPérez Cabeza Vanesa Roldán schilling carl.s Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.s) at *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2Ds2-VAsc(4.5 ± 1.3 vs.3.0 ± 1.4;P s-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P se of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAs-BLED score with major *** in clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding