Increased locomotor activity in estrogen-treated ovariectomized rats is associated with nucleus accumbens dopamine and is not reduced by dietary sodium deprivation

作     者：Enith ESPINOSA Kathleen S.CURTIS Oklahoma 

作者机构：State University-Center for Health SciencesTulsaOklahomaUSA 

出 版 物：《Integrative Zoology》 (整合动物学（英文版）)

年 卷 期：2018年第13卷第6期

页      面：783-794页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 10[医学] 

基　　金：This study was supported by IDeA Networks of Biomedical Research Excellence(8P20GM103447,E.E.) the Oklahoma Center for the Advancement of Science and Technology(OCAST HR12-196,K.S.C.) 

主　　题：locomotor activity reproductive hormones reward pathways 

摘      要：Estrogens are well known to increase locomotor activity in laboratory rodents;however,the underlying mechanism remains *** used voluntary wheel running by female rats as an index of locomotor behavior to investigate this *** first determined whether the estrogen-induced increase in locomotion was susceptible to inhibition by a physiological challenge,and next whether it was associated with dopaminergic activation in the central reward area,nucleus *** rats were given estradiol or the oil vehicle and housed in cages with or without running *** rats were given regular rodent chow for 1 week,a sodium-deficient diet for the next week,and then were returned to a regular diet for another *** the end of the last week,all rats were killed,brains were extracted and dopamine levels in the nucleus accumbens were *** expected,estradiol treatment increased distance ***,dietary sodium deprivation further increased running,but this appeared to be related to experience with wheel running,rather than to sodium deprivation,per *** was greater in the nucleus accumbens of estradiol-treated rats that ran compared to all other ***,the estrogen-induced increase in locomotion is a robust phenomenon that is not inhibited by a body sodium challenge and is associated with elevated levels of dopamine in reward *** findings raise the possibility that the estrogen-induced increase in locomotor activity,which occurs during a hormonal milieu conducive to reproduction,may reflect mate-seeking behavior and,thereby,maximize reproductive success.