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N-cadherin expression in the midbrain substantia nigra of perinatal rats

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Neural Regeneration Research 2008年第10期3卷 1136-1140页

作者： Junping cao yu sun Xia Du Dianshuai Gao Department of Neurobiology Xuzhou Medical College Xuzhou 221002 Jiangsu Province China

BACKGROUND： Cellular adhesion molecule mediates the effects of glial cell line-derived neurotrophic factor in dopaminergic neurons during nervous system development. It is assumed that cellular adhesion molecule plays an important role in dopaminergic neuron development. OBJECTIVE： To investigate N-cadherin expression in the midbrain substantia nigra during rat development. DESIGN, TIME AND SETTING： The developmental biology, controlled study was performed at the Laboratory of Research Center of Neurobiology, Xuzhou Medical College, China from April to October 2007. MATERIALS： Sprague Dawley rats （embryonic days 16, 18, and 20, as well as postnatal days 1, 3, 7, 14, and 21） were selected for this study. N-cadherin antibody was purchased from Santa Cruz, USA. METHODS： N-cadherin expression in the midbrain substantia nigra of perinatal rats was detected using reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry methods. N-cadherin-positive cells were counted. MAIN OUTCOME MEASURES： N-cadherin mRNA, protein, and positive cells in the rat midbrain substantia nigra were quantified. RESULTS： The results of reverse transcription polymerase chain reaction and Western blot demonstrated that altered N-cadherin mRNA levels were similar to protein levels in the midbrain substantia nigra. N-cadherin mRNA and protein expression was low in the midbrain substantia nigra of embryonic day 16 rats but gradually increased, and reached a peak at postnatal day 1. N-cadherin mRNA and protein levels were still high at postnatal days 3 and 7, but significantly decreased at postnatal day 14. There was no significant difference in N-cadherin mRNA and protein expression between postnatal days 14 and 21 （P 〉 0.05）. The immunohistochemistry results demonstrated that there was no significant difference in the quantity of N-cadherin-positive cells per area in rats from embryonic day 16 to postnatal day 7 （P 〉 0.05）. The quantity of N-cadherin-positive cells per a

关键词： N-cadherin substantia nigra nervous system development

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-yue Wei Wen-Bo cao Sai-Jun Mo Zhi-Yan sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

抗VEGF联合复合式小梁切除术治疗新生血管性青光眼

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国际眼科杂志 2020年第9期20卷 1583-1586页

作者：孙曹毓刘驰周晶王辉中国辽宁省沈阳市第四人民医院沈阳市眼病研究所沈阳市眼病医院110031 中国辽宁省沈阳市第四人民医院青光眼三科沈阳市眼病研究所沈阳市眼病医院110031

目的:探讨抗VEGF联合复合式小梁切除术治疗新生血管性青光眼的临床疗效。方法:选取2017-01/2019-06就诊于沈阳市第四人民医院并入院治疗的符合研究条件的新生血管性青光眼患者42例43眼。患者入组后行血常规、尿常规、心电图、视力、眼... 详细信息

目的:探讨抗VEGF联合复合式小梁切除术治疗新生血管性青光眼的临床疗效。方法:选取2017-01/2019-06就诊于沈阳市第四人民医院并入院治疗的符合研究条件的新生血管性青光眼患者42例43眼。患者入组后行血常规、尿常规、心电图、视力、眼压、眼前节照相,根据屈光间质状态完善眼底检查。根据入院眼压情况予全身及局部联合降眼压治疗,术前抗生素滴眼。入院第3d患者术眼行抗VEGF治疗,根据患者自主选择予玻璃体腔注射雷珠单抗或康柏西普,分为雷珠单抗组和康柏西普组;注药72h后行复合式小梁切除术(结膜下及巩膜瓣局部应用氟尿嘧啶浸润+可调节缝线+房角分离)。术后随访6mo(1d,1、2wk,1、2、3、6mo),比较两组新生血管消退情况、视力、眼压。结果:康柏西普眼内注射液和雷珠单抗眼内注射液均可有效消退虹膜新生血管,治疗新生血管性青光眼疗效无差别。术后1d,1、2wk,1、2、3、6mo大部分患者眼压均明显下降,部分患者视力提高。结论:抗VEGF联合复合式小梁切除术可有效控制新生血管性青光眼眼压,部分患者可提高视力,提升患者生活质量。

关键词：新生血管性青光眼小梁切除术 VEGF

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo yu Zhenyu sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

The correlation between CB expression and the receptors of GDNF in the early development SN

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The correlation between CB expression and the receptors of G...

In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Hong-Jun WANG,Jun-Ping cao,yu sun,Hong-Hua yuAN,Dian-Shuai GAO~* Department of Neurobiology and Human Anatomy,Xuzhou Medical College,Xuzhou,221002,China

＜正＞Many studies indicated that DA neurons containing calbindin D28k（CB） has ability of anti-degeneration,and GDNF can protect DA neurons from degeneration by promoting CB expression in DA *** purpose of this study was to investigate which transmembrane receptor of GDNF was involved in mediating the expressions of CB in SN during rat early development ***-PCR and Western blot were performed to detect CB expression in SN of perinatal SD rats at mRNA and protein level respectively;Western blot was also performed to detect the expression of the transmembrane receptors including Ret,neural cell adhesion molecule-140（NCAM-140）,intergrinβ1 and *** results showed: CB mRNA expression had no correlation with the above-mentioned four molecules;there was a positive correlation of there was a positive correlation of CB protein expression with both integrinβ1 and N-cadherin protein expression,while no correlation with Ret and NCAM-140 protein *** data suggested that the expression of CB mRNA and CB protein were regulated by different receptor combinations.

关键词： glial cell line-derived neurotrophic factor GDNF dopaminergic neurons substantia nigra pars compacta tyrosine hydroxylase calbindin D28k Ret cell adhesion molecules

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Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo Peng Zhou Xiaowei Lv Panpan sun Xiaohua sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan sun Shuai Wang Yanbo Liang Chao Wang yunhong Zhang Hong Liu yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan yu Haiye Zhu Yongjiang sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China yunnan yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

环状RNA CHACR调控压力超负荷诱导心肌肥大和氧化应激损伤

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中国组织工程研究 2025年第25期29卷 5362-5373页

作者：王霜韩瑜袁敏曹济民孙腾山西医科大学细胞生理学教育部重点实验室山西省细胞生理学重点实验室山西医科大学基础医学院生理学系山西省太原市030001

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方... 详细信息

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方法:①心脏原位注射环状RNA CHACR过表达慢病毒1周后进行横向主动脉缩窄手术诱导小鼠心肌肥大。术后8周,计算心脏质量/胫骨长比值和肺质量/胫骨长比值,测量心肌细胞表面积,检测肥大标志基因表达水平和心肌纤维化程度,评估心功能。②H9c2心肌细胞给予环状RNA CHACR过表达慢病毒处理72 h,然后加入1μmol/L血管紧张素Ⅱ处理24 h诱导心肌细胞肥大。通过检测心肌细胞表面积、肥大标志基因表达水平、蛋白质/DNA比值评估细胞肥大情况,通过检测活性氧水平和线粒体膜电位评估氧化应激损伤情况。结果与结论:①在体内和体外心肌肥大模型中,环状RNA CHACR的表达水平均显著降低(P<0.01);②过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心肌肥大表型,主要表现为心脏体积减小、心脏质量/胫骨长比值显著降低(P<0.05),肺质量/胫骨长比值显著降低(P<0.05),心肌细胞表面积显著减小(P<0.05),以及心肌肥大相关标志基因心房利钠肽(P<0.05)、脑钠肽(P<0.05)表达水平降低;③过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心脏纤维化,表现为纤维化面积减小(P<0.01)和纤维化标志基因Acta1的表达水平降低(P<0.05);④过表达环状RNA CHACR显著改善了小鼠心功能,主要表现为射血分数(P<0.05)和短轴缩短率(P<0.01)显著升高;(5)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的心肌细胞肥大,主要表现为心肌细胞表面积显著减小(P<0.05),心房利钠肽(P<0.05)和脑钠肽(P<0.05)表达水平显著下调,以及蛋白质/DNA比值显著减小(P<0.05);(6)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的活性氧水平升高(P<0.001)和线粒体膜电位降低(P<0.05)。结果表明,环状RNA CHACR在体内和体外心肌肥大模型中表达水平显著降低,过表达环状RNA CHACR显著抑制心肌肥大,减轻心肌纤维化,改善心功能,并且显著减轻了血管紧张素Ⅱ诱导的心肌细胞氧化应激损伤。

关键词：心肌肥大环状RNA CHACR 血管紧张素Ⅱ 横向主动脉缩窄手术氧化应激损伤