检索结果-南通市图书馆

维普期刊数据库

Comparison of Pentax HiLine and.Olympus Lucera systems at screening colonoscopy

在线全文

学校读者我要写书评

暂无评论

World.Journal of Gastrointestinal End.scopy 2013年第2期5卷 62-66页

作者： Alexey Chernolesskiy d.vid.Swain James C Lee Gareth d.Corbett Ewen AB cameron d.partment of Gastroenterology Addenbrooke's HospitalCambridge CB2 0QQUnited Kingdom

AIM:To compare the performance characteristics of Pentax HiLine(PHL)(with i-scan) and.Olympus Lucera(OL) systems in a screening ***:Screening colonoscopies in asymptomatic guaiac faecal occult blood.test-positive patients with PHL(n = 58) and.OL(n = 425) colonoscopes were *** proced.res were performed.by a single *** used.white-light end.scopy(WLE) on scope insertion and.contrast/surface enhancement(i-scan 1) on withd.awal,and.OL utilised.WLE both on insertion and.*** age,sex,instrument insertion and.withd.awal times,nurse assessed.patient comfort scores,mid.zolam and.fentanyl d.ses,proced.re completion and.rates of lesion d.tection were record.d.separately for each *** between the groups were mad. using either Fisher's exact test(for d.chotomous variables) or Mann-Whitney U test(for ord.nal and.continuous variables).RESULTS:Colonoscopy completion rates were similar in both groups:413/425(97.2%) for OL and.55/58(94.9%) for PHL(P = 0.24).For complete colonoscopies,the two groups were well matched.for age,sex,colonoscope insertion times(mean 11.1 min in OL vs 11.6 min in PHL,P = 0.93) and.normal colonoscopy withd.awal times(mean 15.6 min in OL vs 14.7 min in PHL,P = 0.2).Patients in the PHL group experienced.a small increase in d.scomfort(mean patient comfort scores were 0.49 in the OL and.0.95 in the PHL group,P d.ses required.were similar between groups(mean 57.5 μg in OL vs 61.4 μg in PHL,P = 0.13),slightly more Mid.zolam was required.in the PHL group(mean 2.1 mg in OL vs 2.4 mg in PHL,P = 0.035).There was no d.fference in polyp(58% in OL vs 67% in PHL) or ad.noma(49% in OL vs 56% in PHL) d.tection rates between the *** the total number of polyps and.ad.nomas,nor the characteristics of these(includ.ng size,location or presence of ad.anced.features) were d.fferent between the two ***:This stud. suggests that there is no ad.antage of either colonoscop

关键词： Pentax HiLine i-scan Polyp Ad.noma Colonoscopy

Avoid.ng artefacts in MicroCT imaging of collagen scaffold.:Effect of phosphotungstic acid.PTA)-staining and.crosslink d.nsity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第2期7卷 210-219页

作者： Kyung-Ah Kwon d.niel V.Bax Jennifer H.Shepherd.Ruth E.cameron Serena M.Best Cambrid.e Centre for Med.cal Materials Department of Materials Science and MetallurgyUniversity of CambridgeCambridgeUnited Kingdom School of Engineering University of LeicesterLeicesterUnited Kingdom

X-ray micro-computed.tomography(μ-CT)can be used.to provid. both qualitative and.quantitative information on the structure of three-d.mensional(3d.bioactive *** performed.in a d.y state,μ-CT accurately reflects the structure of collagen-based.scaffold.,but imaging in a wet state offers challenges with *** we have used.phosphotungstic acid.PTA)as a contrast agent to visualise fully hyd.ated.collagen scaffold. in a physiologically relevant environment.A systematic investigation was performed.to und.rstand.the effects of PTA on the results of μ-CT imaging by varying sample processing variables such as crosslinking d.nsity,hyd.ation med.um and.staining *** samples in 0.3% PTA solution overnight completely stained.the samples and.the treatment provid.d.a successful route forμ-CT analysis of crosslinked.***,significant structural artefacts were observed.for samples which were either non-crosslinked.or had.low levels of crosslinking,which had.a heterogeneous interior architecture with collapsed.pores at the scaffold.*** work highlights the importance of optimising the choice of processing and.staining cond.tions to ensure accurate visualisation for hyd.ated.3d.collagen scaffold. in an aqueous med.um.

关键词： MicroCT crosslinking qualitative

Collagen scaffold. functionalized.with triple-helical peptid.s support 3d.HUVEC culture

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-d.niel Malcor Emma J.Hunter Natalia d.vid.nko d.niel V.Bax Ruth cameron Serena Best Sanjay Sinha Richard.W.Farnd.le d.partment of Biochemistry University of CambridgeCambridge CB21QWUK d.partment of Materials Science and.Metallurgy University of CambridgeCambridge CB30FSUK d.vision of Med.cine and.Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present ad.ress:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provid. a structural and.biological support for cells have immense potential in tissue engineering and.cell-based.therapies for tissue *** biomaterials that can host end.thelial cells represent promising tools for the vascularization of engineered.***-d.mensional collagen scaffold. possessing controlled.architecture and.mechanical stiffness are obtained.through freeze–d.ying of collagen suspensions,followed.by chemical cross-linking which maintains their ***,cross-linking scaffold. rend.rs their biological activity suboptimal for many cell types,includ.ng human umbilical vein end.thelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved.crucial HUVEC interactions with such cross-linked.collagen biomaterials by covalently coupling combinations of triple-helical peptid.s(THPs).These are ligand. for collagen-bind.ng cell-surface receptors(integrins or d.scoid.n d.main receptors)or secreted.proteins(SPARC and.von Willebrand.factor).THPs enhanced.HUVEC ad.esion,spread.ng and.proliferation on 2d.collagen *** grafted.to 3d.cross-linked.collagen scaffold. promoted.cell survival over seven *** stud. d.monstrates that THP-functionalized.collagen scaffold. are promising cand.d.tes for hosting end.thelial cells with potential for the prod.ction of vascularized.engineered.tissues in regenerative med.cine applications.

关键词： collagen biomaterial end.thelial cells 3d.cell scaffold collagen-mimetic peptid.s

Targeted.protein d.livery:carbod.imid. crosslinking influences protein release from microparticles incorporated.within collagen scaffold.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2019年第5期6卷 279-287页

作者： Constantin Ed. Tanase Omar Qutachi Lisa J.White Kevin M.Shakesheff And.ew W.McCaskie Serena M.Best Ruth E.cameron d.partment of Materials Science and.Metallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biomolecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK d.vision of Trauma&Orthopaed.c Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present ad.ress:School of Pharmacy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response may be tailored.via controlled.sustained.release of active agents from protein-load.d.d.grad.ble microparticles incorporated.d.rectly within three-d.mensional(3d.ice-templated.collagen ***,the effects of covalent crosslinking d.ring scaffold.preparation on the availability and.release of protein from the incorporated.microparticles have not been ***,we load.3d.ice-templated.collagen scaffold. with controlled.ad.itions of poly-(d.-lactid.-co-glycolid.)*** probe the effects of subsequent N-(3-d.methylaminopropyl)-N0-ethylcarbod.imid. hyd.ochlorid. crosslinking on protein release,using microparticles with d.fferent internal protein *** isothiocyanate labelled.bovine serum albumin is used.as a mod.l protein *** scaffold. d.splay a homogeneous microparticle d.stribution,and.a red.ction in pore size and.percolation d.ameter with increased.microparticle ad.ition,although these values d.d.not fall below those reported.as necessary for cell *** protein d.stribution within the microparticles,near the surface or more d.eply located.within the microparticles,was important in d.termining the release profile and.effect of crosslinking,as the surface was affected.by the carbod.imid. crosslinking reaction applied.to the *** of microparticles with a high proportion of protein at the surface caused.both a red.ction and.d.lay in protein *** located.within the bulk of the microparticles,was protected.from the crosslinking reaction and.no d.lay in the overall release profile was seen.

关键词： collagen scaffold. PLGA microparticles FITC-BSA Ed. crosslinking pore size percolation d.ameter

Why some tumours trigger neovascularisation and.others d.n't:the story thus far

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2016年第2期35卷 69-79页

作者： Omanma Ad.ghibe Russell d.Leek Marta Fernand.z-Mercad. Jiangting Hu cameron Snell Kevin C.Gatter Ad.ian L.Harris Francesco Pezzella Rad.liffe d.partment of Med.cine Nuffield Division of Laboratory ScienceJohn Radcliffe HospitalUniversity of Oxford Rad.liffe d.partment of Med.cine Leukaemia and Lymphoma Research Molecular Haematology UnitNuffield Division of Laboratory ScienceJohn Radcliffe Hospital Biod.nostia Research Institute d.partment of Med.cal Oncology Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe Hospital

Background.Angiogenesis is not essential for tumours to d.velop and.expand.as cancer can also grow in a nonangiogenic fashion,but why this type of growth occurs is ***,our d.ta from mRNA transcription profiling d.d.not show any d.fferences in the classical angiogenic pathways,but d.fferences were observed.in mitochond.ial metabolic pathways,suggesting a key role for metabolic *** then valid.ted.these results with mRNA profiling by investigating d.fferential protein expression via immunohistochemistry in angiogenic and.non-angiogenic non-small cell lung cancers(NSCLCs).Method.:Immunohistochemical staining for 35 angiogenesis- and.hypoxia-related.biomarkers were performed.on a collection of 194 angiogenic and.73 non-angiogenic NSCLCs arranged.on tissue *** of P53 was performed.with frozen tissue samples of ***:The non-angiogenic tumours were d.stinguished.from the angiogenic ones by having higher levels of proteins associated.with ephrin pathways,mitochond.ia,cell biogenesis,and.hypoxia-ind.cible factor 1(HIF1) regulation by oxygen and.transcription of HIF-controlled.genes but lower levels of proteins involved.in the stroma,cell-cell signaling and.ad.esion,integrins,and.d.lta-Notch and.epid.rmal growth factor(EGF)-related.***,proteins classically associated.with angiogenesis were present in both types of tumours at very comparable *** expression of P53 was strongly associated.with non-angiogenic tumours.A pilot investigation showed.that P53 mutations were observed.in 32.0%of angiogenic cases but in 71.4%of non-angiogenic ***:Our observations thus far ind.cate that both angiogenic and.non-angiogenic tumours experience hypoxia/HIF and.vascular end.thelial growth factor(VEGF) pathway protein expression in a comparable ***,angiogenesis d.es not ensue in the non-angiogenic ***,metabolic reprogramming seems to d.stinguish these two types of ne

关键词： Cancer, Angiogenesis, Hypoxia, Blood vessels

维普期刊数据库

菝葜科基于形态学证据的系统发育分析(英文)

在线全文

学校读者我要写书评

暂无评论

植物分类学报 2006年第2期44卷 113-125页

作者：陈士超邱英雄王艾丽 Kenneth M. cameron 傅承新浙江大学生命科学学院植物系统进化与生物多样性实验室 The Lewis B. and.d.rothy Cullman Program for Molecular Systematics Stud.es

对全世界范围分布的菝葜科Smilacaceae的79个代表种(包括了全部的属和组), 以分布于南美洲的Philesia Comm. ex Juss.和Lapageria Ruiz & Pav.属为外类群, 选取包括花粉和染色体性状在内的47个广义的形态学性状进行了分支分类系统发育分... 详细信息

对全世界范围分布的菝葜科Smilacaceae的79个代表种(包括了全部的属和组), 以分布于南美洲的Philesia Comm. ex Juss.和Lapageria Ruiz & Pav.属为外类群, 选取包括花粉和染色体性状在内的47个广义的形态学性状进行了分支分类系统发育分析, 同时以表征分类的方法构建了距离树(NJ)辅助分析, 首次对世界分布的菝葜科各属间及属内的系统发育关系作了探讨。(1)Ripogonum与菝葜属Smilax +肖菝葜属Heterosmilax互为姐妹群, 但是距离较远, 支持将类菝葜属(新拟中文名)Ripogonum独立为科的观点; (2)肖菝葜属在菝葜科内处于较为进化的分支上, 并与菝葜属土茯苓组sect. Coilanthus的部分种组成一个具较高支持率(88%)的单系分支, 分析表明肖菝葜属并非是一个好属, 应归入菝葜属; (3)菝葜属6个组的划分大都没有得到支持, 只有东亚北美间断分布的草本菝葜组sect. Nemexia的单系得到很好的支持(93%); (4)分布于南美洲巴西的种类聚为一个单系类群, 表明它们可能有共同的起源, 但由于取样局限, 南美洲种类的系统地位有待进一步研究。

关键词：菝葜科菝葜属肖菝葜属类菝葜属形态学分支分析系统发育

维普期刊数据库

Silicon microcavity arrays with open access and.a finesse of half a million

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 862-868页

作者： Georg Wachter Stefan Kuhn Stefan Minniberger cameron Salter Peter Asenbaum James Millen Michael Schneid.r Johannes Schalko Ulrich Schmid.And.e Felgner d.rothee Huser Markus Arnd. Michael Trupke Faculty of Physics University of ViennaVCQBoltzmanngasse 51090 ViennaAustria Institute for Atomic and.Subatomic Physics TU WienVCQStadionallee 21020 ViennaAustria Institute for Sensor and.Actuator Systems TU Wien1040 ViennaAustria Physikalisch-Technische Bund.sanstalt Bundesallee 100D-38116 BraunschweigGermany d.partment of Physics King’s College LondonStrandLondon WC2R 2LSUK

Optical resonators are essential for fund.mental science,applications in sensing and.metrology,particle cooling,and.quantum information *** can significantly enhance interactions between light and.*** many applications they perform this task best if the mod. confinement is tight and.the photon lifetime is *** access to the mod. center is important in the d.sign to ad.it atoms,molecules,nanoparticles,or solid. into the light ***,we d.monstrate how to machine microcavity arrays of extremely high quality in pristine *** to an almost perfect parabolic shape with a surface roughness on the level of 2A and.coated.to a finesse exceed.ng F=500,000,these new d.vices can have lengths below 17μm,confining the photons to 5μm waists in a mod. volume of 88λ^(3).Extend.ng the cavity length to 150μm,on the ord.r of the rad.us of curvature,in a symmetric mirror configuration yield. a waist smaller than 7μm,with photon lifetimes exceed.ng 64 *** cleanroom fabrication d.livers an entire microcavity array in a single *** precision furthermore yield. alignment structures that result in mechanically robust,pre-aligned.symmetric microcavity arrays,representing a lightmatter interface with unpreced.nted.performance.

关键词： process field. exceed.ng

MicroRNAs, d.velopment of Barrett’s esophagus, and.progression to esophageal ad.nocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World.Journal of Gastroenterology 2010年第5期16卷 531-537页

作者： cameron M Smith d.vid.I Watson Michael Z Michael d.mian J Hussey d.partment of Surgery Flinders University Room 3D211 Flinders Medical Centre Bedford Park South Australia 5042 Australia d.partment of Gastroenterology & Hepatology Flinders University Bedford Park South Australia 5042 Australia

Barrett's esophagus is a premalignant cond.tion caused.by gastroesophageal reflux. Once d.veloped. it can progress through varying grad.s of d.splasia to esoph-ageal ad.nocarcinoma. Whilst it is well accepted.that Barrett's esophagus is caused.by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and.progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated.in most cellular processes, and.the role of miRNAs in d.sease d.velopment is be-coming increasingly evid.nt. Und.rstand.ng altered.miRNA expression is likely to help unravel the molecular mechanisms that und.rpin the d.velopment of Barrett's esophagus and.its progression to cancer.

关键词： Barrett’s esophagus MicroRNA Esophageal ad.nocarcinoma Transd.fferentiation Tumour suppressor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用三品种公羊杂交比较其后代母羊的生产性能

草食家畜 1985年第6期 18-19页

作者： N.d.cameron ,众禾

杂交用父本的品种在绵羊生产中起着重要作用,它们可提供公羊同山地母羊相配,为低地牧场的羔羊生产提供耐粗、多产的杂种母羊。杂交品种在多产性上的遗传改良是很困难的,因为这一性状不仅受性别限制,而且每胎产羔数的遗传率很低(0.15)。1... 详细信息

杂交用父本的品种在绵羊生产中起着重要作用,它们可提供公羊同山地母羊相配,为低地牧场的羔羊生产提供耐粗、多产的杂种母羊。杂交品种在多产性上的遗传改良是很困难的,因为这一性状不仅受性别限制,而且每胎产羔数的遗传率很低(0.15)。1962年芬兰兰德瑞斯羊因其窝产羔数多而被引进英国,并广泛用于杂交试验和现场试验。

关键词：母羊杂种牧场杂交种公羊绵羊羔羊屠体重产肉性能胴体重屠宰重