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科学知识与社会学理论

筛查左心室收缩功能障碍具有最佳成本-效果的策略:利钠肽、心电图、手持式超声心动图、传统超声心动图或联合应用以上方法?

丛书名：知识与社会译丛

2001年

作者：（英）巴里·巴恩斯（Barry barnes）鲁旭东译

自19世纪特别是20世纪以来，科学取得了令人眼花缭乱的巨大成就，因此，不少人对它产生了一种崇敬甚至崇拜之情，认为科学知识是人类理性活动的最高成果，是其他学科的楷模。本书作者从社会学角度提出了相反的观点。

ISBN: (纸本)7506015323

关键词：知识社会学学科:研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 30-31页

作者： Galasko G.I.W barnes S.c collinson P. R.Senior 杜媛 Department of cardiovascular Medicine Northwick Park Hospital Watford Road Harrow HA1 3UJ Middlesex United Kingdom

Aims: To assess the screening characteristics and cost-effectiveness of screening for left ventricular systolic dysfunction(LVSD) in community subjects. Methods and results: A total of 1392 members of the general public and 928 higher risk subjects were randomly selected from seven community practices. Attending subjects underwent an EcG, N-terminal pro-brain natriuretic peptide(NTproBNP) serum levels, and traditional echocardiography(TE). A total of 533 consecutive subjects underwent hand-held echocardiography(HE). The screening characteristics and cost-effectiveness(cost per case of LVSD diagnosed) of eight strategies to predict LVSD(LVSD compared. A total of 1205 subjects attended. Ninety six per cent of subjects with LVSD in the general population had identifiable risk factors. All screening strategies gave excellent negative predictive value. Screening high-risk subjects was most cost-effective, screening low-risk subjects least cost-effective. TE screening was the least cost-effective strategy. NTproBNP screening gave similar cost savings to EcG screening; HE screening greater cost-savings, and HE screening following NTproBNP or EcG pre-screening the greatest cost-savings, costing ～ 650 Euros per case of LVSD diagnosed in high-risk subjects(63% cost-savings vs. TE). conclusion: Thus several different modalities allow cost-effective community-based screening for LVSD, especially in high-risk subjects. Such programmes would be cost-effective and miss few cases of LVSD in the community.

关键词：左心室收缩功能障碍成本-效果超声心动图心电图检查脑利钠肽手持式筛查阴性预测值上方联合

Application of the KeratinoSens assay to prediction of dermal sensitization hazard for botanical cosmetic ingredients

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Application of the KeratinoSens assay to prediction of derma...

中国毒理学会第六届全国毒理学大会

作者： David GAN Kimberly NORMAN Nicole barnes Hans A.RAABE cristi GOMEZ Xuejun J.YIN John HARBELL Mary Kay Inc.

OBJEcTIVE The goal of the study was to determine the potential for the KeratinoSens assay to identify electrophile allergens within a botanical extract *** In the KeratinoSens assay,the induction of a luciferase gene under the control of the antioxidant response element(ARE) derived from the human gene AKR1c2 gene is *** parallel,cytotoxicity is assessed by both Neutral Red Uptake(NRU)and MTT *** samples included gluteraldehyde(GA),dimethyl maleate(DM)and cinnamic aldehyde(cA)spiked into four different botanical extracts(including different excipient solvent systems).Test concentrations ranged up to 1 g·L(of complete extract)and a test concentration was considered positive if the relative viability was≥70%and the fold induction of luciferase was 1.5x relative to the solvent *** was measured relative to the Ec1.5 of the neat sensitizer as a function of sensitizer concentration and extract *** independent trials were performed on each test *** No appreciable cytotoxicity was observed with any of the *** spiked at 1%to 2%were sufficient to induce a positive up regulation of the ARE below the maximum test material concentration of up to 1 g·*** responses occurred at cell survivals well in excess of 70%.The botanical matrix impacted recovery for both gluteraldehyde and dimethyl maleate *** recovery of the GA spike required at least a -3 fold increase in concentration relative to the chemical alone and botanical extract #3 reduced the activity below *** DM and cA showed activity at about the same effective concentrations as the neat chemical although the DM showed reduced activity in botanical extract #3 as *** These data suggest that the KeratinoSens assay has the potential to identify electrophile allergens within a botanical extract matrix.

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利用GPS信号进行最佳时间和频率的传输

宇航计测技术 1984年第S1期 127-135页

作者： David W.Allan James A.barnes 乔石琼

一、引言 GPS卫星系统的实现使原子钟的信号能到达任何一个拥有接收机的用户。原子钟和用户网两者的确切表征对获取最佳的时间和频率信息是重要的。本文将叙述从GPS的一套数据中获取最佳的时间和频率信息的方法和某些接近最佳且简单的... 详细信息

一、引言 GPS卫星系统的实现使原子钟的信号能到达任何一个拥有接收机的用户。原子钟和用户网两者的确切表征对获取最佳的时间和频率信息是重要的。本文将叙述从GPS的一套数据中获取最佳的时间和频率信息的方法和某些接近最佳且简单的数据处理技术。考虑三种简单的情况:情况A为“共视法”(common-View approach);情况B为直接观测单个卫星,采样时间为几秒到几小时;情况c为观测单个卫星,每天几分钟,

关键词： GPS 卫星导航星卡尔曼滤波器 Kalman滤波器数字滤波器稳定度协调世界时共视电离层大气圈

PsychoGrapho： A Double-Blind cohort Study of Jungian Typology and Handwriting Analysis

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Psychology Research 2016年第1期6卷 50-56页

作者： E. Marcus barnes Jan Six Raymond c. Hawkins II Institute of Neuroscience and consciousness Studies Austin USA Fielding Graduate University & University of Texas at Austin Austin USA

The Alkaloids from Leaves of croton hemiargyerius var. gymnodiscus

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Journal of chinese Pharmaceutical Sciences 2003年第3期12卷 117-122页

作者：林文翰付宏征李军程刚 Roderick A.barnes 北京大学天然药物及仿生药物国家重点实验室北京100083 里约联邦大学天然产物研究中心

Aim Investigation of alkaloids from the leaves of Brazilian medicinal plantcroton hemiargyerius var. gymnodiscus. Methods Silica gel column chromatography was used repeatedlyfor the isolation and purification, and their structures were identified by extensive spectroscopyand comparison of the chemical and physical data with those of authentic samples reported inliterature. Results Twelve alkaloids were isolated and their structures were identified. conclusionFour new alkaloids named hemiargines A (1), B (5), c (6) and D (7), together with eight knownalkaloids namely isoc-orydine (2), corydine (3), norcorydine (4), salutaridine (8), glaucine (9),tetrahydropalmatrubine (10), xylopinoine (11), and norlaudanosine (12) were isolated.

关键词： csroton hemiargyerius new alkaloids hemiargines A, B, c, D

chemical Solution Deposition of YBa2cu3O7 Films on YSZ （100） Substrates

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Journal of chemistry and chemical Engineering 2014年第6期8卷 547-551页

作者： Henry Elías Sanchez comejo Angel Bustamante Dominguez1 Ana María Osorio Luis De Los Santos Valladares José Albino Aguiar crispin H. W. barnes ceramics and Nanomaterials Laboratory Department of Physics Major National University of San Marcos Lima 14-0149 Peru Department of chemistry and chemical Engineering Major National University of San Marcos Lima 14-0149 Peru Superconductivity and Advanced Materials Laboratory Department of Physics Federal University of Pernambuco Recife50670-901 Brazil cavendish Laboratory Department of Physics University of Cambridge Cambridge CB3 0HE United Kingdom

We report the epitaxial growth of YBcO （YBa2cu3O7） films on YSZ （Yttria-stabilized Zirconia）（100） substrates by chemical solution deposition. The precursor solution was prepared by dissolving stoichiometric amounts of acetates of Y（OOccH3）3·4H2O, Ba（OOccH3）2 and cu（OOccH3）·2H2O in an aqueous solution of oxalic acid （H2c2O4） and following the sol-gel route. This solution was directly dripped onto YSZ （100） substrates with the help of a Fisher pipette. To form the YBcO film, the sample was crystallized by annealing at 860 ℃ for 12 h in an oxidizing atmosphere. The characterization was performed by XRD （X-ray diffraction） analysis which revealed high intensity （001） reflections and denoted that most of the grains were c-axis oriented. Randomly oriented grains and other phases such as Y2BacuO5 and cuO were also detected. The superconducting YBcO phase is demonstrated from the susceptibility versus temperature measurements which indicate a superconducting critical temperature ≈ 90 K. In addition, a surface morphology analysis was performed by optical microscopy and atomic force microscopy which revealed an average roughness of 0.2197 μm.

关键词： Sol-gel method epitaxial growth YBcO superconductor layers.

采用预测技术,使用动态电压恢复器减轻电压下跌

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供用电 2002年第1期19卷 48-52页

作者： c.P.Fitzer Y.S.Lim c.Zhan V.K.Ram achan daramurthy A.Arulampalam M.barnes G.Strbac N.Jenkins 陈警众

本文提出了用于确定串联补偿装置的有功功率要求的电压下跌预测技术 ,还提出了带有功储能设备的串联补偿装置所需的控制原理。

关键词：动态电压恢复器电压下跌预测技术电压测量

Secondary Prevention Following coronary Artery Bypass Surgery: A Pilot Study for Improved Patient Education

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International Journal of clinical Medicine 2012年第4期3卷 286-294页

作者： Jeffrey B. Kramer Patricia A. Howard Brian J. barnes Bashar Ababneh Purna Mukhopadhyay Mazda Biria Gregory F. Muehlebach Emmanuel Daon George L. Zorn William A. Reed James L. Vacek cardiovascular Division Department of Internal Medicine School of Medicine The University of Kansas Medical Center Kansas City Kansas cardiovascular Division Department of Internal Medicine School of Medicine.The University of Kansas Medical Center Kansas City Kansas Department of Biostatistics School of Medicinel The University of Kansas Medical Center Kansas City Kansas Department of Pharmacy Practice School of Pharmacy The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and cardiovascular Surgeons The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and cardiovascular Surgeons The University of Kansas Medical Center Kansas City Kansas.

Background: Sustained positive outcomes after coronary artery bypass grafting (cABG) requires risk factor modification and secondary prevention medications. Much attention has been focused on planning at hospital discharge;however longer-term patient compliance is not well described. Hypothesis: A follow-up multidisciplinary educational program improves disease understanding, motivation to reduce cardiovascular risk, and secondary prevention medication prescribing following hospital discharge. Methods: Using a prospective, randomized, controlled design, patients undergoing cABG completed surveys over a year period, assessing disease understanding and motivation. Four to six weeks after cABG, intervention subjects completed a one-time educational program with a multidisciplinary team. The primary endpoint was a composite score of reduced risk factors, medication use, and awareness of prescribed medications. Secondary endpoints evaluated survey scores and medication use rates. Wilcoxon Rank Sum and chi Square tests compared data between specific time points. Generalized estimating equations and linear contrasts of the parameter estimates compared data at the three time points. Results: The final analysis included 98 subjects (Intervention = 49, control = 49). The composite score was not different between groups (I = 12.8 ± 4.5 points, c = 12.7 ± 4.9 points, p = 0.9405). Improvements were noted in understanding and motivation in the entire cohort, but these changes were not influenced by the intervention. Medication prescribing declined at 3 and 12 months after cABG without significant differences between the groups. conclusions: Disease understanding, motivation to reduce risk, and medication use are robust at hospital discharge but the latter declines with time and was not improved by our intervention. These findings are concerning and warrant further study.

关键词： Secondary Prevention coronary Artery Disease coronary Artery Bypass