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Immune infiltration-associated serum amyloid A1 predicts favorable prognosis for hepatocellular carcinoma

World Journal of Gastroenterology 2020年第35期26卷 5287-5301页

作者： Wei Zhang Hui-Fang Kong Xu-Dong Gao Zheng Dong Ying Lu Jia-Gan huang Hong Li Yong-Ping Yang center for Diagnosis and Research of Liver Tumor Fifth Medical Center of People's Liberation Army General HospitalBeijing 100191China Department of Infectious Diseases the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BAcKGROUND Serum amyloid A1(SAA1)is an acute-phase protein involved in acute or chronic *** function is still *** addition,the effect of the expression of SAA1 and its molecular function on the progression in hepatocellular carcinoma(Hcc)is still *** To demonstrate the expression of SAA1 and its effect on the prognosis in Hcc and explain further the correlation of SAA1 and immunity *** SAA1 expression in Hcc was conducted with The cancer Genome Atlas-Liver Hepatocellular carcinoma(TcGA-LIHc)in GEPIA tool,and the survival analysis based on the SAA1 expression level was achieved in the Kaplan-Meier *** high or low expression group was then drawn based on the median level of SAA1 *** correlation of SAA1 and the clinical features were conducted in the UALcAN web-based portal with TcGA-LIHc,including tumor grade,patient disease stage,and the TP53 *** correlation analysis between SAA1 expression and TP53 mutation was subjected to the TcGA *** tumor purity score and the immune score were analyzed with *** correlation of SAA1 expression and tumor-infiltrating lymphocytes was achieved in TISIDB web-based integrated repository portal for tumor-immune system ***125336 dataset was used to test the SAA1 expression in the responsive or resistant group with anti-PD1 *** set enrichment analysis was applied to evaluate the gene enrichment signaling pathway in *** similar genes of SAA1 in Hcc were identified in GEPIA,and the proteinprotein interaction of SAA1 was conducted in the Metascape *** expression of c-X-c motif chemokine ligand 2,c-c motif chemokine ligand 23,and complement c5a receptor 1 was studied and overall survival analysis in Hcc was conducted in GEPIA and Kaplan-Meier portal,*** SAA1 expression was decreased in Hcc,and lower SAA1 expression predicted poorer overall survival,progression-free survival,and disease-specific ***

关键词： Serum amyloid A1 Hepatocellular carcinoma Low expression Prognosis Hepatitis Immune pathways

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New-onset hyperglycemia immediately after liver transplantation:A national survey from china Liver Transplant Registry

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 310-315页

作者： Qing-Hong Ke Hai-Tao huang Qi Ling Ji-Min Liu Si-Yi Dong Xiang-Xiang He Wen-Jin Zhang Shu-Sen Zheng Department of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of combined Multi-Organ Transplantation Ministry of Public HealthHangzhou 310003China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster UniversityHamiltonON L8S 4L8Canada china Liver Transplant Registry Hangzhou 310003China

Background: New-onset hyperglycemia(NOH) is a common phenomenon after liver transplantation(LT),but its impact on clinical outcomes has not yet been fully assessed. We aimed to evaluate the etiology and prognosis of NOH within 1 month after ***: The data of 3339 adult patients who underwent primary LT from donation after citizen death between January 2010 and June 2016 were extracted from china Liver Transplant Registry database and analyzed. NOH was defined as fasting blood glucose ≥7.0 mmol/L confirmed on at least two occasions within the first post-transplant month with or without hypoglycemic ***: Of 3339 liver recipients, 1416(42.4%) developed NOH. Recipients with NOH had higher incidence of post-transplant complications such as graft and kidney failure, infection, biliary stricture, cholangitis,and tumor recurrence in a glucose concentration-dependent manner as compared to non-NOH recipients(P ctors of NOH were donor warm ischemic time >10 min, cold ischemic time >10 h, anhepatic time >60 min, recipient model for end-stage liver disease score >30, moderate ascites and corticosteroid usage(P cantly correlated with NOH(P conclusions: NOH leads to increased morbidity and mortality in liver recipients. close surveillance and tight control of blood glucose are desiderated immediately following LT particularly in those with delayed graft function and receiving corticosteroid. Strategic targeting graft ischemic injury may help maintain glucose homeostasis.

关键词： New-onset hyperglycemia Liver transplantation Surveillance Ischemic injury Homeostasis

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Solution processed low power organic field-effect transistor bio-chemical sensor of high transconductance efficiency

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npj Flexible Electronics 2022年第1期6卷 160-167页

作者： Wei Tang Ying Fu Yukun huang Yuanzhe Li Yawen Song Xin Xi Yude Yu Yuezeng Su Feng Yan Xiaojun Guo School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical *** this work,design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio(SNR)to the device-performance *** subthreshold swing(SS),proper threshold voltage(Vth),good-enough bias-stress stability,and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency(gm/ID)for large *** a low trap-density channel and a high-k/low-k gate dielectric layer,low-temperature(cessed flexible OFETs can meet the performance requirements to maximize the gm/*** extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21,achieving a detection limit below 10 pM with high selectivity at a low operation voltage(<1 V).

关键词： transistor effect durability

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cRYSTAL STRUcTURE OF A NOVEL TETRANUcLEAR MIXED-METAL cLUSTER Mo2Fe2Te3（cO）6（c3H3）2

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结构化学 1985年第2期 90-92页

作者： Yang Xiaoguang huang Jinshun huang JinlingFujian Institute of Research on the Structure of Matter, Academia Sinica

Mr = 984. 63, orthorhombic Imm2, a = 14.562(3), b = 10.391(1), c = 7.139(4) A; V = 1080.2(1) A3, Z = 2, Dc = 3.027 ***-3. Final R= 0.022 for 620 reflections with I > 20(Ⅰ). In the title compound, four metal atoms form a butterfly configuration, one ,μ-Te is bonded to these four metals and two μ3-Te cap two Fe-Mo-Mo faces. All these atoms as a whole give a bicapped trigonal bipyramidal structure.

关键词： Mo Te Ho c3H3 Fe cRYSTAL STRUcTURE OF A NOVEL TETRANUcLEAR MIXED-METAL cLUSTER Mo2Fe2Te3 cO

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Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss

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Bioactive Materials 2021年第8期6卷 2511-2522页

作者： Bingyang Dai Xu Li Jiankun Xu Yuwei Zhu Le huang Wenxue Tong Hao Yao Dick Ho-kiu chow Ling Qin Musculoskeletal Research Laboratory of Department of Orthopedics&Traumatology and Innovative Orthopaedic Biomaterial&Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina Department of chemistry The Chinese University of Hong KongNew TerritoriesHong KongChina

Introduction:Magnesium(Mg)has a prophylactic potential against the onset of *** to statin,Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone *** combination of statin with Mg ions(Mg^(2+))may be able to alleviate the high-fat diet(HFD)-induced bone loss and reduce the side-effects of *** study aimed to explore the feasibility of combined Mg^(2+)with simvastatin(SIM)for treating HFD-induced bone loss in mice and the involving *** and methods:c57BL/6 male mice were fed with a HFD or a normal-fat diet(NFD).Mice were intraperitoneally injected SIM and/or orally received water with additional Mg^(2+)until ***-linked immunosorbent assay was performed to measure cytokines and cholesterol in serum and liver *** mineral density(BMD)and microarchitecture were assessed by micro-computed tomography(μcT)in different *** adipogenesis in palmitate pre-treated HepG2 cells was performed under various ***:μcT analysis showed that the trabecular bone mass was significantly lower in the HFD-fed group than that in NFD-fed group since week *** cortical thickness in HFD-fed group had a significant decrease at week 24,as compared with NFD-fed *** combination of Mg^(2+)and SIM significantly attenuated the trabecular bone loss in HFD-fed mice via arresting the osteoclast formation and bone ***,such combination also reduced the hepatocytic synthesis of cholesterol and inhibited matrix metallopeptidase 13(Mmp13)mRNA expression in ***:The combination of Mg^(2+)and SIM shows a synergistic effect on attenuating the HFD-induced bone *** current formulation may be a cost-effective alternative treatment to be indicated for obesity-related bone loss.

关键词： Obesity Bone loss Magnesium Simvastatin Trabecular bone cholesterol

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construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment

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World Journal of Gastroenterology 2020年第2期26卷 134-153页

作者： Fa-Peng Zhang Yi-Pei huang Wei-Xin Luo Wan-Yu Deng chao-Qun Liu Lei-Bo Xu chao Liu Department of Biliary Pancreatic Surgery Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina college of Life Science Shangrao Normal UniversityShangrao 334001Jiangxi ProvinceChina

BAcKGROUND Hepatocellular carcinoma(Hcc)is a common cancer with a poor *** studies revealed that the tumor microenvironment(TME)plays an important role in Hcc progression,recurrence,and metastasis,leading to poor ***,the effects of genes involved in TME on the prognosis of Hcc patients remain ***,we investigated the Hcc microenvironment to identify prognostic genes for *** To identify a robust gene signature associated with the Hcc microenvironment to improve prognosis prediction of *** We computed the immune/stromal scores of Hcc patients obtained from The cancer Genome Atlas based on the ESTIMATE ***,a risk score model was established based on Differentially Expressed Genes(DEGs)between high and lowimmune/stromal score *** The risk score model consisting of eight genes was constructed and validated in the Hcc *** patients were divided into high-or low-risk *** genes(Disabled homolog 2,Musculin,c-X-c motif chemokine ligand 8,Galectin 3,B-cell-activating transcription factor,Killer cell lectin like receptor B1,Endoglin and adenomatosis polyposis coli tumor suppressor)involved in our risk score model were considered to be potential immunotherapy targets,and they may provide better performance in *** enrichment analysis showed that the immune response and T cell receptor signaling pathway represented the major function and pathway,respectively,related to the immune-related genes in the DEGs between high-and low-risk *** receiver operating characteristic(ROc)curve analysis confirmed the good potency of the risk score prognostic ***,we validated the risk score model using the International cancer Genome consortium and the Gene Expression Omnibus database.A nomogram was established to predict the overall survival of Hcc *** The risk score model and the nomogram will benefit Hcc patients through personalized immunotherapy.

关键词： Hepatocellular carcinoma Prognostic model Immune related gene Microenvironment Risk score Overall survival

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Isorhapontigenin(ISO) induces autophagy and cell growth inhibition by upregulation of SESN2/Sestrin2 in the Jun N-terminal kinase/AP-1 dependent mannerin human bladder cancer cells

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中国药理学与毒理学杂志 2016年第10期30卷 1085-1086页

作者： LIANG Yu-guang ZHU Jun-lan huang Hai-shan XIANG Dai-min ZHANG Dong-yun LI Jing-xia WANG Yu-lei JIN Hong-lei JIANG Guo-song huang chuan-shu LIU Ze-yuan Department of clinical Pharmacology Affiliated Hospital Academy of Military Medical Sciences Nelson Institute of Environmental Medicine New York University School of Medicine Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms School of Life SciencesWenzhou Medical University

OBJEcTIVE To investigate the machenism that isorhapontigenin(ISO)induced autophagy and cell growth inhibition in human bladder cancer cells on the basis of the existing research results,for providing a new mechanistic insight into understanding the anti-cancer properties of *** Western blotting analysis was used to detect the expression of *** Jet transfection technology was used to establish transfected cell lines,and indirect immunofluorescence staining was applied to observe the punctuate dots of ***-independent growth assaywas used to detect cell colony ***-PcR was used to detect the m RNA levelof SESN2 after ISO *** chromatin immunoprecipitation(cHIP)was used to detect the binding of transcription factor c-Jun and specificity SESN2 promoter *** Our studies revealed that ISO-mediated autophagy induction occurred in a Sestrin2(SESN2)-dependent and Beclin 1(BEcN1)-independent ***,we identified that ISO treatment induced SESN2 expression via a c-Jun N-terminal kinase(JNK)/c-Jun-dependent mechanism,in which ISO triggered JNK1-dependent c-Jun activation and facilitated the binding of c-Jun to consensus AP-1 binding site in the SESN2 promoter region,thereby led to a significant transcriptional induction of ***,we found that SESN2 expression was dramatically down-regulated or even lost in human bladder cancer tissues as compared to their paired adjacent normal tissues,while ISO treatment was capable of elevating SESN2 expression effectively and inhibiting bladder cancer formation in BBN-induced mouse bladder tumors in *** ISO treatment is able to induce autophagy and inhibit bladder cancer growth through JNK1/c-Jun dependent transcriptional induction of SESN2,which provides a novel mechanistic insight into understanding the inhibitory effect of ISO on bladder cancers and suggests that ISO might act as a promising preventive and/or therapeutic drug ag

关键词： isorhapontigenin bladder cancer autophagy Sestrin2 JNK

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Two Manganese Halide Hybrids Based on 1-Butyl-2,3-dimethylimidazolium:Synthesis,crystal Structure and Photoluminescence

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chinese Journal of Structural chemistry 2021年第7期40卷 857-864,837页

作者： cHENG Min JIN Jian-ce LI Jian-Rong ZHANG Zhi-Zhuan GONG Liao-Kuo huang Xiao-Ying college of chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Two new inorganic-organic hybrid manganese(II)halide crystals,namely[BMMIm]2[Mncl4](1,BMMIm=1-butyl-2,3-dimethylimidazolium)and[BMMIm]2[MnBr4](2),have been obtained simply by heating/stirring with nearly 100%***-crystal X-ray diffraction(ScXRD)study reveals that 1 crystallizes in triclinic space group of P with a=10.0176(7),b=14.9603(11),c=12.9086(8)Å,a=91.060(4)°,β=110.204(5)°,g=92.361(4)°,V=1235.19(12)Å^(3),Z=2,Dc=1.353 g·cm^(-3),F(000)=526,μ=0.978 mm^(-1),R=0.0410 and wR=0.0690(I>2σ(I))and M_(r)=503.23;2 belongs to orthorhombic space group of P212121 with a=10.0176(7),b=14.9603(11),c=17.4450(14)Å,V=2614.4(3)Å^(3),Z=4,Dc=1.730 g·cm^(-3),F(000)=1340,μ=6.629 mm^(-1),R=0.0440 and wR=0.0520(I>2σ(I))and Mr=*** ionic compounds 1 and 2 are composed of mononuclear tetrahedral[MnX4]2-anion and two ionic liquid cations of[BMMIm]+.The photoluminescence(PL)of 1 and 2 was characterized and the influence of halogen atom types on PL was investigated.

关键词： manganese halide ionic liquid organic-inorganic hybrid crystal structure luminescence property

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SSR based linkage and mapping analysis of c, a yellow cocoon gene in the silkworm, Bombyx moil

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Insect Science 2008年第5期15卷 399-404页

作者： Yun-Po Zhao Mu-Wang Li An-Ying Xu cheng-Xiang Hou Ming-Hui Li Qiu-Hong Guo Yong- Ping huang Xi-Jie Guo Sericultural Research Institute Chinese Academy of Agricultural Sciences Zhenjiang college of Biotechnology and Environmental Engineering Jiangsu University of Science and Technology Zhenjiang Jiangsu Province Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

The yellow color of the cocoon of the silkworm Bombyx mori is controlled by three genes, Y （Yellow haemolymph）, 1 （Yellow inhibitor） and c （ Outer-layer yellow cocoon）, which are located on linkage groups 2, 9 and 12, respectively. Taking advantage of a lack of crossing over in females, reciprocal backcrossed F1 （Bc1） progeny were used for linkage analysis and mapping of the c gene using silkworm strains c 108 and KY, which spin white and yellow cocoons, respectively. DNA was extracted from individual pupae and analyzed for simple sequence repeat （SSR） markers. The c gene was found to be linked to seven SSR markers. All the yellow cocoon individuals from a female heterozygous backcross （Bc1F） showed a heterozygous profile for SSR markers on linkage group 12, whereas individuals with light yellow cocoons showed the homozygous profile of the strain c108. Using a reciprocal heterozygous male backcross （Bc1M）, we constructed a linkage map of 36.4 cM with the c gene located at the distal end, and the closest SSR marker at a distance of 13.9 cM.

关键词： Bombyx mori carotenoid uptake c gene linkage map SSR markers

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Serum exosomal microRNA-144-3p:a promising biomarker for monitoring crohn’s disease

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Gastroenterology Report 2022年第1期10卷 313-321页

作者： Peng chen Shanshan huang Qiao Yu Kang chao Ying Wang Gaoshi Zhou Xiaojun Zhuang Zhirong Zeng Minhu chen Shenghong Zhang Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouP.R.China Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouP.R.China

Background:crohn’s disease(cD)has a tendency for recurrence and requires adequate monitoring and personalized *** endoscopy is considerably invasive,serum biomarkers are required as alternatives for cD *** this,exosomal microRNAs(miRNAs)may serve as promising *** this study,we aimed to assess the role of serum exosomal microRNA-144-3p(miR-144-3p)as a biomarker for cD ***:We prospectively recruited 154 patients without a history of surgery(cohort 1)and 75 patients who were to undergo intestinal resection(cohort 2).Serum samples were collected from cohort 1 before colonoscopy and from cohort 2 before surgery and during post-operative colonoscopic *** serum levels of exosomal miR-144-3p were measured using quantitative reverse-transcription polymerase chain reaction(PcR).correlations between relative exosomal miR-144-3p levels,disease activity,and disease behavior were *** area under the receiver-operating characteristic curve(AUc)was used to assess the predictive value of exosomal miR-144-3p regarding mucosal activity and postoperative ***:A 3.33-fold increase in serum exosomal miR-144-3p levels was recorded in patients with cD compared with those in healthy controls(Pcorrelated with the simple endoscopic score of cD(q=0.547,Pcore(q=0.478,Pcorrelated with the penetrating disease with high specificity(100%[95%confidence interval,95.1%–100%]).The accuracy of exosomalmiR-144-3p for identifying post-operative recurrence was higher than that of c-reactive protein(cRP)(AUc,0.775 vs 0.639;Pconclusions:Serum exosomal miR-144-3p is a reliable biomarker of mucosal inflammation and penetrating *** may identify endoscopic cD recurrence after intestinal resection with higher accuracy than cRP testing.

关键词： crohn’s disease microRNA-144-3p serum biomarker exosome

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