Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss

作     者：Bingyang Dai Xu Li Jiankun Xu Yuwei Zhu Le Huang Wenxue Tong Hao Yao Dick Ho-kiu Chow Ling Qin 

作者机构：Musculoskeletal Research Laboratory of Department of Orthopedics&Traumatology and Innovative Orthopaedic Biomaterial&Drug Translational Research LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina Department of ChemistryThe Chinese University of Hong KongNew TerritoriesHong KongChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第8期

页      面：2511-2522页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by Theme-based Research Scheme from RGC-Hong Kong(No.T13-402/17N) partially supported by Health and Medical Research Fund(17180671) National Natural Science Foundation of China(81802152) 

主　　题：Obesity Bone loss Magnesium Simvastatin Trabecular bone Cholesterol 

摘      要：Introduction:Magnesium(Mg)has a prophylactic potential against the onset of *** to statin,Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone *** combination of statin with Mg ions(Mg^(2+))may be able to alleviate the high-fat diet(HFD)-induced bone loss and reduce the side-effects of *** study aimed to explore the feasibility of combined Mg^(2+)with simvastatin(SIM)for treating HFD-induced bone loss in mice and the involving *** and methods:C57BL/6 male mice were fed with a HFD or a normal-fat diet(NFD).Mice were intraperitoneally injected SIM and/or orally received water with additional Mg^(2+)until ***-linked immunosorbent assay was performed to measure cytokines and cholesterol in serum and liver *** mineral density(BMD)and microarchitecture were assessed by micro-computed tomography(μCT)in different *** adipogenesis in palmitate pre-treated HepG2 cells was performed under various ***:μCT analysis showed that the trabecular bone mass was significantly lower in the HFD-fed group than that in NFD-fed group since week *** cortical thickness in HFD-fed group had a significant decrease at week 24,as compared with NFD-fed *** combination of Mg^(2+)and SIM significantly attenuated the trabecular bone loss in HFD-fed mice via arresting the osteoclast formation and bone ***,such combination also reduced the hepatocytic synthesis of cholesterol and inhibited matrix metallopeptidase 13(Mmp13)mRNA expression in ***:The combination of Mg^(2+)and SIM shows a synergistic effect on attenuating the HFD-induced bone *** current formulation may be a cost-effective alternative treatment to be indicated for obesity-related bone loss.