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Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

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生物活性材料(英文) 2023年第2期20卷 16-28页

作者： Xinghui Wei Wenhao Zhou Zhen Tang Hao Wu Yichao Liu Hui Dong Ning Wang Hai Huang Shusen Bao Lei Shi Xiaokang Li Yufeng Zheng Zheng Guo Department of Orthopaedics Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China Northwest Institute for Nonferrous Metal Research Xi’anShaanxi710016China Department of Orthopaedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Polyetheretherketone(PEEK)has been an alternative material for titanium in bone defect repair,but its clinical application is limited by its poor osseointegration.In this study,a porous structural design and activated surface modification were used to enhance the osseointegration capacity of PEEK materials.Porous PEEK scaffolds were manufactured via fused deposition modeling and a polydopamine(PDA)coating chelated with Magnesium ions(Mg^(2+))was utilized on the surface.After surface modification,the hydrophilicity of PEEK scaffolds was significantly enhanced,and bioactive Mg^(2+)could be released.In vitro results showed that the activated surface could promote cell proliferation and adhesion and contribute to osteoblast differentiation and mineralization;the released Mg^(2+)promoted angiogenesis and might contribute to the formation of osteogenic H-type vessels.Furthermore,porous PEEK scaffolds were implanted in rabbit femoral condyles for in vivo evaluation of osseointegration.The results showed that the customized three-dimensional porous structure facilitated vascular ingrowth and bone ingrowth within the PEEK scaffolds.The PDA coating enhanced the interfacial osseointegration of porous PEEK scaffolds and the released Mg^(2+)accelerated early bone ingrowth by promoting early angiogenesis during the coating degradation process.This study provides an efficient solution for enhancing the osseointegration of PEEK materials,which has high potential for translational clinical applications.

关键词： Polyetheretherktone Porous Magnesium Angiogenesis Osteogenesis

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Collagen membrane functionalized with Magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties

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Bioactive Materials 2023年第12期30卷 46-61页

作者： Soumya Saha Raphael Cavalcante Costa Mirela Caroline Silva Joao Matheus Fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorative Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and implantation.However,collagen must be supplemented with additional coating materials for improved osteointegration.Here,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with MgO.Characterization techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the film.Scanning electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of MgO.Slow release of Magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦C.The coated collagen membrane had a superhydrophilic surface immediately after the deposition of MgO.The film was not toxic to human cells and demonstrated antibacterial properties against bacterial biofilms.Furthermore,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated collagen.Based on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating Magnesium atomic

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Linking the effect of localised pitting corrosion with mechanical integrity of a rare earth Magnesium alloy for implant use

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Bioactive Materials 2023年第3期21卷 32-43页

作者： Kerstin van Gaalen Conall Quinn Felix Benn Peter E.McHugh Alexander Kopp Ted J.Vaughan Biomechanics Research Centre(BioMEC) Biomedical EngineeringSchool of EngineeringNational University of Ireland GalwayGalwayIreland Meotec GmbH AachenGermany School of Mechanical and Aerospace Engineering Queen’s University BelfastBelfastUnited Kingdom

This study presents a computational framework that investigates the effect of localised surface-based corrosion on the mechanical performance of a Magnesium-based alloy.A finite element-based phenomenological corrosion model was used to generate a wide range of corrosion profiles,with subsequent uniaxial tensile test simulations to predict the mechanical response to failure.The python-based detection framework PitScan provides detailed quantification of the spatial phenomenological features of corrosion,including a full geometric tracking of corroding surface.Through this approach,this study is the first to quantitatively demonstrate that a surface-based non-uniform corrosion model can capture both the geometrical and mechanical features of a magne-sium alloy undergoing corrosion by comparing to experimental data.Using this verified corrosion modelling approach,a wide range of corrosion scenarios was evaluated and enabled quantitative relationships to be established between the mechanical integrity and key phenomenological corrosion features.In particular,we demonstrated that the minimal cross-sectional area parameter was the strongest predictor of the remaining mechanical strength(R2=0.98),with this relationship being independent of the severity or spatial features of localised surface corrosion.Interestingly,our analysis demonstrated that parameters described in ASTM G46-94 showed weaker correlations to the mechanical integrity of corroding specimens,compared to parameters determined by Pitscan.This study establishes new mechanistic insight into the performance of the Magnesium-based materials undergoing corrosion.

关键词： Magnesium Localised corrosion Corrosion modelling Phenomenology FEM

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Two central circadian oscillators OsPRR59 and OsPRR95 modulate Magnesium homeostasis and carbon fixation in rice

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Molecular Plant 2022年第10期15卷 1602-1614页

作者： Chun-Qu Chen Xin-Yue Tian Jian Li Shuang Bai Zhuo-Yan Zhang Yuan Li Hong-Rui Cao Zhi-Chang Chen Root Biology Center Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Biological and Environmental Engineering Binzhou UniversityBinzhou 256603China

Photosynthesis,which provides oxygen and energy for all living organisms,is circadian regulated.Photosynthesis-associated metabolism must tightly coordinate with the circadian clock to maximize the efficiency of the light-energy capture and carbon fixation.However,the molecular basis for the interplay of photosynthesis and the circadian clock is not fully understood,particularly in crop plants.Here,we report two central oscillator genes of circadian clock,OsPRR95 and OsPRR59 in rice,which function as transcriptional repressors to negatively regulate the rhythmic expression of OsMGT3 encoding a chloroplast-localized Mg2+transporter.OsMGT3-dependent rhythmic Mg fluctuations modulate carbon fixation and consequent sugar output in rice chloroplasts.Furthermore,sugar triggers the increase of superoxide,which may act as a feedback signal to positively regulate the expression of OsPRR95 and OsPRR59.Taken together,our results reveal a negative-feedback loop that strengthens the crosstalk between photosynthetic carbon fixation and the circadian clock,which may improve plan adaptation and performance in fluctuating environments.

关键词： OsPRR OsMGT3 photosynthesis Magnesium rice

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Degradation particles derived from high-purity Magnesium inhibit osteogenic differentiation through regulation of macrophage polarization

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Journal of Materials Science & Technology 2023年第8期139卷 113-119页

作者： Yu Sun Han Yu Hongzhou Peng Xinbao Kang Zhaoxiang Peng Xieping Dong Wenhui Wang Yang Song Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Orthopaedic Surgery Ningbo Medical Treatment Center Lihuili HospitalNingbo 315040China Department of Orthopaedic Surgery Jiangxi People’s HospitalNanchang 330006China Suzhou Origin Medical Technology Co.Ltd. Jiangsu 215513China

Magnesium(Mg)and its alloys have great potential as orthopedic implant candidates,which could release various bioactive substances during degradation.Degradation particles(DPs)are one of the degradation products,but the osteoimmunology effects are still unclear.In this study,the effect of DPs on the polar-ization of macrophages and their release of cytokines was investigated.The results verify that excessive generation of DPs from biodegradable Mg can induce macrophages to realize polarization of proinflamma-tory M1 phenotype.Moreover,macrophages secrete proinflammatory cytokines to inhibit the osteogenic differentiation of rat bone marrow stem cells(rBMSCs).This suggests that the effects of DPs should be considered when evaluating Mg-based implants.DPs continuously produced with the degradation of Mg-based implants may influence osseointegration.

关键词： Magnesium Degradation particles Macrophage Phagocytosis Osteoimmunology

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Embryo-to-lamella transition of grain boundary twins in Magnesium

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Journal of Magnesium and Alloys 2023年第12期11卷 4485-4497页

作者： Mariyappan Arul Kumar Irene J Beyerlein Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Mechanical Engineering Department Materials DepartmentUniversity of CaliforniaSanta BarbaraCA 93106USA

A combined experimental and computational analysis is performed to investigate the less commonly studied embryo-to-lamella transition of deformation twins in Magnesium. This work aims to understand the structural variables controlling the embryo-to-lamella transition from grain boundaries. Statistical analysis of hundreds of early-stage twins in the lightly deformed microstructure reveals a prevailing wedge shape,with a much thicker base along the grain boundary(GB) where they originate and a thinner tip terminating in the crystal. The analysis also shows that the GB base is super thick and identifies a minimum GB twin thickness among all early-stage twins that is about one micron. A crystal plasticity-based full-field model is employed to calculate the driving forces to migrate the boundary of a three-dimensional GB twin embryo. The stress analysis, considering a full range of embryo shapes and neighboring grain orientations, indicate that the twin embryo is most likely going to form a wedge shape when it first propagates. The calculations predict that the thickness of the embryo at the GB needs to be significantly larger than its length into the crystal in order to propagate into the crystal. The analysis finds that the more aligned the twin embryo variant is with basal slip in the neighboring grain, the thinner the twin embryo needed for propagation.

关键词： Magnesium Twin embryo Crystal plasticity Nucleation Grain neighbor

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Magnesium metal and its corrosion products:Promising materials for tumor interventional therapy

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Journal of Magnesium and Alloys 2023年第3期11卷 763-775页

作者： Binghui Xu Yuna Song Kairan Yang Yichen Li Bendong Chen Xia Liao Qingan Jia Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi’an 710038China Shaanxi Provincial Key Laboratory of Infection and Immune Disease Shaanxi Provincial People's HospitalXi’an 710038China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710038China Department of Hepatobiliary Surgery General HospitalNingxia Medical UniversityYinchuan 750001China Department of Nutrition First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710038China Institute of Medical Research Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China

Magnesium is generally known to degrade in aqueous environments by an electrochemical reaction.The corrosion products of Magnesium include hydrogen gas,Mg^(2+),and Mg(OH)_(2).Here,we summarize the published literature describing the corrosion characteristics of Magnesium,and the antitumor properties of Magnesium-associated corrosion products,aiming to induce the therapeutic properties of Magnesium and Magnesium alloys in solid tumors.The therapeutic potential of corrosion products of Magnesium is enormous.Hydrogen gas exhibits antioxidant and anti-inflammatory properties,which amount to potential anti-tumor characteristics.Mg(OH)_(2),which creates a localized alkaline microenvironment,represents a second approach for anti-tumor therapy with Magnesium metal.Upregulated concentrations of Mg^(2+)ions in the local tumor microenvironment remodelling are considered a third approach for anti-tumor therapy.Therefore,we speculate about the different physical forms of Magnesium that could create an anti-tumor microenvironment upon tumor interventional therapy,a technique that precisely places anti-tumor implants like particles and stents.Finally,we present our viewpoints on the potential use of Magnesium in diverse solid tumor therapies to inhibit tumor progression.

关键词： Magnesium Hydrogen gas Mg(OH)_(2) Mg^(2+) Cancer Interventional therapy

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Symptoms and comorbidities associated with abnormal levels of serum calcium,Magnesium,and phosphate in the emergency department:a prospective observational study

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World Journal of Emergency Medicine 2023年第1期14卷 59-61页

作者： Korsin Laohavisudhi Phichayut Phinyo Borwon Wittayachamnankul Boriboon Chenthanakij Theerapon Tangsuwanaruk Parinya Tianwibool Pavita Laohakul Wachira Wongtanasarasin Department of Emergency Medicine Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Family Medicine Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Center for Clinical Epidemiology and Clinical Statistics Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Emergency Medicine University of California Davis School of MedicineSacramentoCalifornia 95817USA

Emergency departments(EDs)play a significant role in hospital healthcare systems.[1]According to the US Centers for Disease Control and Prevention,130 million individuals visited the ED in 2018.[2]A previous study has demonstrated that unnecessary laboratory tests did not change the management plan.[3]These actions led to ED overcrowding,causing consequences to patient outcomes.

关键词： morbid Magnesium prospective

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Enhancement of critical-sized bone defect regeneration by Magnesium oxide-reinforced 3D scaffold with improved osteogenic and angiogenic properties

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Journal of Materials Science & Technology 2023年第4期135卷 186-198页

作者： Bo Chen Zhengjie Lin Qimanguli Saiding Yongcan Huang Yi Sun Xinyun Zhai Ziyu Ning Hai Liang Wei Qiao Binsheng Yu Kelvin W.K.Yeung Jie Shen Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China D Printing Clinical Translational and Regenerative Medicine Center Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518067China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518036China Department of Orthopaedics and Traumatology the University of Hong KongChina Hong Kong Special Administrative RegionChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma the University of Hong Kong Shenzhen HospitalShenzhen 518053China School of Materials Science and Engineering Nankai UniversityTianjin 300071China Department of Pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Stomatology Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518067China Applied Oral Sciences and Community Dental Care Faculty of Dentistrythe University of Hong KongChina Hong Kong Special Administrative RegionChina China Orthopaedic Regenerative Medicine Group(CORMed) Hangzhou 310000China

The healing of critical-sized bone defects(CSD)remains a challenge in orthopedic medicine.In recent years,scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional(3D)printing technology have lighted up the treatment of the CSD due to the elaborate microenvironments and support they may build.Here,we established a Magnesium oxide-reinforced 3D-printed biocompos-ite scaffold to investigate the effect of Magnesium-enriched 3D microenvironment on CSD repairing.The composite was prepared using a biodegradable polymer matrix,polycaprolactone(PCL),and the disper-sion phase,Magnesium oxide(MgO).With the appropriate surface treatment by saline coupling agent,the MgO dispersed homogeneously in the polymer matrix,leading to enhanced mechanical performance and steady release of Magnesium ion(Mg^(2+))for superior cytocompatibility,higher cell viability,advanced osteogenic differentiation,and cell mineralization capabilities in comparison with the pure PCL.The in-vivo femoral implantation and critical-sized cranial bone defect studies demonstrated the importance of the 3D Magnesium microenvironment,as a scaffold that released appropriate Mg^(2+) exhibited remarkably increased bone volume,enhanced angiogenesis,and almost recovered CSD after 8-week implantation.Overall,this study suggests that the Magnesium-enriched 3D scaffold is a potential candidate for the treatment of CSD in a cell-free therapeutic approach.

关键词： 3D printing Magnesium Critical-sized defect Bone regeneration Angiogenesis Scaffold

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(EDTA)^(4-) supplements as superior modifier of the in-vitro-degradation properties of the Magnesium alloy coated through discharge-assisted process

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Journal of Magnesium and Alloys 2023年第3期11卷 945-957页

作者： Zeeshan Ur Rahman Maqsood Ali Ye-Tang Pan David G.Churchill Bon Heun Koo College of Mechatronic Engineering Changwon National UniversityChangwonGyeongsangnam-doRepublic of Korea Department of Regenerative Medicines College of MedicinesSoonChunhyang UniversityCheonanRepublic of Korea National Engineering Technology Research Center of Flame Retardant Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijingPR China Department of Chemistry Molecular Logic Gate LaboratoryKorea Advanced Institute of Science and Technology(KAIST)Republic of Korea

The(EDTA)^(4-)organic substituents were supplemented with alkaline silicates electrolyte,however in varying concentration to explore the microstructure,chemical composition and subsequent effects on the biodegradation of the PEO coated Mg AZ91 alloy.From surface analysis-,carried out through SEM,samples with zero-(EDTA)^(4-)were found-,lacking pancake structural features;however,supplementing electrolyte with(EDTA)^(4-),bulky and layered pancakes were obtained with minimum cracks and minimum porosity for EDT-1.From the phase and inner layer analysis,it was found that EDTA can significantly alter the surface layers composition and could act as a passivation agent-;however,individual polycrystalline phases were not found to form.The hardness value obtained for EDT-1 was~909.69 HV,the highest value found here which occurs with the shallowest indents found in this study.In-vitro degradation analysis was carried out using potentiodynamic polarization at room temperature,cyclic polarization at RT and high fever conditions(HFT~40°C).The corrosion potential for coated AZ91 was obtained as a positive value of~0.1 V,for the first time in the PEO research;however,the results were not supported by the cyclic polarization tests at room temperature and at HFT.The post corrosion microstructural analysis confirmed the effective role of EDTA up to 1.0 g·L^(-1)and revealed the formation of thin films during the forward polarization at HFT.

关键词： EDTA Soft plasma Magnesium Biodegradation Corrosion SBF

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