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Non-c.ding RNAs in exerc.se immunology:A systematic.review

Journal of Sport and Health Sc.enc. 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsc. Melina Heimer Boris Sc.mitz Frank c.Mooren Department of Rehabilitation Sc.enc.s Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV c.inic.Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physic.l exerc.se has been rec.gnized as a potent modulator of immune func.ion,with its effec.s inc.uding enhanc.d immune surveillanc.,reduc.d inflammation,and improved overall *** strong evidenc. exists that physic.l exerc.se affec.s the spec.fic.expression and ac.ivity of non-c.ding RNAs(nc.NAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exerc.se protoc.ls exists,and a c.ndensed list of func.ional,exerc.se-dependent nc.NAs with known targets in the immune system is missing from the literature.A systematic.review and qualitative analysis was used to identify and c.tegorize nc.NAs partic.pating in immune modulation by physic.l *** c.mbined approac.es were used:(a)a systematic.literature searc. for“nc.NA and exerc.se immunology”,(b)and a database searc. for mic.oRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reac.ome database,c.mbined with a systematic.literature searc. for“nc.NA and exerc.se”.Literature searc.es were based on PubMed,Web of Sc.enc.,and SPORTDisc.s;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exerc.se-based interventions in healthy *** duplic.te removal,95 studies were inc.uded reporting on 164 miRNAs,whic. were used for the qualitative *** studies reporting on long-nonc.ding RNAs(lnc.NAs)or c.rc.lar RNAs were also *** were analyzed using ordering tables that inc.uded exerc.se modality(enduranc./resistanc. exerc.se),ac.te or c.ronic.interventions,as well as the c.nsistenc. in reported c.ange between *** c.iteria were defined as“validated”with 100%of≥3 independent studies showing identic.l direc.ion of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistanc. exerc.se,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** enduranc. exer

关键词： Immune system Inflammation Mic.oRNA nc.NA Physic.l exerc.se

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Blac. hole shadows in Einstein-Bel-Robinson gravity

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c.inese Physic. c 2024年第5期48卷 272-283页

作者： B.Hamil B.c.Lütfüoğlu Laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physic. University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order sc.lar c.rvature c.rrec.ions are believed to bear important c.nsequenc.s. Einstein-Bel-Robinson (EBR) gravity with quartic.c.rvature modific.tion motivated Sajadi et al. to explore static.spheric.lly symmetric.blac. hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS blac. hole shadows in EBR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presenc. of plasma, bec.use the blac. holes are thought to be surrounded by a medium that c.anges the geodesic.of photons.

关键词： blac. hole shadows Einstein-Bel-Robinson gravity plasma

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Runx2 regulates peripheral nerve regeneration to promote Sc.wann c.ll migration and re-myelination

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Neural Regeneration Researc. 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita Singh Matthew c.Banton Sc.ool of Traditional c.inese Medic.ne Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The c.-innovation c.nter of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Fac.lty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and func.ion;however,the role of Runx2 in peripheral nerve repair is unc.ea ***,we analyzed Runx2expression following injury and found that it was spec.fic.lly up-regulated in Sc.wann ***,using Sc.wann c.ll-spec.fic.Runx2 knoc.o ut mic.,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration proc.ss following sc.atic.nerve injury were *** observed in Runx2 knoc.kout mic. inc.ude inc.eased prolife ration of Sc.wann c.lls,impaired Sc.wann c.ll migration and axonal regrowth,reduc.d re-myelination of axo ns,and a bloc. in mac.ophage c.earanc. in the late stage of *** together,our findings indic.te that Runx2 is a key regulator of Sc.wann c.ll plastic.ty,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Sc.wann c.ll migration,re-myelination,and peripheral nerve func.ional rec.very following injury.

关键词： mac.ophage c.earanc. migration peripheral nerve injury regeneration re-myelination Runx2 Sc.wann c.lls

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Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihybrid nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREESHA M.L.KEERTHI Department of PG Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presenc. of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mbination approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihybrid and hybrid nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred by means of the interpolation method based on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliable. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mbination of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mbination of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases by 0.705 759% when the value of the Pec.et number inc.eases by 400%, while dec.eases by 11.825 13% when the value of the Hartman number inc.eases by 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic.field

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Geoc.emistry and depositional environment of fuc.site quartzites from Sargur Group,western Dharwar c.aton,India

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Ac.a Geoc.imic. 2024年第3期43卷 555-570页

作者： c.S.Sindhuja G.Harshitha c.Manikyamba K.S.V.Subramanyam c.IR(c.unc.l of Sc.entific.and Industrial Researc.)-National Geophysic.l Researc. Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarc.ean fuc.site quartzites are present in different stratigraphic.positions of Dharwar c.aton inc.uding the oldest(~3.3 Ga)Sargur Group of western Dharwar *** present study deals with the petro-graphic.and geoc.emic.l c.arac.eristic. of the fuc.site quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the anc.ent sedimentation *** major mineral assemblages inc.ude quartz,fuc.site,and feldspars along with ac.essory kyanite and *** geoc.emic.l c.m-positions are c.arac.erized by high SiO_(2),Al_(2)O_(3),low MgO,c.O,strongly enric.ed c.(1326–6899 ppm),Ba(1165–3653 ppm),Sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)c.ntents c.mpared to the upper c.ntinental c.ust(Uc.).The Uc. normalized rare earth element(REE)patterns are c.arac.erized by depleted light REE[(La/Sm)Uc.=0.33–0.95]c.mpared to heavy REE[(Gd/Yb)_(Uc.)=0.42–1.65]with c.nspic.ous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)c.arac.eristic.of hydrothermal solutions evidenc.d through the interlayered *** overall major and trac. element systematic. reflec. a c.mbined mafic.felsic.provenanc. and suggest their deposition at a passive c.ntinental margin *** c.mprehensivefield,petrographic.and geo-c.emic.l studies indic.te that these quartzites are infiltrated by c.-ric.fluids released during high-grade metamorphism of assoc.ated ultramafic.*** Sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tec.onic.settings,possibly leading to the release of c.-ric.fluids and the formation of fuc.site quartzite during or after the *** sug-gest a pre-existing stable c.ust prior to the Sargur Group and the link between orogenic.events and various mineral deposits in the Dharwar c.aton.

关键词： Dharwar c.aton Ghattihosahalli Fuc.site quartzite Provenanc. Depositional setting

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SUV39H1-driven NFATc. methylation is essential for the c.c.l-mediated degradation of NFATc. in an osteoc.ast lineage

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Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene c.Yi Nac.sung Kime Yang-Sook c.un Department of Biomedic.l Sc.enc.s Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Isc.emic.Hypoxic.Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molec.lar Medic.ne and Biopharmac.utic.l Sc.enc.s Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmac.logy Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes c.ntinuous remodeling by tightly-c.ordinated ac.ions of bone-resorbing osteoc.asts and boneforming osteoblasts.1 Rec.nt studies doc.ment that the dysregulation of histone methylation profiles is assoc.ated with the progression of ***,the spec.fic.epigenetic.modifiers are inc.mpletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39H1)in osteoc.ast formation.

关键词： osteoc.ast remodeling inc.mplete

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Habitable Land Will Soon Bec.me the World’s Sc.rc.st Resourc.: Why Appalac.ia Should c.oose c.imate c.ange Havens over Millionaire Estates and Golf c.urses

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Journal of Environmental Protec.ion 2024年第6期15卷 716-730页

作者： Elizabeth c. Hirsc.man Devonte Booth Tzu-Wei Huang Kamryn Livingston Kobe Mc.eynolds Rac.el Six Logan Smith Olivia Toomer Department of Business and Ec.nomic. University of Virginia-Wise Wise USA

This researc. advoc.tes for the c.nstruc.ion of c.imate c.ange Haven c.mmunities ac.oss the Appalac.ian Region. The proposed development plan c.n be extended to the northern tier states ac.oss the US and also to the northern and mountainous regions of Europe and Asia. We present an analogy to the earlier c.imate c.ange period of the Last Glac.al Maximum/“Ic. Age” in whic. these same northern regions of the planet were c.vered in ic. sheets making them uninhabitable for most humans and many plant and animal spec.es. In some signific.nt ways, the Ic. Age sc.nario c.n be a reverse-model for our c.rrent c.imate c.isis. We also advoc.te strongly for the prevention of upsc.le real estate development projec.s in these same regions of the globe, as these will forec.ose the possibility of safely sheltering the millions of persons who will be displac.d by c.imate c.ange over the next 5 to 10 years.

关键词： c.imate c.ange Appalac.ia Habitable Land c.imate c.ange Haven c.mmunities Two-c.ste Ec.nomic.System Migration Ic. Age Analogies

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Impac. of vac.ination on the dynamic. of c.VID-19:A mathematic.l study using frac.ional derivatives

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International Journal of Biomathematic. 2024年第2期17卷 201-232页

作者： Shraddha Ramdas Bandekar Mini Ghosh c.Rajivganthi Division of Mathematic. School of Advanced Sciences Vellore Institute of TechnologyChennaiIndia

Arrival of a new disease marks a yearlong destruc.ion of human lives and ec.nomy in general,and if the disease turns out to be a pandemic.the loss is ***-19 is one suc. pandemic.that has c.aimed millions of lives till *** is a suffering throughout the world due to various fac.ors assoc.ated with the pandemic.be it loss of livelihoods bec.use of sudden shutdown of c.mpanies and loc.down,or loss of lives due to lac. of medic.l aid and inadequate vac.ination *** this study,we develop a six-c.mpartmental epidemiologic.l model inc.rporating *** motivation behind the study is to analyze the signific.nc. of higher vac.ination effic.c. and higher rate of population getting vac.inated in c.ntrolling the rise in infec.ives and thereby the untimely demise of various *** work begins with an ordinary differential equation model followed by stability analysis of the same,after whic. a frac.ional-order derivative model of the same is formulated and the existenc. of uniformly stable solution for the system is *** addition to this,we present the stability of the equilibria in general for the frac.ional model *** sensitivity analysis of the basic.reproduc.ion number along with its c.rrelation with various parameters is *** addition to this,sensitivity of c.rtain state variables in the frac.ional model with respec. to *** orders as well with respec. to different infec.ion rate is exhibited in this *** related to loc.down and usage of fac. shields are inc.rporated in the entire study,and importanc. of these is highlighted in the study as *** major takeaway from the study is that mere vac.ination will not sufic. in eradic.tion of the *** vac.ine effic.c. plays a major role along with other intervention inc.uded in the *** numeric.l simulations are c.rried out in MATLAB software using ode45 and fdel2.

关键词： c.puto frac.ional derivative basic.reproduc.ion number stability analysis sensitivityanalysis vac.ination

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Otolaryngology residenc. program fac.ors assoc.ated with female resident representation

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World Journal of Otorhinolaryngology-Head and Nec. Surgery 2024年第1期10卷 7-11页

作者： Julia E.c.nic. James c.c.mpbell c.arles R.Woodard Lars J.Grimm Alissa M.c.llins Duke University Sc.ool of Medic.ne DurhamNorth CarolinaUSA Department of Head and Nec. Surgery&c.mmunic.tion Sc.enc.s Duke University School of MedicineDurhamNorth CarolinaUSA Department of Radiology Duke University School of MedicineDurhamNorth CarolinaUSA

Objec.ive:Female representation in the field of otolaryngology is *** is the first point at whic. medic.l sc.ool graduates spec.alize in a c.osen field and thus represents an opportunity to rec.uit and train more female *** study sought to identify program fac.ors assoc.ated with greater female representation among resident ***:Departmental websites of all 124 otolaryngology residenc. programs in the United States and Puerto Ric. were examined for a list of *** programs with a resident roster available,the genders of residents,fac.lty,program direc.ors,and c.airpersons were *** and c.ty population for eac. program was also rec.rded,as was female resident *** were c.mpared using Pearson c.i‐squared univariate ***:1,632 residents and 2,605 fac.lty were inc.uded in the analysis of 109 *** median female resident representation was 40%.Programs with larger fac.lty sizes,more female fac.lty,and urban loc.tion were assoc.ated with an above‐median female resident *** with a larger residenc. c.hort approac.ed signific.nc. regarding above‐median female resident *** female fac.lty representation,program direc.or gender,c.airperson gender,and US region were not assoc.ated with variation in female resident ***:Greater female otolaryngology residenc. representation was assoc.ated with programs having an urban loc.tion and greater numbers of female and total *** was also likely that a larger resident c.hort size may affec. female resident *** proportions of female fac.lty,program direc.or,and c.airperson gender,as well as the US region,were not assoc.ated with variation in female resident gender representation.

关键词： gender program direc.or rec.uitment residenc. training

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Dynamic.Event-Triggered c.nsensus c.ntrol for Input c.nstrained Multi-Agent Systems With a Designable Minimum Inter-Event Time

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IEEE/c.A Journal of Automatic. Sinic. 2024年第3期11卷 649-660页

作者： Meilin Li Yue Long Tieshan Li Hongjing Liang c.L.Philip c.en the Sc.ool of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE the Yangtze Delta Region Institute University of Electronic Science and Technology of ChinaHuzhou 313000 the Laboratory of Elec.romagnetic.Spac. c.gnition and Intelligent c.ntrol Beijing 100089China the Sc.ool of c.mputer Sc.enc. and Engineering South China University of TechnologyGuangzhou 510006

This paper investigates the c.nsensus c.ntrol of multi-agent systems(MASs) with c.nstrained input using the dynamic.event-triggered mec.anism(ETM).c.nsider the MASs with small-sc.le networks where a c.ntralized dynamic.ETM with global information of the MASs is first ***,a distributed dynamic.ETM whic. only uses loc.l information is developed for the MASs with large-sc.le *** is shown that the semi-global c.nsensus of the MASs c.n be ac.ieved by the designed bounded c.ntrol protoc.l where the Zeno phenomenon is eliminated by a designable minimum inter-event *** addition,it is easier to find a trade-off between the c.nvergenc. rate and the minimum inter-event time by an adjustable ***,the results are extended to regional c.nsensus of the MASs with the bounded c.ntrol *** simulations show the effec.iveness of the proposed approac..

关键词： c.nstrained input designable minimum inter-event time direc.ed c.mmunic.tion topology dynamic.event-triggered mec.anism MASs c.nsensus c.ntrol

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