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Clinical Follow-Up Nursing Quality in Child Health

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Health 2015年第10期7卷 1235-1242页

作者： Fábia Barbosa de Andrade Tainara Lorena dos Santos Ferreira Tiago Jose Barbosa de Andrade Jéssica Isabelle dos Santos dutra dídia de Oliveira Pereira brenda Kalyny Silva brenda Kalyny Silva Ingrid Katianne Marques Araújo Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil University Center of Joao Pessoa(UNIPe) Joao PessoaBrazil

Objective: The present work aims to evaluate the impact of the activities of nursing consultations on health conditions of children served in Clínica de Enfermagem Salvando Vidas com Educa??o. Methods: This is an exploratory, descriptive study with a quantitative approach, realized from January through december 2012, at the Clínica de Enfermagem (Nursing Clinic), in the Santa Cruz County, Rio Grande do Norte’s countryside, Brazil. Results: The obtained results showed a significant correlation between the type of pathology and final treatment proven by the value of p = 0.000;as for assessed 60%, more than half were discharged;the most prevalent diseases were the association between cutaneous and gastric with 11% who were discharged and, lastly, the association between gastric and respiratory with 7% discharged. Conclusion: Thus, the activities developed by the project are not restricted to the examination during the nursing consultation, since educational activities are planned from the data obtained in those consultations.

关键词： Child Nursing School Care

Predictors of Successful Weight Loss Maintenance: A Qualitative Comparative Analysis

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Open Journal of Preventive Medicine 2014年第5期4卷 257-269页

作者： Mary E. Baugh Jyoti Savla Jeremy d. Akers Hollie A. Raynor Kevin P. davy brenda M. davy Center for Gerontology and department of Human development Virginia Tech Blacksburg USA department of Health Sciences James Madison University Harrisonburg USA department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA department of Nutrition University of Tennessee at Knoxville Knoxville USA

Individuals successful at weight loss maintenance (WTLM) utilize similar behaviors but in varying amounts and combinations. Research identifying characteristics which predict WTLM success could be used to develop effective WTLM treatment programs. The purpose of this retrospective analysis was to determine behavioral (e.g., self monitoring of dietary intake) and biological factors (e.g., sex) which may influence WTLM success. Methods: In a previously conducted 12-month WTLM study, weight-reduced middle-aged and older men and women (n = 39) were assigned behavioral goals and asked to daily self-monitor body weight, fruit and vegetable intake, water consumption, and physical activity. This investigation utilized a crisp set qualitative comparative analysis (QCA) to characterize individuals’ weight changes and behaviors. Sex difference in clinically significant weight loss (WL) (≥5% WL) at 12 months was investigated, and growth curve models estimated interaction effects between sex and WTLM predictors. Results: QCA findings suggest patterns of weight change during the initial three months of WTLM treatment may dictate 12-month weight outcomes. No sex difference was found in clinically significant WL or in the interaction of sex and behaviors on weight change. Conclusions: WTLM treatments should provide more intensive support during transition from WL to WTLM, particularly during the first three months.

关键词： Weight Loss Maintenance Obesity Sex differences Behaviors Predictors

Process for the Obtention of Coumaric Acid from Coumarin: Analysis of the Reaction Conditions

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Advances in Chemical Engineering and Science 2013年第3期3卷 195-201页

作者： Néstor N. López-Castillo Alma d. Rojas-Rodríguez brenda M. Porta M. Javier Cruz-Gómez Chemical Engineering department of the Faculty of Chemistry Universidad Nacional Autónoma de México (UNAM) Coyoacan D. F. México México

Coumaric acid can be obtained from basic hydrolysis of coumarin, through a reaction process consisting on opening the lactone ring and cis-trans isomerization. Parameters such as reaction time, temperature, NaOH concentration, solvent and reaction atmosphere, have been thoroughly studied and analyzed, in order to determine the appropriate conditions for the maximum conversion efficiency of coumarin into coumaric acid. Experimental results show that the best conditions are a 1 hour reaction time, at 160℃, with a 20% sodium hydroxide aqueous solution, and in an inert reaction atmosphere.

关键词： Coumarin Coumaric Acid Ester Hydrolysis

Conductive Behavior and Morphology of Axially Modified Gallium Phthalocyanine Thin Films onto Indium Tin Oxide Substrates

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Advances in Materials Physics and Chemistry 2016年第7期6卷 211-219页

作者： Margarita Rivera brenda Reyes María Elena Sánchez-Vergara Luis Humberto Mendoza-Huizar Instituto de Física Departamento de Materia Condensada Universidad Nacional Autónoma de México D.F. México México Facultad de Ingeniería Universidad Anáhuac México Norte Huixquilucan Estado de México México Centro de Investigaciones Químicas Mineral de la Reforma Universidad Autónoma del Estado de Hidalgo Hidalgo México

Semiconductor molecular films based on a gallium phthalocyanine chloride (GaPcCl) and a bidentate amine were prepared by using vacuum thermal evaporation and electrochemical techniques in order to investigate the preferred conduction paths within the films. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) were employed to characterize the morphology of the films. The conductivity measurements were performed with two different methods in order to investigate preferential conduction directions. The film transverse conductivity was obtained by using scanning tunneling spectroscopy (STS) and the in-plane film conductivity was measured with a four-point probe system. From spectroscopy measurements, the tunneling conductance (dI/dV) was also obtained. From these results, it was found that the conductive nature of the films was strongly influenced by the deposition technique which in turn defined the morphological characteristics of the film. The evaporated method showed better conductivity response and provided semiconductor characteristics in the film transverse direction with an in-plane ohmic response. Finally, contact angle measurements were performed and showed hydrophobic characteristics in all cases.

关键词： Thin Films Phthalocyanines Electronic Properties Electrical Conductivity

对医疗卫生人员“绝经治疗”的继续医学教育需求评估

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中国继续医学教育 2012年第2期4卷 23-25页

作者： Jan E.Patterson brenda Johnson Amruta d.Parekh 德克萨斯大学安东尼奥健康科学中心

1 背景介绍 1991年,由美国国立卫生研究院主持开展的妇女健康研究(Women's Health Initiative,WHI)评估了激素治疗(hormone therapy,HT)和发生心脏病、骨折、乳腺癌和结肠癌的风险的关系。WHI研究并未显示HT可以明显缓解受试者的绝经症... 详细信息

1 背景介绍 1991年,由美国国立卫生研究院主持开展的妇女健康研究(Women's Health Initiative,WHI)评估了激素治疗(hormone therapy,HT)和发生心脏病、骨折、乳腺癌和结肠癌的风险的关系。WHI研究并未显示HT可以明显缓解受试者的绝经症状,因此影响了美国广大医疗卫生人员和患者对HT的态度,接受HT的患者数量明显减少。但最近有研究支持HT在围绝经期对绝经症状的治疗效果,并发现在绝经期应用HT可以降低骨质疏松和骨折的风险。

关键词：医疗卫生人员患者 HT 渠道输水建筑物继续医学教育需求评估

Biomarkers screening for cardiac conduction diseases

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Biomarkers screening for cardiac conduction diseases

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： brenda B.Su Marco Capecchi Cedric Manlhiot Yuqing Yan Edgar T Jaeggi Earl d.Silverman Robert M.Hamilton. 生命科学与生物技术学院哈尔滨师范大学哈尔滨医科大学生物信息科学与技术学院多伦多大学病童医院

Rational:Cardiac conduction disease is multifactorial complex *** factors play critical roles in formation of cardiac conductive tissue during fetal heart *** has been recognized that environmental factors also alter during fetal development increase the risk of cardiac conduction *** are few genes shown can be altered and effect on heart structure formation during the ***,the gene expression in conductive tissue in human fetal heart and the underlying molecular mechanisms remain poorly *** this study,we identify genes expressed preferentially within the atrial ventricular conductive junctional tissue(AVJ) in human fetal hearts as compared to the apical myocardium(Apx). Methods:Total RNA from six fetal hearts was extracted using Qiagen RNA kit and applied onto Affymetrix human Genome U133 plus 2(micro)*** results were analyzed by Affymetrix console and Partek? Genomics SuiteTM. Results:We found that 1532 genes significantly(pd in atrial ventricular conductive junctional tissue than that in apex at 20-23 weeks of gestation,including 496 genes greater than 2-fold differential expression between fetal cardiac atrial ventricular junction and ***1d,CACNA1G and HTR4 expressed preferentially in human atrial ventricular conductive tissue.A subset of the data was confirmed by Real-Time PCR and immunostaining.245 genes highly expressed in human atrial ventricular conductive junctional tissue were matched to the gene expression in mouse atrial ventricular nodal cells and 103 genes were matched to E10.5 mouse the atrial ventricular node(pde specific markers for the human fetal atrial ventricular conduction system,which might be important targets in the pathophysiology of cardiac conduction diseases in heart development.

关键词： cardiac conduction diseases gene expression microarray atrial ventricular tissue

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer MSilvia Román-Azcona Javier Pizarro-delgado Ana Planavila Francesc Villarroya brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy Mdavidson Emma Barroso Manuel Vázquez-Carrera department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCNatal-Barcelona Center for Maternal–Fetal and Neonatal Medicine(Hospital Clínic and Hospital Sant Joan de deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the dNA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac

Executive functioning in TBI from rehabilitation to social reintegration: COMPASS^(goal), a randomized controlled trial(grant: 1I01RX000637-01A3 by the VA ORd RR&d, 2013–2016)

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Military Medical Research 2015年第4期3卷 181-200页

作者： Alexander V.Libin Joel Scholten Manon Maitland Schladen Ellen danford Nawar Shara Walter Penk Jordan Grafman Linda Resnik dwan Bruner Samantha Cichon Miriam Philmon brenda Tsai Marc Blackman Alexander dromerick Mental Health Service Washington DC VA Medical Center Med Star National Rehabilitation Hospital Med Star Health Research Institute Physical Medicine and Rehabilitation Service Washington DC VA Medical Center Research Service Washington DC VA Medical Center Texas A&M College of Medicine Rehabilitation Institute of Chicago Research Service Providence VA Medical Center

Background: Traumatic brain injury is a major health problem that frequently leads to deficits in executive function. Self-regulation processes, such as goal-setting, may become disordered after traumatic brain injury, particularly when the frontal regions of the brain and their connections are involved. Such impairments reduce injured veterans' ability to return to work or school and to regain satisfactory personal lives. Understanding the neurologically disabling effects of brain injury on executive function is necessary for both the accurate diagnosis of impairment and the individual tailoring of rehabilitation processes to help returning service members recover independent ***/design: The COMPASSgoal(Community Participation through Self-Efficacy Skills development) program develops and tests a novel patient-centered intervention framework for community reintegration psychosocial research in veterans with mild traumatic brain injury. COMPASSgoal integrates the principles and best practices of goal self-management. Goal setting is a core skill in self-management training by which persons with chronic health conditions learn to improve their status and decrease symptom effects. Over a three-year period, COMPASSgoal will recruit 110 participants with residual executive dysfunction three months or more post-injury. Inclusion criteria combine both clinical diagnosis and standardized scores that are >1 Sd from the normative score on the Frontal Systems Rating Scale. Participants are randomized into two groups: goal-management(intervention) and supported discharge(control). The intervention is administered in eight consecutive, weekly sessions. Assessments occur at enrollment, post-intervention/supported discharge, and three months post-treatment ***: Goal management is part of the "natural language" of rehabilitation. However, collaborative goal-setting between clinicians/case managers and clients can be hindered by the cognitive deficits

关键词： Executive function Traumatic brain injury Goal-setting Community reintegration Veterans Randomized controlled trial Manualized psychosocial intervention

BME 2.0: Engineering the Future of Medicine

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Biomedical Engineering Frontiers 2023年第1期4卷 217-227页

作者： Michael I.Miller Andrew O.Brightman Frederick H.Epstein KJane Grande-Allen Jordan J.Green Eileen Haase Cato T.Laurencin Elizabeth Logsdon Feilim Mac Gabhann brenda Ogle Chun Wang George R.Wodicka Raimond L.Winslow department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Biomedical Engineering University of VirginiaCharlottesvilleVAUSA department of Bioengineering Rice UniversityHoustonTXUSA department of Biomolecular Engineering and department of Orthopaedic Surgery University of ConnecticuttStorrsCTUSA department of Biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

If the 20th century was the age of mapping and controlling the external world,the 21st century is the biomedical age of mapping and controlling the biological internal *** biomedical age is bringing new technological breakthroughs for sensing and controlling human biomolecules,cells,tissues,and organs,which underpin new frontiers in the biomedical discovery,data,biomanufacturing,and translational *** article reviews what we believe will be the next wave of biomedical engineering(BME)education in support of the biomedical age,what we have termed BME *** 2.0 was announced on October 122017 at BMES 49(https://***/news-events/news/miller-opens-2017-bmes-annual-meeting-with-vision-for-new-bme-era/).We present several principles upon which we believe the BME 2.0 curriculum should be constructed,and from these principles,we describe what view as the foundations that form the next generations of curricula in support of the BME *** core principles of BME 2.0 education are(a)educate students bilingually,from day 1,in the languages of modern molecular biology and the analytical modeling of complex biological systems;(b)prepare every student to be a biomedical data scientist;(c)build a unique BME community for discovery and innovation via a vertically integrated and convergent learning environment spanning the university and hospital systems;(d)champion an educational culture of inclusive excellence;and(e)codify in the curriculum ongoing discoveries at the frontiers of the discipline,thus ensuring BME 2.0 as a launchpad for training the future leaders of the biotechnology *** envision that the BME 2.0 education is the path for providing every student with the training to lead in this new era of engineering the future of medicine in the 21st century.

关键词： organs education frontier