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Journal of Traditional Chinese Medicine 2024年第3期44卷 545-553页

作者： JIN Xiao wu bingxin LIN Miaoyang ZHONG Biying LIN Luoqi XU Danping Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan UniversityJinan University Department of Cardiology Second Clinical College of Guangzhou University of Chinese Medicine Department of Traditional Chinese Medicine the Eighth Affiliated HospitalSun Yat-Sen University

OBJECTIVE: To evaluate the clinical efficacy and safety of Shenzhu Guanxin recipe granules(参术冠心颗粒, SGR) in treating patients with intermediate coronary lesions(ICL), and to investigate the potential mechanism though a transcriptome sequencing approach. METHODS: ICL patients with Qi deficiency and phlegm stasis were adopted and randomly assigned to a case group or a control by random number generator in a 1∶1 randomization ratio to evaluate the clinical efficacy. RESULTS: There was no significant difference between the two groups in coronary computed tomography angiography related indexes in the two groups before and after intervention. Through the gene chip expression analysis, it is finally concluded that there are 355 differential mRNAs(190 up-regulated genes and 165 down regulated genes) when compared the SGR group and placebo group. Through protein-protein interaction network analysis of differentially expressed genes, 10 hub genes were finally obtained: CACNA2D2, CACNA2D3, DNAJC6, FGF12, SGSM2, CACNA1G, LRP6, KIF25, OXTR, UPB1. CONCLUSIONS: SGR combined with Western Medicine can be safely used to treat ICL patients with Qi deficiency and phlegm stasis. The possible mechanism of action and relevant gene loci and pathway were proposed.

关键词： Shenzhu Guanxin recipe granules deficiency and phlegm stasis gene expression profiling intermediate coronary lesions

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The chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn‑soybean meal diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 826-843页

作者： Shengchen Wang bingxin wu Ling Zhu Weiyun Zhang Liyang Zhang We wu Jiaqi wu Yun Hu Tingting Li Xiaoyan Cui Xugang Luo College of Animal Science and Technology Yangzhou UniversityYangzhou 225000People’s Republic of China Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Background Our previous studies demonstrated that divalent organic iron(Fe)proteinate sources with higher complexation or chelation strengths as expressed by the greater quotient of formation(Qf)values displayed higher Fe bioavailabilities for *** iron ethylenediaminetetraacetate(NaFeEDTA)is a trivalent organic Fe source with the strongest chelating ligand ***,the bioavailability of Fe when administered as NaFeEDTA in broilers and other agricultural animals remains ***,the chemical characteristics of 12 NaFeEDTA products were *** these,one feed grade NaFeEDTA(Qf=2.07×10^(8)),one food grade NaFeEDTA(Qf=3.31×10^(8)),and one Fe proteinate with an extremely strong chelation strength(Fe-Prot ES,Qf value=8,590)were *** bioavailabilities relative to Fe sulfate(FeSO_(4)·7H_(2)O)for broilers fed with a conventional corn-soybean meal diet were evaluated during d 1 to 21 by investigating the effects of the above Fe sources and added Fe levels on the growth performance,hematological indices,Fe contents,activities and gene expressions of Fe-containing enzymes in various tissues of *** NaFeEDTA sources varied greatly in their chemical *** Fe concentration(PI),transferrin saturation(TS),liver Fe content,succinate dehydrogenase(SDH)activities in liver,heart,and kidney,catalase(CAT)activity in liver,and SDH mRNA expressions in liver and kidney increased linearly(P<0.05)with increasing levels of Fe ***,differences among Fe sources were detected(P<0.05)only for PI,liver Fe content,CAT activity in liver,SDH activities in heart and kidney,and SDH mRNA expressions in liver and *** on slope ratios from multiple linear regressions of the above indices on daily dietary analyzed Fe intake,the average bioavailabilities of Fe-Prot ES,feed grade NaFeEDTA,and food grade NaFeEDTA relative to the inorganic FeSO_(4)·7H_(2)O(100%)for broilers were 139%,155%,and 166%,***

关键词： Broilers Chelation strengths Fe-containing enzymes NaFeEDTA Relative bioavailabilities

Dietary copper requirement of broilers fed a corn-soybean meal diet during 22—42 d of age

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Animal Nutrition 2024年第1期16卷 96-104页

作者： Ling Zhu Wei wu bingxin wu Yun Hu Liyang Zhang Weiyun Zhang Tingting Li Xiaoyan Cui Feiyu Gao Ding Li Xugang Luo Shengchen Wang Poultry Mineral Nutrition Laboratory College of Animal Science and TechnologyYangzhou UniversityYangzhou 225000China Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

This research was to assess the dietary copper(Cu)requirement of broiler chickens fed a practical cornsoybean meal diet during 22—42 d of age.A total of 288 numbered Arbor Acres male broilers at 22 d of age were randomly allotted 6 treatments with 8 replicate cages(6 broilers per cage)per *** were fed a Cu-unsupplemented corn-soybean meal basal diet(control,containing 7.36 mg Cu/kg)or the basal diet added with 3,6,9,12,or 15 mg Cu/kg from CuSO_(4)·5H_(2)O for 21 ***,asymptotic and broken-line models were fitted and the best fitted models were selected to determine dietary Cu *** results revealed that the contents of Cu in serum and liver,m RNA expression levels of Cu-and zinc-containing superoxide dismutase(CuZnSOD)in liver and monoamine oxidase b(MAO B)in heart,as well as protein expression level of CuZnSOD in liver were affected(P<0.05)by supplemental Cu levels,and the above indices varied linearly and quadratically(P<0.05)with increasing Cu *** Cu requirements assessed according to the best fitted broken-line models(P<0.05)of the above indexes were 10.45—13.81 mg/*** was concluded that mRNA expression levels of CuZnSOD in liver and MAO B in heart,as well as liver CuZnSOD protein expression level were new specific sensitive biomarkers for estimating dietary Cu requirements,and the dietary Cu requirement was recommended to be 14 mg/kg to support Cu metabolic needs related to key Cucontaining enzymes in broilers fed the corn-soybean meal diet during 22—42 d of age,which was higher than the dietary Cu requirement(8 mg/kg)for broilers at the corresponding stage suggested by the Chinese Feeding Standard of Chicken.

关键词： Copper Copper content Gene expression of copper-containing enzyme Requirement Broiler

Graphene-based hemostatic sponge

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Chinese Chemical Letters 2022年第2期33卷 703-713页

作者： bingxin wu Fanglin Du Wenjing A Guofeng Li Xing Wang State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical Technology Beijing100029China

Graphene-based sponge is a novel hemostatic material prepared by chemical cross-link of graphene oxide. It has a fast fluid absorption capacity to quickly absorb blood from wounds, activate clotting pathways, and achieve rapid hemostasis. In addition, graphene-based sponge is also a good platform *** can be prepared by organic cross-linking, compounding with inorganic clay, and adding bioactive factors to enhance coagulation stimulation. By these methods, the hemostatic performance of the sponge is further improved, which shows great potential for application in the field of trauma hemostasis. This article reviews the research progress of graphene-based sponges from three different preparation strategies(organic cross-linking, inorganic compounding and adding bioactive factor), summarizes their hemostatic mechanisms, and prospects the development of graphene-based hemostatic sponges.

关键词： Graphene Hemostatic sponge Composite materials Synergistic effect Coagulation stimulation

抑郁、失眠在针刺治疗下的交互作用:随机对照试验二次分析

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中国针灸 2024年第6期44卷 618-624页

作者：王舢泽高金凤吴炳鑫吴倩温秀云宁百乐梁雪松符文彬广州中医药大学第二临床医学院广东广州510120 广州中医药大学针灸康复临床医学院广东药科大学健康学院

目的:探索优化针刺方案改善抑郁失眠共病患者情绪与失眠症状的交互作用。方法:对一项针刺治疗抑郁失眠共病的多中心随机对照试验进行二次分析。试验将140例抑郁失眠共病患者随机分为优化针刺组(70例,脱落8例)和常规针刺组(70例,脱落8例... 详细信息

目的:探索优化针刺方案改善抑郁失眠共病患者情绪与失眠症状的交互作用。方法:对一项针刺治疗抑郁失眠共病的多中心随机对照试验进行二次分析。试验将140例抑郁失眠共病患者随机分为优化针刺组(70例,脱落8例)和常规针刺组(70例,脱落8例)。常规针刺组针刺印堂、百会及双侧合谷、太冲;优化针刺组在常规针刺组基础上加刺双侧列缺、照海,并于双侧心俞、胆俞及双侧肾俞、安眠两组穴位交替施皮内针疗法。两组均每周治疗2次,连续治疗6周。分别于治疗前后观察两组患者24项汉密尔顿抑郁量表(HAMD-24)及匹兹堡睡眠质量指数(PSQI)评分。采用中介效应分析分别评价PSQI与HAMD-24情绪相关因子的中介效应;根据HAMD-24评分采用潜剖面分析对患者进行亚组分类,并进一步对各亚组进行组间疗效比较。结果:PSQI在优化针刺方案改善抑郁情绪的间接效应为3.052(95%CI[1.407,4.697]),占总效应的77.5%;抑郁情绪在优化针刺方案改善PSQI的间接效应为0.479(95%CI[0.024,0.935]),占总效应的14.8%。潜剖面分析根据抑郁情绪和失眠症状将患者分为3类,仅在抑郁情绪和失眠症状相对较轻的亚组中可见优化针刺方案疗效优于常规针刺方案(PSQI:95%CI[-10.98,-5.44],P<0.001;HAMD-24:95%CI[-12.31,-3.73],P=0.001)。结论:优化针刺方案主要通过改善失眠症状进一步改善抑郁情绪,相比常规针刺方案其在轻症患者中更能体现疗效优势。

关键词：抑郁障碍失眠针刺随机对照试验二次分析中介效应潜剖面分析

饲粮锌缺乏对22~42日龄肉仔鸡生长性能、小肠形态、屏障功能及空肠中紧密连接蛋白mRNA表达的影响

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动物营养学报 2024年第1期36卷 235-244页

作者：吴伟胡阳阳高飞宇张卫云吴炳鑫张丽阳崔小燕李婷婷汪圣晨胡云罗绪刚扬州大学动物科学与技术学院家禽矿物元素营养实验室扬州225009 中国农业科学院北京畜牧兽医研究所矿物元素营养研究室北京100193

本试验旨在研究饲粮锌缺乏对22~42日龄肉仔鸡生长性能、小肠形态、屏障功能及空肠中紧密连接蛋白mRNA表达的影响。试验选用140只1日龄爱拔益加肉仔鸡公雏,1~21日龄统一饲喂正常添加七水合硫酸锌(ZnSO 4·7H 2O)的试验饲粮(实测锌含量为8... 详细信息

本试验旨在研究饲粮锌缺乏对22~42日龄肉仔鸡生长性能、小肠形态、屏障功能及空肠中紧密连接蛋白mRNA表达的影响。试验选用140只1日龄爱拔益加肉仔鸡公雏,1~21日龄统一饲喂正常添加七水合硫酸锌(ZnSO 4·7H 2O)的试验饲粮(实测锌含量为84.40 mg/kg);22日龄时,从中选取体重接近的112只肉仔鸡,采用单因子完全随机试验设计,随机分为2组(每组7个重复,每个重复8只鸡),对照组饲喂满足肉仔鸡锌需要量的试验饲粮(基础饲粮中添加40 mg/kg锌,实测锌含量为64.36 mg/kg),锌缺乏组饲喂不添加锌的试验饲粮(基础饲粮中不添加锌,实测锌含量为22.23 mg/kg)。试验期42 d。结果表明,与对照组相比:1)锌缺乏组22~42日龄肉仔鸡料重比显著增加(P<0.05);2)锌缺乏组42日龄肉仔鸡十二指肠和空肠隐窝深度显著增加(P<0.05),42日龄肉仔鸡十二指肠、空肠和回肠绒毛高度/隐窝深度以及空肠绒毛高度和绒毛表面积显著降低(P<0.05);3)锌缺乏组42日龄肉仔鸡翅静脉和肝门静脉血清二胺氧化酶活性和异硫氰酸荧光素-葡聚糖含量显著增加(P<0.05);4)锌缺乏组42日龄肉仔鸡空肠中黏膜闭合蛋白-1(Claudin-1)的mRNA表达水平显著降低(P<0.05)。综上所述,饲粮锌缺乏可能通过降低紧密连接蛋白Claudin-1的mRNA表达而损伤肉仔鸡小肠黏膜完整性和屏障功能,进而降低其饲料转化效率。

关键词：锌缺乏肉仔鸡生长性能肠道屏障功能紧密连接蛋白

乙二胺四乙酸铁钠对肉仔鸡生长性能和组织中铜、锌和锰元素沉积的影响

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中国家禽 2024年第3期46卷 30-36页

作者：吴炳鑫朱玲李鼎高飞宇吴伟胡云崔小燕李婷婷张丽阳汪圣晨罗绪刚扬州大学动物科学与技术学院江苏扬州225009 中国农业科学院北京畜牧兽医研究所北京100193

试验旨在研究饲粮添加乙二胺四乙酸铁钠(NaFeEDTA)对肉仔鸡生长性能和不同组织中铜、锌和锰沉积的影响。试验按3(铁源)×3(添加铁水平)+1(不加铁对照组)双因子完全随机试验设计,将560只1日龄AA肉公鸡随机分成10组,每组7个重复,每个重复... 详细信息

试验旨在研究饲粮添加乙二胺四乙酸铁钠(NaFeEDTA)对肉仔鸡生长性能和不同组织中铜、锌和锰沉积的影响。试验按3(铁源)×3(添加铁水平)+1(不加铁对照组)双因子完全随机试验设计,将560只1日龄AA肉公鸡随机分成10组,每组7个重复,每个重复8只鸡,分别饲喂未添加铁的玉米-豆粕型基础日粮(对照组)和在此基础日粮中分别添加20、40和60 mg/kg铁(分别源于硫酸亚铁(FeSO_(4)·7H_(2)O)、饲料级NaFeEDTA和食品级NaFeEDTA的饲粮21 d。结果显示:与FeSO_(4)·7H_(2)O组相比,饲粮添加不同来源的NaFeEDTA对肉仔鸡生长性能无显著影响(P>0.05);食品级和饲料级NaFeEDTA组心脏中铜、胫骨中锌以及肝脏和胫骨中锰元素的含量显著提高(P<0.05)。由此可见,添加NaFeEDTA从整体上促进了肉仔鸡心脏中铜、胫骨中锌以及肝脏和胫骨中锰元素的沉积。

关键词：肉仔鸡乙二胺四乙酸铁钠铁水平生长性能矿物元素沉积

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电镀液添加剂成分对钯镀层的影响研究

电镀与精饰 2024年第8期46卷 11-17页

作者：奚菊芳武冰鑫唐振艳刘朝能李江民侯文明戴云生云南贵金属实验室有限公司云南昆明650000 贵研化学材料(云南)有限公司云南昆明650000 云南大学生命科学学院云南昆明650000

采用二氯四氨钯为主盐,润湿剂A、光亮剂B、稳定剂C为组合添加剂配制成电镀液,进行侯氏槽测试,电沉积获得钯镀层。通过设计正交试验对添加剂的组成及含量进行了筛选,采用扫描电子显微镜、X射线衍射表征了钯镀层的形貌和结构,考察了添加... 详细信息

采用二氯四氨钯为主盐,润湿剂A、光亮剂B、稳定剂C为组合添加剂配制成电镀液,进行侯氏槽测试,电沉积获得钯镀层。通过设计正交试验对添加剂的组成及含量进行了筛选,采用扫描电子显微镜、X射线衍射表征了钯镀层的形貌和结构,考察了添加剂组分及含量对镀钯层表观形貌、微观形貌以及硬度的影响。正交试验研究结果表明:在电流密度0.85 A/dm^(2)、镀液pH 8.0,50℃施镀20 min的电镀工艺下,添加剂中稳定剂含量对于电沉积的影响较为明显,稳定剂含量大的镀层外观和硬度比较好,而光亮剂和润湿剂起辅助性作用。稳定剂与钯离子络合,阻止钯离子被还原,提高了镀液稳定性;光亮剂吸附在阴极表面,增大阴极极化值,形成活性位点,提高了晶核的生成速度,能够获得结晶细致紧密的镀层;润湿剂降低了阴极电沉积过程中产生的氢气气泡附着力,扩展了低电流区镀层,提高抗杂质干扰能力使镀层光亮平整。添加剂中各组分的协同提高了镀液整平能力及低电流密度区镀层光亮性,获得的纯钯镀层阴极电流密度范围更宽。

关键词：钯镀层电沉积镀液添加剂

Construction and Analysis of an LncRNA-miRNA-mRNA Network Based on Competitive Endogenous RNA Reveal miRNAs Potentially Involved in In-stent Restenosis after Percutaneous Coronary Intervention

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Cardiology Discovery 2023年第4期3卷 239-248页

作者： Xiao Jin bingxin wu Li Han Xiaofeng Zhu Department of Traditional Chinese Medicine The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)GuangzhouGuangdong 510120China

Objective:Percutaneous coronary intervention is one of the most common procedures used for the invasive treatment of patients with coronary heart disease;the incidence of in-stent restenosis(ISR)after percutaneous coronary intervention is 5%to 15%.In this study,a competitive endogenous RNA(ceRNA)network was constructed to investigate potential mechanisms involved in ***:The expression data for differentially expressed microRNAs(DEmiRNAs)and messenger RNAs(mRNAs)between patients with and without ISR were obtained using limma *** noncoding RNAs(lncRNAs)were predicted based on the DEmiRNAs using the miRDB,miRTarBase,and TargetScan *** ISR-specific ceRNA network was subsequently constructed and *** verify the key miRNAs of ceRNA,patients with and without ISR were enrolled from Guangdong Provincial Hospital of Chinese Medicine between January 2017 and December 2018(n=8,respectively);plasma was collected from all enrolled ***:Based on the raw data obtained from the Gene Expression Omnibus database,472 DEmiRNAs and 304 differentilly expressed messenger RNAs between patients with and without ISR were identified.A ceRNA network was constructed by combining 270 IncRNAs,3 miRNAs(miR-125,miR-140,and miR-206),and 4 mRNAs(STRADB,TKT,PCTP,and BTG2).The hub genes of the ceRNA network of ISR included the following:miR-125,miR-206,miR-140,PCDHB9,CASC2,BAK1P1,CSPG4P3Y,CSPG4P4Y,STRCP1,and *** of miRNAs of ceRNA also showed that the expression of miR-206 was upregulated in patients with ISR *** without ISR(P<0.05).In contrast,the expression of miR-140 and miR-125 was downregulated in patients with ISR *** without ISR(P<0.05).Conclusions:This study constructed noncoding RNA-related ceRNA networks for *** results indicated that miR-206,miR-125,and miR-140 may be biomarkers of ISR.

关键词： Percutaneous coronary intervention In-stent restenosis Competitive endogenous RNA Gene Expression Omnibus datasets

饲粮氯化钠缺乏或过量对22~42日龄肉仔鸡生长性能、肠道形态、盲肠菌群及短链脂肪酸含量的影响

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中国家禽 2024年第4期46卷 40-46页

作者：高飞宇张卫云李鼎张丽阳吴炳鑫吴伟朱玲胡云崔小燕汪圣晨李婷婷罗绪刚扬州大学动物科学与技术学院江苏扬州225009 中国农业科学院北京畜牧兽医研究所北京100193

试验旨在研究饲粮氯化钠缺乏或过量对22~42日龄肉仔鸡生长性能、肠道形态、盲肠菌群和短链脂肪酸含量的影响。144只22日龄AA+肉公鸡按平均体重随机分3组,每组8个重复,分别饲喂氯化钠缺乏(0.00%)、适量(0.20%)和过量(0.50%)3种饲粮。结... 详细信息

试验旨在研究饲粮氯化钠缺乏或过量对22~42日龄肉仔鸡生长性能、肠道形态、盲肠菌群和短链脂肪酸含量的影响。144只22日龄AA+肉公鸡按平均体重随机分3组,每组8个重复,分别饲喂氯化钠缺乏(0.00%)、适量(0.20%)和过量(0.50%)3种饲粮。结果显示:与氯化钠适量组相比,氯化钠缺乏显著降低42日龄肉仔鸡体重、空肠隐窝深度、盲肠菌群多样性、22~42日龄平均日采食量、平均日增重和平均日饮水量(P<0.05),显著提高42日龄盲肠厚壁菌门和考拉杆菌属相对丰度及丁酸含量(P<0.05);氯化钠过量显著降低42日龄空肠隐窝深度、拟杆菌门和另支菌属相对丰度(P<0.05),显著提高变形菌门、酸杆菌门、芽单胞菌门和绿弯菌门相对丰度(P<0.05)。研究表明,氯化钠缺乏或过量均影响肉仔鸡肠道形态、盲肠菌群结构和多样性;氯化钠缺乏可能通过降低采食量、盲肠菌群多样性及改变盲肠菌群结构而抑制肉仔鸡生长性能。

关键词：肉鸡氯化钠生长性能肠道形态盲肠菌群短链脂肪酸