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Real-time arrival picking of rock microfracture signals based on convolutional-recurrent neural network and its engineering application

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 761-777页

作者： bing-rui chen Xu Wang Xinhao Zhu Qing Wang Houlin Xie State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Accurately picking P-and S-wave arrivals of microseismic(MS)signals in real-time directly influences the early warning of rock mass failure.A common contradiction between accuracy and computation exists in the current arrival picking ***,a real-time arrival picking method of MS signals is constructed based on a convolutional-recurrent neural network(CRNN).This method fully utilizes the advantages of convolutional layers and gated recurrent units(GRU)in extracting short-and long-term features,in order to create a precise and lightweight arrival picking ***,the synthetic signals with field noises are used to evaluate the hyperparameters of the CRNN model and obtain an optimal CRNN *** actual operation on various devices indicates that compared with the U-Net method,the CRNN method achieves faster arrival picking with less performance *** application of large underground caverns in the Yebatan hydropower station(YBT)project shows that compared with the short-term average/long-term average(STA/LTA),Akaike information criterion(AIC)and U-Net methods,the CRNN method has the highest accuracy within four sampling points,which is 87.44%for P-wave and 91.29%for S-wave,*** sum of mean absolute errors(MAESUM)of the CRNN method is 4.22 sampling points,which is lower than that of the other *** the four methods,the MS sources location calculated based on the CRNN method shows the best consistency with the actual failure,which occurs at the junction of the shaft and the second ***,the proposed method can pick up P-and S-arrival accurately and rapidly,providing a reference for rock failure analysis and evaluation in engineering applications.

关键词： Rock mass failure Microseismic event P-wave arrival S-wave arrival Deep learning

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Genome-wide analysis of AP2/ERF superfamily in Isatis indigotica

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Journal of Integrative Medicine 2023年第1期21卷 77-88页

作者： Liang Xiao Jun-ze Ren Qing Li Bin Yang Zhen-jiang Liu rui-bing chen Lei Zhang Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China Medical School of Nantong University Nantong 226001Jiangsu ProvinceChina Department of Pharmacy Changzheng HospitalNaval Medical UniversityShanghai 200433China School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China

Objective AP2/ERF(APETALA2/ethylene-responsive factor)superfamily is one of the largest gene families in plants and has been reported to participate in various biological processes,such as the regulation of biosynthesis of active ***,few studies have investigated the genome-wide role of the AP2/ERF superfamily in Isatis *** study establishes a complete picture of the AP2/ERF superfamily in *** and contributes valuable information for further functional characterization of IiAP2/ERF genes and supports further metabolic *** To identify the IiAP2/ERF superfamily genes,the AP2/ERF sequences from Arabidopsis thaliana and Brassica rapa were used as query sequences in the basic local alignment search *** analyses were conducted to investigate the protein structure,motif composition,chromosome location,phylogenetic relationship,and interaction network of the IiAP2/ERF superfamily *** accuracy of omics data was verified by quantitative polymerase chain reaction and heatmap *** One hundred and twenty-six putative IiAP2/ERF genes in total were identified from the *** genome database in this *** sequence alignment and phylogenetic analysis,the IiAP2/ERF genes were classified into 5 groups including AP2,ERF,DREB(dehydration-responsive element-binding factor),Soloist and RAV(related to abscisic acid insensitive 3/viviparous 1)*** which,122 members were unevenly distributed across seven *** alignment showed that *** and *** had 30 pairs of orthologous genes,and we constructed their interaction *** comprehensive analysis of gene expression pattern in different tissues suggested that these genes may play a significant role in organ growth and development of *** that may regulate lignan biosynthesis in roots were also preliminarily *** acid sequencing analysis revealed that the expression of 76 IiAP2

关键词： Isatis indigotica AP2/ERF Genomean alysis Expression pattern Lignan biosynthesis

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Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum

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Cancer Biology & Medicine 2015年第3期12卷 246-254页

作者： Hua-Jun Gao Ya-Jing chen Duo Zuo Ming-Ming Xiao Ying Li Hua Guo Ning Zhang rui-bing chen Research Center of Basic Medical Sciences & School of Medical Laboratory Tianjin Medical University Laboratory of Cancer Cell Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Prevention and Therapy

Objective： Hepatocellular carcinoma （HCC） is a leading cause of cancer-related deaths. Novel serum biomarkers are required to increase the sensitivity and specificity of serum screening for early HCC diagnosis. This study employed a quantitative proteomic strategy to analyze the differential expression of serum glycoproteins between HCC and normal control serum samples. Methods： Lectin affinity chromatography （LAC） was used to enrich glycoproteins from the serum samples. Quantitative mass spectrometric analysis combined with stable isotope dimethyl labeling and 2D liquid chromatography （LC） separations were performed to examine the differential levels of the detected proteins between HCC and control serum samples. Western blot was used to analyze the differential expression levels of the three serum proteins. Results： A total of 2,280 protein groups were identified in the serum samples from HCC patients by using the 2D LC-MS/MS method. Up to 36 proteins were up-regulated in the HCC serum, whereas 19 proteins were down-regulated. Three differential glycoproteins, namely, fibrinogen gamma chain （FGG）, FOS-like antigen 2 （FOSL2）, and a-l, 6-mannosylglycoprotein 6-^-N-acetylglucosaminyltransferase B （MGATSB） were validated by Western blot. All these three proteins were up-regulated in the HCC serum samples. Conclusion： A quantitative glycoproteomic method was established and proven useful to determine potential novel biomarkers for HCC.

关键词： Glycoprotein hepatocellular carcinoma (HCC) mass spectrometry proteomics serum

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Simultaneous Determination of Two Major Triterpenoid Saponins:Celosins Ⅰ and Ⅱ in Celosiae Semen by HPLC-ELSD

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Chinese Herbal Medicines 2015年第2期7卷 185-190页

作者： rui-bing chen Yu-yang Zhang Jian-ming He Wen-dan Wu Mei-li Guo Department of Pharmacognosy School of Pharmacy Second Military Medical University Health Team of Zhoucun Airforce Station

Objective To establish an analytical method for the simultaneous determination of celosin Ⅰ and celosin Ⅱ, two major triterpenoids in Celosia Semen and compare the contents of celosin Ⅰ and celosin Ⅱ from different habitats to screen the resources of elite germplasm for further applications. Methods A sensitive and simple high- performance liquid chromatography coupled with evaporative light-scattering detector（HPLC-ELSD） method was developed for the first time for the simultaneous determination of celosin Ⅰ and celosin Ⅱ. Using this method, 21 batches of Celosiae Semen were determined from different habitats in China. Results There was an obvious difference in the contents of celosin Ⅰ and celosin Ⅱ among Celosiae Semen species from various habitats across China. The crude drug from Yongzhou, Hunan province, Zhuhai, Guangdong province, and Nanning, Guangxi province showed the highest contents of all habitats, while Anguo, Hebei province, Haidian, Beijing, and Zhengzhou, Henan province showed the lowest content. The results also showed that geographical location had a great influence on the contents of the two compounds. The batches from lower latitudes were higher in contents of celosin Ⅰ and celosin Ⅱ. Conclusion The sun light may be a key factor influencing the contents of the two saponins, indicating that the environment has a great impact on the quality of Celosiae Semen.

关键词： Celosiae Semen HPLC-ELSD quantitative determination triterpenoids celosin

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EFFECT OF SENSOR ARRAY GEOMETRY ON MICROSEISMIC SOURCE LOCATION ALGORITHMS

EFFECT OF SENSOR ARRAY GEOMETRY ON MICROSEISMIC SOURCE LOCAT...

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The 7th International Symposium on Rockburst and Seismicity in Mines(RaSiM7)

作者： bing-rui chen,XIA-TING FENG State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,the Chinese Academy of Sciences,Wuhan 430071,P.R.China

The algorithms of source location can be classified into four classes in terms of required solved parameters theoretically:firstly,velocity structure is given,and locations of microseismic sources and time of microseismic occurrence are identified on basis of arrival time recorded;secondly,given locations of microseismic sources, velocity structure and time of microseismic occurrence are solved in terms of arrival time;thirdly,velocity structure and locations of microseismic sources are inversed based on the time difference of sensor-pairs;lastly,velocity structure,locations of microseismic sources and time of microseismic occurrence are recognized together based on arrival *** effect of sensor array geometry on the four algorithms of source location is studied systematacially. Studies show that velocity of convergence is faster and precision of convergence is higher in ranges of sensor array than out of sensor array for the first algorithm;if only sensors can receive microseismic signals,the solution is unique and sensor locations are unlimited theoretically for the second conditions;the same association characteristics are found for the last two algorithms by theoretical analysis and the necessary condition that the association occurs, isΔL/V=Δ*** to improve precision of source location,the different algorithms should adopt different strategy for acquiring good sensor array geometry.

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Location method of ill-conditioned microseismic source and its engineering application

Deep Resources Engineering

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Deep Resources Engineering 2024年第3期1卷 30-42页

作者： bing-rui chen Tao Li Xinhao Zhu Xu Wang Qing Wang Canxun Du Sanlin Du Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang 110819China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanHubei 430071China University of Chinese Academy of Sciences Beijing 100049China Huaneng Tibet Hydropower Safety Engineering Technology Research Center NyingchiTibet 860061China

Microseismic event location is one of the core parameters in microseismic monitoring,and the accuracy of localization will directly affect the effectiveness of engineering ***,limited by spatial factors,the geometry of the sensor installation will be close to linear,which makes the localization equation suffer from the pathological problem,and the localization accuracy is greatly *** address this problem,the reasons for the pathological problem are analyzed from the perspective of the objective function residuals and coefficient *** pathological problem is caused by the combined effect of the poorer sensor array and data errors,and its residual isosurface shows a conical distribution,and as the residual value decreases,the apex of the isosurface gradually extends to the far side,and the localization results do not *** this reason,an improved regularized Newton downhill localization algorithm is *** this method,firstly,the Newtonian downhill method is improved so that the magnitudes of the seismic source parameters are the same,and the condition number of the coefficient matrix is reduced;then,the L-curve method is used to calculate the regularization factor for the pathological equations,and the coefficient matrix is improved;finally,the pathological equations are regularized,and the seismic source coordinates are obtained by the improved Newtonian downhill *** results of engineering applications show that compared with the traditional algorithm based on automatic of P-arrival picking,the number of effective microseismic events calculated by the proposed localization algorithm is increased by 194.7%,and the localization accuracy is substantially *** proposed algorithm reduces the problem of low accuracy of S-arrival picking and allows localization using only P-wave *** method reduces the quality requirements of the data and significantly improves the utilization of microseismic events and positi

关键词： Microseismic Location method III-conditioned problem Condition number singular value Regularization Newton downhill method

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肉制品加工中有害物检测及控制技术研究进展

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食品安全质量检测学报 2017年第6期8卷 1954-1960页

作者：张苏苏苑冰冰赵子瑞陈治旭张凌周亚军吉林大学食品科学与工程学院长春130062

随着人们生活水平的提高,肉制品的消费量日益增多,肉制品的安全性也倍受广大消费者的关注。肉制品加工过程中带来或产生的亚硝胺类、杂环胺类、多环芳烃类以及生物胺类等有害物质,一定程度上会危害消费者健康。有关这些有害物质的检测... 详细信息

随着人们生活水平的提高,肉制品的消费量日益增多,肉制品的安全性也倍受广大消费者的关注。肉制品加工过程中带来或产生的亚硝胺类、杂环胺类、多环芳烃类以及生物胺类等有害物质,一定程度上会危害消费者健康。有关这些有害物质的检测与控制技术已成为肉品科学领域中的研究热点,国内外学者对此展开了大量的研究。本文综述了高效液相色谱法、气相色谱法、液相色谱-质谱法和毛细管电泳法等技术在肉制品有害物检测中的应用研究进展,并阐述了肉制品加工中的有害物质(亚硝酸盐及亚硝胺类、杂环胺类、多环芳烃类以及生物胺类)的控制技术,为建立肉制品加工中有害物质的高效准确检测方法及控制技术提供理论参考。

关键词：肉制品加工有害物质检测控制

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