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Sporadic gastrinoma with refractory benign esophageal stricture:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1284-1289页

作者： Qian-Nan Chen Bing-Qing bai Yan Xu qiao Mei Xiao-Chang liu Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Gastrinoma is characterized by an excessive release of gastrin,leading to hypersecretion of gastric acid,subsequently resulting in recurrent peptic ulcers,chronic diarrhea,and even esophageal strictures.This case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture(RBES).Additionally,it highlights the persistent challenges that gastroenterologists encounter in managing RBES.CASE SUMMARY This case demonstrates a patient with gastrinoma who developed RBES and complete esophageal obstruction despite management with maximal acid suppressive therapy,multiple endoscopic bougie dilations and endoscopic incisional therapy(EIT).CONCLUSION It is essential to diagnose gastrinoma as early as possible,as inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal strictures.In patients with esophageal strictures causing complete luminal obstruction,blind reopening EIT presents challenges and carries a high risk of perforation.

关键词： Gastrinoma Zollinger-Ellison syndrome Neuroendocrine neoplasm Chronic diarrhea Refractory benign esophageal stricture Case report

A visible-light-assisted Pd/TiO_(2)gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

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Rare Metals 2024年第1期43卷 257-266页

作者： Can liu qiao-qiao Zou Bin liu Yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment management.However,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to capture.Herein,a visible-light-assisted Pd/TiO_(2)gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating temperature.Benefiting from the enhanced photocatalytic properties of TiO_(2)by Pd decoration,the visible-light-assisted Pd/TiO_(2)gas sensor can detect the HCHO gas as low as80×10^(–9)at room temperature.The successful preparation of nanoscale TiO_(2)sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal electrode.In addition,the whole preparation process of the Pd/TiO_(2)gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas sensors.It is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2) Trace HCHO detection Carbon nanotubes electrodes

Adolescent suicide risk factors and the integration of socialemotional skills in school-based prevention programs

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World Journal of Psychiatry 2024年第4期14卷 494-506页

作者： Xin-qiao liu Xin Wang School of Education Tianjin UniversityTianjin 300350China

Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of suicide.Psychological,social,family,individual,and environmental factors are important risk factors for suicidal behavior among teenagers and may contribute to suicide risk through various direct,indirect,or combined pathways.Social-emotional learning is considered a powerful intervention measure for addressing the crisis of adolescent suicide.When deliberately cultivated,fostered,and enhanced,selfawareness,self-management,social awareness,interpersonal skills,and responsible decision-making,as the five core competencies of social-emotional learning,can be used to effectively target various risk factors for adolescent suicide and provide necessary mental and interpersonal support.Among numerous suicide intervention methods,school-based interventions based on social-emotional competence have shown great potential in preventing and addressing suicide risk factors in adolescents.The characteristics of school-based interventions based on social-emotional competence,including their appropriateness,necessity,cost-effectiveness,comprehensiveness,and effectiveness,make these interventions an important means of addressing the crisis of adolescent suicide.To further determine the potential of school-based interventions based on social-emotional competence and better address the issue of adolescent suicide,additional financial support should be provided,the combination of socialemotional learning and other suicide prevention programs within schools should be fully leveraged,and cooperation between schools and families,society,and other environments should be maximized.These efforts should be considered future research directions.

关键词： Adolescent suicide Risk factors Social-emotional skills Social and emotional learning School Prevention

Unlocking the power of physical activity in easing psychological distress

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World Journal of Psychiatry 2024年第1期14卷 1-7页

作者： Xin-qiao liu Xin Wang School of Education Tianjin UniversityTianjin 300350China

The severity of the current global mental health situation and the importance of maintaining psychological well-being call for more powerful,convenient,and efficient solutions for addressing psychological issues and relieving mental stress.Physical activity not only effectively improves physical fitness and reduces negative emotions such as anxiety and depression but also increases the improvement of psychological health and sense of well-being.At the same time,physical activity interventions for mental health have unique advantages,including reducing the side effects of psychological interventions and increasing necessity,convenience,and cost-effectiveness,as well as flexible adaptability across multiple methods,groups,and age ranges,providing stronger support for relieving psychological stress and addressing psychological issues.Although physical activity is an important intervention measure in relieving psychological stress,its value and role in mental health care seem to have not yet received sufficient attention,and its potential remains to be further revealed.Given the significant advantages and effectiveness of physical activity in mental health intervention practices,it is necessary to stimulate its potential in relieving psychological stress through various means in future studies to better safeguard the public’s physical and mental health.Developing guidelines for physical activity for improved mental health,enhancing organic integration with other intervention measures,and providing necessary respect,encouragement,and support are important directions to consider.

关键词： Physical activity Psychological distress Mental health Artificial intelligence Guidance

A Converse Theorem for Split SO_(2l) over Finite Fields

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Acta Mathematica Sinica,English Series 2024年第3期40卷 731-771页

作者： Alexander HAZELTINE bai Ying liu Department of Mathematics Purdue University150 N.University St.West LafayetteIN 47907USA E-mail:ahazelti@purdue.edu liu2053@purdue.edu

We prove a converse theorem for split even special orthogonal groups over finite fields.This is the only case left on converse theorems of classical groups and the difficulty is the existence of the outer automorphism... 详细信息

关键词： Converse theorems generic cuspidal representations even special orthogonal groups

Cooperative Covert Communication in Multi-Antenna Broadcast Channels

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China Communications 2024年第6期21卷 246-260页

作者： qiao Sen liu Guangjie Ji Xiaopeng liu Weiwei School of Electrical and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China School of Automation Nanjing University of Science and TechnologyNanjing 210094China

With the gradual popularization of 5G communications,the application of multi-antenna broadcasting technology has become widespread.Therefore,this study aims to investigate the wireless covert communication in the two-user cooperative multi-antenna broadcast channel.We focus on the issue that the deteriorated reliability and undetectability are mainly affected by the transmission power.To tackle this issue,we design a scheme based on beamforming to increase the reliability and undetectability of wireless covert communication in the multi-antenna broadcast channel.We first modeled and analyzed the cooperative multi-antenna broadcasting system,and put forward the target question.Then we use the SCA(successive convex approximation)algorithm to transform the target problem into a series of convex subproblems.Then the convex problems are solved and the covert channel capacity is calculated.In order to verify the effectiveness of the scheme,we conducted simulation verification.The simulation results show that the proposed beamforming scheme can effectively improve the reliability and undetectability of covert communication in multi-antenna broadcast channels.

关键词： beamforming covert communication multi-antenna broadcast channels OFDM

NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis

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Journal of Integrative Plant Biology 2024年第1期66卷 54-65页

作者： qiao‐Yun Zhu Lin‐Lin Zhang Jian‐Xiang liu State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China

Plants are highly susceptible to abiotic stresses,particularly heat stress during the reproductive stage.However,the specific molecular mechanisms underlying this sensitivity remain largely unknown.In the current study,we demonstrate that the Nuclear Transcription Factor,X-box Binding Protein 1-Like 1(NFXL1),directly regulates the expression of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A(DREB2A),which is crucial for reproductive thermotolerance in Arabidopsis.NFXL1 is upregulated by heat stress,and its mutation leads to a reduction in silique length(seed number)under heat stress conditions.RNA-Seq analysis reveals that NFXL1 has a global impact on the expression of heat stress responsive genes,including DREB2A,Heat Shock Factor A3(HSFA3)and Heat Shock Protein 17.6(HSP17.6)in flower buds.Interestingly,NFXL1 is enriched in the promoter region of DREB2A,but not of either HSFA3 or HSP17.6.Further experiments using electrophoretic mobility shift assay have confirmed that NFXL1 directly binds to the DNA fragment derived from the DREB2A promoter.Moreover,effector-reporter assays have shown that NFXL1 activates the DREB2A promoter.The DREB2A mutants are also heat stress sensitive at the reproductive stage,and DEREB2A is epistatic to NFXL1 in regulating thermotolerance in flower buds.It is known that HSFA3,a direct target of DREB2A,regulates the expression of heat shock proteins genes under heat stress conditions.Thus,our findings establish NFXL1 as a critical upstream regulator of DREB2A in the transcriptional cassette responsible for heat stress responses required for reproductive thermotolerance in Arabidopsis.

关键词： Arabidopsis DREB2A heat stress NFXL1 reproductive thermotolerance

Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cell 2024年第4期15卷 239-260页

作者： Jia-Hao Dai Xi-Rong Tan Han qiao Na liu State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical evaluation.As promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly appreciated.Here,recent progress in this field is reviewed.We describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,respectively.In addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,including chemotherapy,radiotherapy,and immunotherapy.Given that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these strategies.This review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.

关键词： microbiome cancer diagnosis prognosis therapy

Potential use of large language models for mitigating students’problematic social media use:ChatGPT as an example

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World Journal of Psychiatry 2024年第3期14卷 334-341页

作者： Xin-qiao liu Zi-Ru Zhang School of Education Tianjin UniversityTianjin 300350China

The problematic use of social media has numerous negative impacts on individuals'daily lives,interpersonal relationships,physical and mental health,and more.Currently,there are few methods and tools to alleviate problematic social media,and their potential is yet to be fully realized.Emerging large language models(LLMs)are becoming increasingly popular for providing information and assistance to people and are being applied in many aspects of life.In mitigating problematic social media use,LLMs such as ChatGPT can play a positive role by serving as conversational partners and outlets for users,providing personalized information and resources,monitoring and intervening in problematic social media use,and more.In this process,we should recognize both the enormous potential and endless possibilities of LLMs such as ChatGPT,leveraging their advantages to better address problematic social media use,while also acknowledging the limitations and potential pitfalls of ChatGPT technology,such as errors,limitations in issue resolution,privacy and security concerns,and potential overreliance.When we leverage the advantages of LLMs to address issues in social media usage,we must adopt a cautious and ethical approach,being vigilant of the potential adverse effects that LLMs may have in addressing problematic social media use to better harness technology to serve individuals and society.

关键词： Problematic use of social media Social media Large language models ChatGPT Chatbots