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Mathematical assessment of the roles of age heterogeneity and vaccination on the dynamics and control of SARS-CoV-2

Infectious Disease Modelling 2024年第3期9卷 828-874页

作者： binod Pant Abba b.Gumel Department of Mathematics University of MarylandCollege ParkMD20742USA Department of Mathematics and Applied Mathematics University of PretoriaPretoria0002South Africa

The COVID-19 pandemic,caused by SARS-CoV-2,disproportionately affected certain segments of society,particularly the elderly population(which suffered the brunt of the burden of the pandemic in terms of severity of the disease,hospitalization,and death).This study presents a generalized multigroup model,with m heterogeneous sub-populations,to assess the population-level impact of age heterogeneity and vaccination on the transmission dynamics and control of the SARS-CoV-2 pandemic in the United *** analysis of the model for the homogeneous case(i.e.,the model with m=1)reveal that its disease-free equilibrium is globally-asymptotically stable for two special cases(with perfect vaccine efficacy or negligible disease-induced mortality)whenever the associated reproduction number is less than *** model has a unique and globally-asymptotically stable endemic equilibrium,for special a case,when the associated reproduction threshold exceeds *** homogeneous model was fitted using the observed cumulative mortality data for the United States during three distinct waves(Waves A(October 17,2020 to April 5,2021),b(July 9,2021 to November 7,2021)and C(January 1,2022 to May 7,2022))chosen to align with time periods when the Alpha,Delta and Omicron were,respectively,the predominant variants in the United *** calibrated model was used to derive a theoretical expression for achieving vaccine-derived herd immunity(needed to eliminate the disease in the United States).It was shown that,using the one-group homogeneous model,vaccine-derived herd immunity is not attainable during Wave C of the pandemic in the United States,regardless of the coverage level of the fully-vaccinated *** sensitivity analysis was carried out to determine the parameters of the model that have the most influence on the disease dynamics and *** analyses reveal that control and mitigation strategies that may be very effective during one wave may not be so very effecti

关键词： COVID-19 SARS-CoV-2 Heterogeneous model Reproduction number Herd immunity

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Neuroendocrine facets of behavior and toxicology

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Aquaculture and Fisheries 2024年第3期9卷 337-338页

作者： Keith b.Tierney balasubramanian Senthilkumaran Department of biological Sciences and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada Department of Animal biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

Professor ***,who I came to know as Senthil,came over to visit the University of Alberta in the summer of 2022 in connection with his Global Ambassador Fellowship program at University of Saskatechewan,***,there was that reason to visit,but there was another one as well,one that tied us *** years before Senthil had been considered for a postdoctoral fellowship with the legend that was Dick ***,it didn’t materialize and then he moved to Japan to do his Post Doc Under *** *** had been Dean and a preeminent endocrinologist at the U of A.I came to know Dick near the end of my PhD;he had brought me out to bamfield Marine Sciences Centre to carryout research using their then-new,and very expensive,simulated *** left an incredible mark on all of us that knew him;he represented all that was wonderful and achievable in *** spent time with him was akin to shaking Sinatra’s hand,at least in the world of biology in that *** this common history,Senthil and I were fast friends.

关键词： Canada shaking carry

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Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreochromis mossambicus

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Aquaculture and Fisheries 2024年第3期9卷 339-346页

作者： Jyoti A.Kumbar C.b.Ganesh Neuroendocrinology Research Laboratory Department of Studies in ZoologyKarnatak UniversityDharwad580003India

Urotensin-I(UI)is a peptide belonging to the corticotropin-releasing hormone family,produced in the urophysis of *** investigation was undertaken to examine the effect of UI on the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,a cichlid *** the first experiment,administration of UI(2μg/100μL saline)for 22 days caused a significant reduction in the number of follicles at stages I,II,III(previtellogenic),IV(vitellogenic),and V(preovulatory),concomitant with a significant increase in the percent atresia of follicles at stages II,III,and IV than in *** the pituitary,gonadotropin-releasing hormone(GnRH)-positive fibres were detected in the proximal pars distalis(PPD)in both controls and UI-treated fish;however,there was a significant reduction in the intensity and percent area of GnRH-immunoreactive fibres in fish treated with UI compared with *** serum luteinizing hormone(LH)level was significantly lower,whereas a significant rise in the serum level of cortisol was noticed in UI-treated fish compared with *** the second experiment,treatment with a low dose of UI(10 mM)did not affect the number of ACTH-secreting cells in vitro,but the number of these cells was significantly higher in high-dose UI(50 mM)-treated pituitaries compared to ***,the present investigation reveals for the first time that the treatment of UI affects the follicular development process through the downregulation of the GnRH-LH axis and activation of the pituitary-interrenal pathway in teleosts.

关键词： Urotensin-I CRH family Gonadotropin-releasing hormone Luteinizing hormone Ovary Oreochromis mossambicus

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Numerical Simulation of Thermocapillary Convection with Evaporation Induced by boundary Heating

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1667-1686页

作者： O.N.Goncharova V.b.bekezhanova Altai State University Institute of Mathematics and Information TechnologiesBarnaul656049Russia Institute of Computational Modelling Sb RAS Department of Differential Equations of MechanicsKrasnoyarsk660036Russia

The dynamics of a bilayer system filling a rectangular cuvette subjected to external heating is *** influence of two types of thermal exposure on the flow pattern and on the dynamic contact angle is *** particular,the cases of local heating from below and distributed thermal load from the lateral walls are *** simulation is carried out within the frame of a two-sided evaporative convection model based on the boussinesq approximation.A benzine–air system is considered as reference *** variation in time of the contact angle is described for both heating *** lateral heating,near-wall boundary layers emerge together with strong convection,whereas the local thermal load from the lower wall results in the formation of multicellular motion in the entire volume of the fluids and the appearance of transition regimes followed by a steady-state *** results of the present study can aid the design of equipment for thermal coating or drying and the development of methods for the formation of patterns with required structure and morphology.

关键词： Thermocapillary convection two-phase system numerical modeling contact angle

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Nonlinear corrections for the nuclear gluon distribution in eA processes

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Chinese Physics C 2024年第3期48卷 52-64页

作者： G.R.boroun b.Rezaei F.Abdi Department of Physics Razi UniversityKermanshah 67149Iran.

An analytical study with respect to the nonlinear corrections for the nuclear gluon distribution function in the next-to-leading order approximation at small x is *** consider the nonlinear corrections to the nuclear gluon distribution functions at low values of x and Q^(2) using the parametrization F_(2)(x,Q^(2))and the nuclear modification factors obtained from the Khanpour-Soleymaninia-Atashbar-Spiesberger-Guzey *** CT18 gluon distribution is used for the baseline proton gluon density at Q^(2)_(0)=*** discuss the behavior of the gluon densities in the next-to-leading order and the next-to-next-to-leading order approximations at the initial scale Q^(2)_(0),as well as the modifications due to the nonlinear *** find that the QCD nonlinear corrections are more significant for the next-to-leading order accuracy than the next-to-next-to-leading order for light and heavy *** results of the nonlinear GLR-MQ evolution equation are similar to those obtained with the Rausch-Guzey-Klasen gluon upward and downward evolutions within the *** magnitude of the gluon distribution with the nonlinear corrections increases with a decrease in x and an increase in atomic number A.

关键词： gluon distribution nonlinear corrections light and heavy nuclei low x physics

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Falcon Optimization Algorithm-based Energy Efficient Communication Protocol for Cluster-based Vehicular Networks

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Computers, Materials & Continua 2024年第3期78卷 4243-4262页

作者： Youseef Alotaibi b.Rajasekar R.Jayalakshmi Surendran Rajendran Department of Software Engineering College of ComputingUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Electronics and Communication Engineering Sathyabama Institute of Science and TechnologyChennai600119India Department of Computer Science and Engineering Panimalar Engineering CollegeChennai600123India Department of Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical ScienceChennai602105India

Rapid development in Information Technology(IT)has allowed several novel application regions like large outdoor vehicular networks for Vehicle-to-Vehicle(V2V)*** networks give a safe and more effective driving experience by presenting time-sensitive and location-aware *** communication occurs directly between V2V and base Station(bS)units such as the Road Side Unit(RSU),named as a Vehicle to Infrastructure(V2I).However,the frequent topology alterations in VANETs generate several problems with data transmission as the vehicle velocity differs with ***,the scheme of an effectual routing protocol for reliable and stable communications is *** research demonstrates that clustering is an intelligent method for effectual routing in a mobile ***,this article presents a Falcon Optimization Algorithm-based Energy Efficient Communication Protocol for Cluster-based Routing(FOA-EECPCR)technique in *** FOA-EECPCR technique intends to group the vehicles and determine the shortest route in the *** accomplish this,the FOA-EECPCR technique initially clusters the vehicles using FOA with fitness functions comprising energy,distance,and trust *** the routing process,the Sparrow Search Algorithm(SSA)is derived with a fitness function that encompasses two variables,namely,energy and distance.A series of experiments have been conducted to exhibit the enhanced performance of the FOA-EECPCR *** experimental outcomes demonstrate the enhanced performance of the FOA-EECPCR approach over other current methods.

关键词： Vehicular networks communication protocol clustering falcon optimization algorithm routing

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Multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H Salas b M Alotaibi S A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(MSM)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** MSM first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order MSM approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the MSM,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(MSM)and He-MSM to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

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Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 862-876页

作者： Aixiang Wu Zhenqi Wang Zhuen Ruan Raimund bürger Shaoyong Wang Yi Mo Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and Departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatemáticasUniversidad de ConcepciónCasilla 160-CConcepciónChile School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Railway Construction Tongguan Investment Co. Ltd.Tongling 244000China

Cemented paste backfill(CPb)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPb ***,difficult flocculation and substandard concentrations of thickened tailings often *** rheological properties and concentration evolution in the thickened tailings remain ***,traditional indoor thickening experiments have yet to quantitatively characterize their rheological *** experiment of flocculation condition optimization based on the box-behnken design(bbD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of ***,optimal flocculation conditions were *** addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and *** results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under *** order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear *** compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under *** order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear ***,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

关键词： thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration

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Chronic hepatitis b virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

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World Journal of Hepatology 2024年第7期16卷 995-1008页

作者： Nejib Y Ismael Semir A Usmael Nega b belay Hailemichael Desalegn Mekonen Asgeir Johannessen Stian MS Orlien Haramaya University College of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma Institute of Pathobiology Addis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for Imported and Tropical Diseases Oslo University HospitalOslo 0450UllevålNorway Internal Medicine Gastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of Infectious Disease Vestfold Hospital TrustTønsberg 3103Norway Institute of Clinical Medicine Oslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway

bACKGROUND Chronic hepatitis b(CHb)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHb will guide appropriate treatment strategies and improve the control and management of CHb in *** To investigate the characteristics of CHb in Eastern Ethiopia and assess the efficacy and safety of antiviral *** This cohort study included 193 adults who were human immunodeficiency virus-negative with CHb between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHb pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis b envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF *** up measures to prevent and control CHb infections in Ethiopia is crucial.

关键词： Chronic hepatitis b Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa

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Exploring Variability in Sea Level at a Tide Gauge Station through Control Charts

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Journal of Environmental & Earth Sciences 2024年第1期6卷 11-18页

作者： H.bâkiİz Independent Scholar Boca Raton Florida33496USA

Monitoring temporal changes in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random *** them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level *** study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control *** approach is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the *** oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.

关键词： Climate change Sea level variance X-bar S control charts

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