Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

作     者：Nejib Y Ismael Semir A Usmael Nega B Belay Hailemichael Desalegn Mekonen Asgeir Johannessen Stian MS Orlien 

作者机构：Haramaya UniversityCollege of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma Institute of PathobiologyAddis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for Imported and Tropical DiseasesOslo University HospitalOslo 0450UllevålNorway Internal MedicineGastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of Infectious DiseaseVestfold Hospital TrustTønsberg 3103Norway Institute of Clinical MedicineOslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第7期

页      面：995-1008页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by the Norwegian Research Council 220622/H10 

主　　题：Chronic hepatitis B Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa 

摘      要：BACKGROUND Chronic hepatitis B(CHB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHB will guide appropriate treatment strategies and improve the control and management of CHB in *** To investigate the characteristics of CHB in Eastern Ethiopia and assess the efficacy and safety of antiviral *** This cohort study included 193 adults who were human immunodeficiency virus-negative with CHB between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHB pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF *** up measures to prevent and control CHB infections in Ethiopia is crucial.