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Biomedical and Environmental Sciences 1989年第1期2卷 36-43页

作者： ayhan gocmen HENRY A.PETERS DEREK J.CRIPPS GEORGE T.BRYAN CARL R.MORRIS Department of Pediatrics School of Medicine University of Hacettepe 06100 Ankara Turkey Center for Health Sciences University of Wisconsin Madison Wisconsin 53706 International Chemical Consultants Alexandria Virginia 22312

During the period 1955-1959, approximately 4000 people in southeast Anatolia developed porphyria due to the ingestion of hexachlorobenzene (HCB), a fungicide added to wheat seedlings. These HCB exposures subsequently led to the development of bullae on sun-exposed areas, hyperpigmentation, hypertrichosis, and porphyrinuria. The condition was called kara yara or 'black sore.' Many of the breast-fed children under the age of 2 years whose mothers had ingested HCB-treated grain died from a disease known as pembe yara or 'pink sore.' In this follow-up study of 252 patients, 20-30 years postexposure, there were 162 males and 90 females, with an average current age of 35.7 years, an average of onset of 7.6 years, and a duration of 2.2 years. Many patients had dermatologic, neurologic, and orthopedic symptoms and signs. The observed clinical findings include scarring of the face and hands (83.7％), hyperpigmentation (65％), hypertrichosis (44.8％), pinched facies (40.1％), painless arthritis (70.2％), small hands (66.6％), sensory shading (60.6％), myotonia (37.9％), cogwheeling (41.9％), enlarged thyroid (34.9％), and enlarged liver (4.8％). Urine and stool porphyrin levels were determined in all patients, and 17 have at least one of the porphyrins elevated. A total of 56 specimens of human milk obtained from mothers with porphyria were analyzed for HCB. The average value was 0.51 ppm in HCB-exposed patients compared to 0.07 ppm in unexposed controls. Offspring of mothers with three decades of HCB-induced porphyria appear normal. 1989 Academic Press, Inc.

关键词： Hexachlorobenzene Episode in Turkey HCB

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Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children

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中华医学杂志(英文版) 2003年第4期 114-117页

作者： Bahar Arif,Iscan Selim,Karademir Ferhan,gocmen Ismail Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey

To evaluate the efficacy of interferon (IFN) alpha-2b and lamivudine therapy in children with chronic hepatitis B virus (HBV) infection Method Ten children who developed chronic hepatitis B infection received IFN alpha-2b 10 million international units (IU)/m 2 body surface area, subcutaneously three times a week for six months IFN+lamivudine therapy began to be used in the cases who were unresponsive to IFN treatment Results Among 27 HBsAg (+) subjects in this study, interferon treatment was given to 11 subjects who developed chronic hepatitis One case was excluded from the study due to detection of Herpes type 1 encephalitis At the end of six months of follow-up, complete response was obtained in three (30%) patients and partial response in four (40%) patients, whereas no response was detected in three (30%) patients Fifty percent of the cases experienced serological response, 70% biochemical response, and all (100%) had histological response In three cases started concomitant IFN+lamivudine therapy, HBV-DNA became negative at the second month of treatment Conclusions IFN-alpha and lamivudine can be used for the treatment of chronic hepatitis B infection in children

关键词： Hepatitis B · interferon · children · hepati tis B virus · lamivudine

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Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children

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Chinese Medical Journal 2003年第4期116卷 593-596页

作者： Bahar Arif Iscan Selim Karademir Ferhan gocmen Ismail Department of Pediatrics GMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadikyDepartment of PediatricsGMMA Haydarpaa Training HospitalKadiky Istanbul 81327TurkeyIstanbul 81327TurkeyIstanbul 81327TurkeyIstanbul 81327Turkey

关键词： Hepatitis B interferon children hepati tis B virus lamivudine

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Effectiveness of some herbals on initial enamel caries lesion

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 846-850页

作者： Gulcin Bilgin gocmen Funda Yanikoglu Dilek Tagtekin George K.Stookey Bruce R.Schemehorn Osman Hayran Kartal Kosuyolu Education and Research Hospital Department of Restorative Dentistry Marmara University Therametric Technologies Inc. Department of Health Science Istanbul Medipol University

Objective: To evaluate the effectiveness of herbal medicaments such as ginger, rosemary and honey on remineralization of initial enamel ***: Demineralized human enamel specimens were measured for baseline surface microhardness and fluorescence methods. Ten specimens in each of four groups were used in this in vitro recycling study with the following treatments which applied three times a day: 1) sodium fluoride toothpaste(Ipana, Procter & Gamble, Turkey), 2) gingerhoney(Arifoglu Herbals, Anzer Honey, Turkey), 3) ginger-honey-chocolate(Bind Chocolate, Turkey), 4) rosemary oil(Arifoglu Herbals, Turkey). Treatment regimens of demineralization and remineralization cycle were applied for 21 days. The post-treatment data were obtained by measurements of surface microhardness and fluorescence *** were statistically analyzed by ANOVA test with Tukey's honest significant difference ***: Enhanced remineralization was observed with several of the treatment systems including ginger + honey and rosemary. Significant differences between treatments were observed by microhardness and Fluore Cam fluorescence assesment, compared to the positive control group(Na F dentifrice). Significantly, greater remineralization was observed with the honey + ginger treatment regimen. No significant differences between groups were observed using the fluorescence assessment method, quantitative lightinduced ***: Herbals(ginger, honey and rosemary) have enhanced remineralization of initial enamel lesion.

关键词： Remineralization Ginger Rosemary Chocolate Honey FluoreCam QLF Initial enamel lesion

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