Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children
Efficacy of interferon alpha-2b and lamivudine therapy for chronic hepatitis B in children作者机构：Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Department of Pediatrics GMMA Haydarpaa Training Hospital Kadiky Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey Istanbul 81327 Turkey
出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)
年 卷 期：2003年第4期
页 面：114-117页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Hepatitis B · interferon · children · hepati tis B virus · lamivudine
摘 要：To evaluate the efficacy of interferon (IFN) alpha-2b and lamivudine therapy in children with chronic hepatitis B virus (HBV) infection Method Ten children who developed chronic hepatitis B infection received IFN alpha-2b 10 million international units (IU)/m 2 body surface area, subcutaneously three times a week for six months IFN+lamivudine therapy began to be used in the cases who were unresponsive to IFN treatment Results Among 27 HBsAg (+) subjects in this study, interferon treatment was given to 11 subjects who developed chronic hepatitis One case was excluded from the study due to detection of Herpes type 1 encephalitis At the end of six months of follow-up, complete response was obtained in three (30%) patients and partial response in four (40%) patients, whereas no response was detected in three (30%) patients Fifty percent of the cases experienced serological response, 70% biochemical response, and all (100%) had histological response In three cases started concomitant IFN+lamivudine therapy, HBV-DNA became negative at the second month of treatment Conclusions IFN-alpha and lamivudine can be used for the treatment of chronic hepatitis B infection in children
同方期刊数据库