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Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： Shah Alam Khan Neelima Shrivastava MdJawaid Akhtar Aftab Ahmad asif husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas

PI3K signaling pathway targeting by using different molecular approaches to treat cancer

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Journal of Chinese Pharmaceutical Sciences 2017年第9期26卷 621-634页

作者： Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad asif husain Ravinesh Mishra Department of Pharmaceutical Chemistry and Pharmacognosy College of Pharmacy and DentistryBuraydah CollegesAl-Qassim 31717Kingdom of Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyJamia Hamdard(Hamdard University)Hamdard NagarNew Delhi-110062India Institute of Pharmacy&Emerging Sciences Baddi University of Emerging Science&TechnologyMakhnumajraBaddiSolan-173205Himachal Pradeshlndia

Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment.

关键词： PI3K AKT mTOR PDK-1 Tumor Suppressor PTEN Signal Pathway

Performance Analysis of Hybrid Wireless Network in Underground Tunnels

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Performance Analysis of Hybrid Wireless Network in Undergrou...

作者：阿西夫（asif husain）西安科技大学

学位级别：硕士

隧道环境对可靠的无线通信网络的需求是巨大的,这意味为了提供更好的服务,网络需要具有可监测,安全和流量控制的特点。由于受到波导效应的影响,隧道环境往往复杂且受到各种条件的制约。在不同的陆路介质中,隧道中的无线信号具有不同的...

隧道环境对可靠的无线通信网络的需求是巨大的,这意味为了提供更好的服务,网络需要具有可监测,安全和流量控制的特点。由于受到波导效应的影响,隧道环境往往复杂且受到各种条件的制约。在不同的陆路介质中,隧道中的无线信号具有不同的衰减系数和传播效果,所以,在优化无线通信网络之前,模型化隧道特点是至关重要的。首先,本文将研究隧道网络的主要信道特性,以分析射频网络在2.4GHz,3.5GHz和5.8GHz等不同频率下的射频信号传播。为了比较不同频率在隧道中的性能,本文会计算每种情况下的衰减情况。其次,本文研究了接收端的信号强度,以验证隧道中基于射频的无线网络的可行性。隧道表面大多是粗糙的,因此还将对衍射损耗进行建模以分析隧道拐角附近的信号损耗。为了分析隧道中的光无线通信的性能,本文将在设定的距离处计算信号强度,以检查光无线通信在隧道中的可行性。最后,提出了一种基于射频和光链路的混合系统,并在隧道环境下对射频和光网络的性能进行了比较。为了克服由于不同的衰减系数而导致的数据丢失问题,当一个通道观测到信号丢失而其他通道正常工作时,混合射频/光学系统将发挥作用,保持通道的一致性。实验证明,该混合系统是改善地下隧道网络通信的理想选择。

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Chemical modification of acetaminophen：PASS assisted in vivo antiinflammatory activity of chalcones,flavanones and Schiff bases

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Journal of Chinese Pharmaceutical Sciences 2017年第8期26卷 611-620页

作者： Syed Misbahul Hasan Shah Alam Khan Kavita Golani Jaswinder Lamba Aftab Ahmad asif husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and Research Jamia Hamdard (Hamdard University)New Delhi 110062 India Faculty of Pharmacy Integral University Lucknow UP 226026 India Department of Pharmacy Oman Medical College PO Box 620 Postal code-130 Muscat Sultanate of Oman Health Information Technology Department Jeddah Community College King Abdulaziz University deddah Kingdom of Saudi Arabia

In the present study,synthetic chalcones,flavanones and Schiff bases were prepared starting from paraceamol,and evaluated their anticipated anti-inflammatory *** were synthesized by reacting 3-acetyl-4-hydroxy acetanilide and aromatic aldehydes in alcoholic potassium hydroxide(KOH) solution under Claisen-Schmidt condensation *** chalcones were cyclized in the presence of piperidine in isoamyl alcohol to obtain flavonone *** bases were synthesized by condensing 3-acetyl-4-hydroxy anilines with aromatic aldehydes in the presence of *** Schiff bases were further reacted with other aromatic aldehydes in alcoholic KOH *** cheminformatics software was used to predict the anti-inflammatory activity of synthesized *** software predicted that chalcone-based Schiff bases 6a–d contained structural features that can exhibit anti-inflammatory *** the prepared derivatives of acetaminophen exhibited moderate to excellent in vivo anti-inflammatory activity in carrageenan-induced edema in rat *** the Schiff bases coupled chalcones showed good anti-inflammatory activity compared with the reference drug,*** evaluation of their therapeutic potential and safety profile is required in the future study.

关键词： p-Acetaminophen Anti-inflammatory Chalcone Flavanone

Quantification of total phenol,flavonoid content and pharmacognostical evaluation including HPTLC fingerprinting for the standardization of Piper nigrum Linn fruits

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Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 101-107页

作者： Aftab Ahmad asif husain Mohd Mujeeb Shah Alam Khan Hani Abdullah Anber Alhadrami Anil Bhandari Health Information Technology Department Jeddah Community CollegeKing Abdulaziz University Faculty of Pharmaceutical Sciences Jodhpur National University Department of Pharmaceutical Chemistry Faculty of PharmacyJamia Hamdard.New DelhiIndia Department of Pharmacognosy Faculty of PharmacyJamia HamdardNew Delhi.India Department of Pharmacy Oman Medical College Department of Medical Laboratory Technology Faculty of Applied Medical ScienceKing Abdulaziz University

Objective:To carry out the physicochemical and phytochemical standardization with high performance thin layer chromatography fingerprinting of Piper nigrum L.(***)fruits in order to ascertain the standard pharmacognostical parameters of this king of ***:Many standardization parameters like extractive values,total ash value,water soluble ash value and acid insoluble ash,moisture content,loss on drying and pH values of *** *** were *** method of Harborne was adopted for the preliminary phytochemicals *** of total phenolic and flavonoid contents,pesticides residues,aflatoxin and heavy metals were also ***-high performance thin layer chromatography system was used for fingerprinting of methanolic extract of *** ***:The results of phytochemicals testing indicated the presence of carbohydrates,phenolic compounds,flavonoids,alkaloids,proteins,saponins,lipids,sterols and tannins in various solvent *** phenolic and flavonoid contents in methanolic extract were found to be 1.728 1 mg/g and 1.087 ug/g,*** metals concentrations were found to be within standard *** and pesticides residues were ***:The outcome of this study might prove beneficial in herbal industries for identification,purification and standardization of *** ***.

关键词： Piper nigrum L.fruits Piperaceae HPTLC fingerprint Black pepper

A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 147-155页

作者： Aftab Ahmad Mohammed F.Abuzinadah Huda M.Alkreathy Hussam I.Kutbi Noor Ahmad Shaik Varish Ahmad Shakir Saleem asif husain Health Information Technology Department Faculty of Applied StudiesKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityP.O.Box 80402 Jeddah-21589JeddahKingdom of Saudi Arabia Department of Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Genetic Medicine Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Public Health College of Health SciencesSaudi Electronic UniversityRiyadhKingdom of Saudi Arabia Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi110062India

Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in ***:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four *** levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were *** dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue *** histopathological study of liver and kidney tissues was also ***:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(P<0.001)while total protein was considerably reduced in the CCl4 group as compared to the normal control(P<0.001),which indicated hepatorenal *** addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.001)while malondialdehyde levels were increased markedly(P<0.001).Treatment with BSVT formulation recovered these parameters towards a normal level in a dose-dependent ***:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent ***,clinical studies are required to confirm its efficacy.

关键词： Boerhavia diffusa Solidago virgaurea Vitex negundo Thymoquinone Cystone^(█) Carbon tetrachloride Hepatorenal

Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fuids

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Journal of Pharmaceutical Analysis 2013年第5期3卷 341-348页

作者： Jamshed Haneef Mohammad Shaharyar asif husain Mohd Rashid Ravinesh Mishra Shama Parveen Niyaz Ahmed Manoj Pal Deepak Kumar Department of Pharmaceutical Chemistry Faculty of Pharmacy Jamia Hamdard (Hamdard University) Department of Chemistry Indian Institute of Technology (IIT) Research Institute of Natural Sciences Department of Chemistry Changwon National University

Liquid chromatography tandem mass chromatography （LC-MS/MS） is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because of high sensitivity and selectivity, LC-MS/MS has been used for pharmacokinetic studies, metabolites identification in the plasma and urine. This manuscript gives comprehensive analytical review, focusing on chromatographic separation approaches （column packing materials, column length and mobile phase） as well as different acquisition modes （SIM, MRM） for quantitative analysis of glucocorticoids and stimulants. This review is not meant to be exhaustive but rather to provide a general overview for detection and confirmation of target drugs using LC-MS/MS and thus useful in the doping analysis, toxicological studies as well as in pharmaceutical analysis.

关键词： LC–MS/MS Ionization techniques Glucocorticoids Stimulants Hyphenated techniques Biological fuid

A review on therapeutic potential of Nigella sativa:A miracle herb

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 337-352页

作者： Aftab Ahmad asif husain Mohd Mujeeb Shah Alam Khan Abul Kalam Najmi Nasir Ali Siddique Zoheir A.Damanhouri Firoz Anwar Health Information Technology Department Jeddah Community CollegeKing Abdulaziz University Department of Pharmaceutical Chemistry Faculty of PharmacyHamdard University Department of Pharmacognosy Faculty of PharmacyHamdard University Oman Medical College Department of Pharmacology Faculty of PharmacyHamdard University Department of Pharmacognosy College of PharmacyKing Saud University Department of Pharmacology Faculty of MedicineKing Abdulaziz University Siddhartha Institute of Pharmacy

Nigella sativa(***)(Family Ranunculaceae)is a widely used medicinal plant throughout the *** is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and *** and oil have a long history of folklore usage in various systems of medicines and *** seeds of *** have been widely used in the treatment of different diseases and *** Islamic literature,it is considered as one of the greatest forms of healing *** has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin *** studies on *** have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,*** to its miraculous power of healing,*** has got the place among the top ranked evidence based herbal *** is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential *** present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant.

关键词： Nigella sativa Miracle herb Ranunculaceae Habat-ul-Sauda Thymoquinone Tibb-e-Nabwi Black seeds Anti-diabetic Antioxidant

Eslicarbazepine acetate:A therapeutic agent of paramount importance in acute anticonvulsant therapy

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Journal of Acute Disease 2017年第6期6卷 245-254,253页

作者： Farah Iram Shah Alam Khan Aftab Ahmad Anees A.Siddiqui asif husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi-110062India Department of Pharmacy Oman Medical CollegeMuscatSultanate of Oman Health Information Technology Department Jeddah Community CollegeKing Abdulaziz UniversityP.O.Box-80283Jeddah-21589Kingdom of Saudi Arabia

Eslicarbazepine acetate (ESL) is a new, once daily, orally administered, third generation antiepileptic drug which is indicated in the treatment of partial-onset seizures. ESL is known to exert it's anticonvulsant effect by blocking the voltage-gated sodium channels. Several clinical trials and pharmacological studies have revealed that seizure control was better with ESL monotherapy (1 200 or 1 600 mg once daily) following a switch from other antiepileptic drugs in comparison with pseudo-placebo patients. The studies have indicated the ESL to be well tolerated and produced only mild to moderate emergent adverse events with the therapy. Being a dibenzazepine family member, structure and chemistry of ESL resembles more or less to carbamazepine and oxcarbazepine. ESL differs structurally from carbamazepine and oxcarbazepine at the 10, 11 position of dibenazepine nucleus. This molecular variation results in differences in metabolism and thus helps to prevent the formation of toxic epoxide metabolites. ESL following oral administration is rapidly metabolised to active metabolite namely S-licarbazepine which is responsible for its pharmacological activity. ESL exhibits acceptable pharmacokinetic profile and shows insignificant drug-drug interactions. In phase III clinical program, ESL was found to be efficacious and well tolerated in adult patients with partial onset seizures previously not controlled with treatment with one or two other antiepileptic drugs.

关键词： Eslicarbazepine acetate Partial-onset seizures Epilepsy Antiepileptic drugs Drug interactions