Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections
作者机构：Department of Pharmaceutical ChemistryCollege of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND)Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical ChemistrySchool of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technologythe Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2024年第17卷第7期
页 面：285-298,I0001-I0007页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Ebola Epidemic Vaccine Ebola virus diseas
摘 要：Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.
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