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Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 21-29页

作者： Keitaro Hayashi Naohiko anzai Department of Pharmacology and Toxicology Dokkyo Medical University School of Medicine Department of Pharmacology Chiba University Graduate School of Medicine

L-type amino acid transporters(LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs(LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1(SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.

关键词： LAT1 Amino acid transporter Molecular target drug Amino acid starvation response Signal transduction

Quantitative evaluation of die casting surface defect severity by analyzing surface height

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China Foundry 2017年第5期14卷 339-345页

作者： Yan Xu Naoya Hirata Koichi anzai Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-85 79Japan

It is necessary in factories to assess the severity of the surface defects of castings, as a slight surface defect will be taken as qualified when it brings no bad effect or it can be removed by the subsequent processing. In practical production, professional technicians visually inspect the surface defect severity according to their individual experience. Therefore, it is difficult for them to maintain the same standard and accuracy in the subjective, tedious and labor-intensive work. Recently, image processing techniques based on optical images have been applied to achieve better accuracy and high efficiency. Unfortunately, optical images cannot directly quantify surface depth, which works as a crucial factor in the practical assessment of surface defect severity. The surface roughness evaluation algorithm, which takes into account of both area and depth information of the assessed surface, was applied to directly characterize surface defect severity based on surface asperity rather than optical image. The results using standard casting pieces show that surface defect severity has no apparent dependence on surface roughness. However, the subsequent results show that the root-mean-squared-deviation(RMSD) of surface gradient of flow line defects positively correlates with the increase of defect severity. The other types of defect do not present such tendency. Thus, practical workpieces with flow line defects on the surface were used to verify the universality of this tendency. The results show that surface roughness of an unqualified workpiece is larger than that of a qualified workpiece after surface slope adjustment, but presents no obvious coincidence before the adjustment. In contrast, the RMSD of an unqualified workpiece, no matter before or after the adjustment, is larger than that of a qualified one.

关键词： die casting surface defect surface roughness

To develop a quantitative method for predicting shrinkage porosity in squeeze casting

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China Foundry 2009年第1期6卷 53-56页

作者： Shaomin Li Kenichiro Mine Shinji Sanakanishi Koichi anzai Ahresty Corporation Toyohashi Japan Tohoku University Sendai Japan

In order to secure high strength and high elongation of suspension parts,it is critical to predict shrinkage porosity quantitatively.A new simulation method for quantitative prediction of shrinkage porosity when replenishing molten metal has been proposed for squeeze casting *** examine the accuracy of the calculation model,the proposed method was applied to a plate model.

关键词： quantitative prediction shrinkage porosity simulation squeeze casting

Visual localization for asteroid touchdown operation based on local image features

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Astrodynamics 2020年第2期4卷 149-161页

作者： Yoshiyuki anzai Takehisa Yairi Naoya Takeishi Yuichi Tsuda Naoko Ogawa The University of Tokyo Tokyo113-8654Japan RIKEN Center for Advanced Intelligence Project Tokyo103-0027Japan Japan Aerospace Exploration Agency Sagamihara252-5210Japan

In an asteroid sample-return mission,accurate position estimation of the spacecraft relative to the asteroid is essential for landing at the target *** the missions of Hayabusa and Hayabusa2,the main part of the visual position estimation procedure was performed by human operators on the Earth based on a sequence of asteroid images acquired and sent by the *** this approach is still adopted in critical space missions,there is an increasing demand for automated visual position estimation,so that the time and cost of human intervention may be *** this paper,we propose a method for estimating the relative position of the spacecraft and asteroid during the descent phase for touchdown from an image sequence using state-of-the-art techniques of image processing,feature extraction,and structure from *** apply this method to real Ryugu images that were taken by Hayabusa2 from altitudes of 20 km-500 *** is demonstrated that the method has practical relevance for altitudes within the range of 5-1 *** result indicates that our method could improve the efficiency of the ground operation in the global mapping and navigation during the touchdown sequence,whereas full automation and autonomous on-board estimation are beyond the scope of this ***,we discuss the challenges of developing a completely automatic position estimation framework.

关键词： visual navigation structure from motion asteroid touchdown Hayabusa2

Genetic diversity in Japanese populations of the Eurasian Collared Dove

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Avian Research 2020年第2期11卷 133-138页

作者： Kazuya Nagai Yusuke Takahashi Ken‑ichi Tokita Tomomi anzai Kiyoshi Uchida Fumihito Nakayama Faculty of Agriculture Iwate UniversityMoriokaIwate 020‑8550Japan Research and Education Centre for Natural Sciences Keio UniversityYokohamaKanagawa 223‑8521Japan Japan Wildlife Research Centre KotoTokyo 130‑8606Japan Satoyama Natural History Study Group AbikoChiba 270‑1153Japan.

Background:Eurasian Collared Dove(Streptopelia decaocto)is a species distributed in the Eurasian continent and North Africa,and inhabiting mainly in Saitama Prefecture in *** Collared Dove is one of the most prosper-ous invaders in the world,and Japanese Eurasian Collared Dove has also been introduced from *** Japa-nese population has declined to one-hundredth over 30 years and is being *** this study,we analyzed its genetic diversity in order to understand the genetic differences between wild populations of Eurasian Collared Dove and those bred in ***:A sequence of about 1.9 kb mtDNA was determined for 20 wild Eurasian Collared Doves living in Saitama,Japan and 20 zoo-bred Eurasian Collared Doves,and population genetic analysis was ***:In the COI gene,778 bp had the same sequence in all the 40 individuals examined,and no mutation sites could be *** the control region,two base substitution sites were confirmed in 1140 bp long *** haplotypes were detected in 20 individuals in wild,whereas all 20 zoo-bred individuals possessed the same haplotypes possessed in the wild ***:Haplotypes of zoo-bred individuals were also retained among the wild individuals,confirming that no genetic problems could occur if the zoo-bred individuals were released to the wild for the Japanese Eurasian Collared Dove propagation program.

关键词： COI Control region Eurasian Collared Dove Genetic diversity mtDNA Phylogeography

Voltammetric response of ferroceneboronic acid to diol and phenolic compounds as possible pollutants

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Journal of Environmental Sciences 2011年第6期23卷 1027-1032页

作者： Shigehiro Takahashi Naoyuki Abiko Nobuhiro Haraguchi Hiroyuki Fujita Eriko Seki Tetsuya Ono Kentaro Yoshida Jun-ichi anzai Graduate School of Pharmaceutical Sciences Tohoku UniversityAramakiAoba-kuSendai 980-8578Japan School of Pharmaceutical Sciences Ohu University31-1 MisumidoTomita-machiKoriyamaFukushima 963-8611Japan

A voltammetric determination of possible organic pollutants such as diol and phenolic compounds in water was studied using ferroceneboronic acid（FBA） as a redox-active marker.A cyclic voltammogram of FBA exhibited a pair of oxidation and reduction peaks at 230 and 170 mV at pH 7.0,respectively,while another pair of redox peaks was observed in the presence of diol or phenolic compounds *** results were rationalized based on the formation of boronate esters of FBA with the added *** changes in the redox peak currents were dependent on the concentration of the additives,suggesting a usefulness of FBA in the electrochemical determination of these compounds in water.

关键词： ferroceneboronic acid sugar phenolic compound cyclic voltammetry pollutants in water electrochemical determination

Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 17-28页

作者： Kun Peng Aike Qiao Makoto Ohta Narendra Kurnia Putra Xinyang Cui Yongliang Mu Hitomi anzai College of Life Science and Bioengineering Beijing University of TechnologyNo.100PingleyuanChaoyang DistrictBeijing100022China Institute of Fluid Science Tohoku UniversitySendaiMiyagi980-85777 Japan Institute of Metallurgical Research Northeastern UniversityShenyangLiaoning110819China

Biodegradable zinc alloy stents are a prospective solution for complications caused by the incompatibility between artery and permanent ***,insufficient scaffolding has limited the clinical application of biodegradable zinc alloy ***,in this study,a new stent concept was designed to improve the *** mechanical performances of the new and a traditional design stent were investigated and compared using finite element analysis(FEA).The new and traditional design stent were expanded to the intended radial displacement of 0.24 mm under the expansion pressure of 0.58 MPa and 0.45 MPa,***,a pressure load of 0.35 MPa was exerted on the outer surfaces of the two stents to compress *** results showed that the radial recoiling ratio were 45.3%and 83.3%for the new and the traditional stent,*** simulations demonstrate that the biodegradable zinc alloy stent offers enhanced support because of the new structural *** study implies that biodegradable zinc alloy stent can be a new competitive intervention device for the future clinical cardiovascular application.

关键词： Biodegradable stent design finite element analysis

A ferrocene-mediated anti-interfering glucose biosensor based on glutin and cellulose acetate

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High Technology Letters 2006年第3期12卷 263-266页

作者：吴宝艳 Li Jing Shi Haibin Huang Jiadong anzai Jun-ichi Osa Tetsuo Chen Qiang College of Life Seienees Nankai University Tianjin 300071. P.R. China Graduate School of Pharnlaceutical Sciences Tohoku University Sendai 9808578 Japan

A ferrocene-mediated glucose biosensor removing interference of ascorbic acid and uric acid was developed by coating of ferrocene, glutin and cellulose acetate on screen-printed gold electrode surface. The resuhs show that it can detect glucose sensitively in the presence of uric acid and ascorbic acid, and also suppress the leakage velocity of fcrrocene. Compared to the currents of the pretreated electrode, it decreases the current of uric acid and ascorbic acid by 99.4% and 98.8% at 400 mV, respectively, with a dynamic range of 0 - 30 mM for glucose, sensitivity of 30.73 nA/mM, response time of 10 s, and correlation coefficient of 0.998 8.

关键词： glucose biosensor anti-interferefering ferrocene glutin cellulose acetate

THE ELECTROCHEMISTRIC CHARACTERISTICS OF CHOLINE BIOSENSORS BASED THE POLYELECTROLYTE/CHOLINE OXIDASE FILMS CONSTRUCTED BY THE LAYER-BY-LAYER TECHNIQUE

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THE ELECTROCHEMISTRIC CHARACTERISTICS OF CHOLINE BIOSENSORS ...